Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 38

1.

Antimalarials: Review of Plasmepsins as Drug Targets and HIV Protease Inhibitors Interactions.

Miller Iii WA, Teye J, Achieng AO, Mogire RM, Akala H, Ong'echa JM, Rathi B, Durvasula R, Kempaiah P, Kwofie SK.

Curr Top Med Chem. 2019;18(23):2022-2028. doi: 10.2174/1568026619666181130133548. Review.

PMID:
30499404
2.

Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya.

Muiruri P, Juma DW, Ingasia LA, Chebon LJ, Opot B, Ngalah BS, Cheruiyot J, Andagalu B, Akala HM, Nyambati VCS, Ng'ang'a JK, Kamau E.

Malar J. 2018 Oct 30;17(1):398. doi: 10.1186/s12936-018-2534-8.

3.

Polymorphisms in the K13 Gene in Plasmodium falciparum from Different Malaria Transmission Areas of Kenya.

de Laurent ZR, Chebon LJ, Ingasia LA, Akala HM, Andagalu B, Ochola-Oyier LI, Kamau E.

Am J Trop Med Hyg. 2018 May;98(5):1360-1366. doi: 10.4269/ajtmh.17-0505. Epub 2018 Mar 22.

4.

Target-similarity search using Plasmodium falciparum proteome identifies approved drugs with anti-malarial activity and their possible targets.

Mogire RM, Akala HM, Macharia RW, Juma DW, Cheruiyot AC, Andagalu B, Brown ML, El-Shemy HA, Nyanjom SG.

PLoS One. 2017 Oct 31;12(10):e0186364. doi: 10.1371/journal.pone.0186364. eCollection 2017.

5.

Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya.

Atilaw Y, Muiva-Mutisya L, Ndakala A, Akala HM, Yeda R, Wu YJ, Coghi P, Wong VKW, Erdélyi M, Yenesew A.

Molecules. 2017 Sep 10;22(9). pii: E1514. doi: 10.3390/molecules22091514.

6.

Antiplasmodial prenylated flavanonols from Tephrosia subtriflora.

Muiva-Mutisya LM, Atilaw Y, Heydenreich M, Koch A, Akala HM, Cheruiyot AC, Brown ML, Irungu B, Okalebo FA, Derese S, Mutai C, Yenesew A.

Nat Prod Res. 2018 Jun;32(12):1407-1414. doi: 10.1080/14786419.2017.1353510. Epub 2017 Jul 16.

PMID:
28714338
7.

Genetically Determined Response to Artemisinin Treatment in Western Kenyan Plasmodium falciparum Parasites.

Chebon LJ, Ngalah BS, Ingasia LA, Juma DW, Muiruri P, Cheruiyot J, Opot B, Mbuba E, Imbuga M, Akala HM, Bulimo W, Andagalu B, Kamau E.

PLoS One. 2016 Sep 9;11(9):e0162524. doi: 10.1371/journal.pone.0162524. eCollection 2016.

8.

Assessment of the Worldwide Antimalarial Resistance Network Standardized Procedure for In Vitro Malaria Drug Sensitivity Testing Using SYBR Green Assay for Field Samples with Various Initial Parasitemia Levels.

Cheruiyot AC, Auschwitz JM, Lee PJ, Yeda RA, Okello CO, Leed SE, Talwar M, Murthy T, Gaona HW, Hickman MR, Akala HM, Kamau E, Johnson JD.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2417-24. doi: 10.1128/AAC.00527-15. Print 2016 Apr.

9.

The Genotypic and Phenotypic Stability of Plasmodium falciparum Field Isolates in Continuous In Vitro Culture.

Yeda R, Ingasia LA, Cheruiyot AC, Okudo C, Chebon LJ, Cheruiyot J, Akala HM, Kamau E.

PLoS One. 2016 Jan 11;11(1):e0143565. doi: 10.1371/journal.pone.0143565. eCollection 2016.

10.

Temporal trends in prevalence of Plasmodium falciparum molecular markers selected for by artemether-lumefantrine treatment in pre-ACT and post-ACT parasites in western Kenya.

Achieng AO, Muiruri P, Ingasia LA, Opot BH, Juma DW, Yeda R, Ngalah BS, Ogutu BR, Andagalu B, Akala HM, Kamau E.

Int J Parasitol Drugs Drug Resist. 2015 Jun 29;5(3):92-9. doi: 10.1016/j.ijpddr.2015.05.005. eCollection 2015 Dec.

11.

Analysis of major genome loci underlying artemisinin resistance and pfmdr1 copy number in pre- and post-ACTs in western Kenya.

Ngalah BS, Ingasia LA, Cheruiyot AC, Chebon LJ, Juma DW, Muiruri P, Onyango I, Ogony J, Yeda RA, Cheruiyot J, Mbuba E, Mwangoka G, Achieng AO, Ng'ang'a Z, Andagalu B, Akala HM, Kamau E.

Sci Rep. 2015 Feb 6;5:8308. doi: 10.1038/srep08308.

12.

Molecular characterization of the cytochrome b gene and in vitro atovaquone susceptibility of Plasmodium falciparum isolates from Kenya.

Ingasia LA, Akala HM, Imbuga MO, Opot BH, Eyase FL, Johnson JD, Bulimo WD, Kamau E.

Antimicrob Agents Chemother. 2015 Mar;59(3):1818-21. doi: 10.1128/AAC.03956-14. Epub 2015 Jan 12.

13.

Antiplasmodial compounds from the stem bark of Neoboutonia macrocalyx pax.

Namukobe J, Kiremire BT, Byamukama R, Kasenene JM, Akala HM, Kamau E, Dumontet V.

J Ethnopharmacol. 2015 Mar 13;162:317-22. doi: 10.1016/j.jep.2014.12.018. Epub 2014 Dec 19.

PMID:
25535086
14.

Five-year tracking of Plasmodium falciparum allele frequencies in a holoendemic area with indistinct seasonal transitions.

Akala HM, Achieng AO, Eyase FL, Juma DW, Ingasia L, Cheruiyot AC, Okello C, Omariba D, Owiti EA, Muriuki C, Yeda R, Andagalu B, Johnson JD, Kamau E.

J Multidiscip Healthc. 2014 Nov 6;7:515-23. doi: 10.2147/JMDH.S67252. eCollection 2014.

15.

Reduced in vitro doxycycline susceptibility in plasmodium falciparum field isolates from Kenya is associated with PfTetQ KYNNNN sequence polymorphism.

Achieng AO, Ingasia LA, Juma DW, Cheruiyot AC, Okudo CA, Yeda RA, Cheruiyot J, Akala HM, Johnson J, Andangalu B, Eyase F, Jura WG, Kamau E.

Antimicrob Agents Chemother. 2014 Oct;58(10):5894-9. doi: 10.1128/AAC.02788-13. Epub 2014 Jul 28.

16.

Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012.

Juma DW, Omondi AA, Ingasia L, Opot B, Cheruiyot A, Yeda R, Okudo C, Cheruiyot J, Muiruri P, Ngalah B, Chebon LJ, Eyase F, Johnson J, Bulimo WD, Akala HM, Andagalu B, Kamau E.

Malar J. 2014 Jul 2;13:250. doi: 10.1186/1475-2875-13-250.

17.

Polymorphisms in Pfmdr1, Pfcrt, and Pfnhe1 genes are associated with reduced in vitro activities of quinine in Plasmodium falciparum isolates from western Kenya.

Cheruiyot J, Ingasia LA, Omondi AA, Juma DW, Opot BH, Ndegwa JM, Mativo J, Cheruiyot AC, Yeda R, Okudo C, Muiruri P, Bidii NS, Chebon LJ, Angienda PO, Eyase FL, Johnson JD, Bulimo WD, Andagalu B, Akala HM, Kamau E.

Antimicrob Agents Chemother. 2014 Jul;58(7):3737-43. doi: 10.1128/AAC.02472-14. Epub 2014 Apr 21.

18.

Bisbenzylisoquinoline and hasubanane alkaloids from Stephania abyssinica (Dillon & A. Rich) (Menispermeceae).

Omole RA, Gathirwa J, Akala H, Malebo HM, Machocho AK, Hassanali A, Ndiege IO.

Phytochemistry. 2014 Jul;103:123-128. doi: 10.1016/j.phytochem.2014.03.026. Epub 2014 Apr 12.

PMID:
24735823
19.

Antiplasmodial quinones from the rhizomes of Kniphofia foliosa.

Induli M, Gebru M, Abdissa N, Akala H, Wekesa I, Byamukama R, Heydenreich M, Murunga S, Dagne E, Yenesew A.

Nat Prod Commun. 2013 Sep;8(9):1261-4.

PMID:
24273862
20.

The role of Pfmdr1 and Pfcrt in changing chloroquine, amodiaquine, mefloquine and lumefantrine susceptibility in western-Kenya P. falciparum samples during 2008-2011.

Eyase FL, Akala HM, Ingasia L, Cheruiyot A, Omondi A, Okudo C, Juma D, Yeda R, Andagalu B, Wanja E, Kamau E, Schnabel D, Bulimo W, Waters NC, Walsh DS, Johnson JD.

PLoS One. 2013 May 13;8(5):e64299. doi: 10.1371/journal.pone.0064299. Print 2013.

21.

Voulkensin C-E, new 11-oxocassane-type diterpenoids and a steroid glycoside from Caesalpinia volkensii stem bark and their antiplasmodial activities.

Ochieng CO, Manguro LA, Owuor PO, Akala H.

Bioorg Med Chem Lett. 2013 May 15;23(10):3088-95. doi: 10.1016/j.bmcl.2013.03.007. Epub 2013 Mar 13.

PMID:
23562058
22.

Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus.

Kerubo LO, Midiwo JO, Derese S, Langat MK, Akala HM, Waters NC, Peter M, Heydenreich M.

Nat Prod Commun. 2013 Feb;8(2):175-6.

PMID:
23513721
23.

Anthraquinones of the roots of Pentas micrantha.

Endale M, Ekberg A, Alao JP, Akala HM, Ndakala A, Sunnerhagen P, Erdélyi M, Yenesew A.

Molecules. 2012 Dec 27;18(1):311-21. doi: 10.3390/molecules18010311.

24.

In vitro antiplasmodial activity of selected Luo and Kuria medicinal plants.

Owuor BO, Ochanda JO, Kokwaro JO, Cheruiyot AC, Yeda RA, Okudo CA, Akala HM.

J Ethnopharmacol. 2012 Dec 18;144(3):779-81. doi: 10.1016/j.jep.2012.09.045. Epub 2012 Oct 4.

PMID:
23041700
25.

Busseihydroquinones A-D from the roots of Pentas bussei.

Endale M, Ekberg A, Akala HM, Alao JP, Sunnerhagen P, Yenesew A, Erdélyi M.

J Nat Prod. 2012 Jul 27;75(7):1299-304. doi: 10.1021/np3002223. Epub 2012 Jun 18.

PMID:
22709138
26.

The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii.

Yenesew A, Akala HM, Twinomuhwezi H, Chepkirui C, Irungu BN, Eyase FL, Kamatenesi-Mugisha M, Kiremire BT, Johnson JD, Waters NC.

Acta Trop. 2012 Aug;123(2):123-7. doi: 10.1016/j.actatropica.2012.04.011. Epub 2012 Apr 30.

PMID:
22575309
27.

Inhibitory activity of ferroquine, versus chloroquine, against western Kenya Plasmodium falciparum field isolates determined by a SYBR Green I in vitro assay.

Eyase FL, Akala HM, Johnson JD, Walsh DS.

Am J Trop Med Hyg. 2011 Dec;85(6):984-8. doi: 10.4269/ajtmh.2011.11-0260.

28.

Antiplasmodial quinones from Pentas longiflora and Pentas lanceolata.

Endale M, Alao JP, Akala HM, Rono NK, Eyase FL, Derese S, Ndakala A, Mbugua M, Walsh DS, Sunnerhagen P, Erdelyi M, Yenesew A.

Planta Med. 2012 Jan;78(1):31-5. doi: 10.1055/s-0031-1280179. Epub 2011 Oct 6.

PMID:
21979929
29.

Antinociceptive and antiplasmodial activities of cassane furanoditerpenes from Caesalpinia volkensii H. root bark.

Ochieng' CO, Owuor PO, Mang'uro LA, Akala H, Ishola IO.

Fitoterapia. 2012 Jan;83(1):74-80. doi: 10.1016/j.fitote.2011.09.015. Epub 2011 Sep 24.

PMID:
21968065
30.

Antimalarial drug sensitivity profile of western Kenya Plasmodium falciparum field isolates determined by a SYBR Green I in vitro assay and molecular analysis.

Akala HM, Eyase FL, Cheruiyot AC, Omondi AA, Ogutu BR, Waters NC, Johnson JD, Polhemus ME, Schnabel DC, Walsh DS.

Am J Trop Med Hyg. 2011 Jul;85(1):34-41. doi: 10.4269/ajtmh.2011.10-0674.

31.

Malaria and other vector-borne infection surveillance in the U.S. Department of Defense Armed Forces Health Surveillance Center-Global Emerging Infections Surveillance program: review of 2009 accomplishments.

Fukuda MM, Klein TA, Kochel T, Quandelacy TM, Smith BL, Villinski J, Bethell D, Tyner S, Se Y, Lon C, Saunders D, Johnson J, Wagar E, Walsh D, Kasper M, Sanchez JL, Witt CJ, Cheng Q, Waters N, Shrestha SK, Pavlin JA, Lescano AG, Graf PC, Richardson JH, Durand S, Rogers WO, Blazes DL, Russell KL; AFHSC-GEIS Malaria and Vector Borne Infections Writing Group, Akala H, Gaydos JC, DeFraites RF, Gosi P, Timmermans A, Yasuda C, Brice G, Eyase F, Kronmann K, Sebeny P, Gibbons R, Jarman R, Waitumbi J, Schnabel D, Richards A, Shanks D.

BMC Public Health. 2011 Mar 4;11 Suppl 2:S9. doi: 10.1186/1471-2458-11-S2-S9. Review.

32.

Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya.

Spalding MD, Eyase FL, Akala HM, Bedno SA, Prigge ST, Coldren RL, Moss WJ, Waters NC.

Malar J. 2010 Nov 24;9:338. doi: 10.1186/1475-2875-9-338.

33.

Vangueria infausta root bark: in vivo and in vitro antiplasmodial activity.

Abosl AO, Mbukwa E, Majinda RR, Raserok BH, Yenesew A, Midiwo JO, Akala H, Liyala P, Waters NC.

Br J Biomed Sci. 2006;63(3):129-33.

PMID:
17058713
34.

Antiplasmodial flavonoids from Erythrina sacleuxii.

Andayi AW, Yenesew A, Derese S, Midiwo JO, Gitu PM, Jondiko OJ, Akala H, Liyala P, Wangui J, Waters NC, Heydenreich M, Peter MG.

Planta Med. 2006 Feb;72(2):187-9.

PMID:
16491458
35.

Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica.

Yenesew A, Induli M, Derese S, Midiwo JO, Heydenreich M, Peter MG, Akala H, Wangui J, Liyala P, Waters NC.

Phytochemistry. 2004 Nov;65(22):3029-32.

PMID:
15504437
36.

Drug susceptibility and genetic evaluation of Plasmodium falciparum isolates obtained in four distinct geographical regions of Kenya.

Mbaisi A, Liyala P, Eyase F, Achilla R, Akala H, Wangui J, Mwangi J, Osuna F, Alam U, Smoak BL, Davis JM, Kyle DE, Coldren RL, Mason C, Waters NC.

Antimicrob Agents Chemother. 2004 Sep;48(9):3598-601.

37.

Anti-plasmodial activities and X-ray crystal structures of rotenoids from Millettia usaramensis subspecies usaramensis.

Yenesew A, Derese S, Midiwo JO, Oketch-Rabah HA, Lisgarten J, Palmer R, Heydenreich M, Peter MG, Akala H, Wangui J, Liyala P, Waters NC.

Phytochemistry. 2003 Oct;64(3):773-9.

PMID:
13679101
38.

Flavonoids and isoflavonoids with antiplasmodial activities from the root bark of Erythrina abyssinica.

Yenesew A, Derese S, Irungu B, Midiwo JO, Waters NC, Liyala P, Akala H, Heydenreich M, Peter MG.

Planta Med. 2003 Jul;69(7):658-61.

PMID:
12898424

Supplemental Content

Support Center