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Items: 1 to 50 of 634

1.

Long-lasting blood pressure lowering effects of nitrite are NO-independent and mediated by hydrogen peroxide, persulfides and oxidation of protein kinase G 1α redox signaling.

Feelisch M, Akaike T, Griffiths K, Ida T, Prysyahna O, Goodwin JJ, Gollop ND, Fernandez BO, Minnion M, Cortese-Krott MM, Borgognone A, Hayes RM, Eaton P, Frenneaux MP, Madhani M.

Cardiovasc Res. 2019 Jul 31. pii: cvz202. doi: 10.1093/cvr/cvz202. [Epub ahead of print]

PMID:
31372656
2.

Mitochondrial cysteinyl-tRNA synthetase is expressed via alternative transcriptional initiation regulated by energy metabolism in yeast cells.

Nishimura A, Nasuno R, Yoshikawa Y, Jung M, Ida T, Matsunaga T, Morita M, Takagi H, Motohashi H, Akaike T.

J Biol Chem. 2019 Jul 26. pii: jbc.RA119.009203. doi: 10.1074/jbc.RA119.009203. [Epub ahead of print]

3.

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload.

Nishimura A, Shimoda K, Tanaka T, Toyama T, Nishiyama K, Shinkai Y, Numaga-Tomita T, Yamazaki D, Kanda Y, Akaike T, Kumagai Y, Nishida M.

Sci Signal. 2019 Jun 25;12(587). pii: eaaw1920. doi: 10.1126/scisignal.aaw1920.

PMID:
31239323
4.

Standard-dose gentamicin does not increase risk of patent ductus arteriosus.

Kishibuchi A, Akaike T, Minamisawa S.

Pediatr Neonatol. 2019 Jun 5. pii: S1875-9572(18)30750-2. doi: 10.1016/j.pedneo.2019.05.011. [Epub ahead of print]

5.

Data-Driven Identification of Hydrogen Sulfide Scavengers.

Yang CT, Wang Y, Marutani E, Ida T, Ni X, Xu S, Chen W, Zhang H, Akaike T, Ichinose F, Xian M.

Angew Chem Int Ed Engl. 2019 Aug 5;58(32):10898-10902. doi: 10.1002/anie.201905580. Epub 2019 Jul 11.

PMID:
31194894
6.

Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.

Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13016-13025. doi: 10.1073/pnas.1904064116. Epub 2019 Jun 11.

7.

Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both.

Akiyama M, Unoki T, Shinkai Y, Ishii I, Ida T, Akaike T, Yamamoto M, Kumagai Y.

Environ Health Perspect. 2019 Jun;127(6):67002. doi: 10.1289/EHP4949. Epub 2019 Jun 5.

8.

Nitrosative stress in patients with asthma-chronic obstructive pulmonary disease overlap.

Kyogoku Y, Sugiura H, Ichikawa T, Numakura T, Koarai A, Yamada M, Fujino N, Tojo Y, Onodera K, Tanaka R, Sato K, Sano H, Yamanaka S, Itakura K, Mitsune A, Tamada T, Akaike T, Ichinose M.

J Allergy Clin Immunol. 2019 May 9. pii: S0091-6749(19)30609-8. doi: 10.1016/j.jaci.2019.04.023. [Epub ahead of print]

PMID:
31077687
9.

Distribution of Polysulfide in Human Biological Fluids and Their Association with Amylase and Sperm Activities.

Ikeda M, Ishima Y, Chuang VTG, Sakai M, Osafune H, Ando H, Shimizu T, Okuhira K, Watanabe H, Maruyama T, Otagiri M, Akaike T, Ishida T.

Molecules. 2019 Apr 30;24(9). pii: E1689. doi: 10.3390/molecules24091689.

10.

Transcriptional profiles in the chicken ductus arteriosus during hatching.

Akaike T, Shinjo S, Ohmori E, Kajimura I, Goda N, Minamisawa S.

PLoS One. 2019 Mar 21;14(3):e0214139. doi: 10.1371/journal.pone.0214139. eCollection 2019.

11.

Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock.

Zhang T, Ono K, Tsutsuki H, Ihara H, Islam W, Akaike T, Sawa T.

Cell Chem Biol. 2019 May 16;26(5):686-698.e4. doi: 10.1016/j.chembiol.2019.02.003. Epub 2019 Mar 7.

PMID:
30853417
12.

The active-site cysteine residue of Ca2+/calmodulin-dependent protein kinase I is protected from irreversible modification via generation of polysulfidation.

Takata T, Tsukuda A, Tsuchiya Y, Akaike T, Watanabe Y.

Nitric Oxide. 2019 May 1;86:68-75. doi: 10.1016/j.niox.2019.02.008. Epub 2019 Mar 4.

PMID:
30844494
13.

8-Nitro-cGMP attenuates context-dependent fear memory in mice.

Kishimoto Y, Kasamatsu S, Yanai S, Endo S, Akaike T, Ihara H.

Biochem Biophys Res Commun. 2019 Mar 26;511(1):141-147. doi: 10.1016/j.bbrc.2019.01.138. Epub 2019 Feb 14.

PMID:
30773263
14.

The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.

Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.

Chem Res Toxicol. 2019 Mar 18;32(3):447-455. doi: 10.1021/acs.chemrestox.8b00340. Epub 2019 Feb 7.

PMID:
30681327
15.

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.

Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.

Redox Biol. 2019 Feb;21:101096. doi: 10.1016/j.redox.2019.101096. Epub 2019 Jan 2.

16.

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.

Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.

Sci Signal. 2018 Nov 13;11(556). pii: eaat5185. doi: 10.1126/scisignal.aat5185.

PMID:
30425165
17.

Prostaglandin E2 Receptor EP4 Inhibition Contracts Rat Ductus Arteriosus.

Sakuma T, Akaike T, Minamisawa S.

Circ J. 2018 Dec 25;83(1):209-216. doi: 10.1253/circj.CJ-18-0761. Epub 2018 Nov 10.

18.

Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E2.

Nagayama K, Miyamoto Y, Kaneko K, Yoshimura K, Sasa K, Akaike T, Fujii S, Izumida E, Uyama R, Chikazu D, Maki K, Kamijo R.

In Vitro Cell Dev Biol Anim. 2019 Jan;55(1):45-51. doi: 10.1007/s11626-018-0304-0. Epub 2018 Nov 5.

PMID:
30397855
19.

SNAP-25 S-Guanylation and SNARE Complex Formation.

Kishimoto Y, Akaike T, Ihara H.

Methods Mol Biol. 2019;1860:163-173. doi: 10.1007/978-1-4939-8760-3_9.

PMID:
30317503
20.

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array.

Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Shibata-Seki T, Yoshimoto K, Sakai R, Hakariya H, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Chen Y, Kamei KI.

J Vis Exp. 2018 Sep 7;(139). doi: 10.3791/57377.

PMID:
30247461
21.

Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling.

Khan S, Fujii S, Matsunaga T, Nishimura A, Ono K, Ida T, Ahmed KA, Okamoto T, Tsutsuki H, Sawa T, Akaike T.

Cell Chem Biol. 2018 Nov 15;25(11):1403-1413.e4. doi: 10.1016/j.chembiol.2018.08.007. Epub 2018 Sep 6.

PMID:
30197193
22.

CCN3 secreted by prostaglandin E2 inhibits intimal cushion formation in the rat ductus arteriosus.

Iwai K, Nagasawa K, Akaike T, Oshima T, Kato T, Minamisawa S.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):3242-3247. doi: 10.1016/j.bbrc.2018.08.138. Epub 2018 Aug 24.

PMID:
30149912
23.

Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell?

Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P.

Br J Pharmacol. 2019 Feb;176(4):646-670. doi: 10.1111/bph.14394. Epub 2018 Aug 23.

PMID:
29909607
24.

The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems.

Bianco CL, Akaike T, Ida T, Nagy P, Bogdandi V, Toscano JP, Kumagai Y, Henderson CF, Goddu RN, Lin J, Fukuto JM.

Br J Pharmacol. 2019 Feb;176(4):671-683. doi: 10.1111/bph.14372. Epub 2018 Jun 28.

PMID:
29809282
25.

Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling.

Sawa T, Ono K, Tsutsuki H, Zhang T, Ida T, Nishida M, Akaike T.

Adv Microb Physiol. 2018;72:1-28. doi: 10.1016/bs.ampbs.2018.01.002. Epub 2018 Feb 26.

PMID:
29778212
26.

Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology.

Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.

FEBS Lett. 2018 Jun;592(12):2140-2152. doi: 10.1002/1873-3468.13090. Epub 2018 May 24. Review.

27.

Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells.

Fujii S, Sawa T, Motohashi H, Akaike T.

Br J Pharmacol. 2019 Feb;176(4):607-615. doi: 10.1111/bph.14356. Epub 2018 Jun 7. Review.

PMID:
29748969
28.

Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell-cell Adhesion in the Postnatal Brain.

Fujikake K, Sawada M, Hikita T, Seto Y, Kaneko N, Herranz-Pérez V, Dohi N, Homma N, Osaga S, Yanagawa Y, Akaike T, García-Verdugo JM, Hattori M, Sobue K, Sawamoto K.

J Neurosci. 2018 May 9;38(19):4598-4609. doi: 10.1523/JNEUROSCI.1960-17.2018. Epub 2018 Apr 16.

29.

Important Role of Endothelial Caveolin-1 in the Protective Role of Endothelium-dependent Hyperpolarization Against Nitric Oxide-Mediated Nitrative Stress in Microcirculation in Mice.

Saito H, Godo S, Sato S, Ito A, Ikumi Y, Tanaka S, Ida T, Fujii S, Akaike T, Shimokawa H.

J Cardiovasc Pharmacol. 2018 Feb;71(2):113-126. doi: 10.1097/FJC.0000000000000552.

PMID:
29419573
30.

Asymmetricity Between Sister Cells of Pluripotent Stem Cells at the Onset of Differentiation.

Nakamura S, Maruyama A, Kondo Y, Kano A, De Sousa OM, Iwahashi M, Hexig B, Akaike T, Li J, Hayashi Y, Ohnuma K.

Stem Cells Dev. 2018 Mar 1;27(5):347-354. doi: 10.1089/scd.2017.0113. Epub 2018 Feb 21.

31.

Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury.

Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pérez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, García-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K.

Cell Stem Cell. 2018 Jan 4;22(1):128-137.e9. doi: 10.1016/j.stem.2017.11.005. Epub 2017 Dec 21.

32.

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons.

Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H.

Biochem Biophys Res Commun. 2018 Jan 15;495(3):2165-2170. doi: 10.1016/j.bbrc.2017.12.088. Epub 2017 Dec 16.

PMID:
29258821
33.

8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL.

Kaneko K, Miyamoto Y, Tsukuura R, Sasa K, Akaike T, Fujii S, Yoshimura K, Nagayama K, Hoshino M, Inoue S, Maki K, Baba K, Chikazu D, Kamijo R.

Nitric Oxide. 2018 Jan 30;72:46-51. doi: 10.1016/j.niox.2017.11.006. Epub 2017 Nov 26.

PMID:
29183803
34.

8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25.

Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.

ACS Chem Neurosci. 2018 Feb 21;9(2):217-223. doi: 10.1021/acschemneuro.7b00363. Epub 2017 Nov 10.

PMID:
29110463
35.

Important Role of Endothelial Caveolin-1 in the Protective Role of EDH against NO-mediated Nitrative Stress in Microcirculation in Mice.

Saito H, Godo S, Sato S, Ito A, Ikumi Y, Tanaka S, Ida T, Fujii S, Akaike T, Shimokawa H.

J Cardiovasc Pharmacol. 2017 Oct 27. doi: 10.1097/FJC.0000000000000552. [Epub ahead of print]

PMID:
29095792
36.

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.

Nat Commun. 2017 Oct 27;8(1):1177. doi: 10.1038/s41467-017-01311-y.

37.

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart.

Akaike T, Du N, Lu G, Minamisawa S, Wang Y, Ruan H.

JACC Basic Transl Sci. 2017 Mar;2(2):160-180. doi: 10.1016/j.jacbts.2016.12.002. Epub 2017 Apr 24.

38.

Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.

Redox Biol. 2018 Apr;14:379-385. doi: 10.1016/j.redox.2017.10.006. Epub 2017 Oct 9.

39.

Diversity and microevolution of CRISPR loci in Helicobacter cinaedi.

Tomida J, Morita Y, Shibayama K, Kikuchi K, Sawa T, Akaike T, Kawamura Y.

PLoS One. 2017 Oct 13;12(10):e0186241. doi: 10.1371/journal.pone.0186241. eCollection 2017.

40.

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

Ihara H, Kasamatsu S, Kitamura A, Nishimura A, Tsutsuki H, Ida T, Ishizaki K, Toyama T, Yoshida E, Abdul Hamid H, Jung M, Matsunaga T, Fujii S, Sawa T, Nishida M, Kumagai Y, Akaike T.

Chem Res Toxicol. 2017 Sep 18;30(9):1673-1684. doi: 10.1021/acs.chemrestox.7b00120. Epub 2017 Sep 7.

PMID:
28837763
41.

Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke.

Takamiya R, Uchida K, Shibata T, Maeno T, Kato M, Yamaguchi Y, Ariki S, Hasegawa Y, Saito A, Miwa S, Takahashi H, Akaike T, Kuroki Y, Takahashi M.

Sci Rep. 2017 Aug 16;7(1):8304. doi: 10.1038/s41598-017-08588-5.

42.

Pulmonary hypertension due to left heart disease causes intrapulmonary venous arterialization in rats.

Fujimoto Y, Urashima T, Kawachi F, Akaike T, Kusakari Y, Ida H, Minamisawa S.

J Thorac Cardiovasc Surg. 2017 Nov;154(5):1742-1753.e8. doi: 10.1016/j.jtcvs.2017.06.053. Epub 2017 Jul 5.

PMID:
28755882
43.

Production of reactive persulfide species in chronic obstructive pulmonary disease.

Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M.

Thorax. 2017 Dec;72(12):1074-1083. doi: 10.1136/thoraxjnl-2016-209359. Epub 2017 Jul 19.

PMID:
28724639
44.

Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue.

Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y.

Biochem J. 2017 Jul 17;474(15):2547-2562. doi: 10.1042/BCJ20170092.

PMID:
28637792
45.

8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage.

Hoshino M, Kaneko K, Miyamoto Y, Yoshimura K, Suzuki D, Akaike T, Sawa T, Ida T, Fujii S, Ihara H, Tanaka J, Tsukuura R, Chikazu D, Mishima K, Baba K, Kamijo R.

Free Radic Biol Med. 2017 Sep;110:63-71. doi: 10.1016/j.freeradbiomed.2017.05.022. Epub 2017 May 27.

PMID:
28559051
46.

Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.

Ikeda M, Ishima Y, Shibata A, Chuang VTG, Sawa T, Ihara H, Watanabe H, Xian M, Ouchi Y, Shimizu T, Ando H, Ukawa M, Ishida T, Akaike T, Otagiri M, Maruyama T.

Anal Chim Acta. 2017 May 29;969:18-25. doi: 10.1016/j.aca.2017.03.027. Epub 2017 Mar 22.

PMID:
28411626
47.

Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling.

Álvarez L, Bianco CL, Toscano JP, Lin J, Akaike T, Fukuto JM.

Antioxid Redox Signal. 2017 Oct 1;27(10):622-633. doi: 10.1089/ars.2017.7081. Epub 2017 Jun 13. Review.

PMID:
28398141
48.

Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments.

Kamei KI, Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Nakajima M, Shibata-Seki T, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Chen Y.

Small. 2017 May;13(18). doi: 10.1002/smll.201603104. Epub 2017 Mar 8.

PMID:
28272774
49.

Synthesis of l-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome.

Ono K, Jung M, Zhang T, Tsutsuki H, Sezaki H, Ihara H, Wei FY, Tomizawa K, Akaike T, Sawa T.

Free Radic Biol Med. 2017 May;106:69-79. doi: 10.1016/j.freeradbiomed.2017.02.023. Epub 2017 Feb 9.

PMID:
28189853
50.

Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors.

Kunikata H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T.

Sci Rep. 2017 Feb 7;7:41984. doi: 10.1038/srep41984.

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