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Items: 1 to 50 of 171

1.

Improved Oxygen Supply to Multicellular Spheroids Using A Gas-permeable Plate and Embedded Hydrogel Beads.

Mihara H, Kugawa M, Sayo K, Tao F, Shinohara M, Nishikawa M, Sakai Y, Akama T, Kojima N.

Cells. 2019 May 31;8(6). pii: E525. doi: 10.3390/cells8060525.

2.

Preferential expression of sialyl 6'-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes.

Tsutsumiuchi M, Hoshino H, Kogami A, Tsutsumiuchi T, Yokoyama O, Akama TO, Kobayashi M.

Lab Invest. 2019 May 31. doi: 10.1038/s41374-019-0267-0. [Epub ahead of print]

PMID:
31148596
3.

GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain.

Narentuya, Takeda-Uchimura Y, Foyez T, Zhang Z, Akama TO, Yagi H, Kato K, Komatsu Y, Kadomatsu K, Uchimura K.

Sci Rep. 2019 Mar 13;9(1):4387. doi: 10.1038/s41598-019-40901-2.

4.

Developmental and age-related changes to the elastic lamina of Bruch's membrane in mice.

Mori H, Yamada H, Toyama K, Takahashi K, Akama T, Inoue T, Nakamura T.

Graefes Arch Clin Exp Ophthalmol. 2019 Feb;257(2):289-301. doi: 10.1007/s00417-018-4184-5. Epub 2018 Nov 29.

PMID:
30498857
5.

Fibro-Adipogenic Remodeling of the Diaphragm in Obesity-Associated Respiratory Dysfunction.

Buras ED, Converso-Baran K, Davis CS, Akama T, Hikage F, Michele DE, Brooks SV, Chun TH.

Diabetes. 2019 Jan;68(1):45-56. doi: 10.2337/db18-0209. Epub 2018 Oct 25.

6.

Medical services at the 2017 Sapporo Asian winter games: injury and illness epidemiology at a 34-nation multisport event.

Watanabe K, Akama T, Asakawa S, Fukuda K, Sakai H, Okuwaki T, Imai T, Sato H, Katayose M, Jegathesan M, Shamali NA.

Br J Sports Med. 2019 Jan;53(1):32-36. doi: 10.1136/bjsports-2018-099061. Epub 2018 Oct 12.

PMID:
30315117
7.

The prevalence of anemia in Japanese Universiade athletes, detected with longitudinal preparticipation medical examinations.

Komatsu T, Yamasawa F, Dohi M, Akama T, Masujima A, Kono I, Kawahara T.

J Gen Fam Med. 2018 Mar 23;19(3):102-108. doi: 10.1002/jgf2.164. eCollection 2018 May.

8.

Keratan Sulfate Phenotype in the β-1,3-N-Acetylglucosaminyltransferase-7-Null Mouse Cornea.

Littlechild SL, Young RD, Caterson B, Yoshida H, Yamazaki M, Sakimura K, Quantock AJ, Akama TO.

Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1641-1651. doi: 10.1167/iovs.17-22716.

9.

Transcription factor 21 (TCF21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells.

Akama T, Chun TH.

J Biol Chem. 2018 Apr 27;293(17):6603-6610. doi: 10.1074/jbc.RA117.000456. Epub 2018 Mar 14.

10.

All-electron relativistic computations on the low-lying electronic states, bond length, and vibrational frequency of CeF diatomic molecule with spin-orbit coupling effects.

Kondo Y, Kobayashi M, Akama T, Noro T, Taketsugu T.

J Comput Chem. 2018 Jun 15;39(16):964-972. doi: 10.1002/jcc.25171. Epub 2018 Jan 30.

11.

Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT).

Akama T, Zhang YK, Freund YR, Berry P, Lee J, Easom EE, Jacobs RT, Plattner JJ, Witty MJ, Peter R, Rowan TG, Gillingwater K, Brun R, Nare B, Mercer L, Xu M, Wang J, Liang H.

Bioorg Med Chem Lett. 2018 Jan 1;28(1):6-10. doi: 10.1016/j.bmcl.2017.11.028. Epub 2017 Nov 20.

12.

Schottky solar cell using few-layered transition metal dichalcogenides toward large-scale fabrication of semitransparent and flexible power generator.

Akama T, Okita W, Nagai R, Li C, Kaneko T, Kato T.

Sci Rep. 2017 Sep 20;7(1):11967. doi: 10.1038/s41598-017-12287-6.

13.

Case of toxic shock syndrome triggered by negative-pressure wound therapy.

Tomura Y, Osada SI, Akama T, Hasunuma N, Nakae H, Manabe M.

J Dermatol. 2017 Dec;44(12):e315-e316. doi: 10.1111/1346-8138.14014. Epub 2017 Sep 1. No abstract available.

PMID:
28862320
14.

Changes in Stress and Appetite Responses in Male Power-Trained Athletes during Intensive Training Camp.

Oshima S, Takehata C, Sasahara I, Lee E, Akama T, Taguchi M.

Nutrients. 2017 Aug 21;9(8). pii: E912. doi: 10.3390/nu9080912.

15.

Membrane-Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limits the Progression of Proliferative Atherosclerotic Lesions.

Barnes RH 2nd, Akama T, Öhman MK, Woo MS, Bahr J, Weiss SJ, Eitzman DT, Chun TH.

J Am Heart Assoc. 2017 Jul 22;6(7). pii: e003693. doi: 10.1161/JAHA.116.003693.

16.

Yoga stretching for improving salivary immune function and mental stress in middle-aged and older adults.

Eda N, Ito H, Shimizu K, Suzuki S, Lee E, Akama T.

J Women Aging. 2018 May-Jun;30(3):227-241. doi: 10.1080/08952841.2017.1295689. Epub 2017 Apr 3.

PMID:
28368782
17.

Latent TGF-β binding protein 2 and 4 have essential overlapping functions in microfibril development.

Fujikawa Y, Yoshida H, Inoue T, Ohbayashi T, Noda K, von Melchner H, Iwasaka T, Shiojima I, Akama TO, Nakamura T.

Sci Rep. 2017 Mar 2;7:43714. doi: 10.1038/srep43714.

18.

Designing 3-D Adipospheres for Quantitative Metabolic Study.

Akama T, Leung BM, Labuz J, Takayama S, Chun TH.

Methods Mol Biol. 2017;1566:177-183. doi: 10.1007/978-1-4939-6820-6_17.

19.

A Novel Role for Flotillin-Containing Lipid Rafts in Negative-Feedback Regulation of Thyroid-Specific Gene Expression by Thyroglobulin.

Luo Y, Akama T, Okayama A, Yoshihara A, Sue M, Oda K, Hayashi M, Ishido Y, Hirano H, Hiroi N, Katoh R, Suzuki K.

Thyroid. 2016 Nov;26(11):1630-1639.

PMID:
27676653
20.

Novel magnetic indenter for rheological analysis of thin biological sheet for regenerative medicine.

Kageshima M, Maruyama T, Akama T, Nakamura T.

Rev Sci Instrum. 2016 Jul;87(7):074302. doi: 10.1063/1.4959268.

PMID:
27475573
21.

Phosphatidylinositol 3-Kinase-Associated Protein (PI3KAP)/XB130 Crosslinks Actin Filaments through Its Actin Binding and Multimerization Properties In Vitro and Enhances Endocytosis in HEK293 Cells.

Yamanaka D, Akama T, Chida K, Minami S, Ito K, Hakuno F, Takahashi S.

Front Endocrinol (Lausanne). 2016 Jul 11;7:89. doi: 10.3389/fendo.2016.00089. eCollection 2016.

22.

Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes.

Dong C, Virtucio C, Zemska O, Baltazar G, Zhou Y, Baia D, Jones-Iatauro S, Sexton H, Martin S, Dee J, Mak Y, Meewan M, Rock F, Akama T, Jarnagin K.

J Pharmacol Exp Ther. 2016 Sep;358(3):413-22. doi: 10.1124/jpet.116.232819. Epub 2016 Jun 27.

PMID:
27353073
23.

Ageing and free-living daily physical activity effects on salivary beta-defensin 2 secretion.

Shimizu K, Hanaoka Y, Akama T, Kono I.

J Sports Sci. 2017 Apr;35(7):617-623. doi: 10.1080/02640414.2016.1182640. Epub 2016 May 30.

PMID:
27237844
24.

Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide.

Zhang YK, Plattner JJ, Easom EE, Akama T, Zhou Y, White WH, Defauw JM, Winkle JR, Balko TW, Cao J, Ge Z, Yang J.

Bioorg Med Chem Lett. 2016 Jul 1;26(13):3182-3186. doi: 10.1016/j.bmcl.2016.04.093. Epub 2016 May 7.

PMID:
27210432
25.

Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide.

Zhang YK, Plattner JJ, Easom EE, Zhou Y, Akama T, Bu W, White WH, Defauw JM, Winkle JR, Balko TW, Guo S, Xue J, Cao J, Zou W.

Bioorg Med Chem Lett. 2015 Dec 1;25(23):5589-93. doi: 10.1016/j.bmcl.2015.10.044. Epub 2015 Oct 23.

PMID:
26508546
26.

Development of efficient time-evolution method based on three-term recurrence relation.

Akama T, Kobayashi O, Nanbu S.

J Chem Phys. 2015 May 28;142(20):204104. doi: 10.1063/1.4921465.

PMID:
26026431
27.

Coenzyme Q10 supplementation downregulates the increase of monocytes expressing toll-like receptor 4 in response to 6-day intensive training in kendo athletes.

Shimizu K, Kon M, Tanimura Y, Hanaoka Y, Kimura F, Akama T, Kono I.

Appl Physiol Nutr Metab. 2015 Jun;40(6):575-81. doi: 10.1139/apnm-2014-0556. Epub 2015 Jan 27.

PMID:
25941765
28.

The exocyst complex regulates free fatty acid uptake by adipocytes.

Inoue M, Akama T, Jiang Y, Chun TH.

PLoS One. 2015 Mar 13;10(3):e0120289. doi: 10.1371/journal.pone.0120289. eCollection 2015.

29.

Development of pro-apoptotic peptides as potential therapy for peritoneal endometriosis.

Sugihara K, Kobayashi Y, Suzuki A, Tamura N, Motamedchaboki K, Huang CT, Akama TO, Pecotte J, Frost P, Bauer C, Jimenez JB Jr, Nakayama J, Aoki D, Fukuda MN.

Nat Commun. 2014 Jul 22;5:4478. doi: 10.1038/ncomms5478.

30.

Use of supplements by Japanese elite athletes for the 2012 Olympic Games in London.

Sato A, Kamei A, Kamihigashi E, Dohi M, Akama T, Kawahara T.

Clin J Sport Med. 2015 May;25(3):260-9. doi: 10.1097/JSM.0000000000000118.

PMID:
24942621
31.

Latent TGF-β binding protein-2 is essential for the development of ciliary zonule microfibrils.

Inoue T, Ohbayashi T, Fujikawa Y, Yoshida H, Akama TO, Noda K, Horiguchi M, Kameyama K, Hata Y, Takahashi K, Kusumoto K, Nakamura T.

Hum Mol Genet. 2014 Nov 1;23(21):5672-82. doi: 10.1093/hmg/ddu283. Epub 2014 Jun 6.

32.

Thyroglobulin increases thyroid cell proliferation via the suppression of specific microRNAs.

Akama T, Luo Y, Sellitti DF, Kawashima A, Tanigawa K, Yoshihara A, Ishido Y, Nakamura K, Tanoue A, Suzuki K.

Mol Endocrinol. 2014 Mar;28(3):368-79. doi: 10.1210/me.2013-1266. Epub 2014 Jan 30.

33.

The effects of Lactobacillus pentosus strain b240 and appropriate physical training on salivary secretory IgA levels in elderly adults with low physical fitness: a randomized, double-blind, placebo-controlled trial.

Shimizu K, Sato H, Suga Y, Yamahira S, Toba M, Hamuro K, Kakumoto K, Kohda N, Akama T, Kono I, Kuno S.

J Clin Biochem Nutr. 2014 Jan;54(1):61-6. doi: 10.3164/jcbn.13-62. Epub 2013 Nov 26.

34.

Leprosy as a model of immunity.

Degang Y, Nakamura K, Akama T, Ishido Y, Luo Y, Ishii N, Suzuki K.

Future Microbiol. 2014;9(1):43-54. doi: 10.2217/fmb.13.140.

PMID:
24328380
35.

Effects of High-Intensity Endurance Exercise on Epidermal Barriers against Microbial Invasion.

Eda N, Shimizu K, Suzuki S, Lee E, Akama T.

J Sports Sci Med. 2013 Mar 1;12(1):44-51. eCollection 2013.

36.

Discovery and structure-activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents.

Akama T, Dong C, Virtucio C, Freund YR, Chen D, Orr MD, Jacobs RT, Zhang YK, Hernandez V, Liu Y, Wu A, Bu W, Liu L, Jarnagin K, Plattner JJ.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5870-3. doi: 10.1016/j.bmcl.2013.08.096. Epub 2013 Sep 6.

PMID:
24075731
37.

Linking phenotype to kinase: identification of a novel benzoxaborole hinge-binding motif for kinase inhibition and development of high-potency rho kinase inhibitors.

Akama T, Dong C, Virtucio C, Sullivan D, Zhou Y, Zhang YK, Rock F, Freund Y, Liu L, Bu W, Wu A, Fan XQ, Jarnagin K.

J Pharmacol Exp Ther. 2013 Dec;347(3):615-25. doi: 10.1124/jpet.113.207662. Epub 2013 Sep 18.

PMID:
24049062
38.

Design of tiling arrays and their application to bacterial transcriptome analysis.

Akama T, Nakamura K, Tanoue A, Suzuki K.

Methods Mol Biol. 2013;1067:23-34. doi: 10.1007/978-1-62703-607-8_2.

PMID:
23975783
39.

Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans.

Sugihara K, Shibata TK, Takata K, Kimura T, Kanayama N, Williams R, Hatakeyama S, Akama TO, Kuo CW, Khoo KH, Fukuda MN.

FEBS Lett. 2013 Oct 1;587(19):3195-201. doi: 10.1016/j.febslet.2013.07.056. Epub 2013 Aug 19.

40.

Effects of yoga exercise on salivary beta-defensin 2.

Eda N, Shimizu K, Suzuki S, Tanabe Y, Lee E, Akama T.

Eur J Appl Physiol. 2013 Oct;113(10):2621-7. doi: 10.1007/s00421-013-2703-y. Epub 2013 Aug 8.

PMID:
23925803
41.

Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.

Akama T, Virtucio C, Dong C, Kimura R, Zhang YK, Nieman JA, Sharma R, Lu X, Sales M, Singh R, Wu A, Fan XQ, Liu L, Plattner JJ, Jarnagin K, Freund YR.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1680-3. doi: 10.1016/j.bmcl.2013.01.072. Epub 2013 Jan 29.

PMID:
23411072
42.

Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5.

Noda K, Dabovic B, Takagi K, Inoue T, Horiguchi M, Hirai M, Fujikawa Y, Akama TO, Kusumoto K, Zilberberg L, Sakai LY, Koli K, Naitoh M, von Melchner H, Suzuki S, Rifkin DB, Nakamura T.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2852-7. doi: 10.1073/pnas.1215779110. Epub 2013 Feb 4.

43.

Discovery of a novel class of boron-based antibacterials with activity against gram-negative bacteria.

Hernandez V, Crépin T, Palencia A, Cusack S, Akama T, Baker SJ, Bu W, Feng L, Freund YR, Liu L, Meewan M, Mohan M, Mao W, Rock FL, Sexton H, Sheoran A, Zhang Y, Zhang YK, Zhou Y, Nieman JA, Anugula MR, Keramane el M, Savariraj K, Reddy DS, Sharma R, Subedi R, Singh R, O'Leary A, Simon NL, De Marsh PL, Mushtaq S, Warner M, Livermore DM, Alley MR, Plattner JJ.

Antimicrob Agents Chemother. 2013 Mar;57(3):1394-403. doi: 10.1128/AAC.02058-12. Epub 2013 Jan 7.

44.

Comprehensive analysis of prokaryotes in environmental water using DNA microarray analysis and whole genome amplification.

Akama T, Kawashima A, Tanigawa K, Hayashi M, Ishido Y, Luo Y, Hata A, Fujitani N, Ishii N, Suzuki K.

Pathogens. 2013 Oct 30;2(4):591-605. doi: 10.3390/pathogens2040591.

45.

In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse.

Suzuki-Anekoji M, Suzuki A, Wu SW, Angata K, Murai KK, Sugihara K, Akama TO, Khoo KH, Nakayama J, Fukuda MN, Fukuda M.

J Biol Chem. 2013 Feb 15;288(7):5007-16. doi: 10.1074/jbc.M112.433474. Epub 2012 Dec 26.

46.

Altered secretory immunoglobulin A on skin surface after intensive exercise.

Eda N, Shimizu K, Suzuki S, Tanabe Y, Lee E, Akama T.

J Strength Cond Res. 2013 Sep;27(9):2581-7. doi: 10.1519/JSC.0b013e31827fd5ec.

PMID:
23249819
47.

Clofazimine modulates the expression of lipid metabolism proteins in Mycobacterium leprae-infected macrophages.

Degang Y, Akama T, Hara T, Tanigawa K, Ishido Y, Gidoh M, Makino M, Ishii N, Suzuki K.

PLoS Negl Trop Dis. 2012;6(12):e1936. doi: 10.1371/journal.pntd.0001936. Epub 2012 Dec 6.

48.

Demonstration of innate immune responses in the thyroid gland: potential to sense danger and a possible trigger for autoimmune reactions.

Kawashima A, Yamazaki K, Hara T, Akama T, Yoshihara A, Sue M, Tanigawa K, Wu H, Ishido Y, Takeshita F, Ishii N, Sato K, Suzuki K.

Thyroid. 2013 Apr;23(4):477-87. doi: 10.1089/thy.2011.0480. Epub 2013 Mar 18.

49.

Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novel benzoxaborole.

Dong C, Sexton H, Gertrudes A, Akama T, Martin S, Virtucio C, Chen CW, Fan X, Wu A, Bu W, Liu L, Feng L, Jarnagin K, Freund YR.

J Pharmacol Exp Ther. 2013 Feb;344(2):436-46. doi: 10.1124/jpet.112.200030. Epub 2012 Nov 28.

PMID:
23192653
50.

Use of supplements by young elite Japanese athletes participating in the 2010 youth Olympic games in Singapore.

Sato A, Kamei A, Kamihigashi E, Dohi M, Komatsu Y, Akama T, Kawahara T.

Clin J Sport Med. 2012 Sep;22(5):418-23. doi: 10.1097/JSM.0b013e318266830a.

PMID:
22890330

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