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Items: 1 to 50 of 623

1.

8-Nitro-cGMP attenuates context-dependent fear memory in mice.

Kishimoto Y, Kasamatsu S, Yanai S, Endo S, Akaike T, Ihara H.

Biochem Biophys Res Commun. 2019 Feb 14. pii: S0006-291X(19)30172-X. doi: 10.1016/j.bbrc.2019.01.138. [Epub ahead of print]

PMID:
30773263
2.

The Uptake and Release of Polysulfur Cysteine Species by Cells: Physiological and Toxicological Implications.

Lin J, Akiyama M, Bica I, Long FT, Henderson CF, Goddu RN, Suarez V, Baker B, Ida T, Shinkai Y, Nagy P, Akaike T, Fukuto JM, Kumagai Y.

Chem Res Toxicol. 2019 Feb 7. doi: 10.1021/acs.chemrestox.8b00340. [Epub ahead of print]

PMID:
30681327
3.

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.

Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.

Redox Biol. 2019 Feb;21:101096. doi: 10.1016/j.redox.2019.101096. Epub 2019 Jan 2.

4.

Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission-associated myocardial senescence.

Nishimura A, Shimauchi T, Tanaka T, Shimoda K, Toyama T, Kitajima N, Ishikawa T, Shindo N, Numaga-Tomita T, Yasuda S, Sato Y, Kuwahara K, Kumagai Y, Akaike T, Ide T, Ojida A, Mori Y, Nishida M.

Sci Signal. 2018 Nov 13;11(556). pii: eaat5185. doi: 10.1126/scisignal.aat5185.

PMID:
30425165
5.

Prostaglandin E2 Receptor EP4 Inhibition Contracts Rat Ductus Arteriosus.

Sakuma T, Akaike T, Minamisawa S.

Circ J. 2018 Dec 25;83(1):209-216. doi: 10.1253/circj.CJ-18-0761. Epub 2018 Nov 10.

6.

Production of 8-nitro-cGMP in osteocytic cells and its upregulation by parathyroid hormone and prostaglandin E2.

Nagayama K, Miyamoto Y, Kaneko K, Yoshimura K, Sasa K, Akaike T, Fujii S, Izumida E, Uyama R, Chikazu D, Maki K, Kamijo R.

In Vitro Cell Dev Biol Anim. 2019 Jan;55(1):45-51. doi: 10.1007/s11626-018-0304-0. Epub 2018 Nov 5.

PMID:
30397855
7.

SNAP-25 S-Guanylation and SNARE Complex Formation.

Kishimoto Y, Akaike T, Ihara H.

Methods Mol Biol. 2019;1860:163-173. doi: 10.1007/978-1-4939-8760-3_9.

PMID:
30317503
8.

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array.

Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Shibata-Seki T, Yoshimoto K, Sakai R, Hakariya H, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Chen Y, Kamei KI.

J Vis Exp. 2018 Sep 7;(139). doi: 10.3791/57377.

PMID:
30247461
9.

Reactive Persulfides from Salmonella Typhimurium Downregulate Autophagy-Mediated Innate Immunity in Macrophages by Inhibiting Electrophilic Signaling.

Khan S, Fujii S, Matsunaga T, Nishimura A, Ono K, Ida T, Ahmed KA, Okamoto T, Tsutsuki H, Sawa T, Akaike T.

Cell Chem Biol. 2018 Nov 15;25(11):1403-1413.e4. doi: 10.1016/j.chembiol.2018.08.007. Epub 2018 Sep 6.

PMID:
30197193
10.

CCN3 secreted by prostaglandin E2 inhibits intimal cushion formation in the rat ductus arteriosus.

Iwai K, Nagasawa K, Akaike T, Oshima T, Kato T, Minamisawa S.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):3242-3247. doi: 10.1016/j.bbrc.2018.08.138. Epub 2018 Aug 24.

PMID:
30149912
11.

Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell?

Bogdándi V, Ida T, Sutton TR, Bianco C, Ditrói T, Koster G, Henthorn HA, Minnion M, Toscano JP, van der Vliet A, Pluth MD, Feelisch M, Fukuto JM, Akaike T, Nagy P.

Br J Pharmacol. 2019 Feb;176(4):646-670. doi: 10.1111/bph.14394. Epub 2018 Aug 23.

PMID:
29909607
12.

The reaction of hydrogen sulfide with disulfides: formation of a stable trisulfide and implications for biological systems.

Bianco CL, Akaike T, Ida T, Nagy P, Bogdandi V, Toscano JP, Kumagai Y, Henderson CF, Goddu RN, Lin J, Fukuto JM.

Br J Pharmacol. 2019 Feb;176(4):671-683. doi: 10.1111/bph.14372. Epub 2018 Jun 28.

PMID:
29809282
13.

Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling.

Sawa T, Ono K, Tsutsuki H, Zhang T, Ida T, Nishida M, Akaike T.

Adv Microb Physiol. 2018;72:1-28. doi: 10.1016/bs.ampbs.2018.01.002. Epub 2018 Feb 26.

PMID:
29778212
14.

Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology.

Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T.

FEBS Lett. 2018 Jun;592(12):2140-2152. doi: 10.1002/1873-3468.13090. Epub 2018 May 24. Review.

15.

Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells.

Fujii S, Sawa T, Motohashi H, Akaike T.

Br J Pharmacol. 2019 Feb;176(4):607-615. doi: 10.1111/bph.14356. Epub 2018 Jun 7. Review.

PMID:
29748969
16.

Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell-cell Adhesion in the Postnatal Brain.

Fujikake K, Sawada M, Hikita T, Seto Y, Kaneko N, Herranz-Pérez V, Dohi N, Homma N, Osaga S, Yanagawa Y, Akaike T, García-Verdugo JM, Hattori M, Sobue K, Sawamoto K.

J Neurosci. 2018 May 9;38(19):4598-4609. doi: 10.1523/JNEUROSCI.1960-17.2018. Epub 2018 Apr 16.

17.

Important Role of Endothelial Caveolin-1 in the Protective Role of Endothelium-dependent Hyperpolarization Against Nitric Oxide-Mediated Nitrative Stress in Microcirculation in Mice.

Saito H, Godo S, Sato S, Ito A, Ikumi Y, Tanaka S, Ida T, Fujii S, Akaike T, Shimokawa H.

J Cardiovasc Pharmacol. 2018 Feb;71(2):113-126. doi: 10.1097/FJC.0000000000000552.

PMID:
29419573
18.

Asymmetricity Between Sister Cells of Pluripotent Stem Cells at the Onset of Differentiation.

Nakamura S, Maruyama A, Kondo Y, Kano A, De Sousa OM, Iwahashi M, Hexig B, Akaike T, Li J, Hayashi Y, Ohnuma K.

Stem Cells Dev. 2018 Mar 1;27(5):347-354. doi: 10.1089/scd.2017.0113. Epub 2018 Feb 21.

19.

Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury.

Jinnou H, Sawada M, Kawase K, Kaneko N, Herranz-Pérez V, Miyamoto T, Kawaue T, Miyata T, Tabata Y, Akaike T, García-Verdugo JM, Ajioka I, Saitoh S, Sawamoto K.

Cell Stem Cell. 2018 Jan 4;22(1):128-137.e9. doi: 10.1016/j.stem.2017.11.005. Epub 2017 Dec 21.

20.

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons.

Masuda K, Tsutsuki H, Kasamatsu S, Ida T, Takata T, Sugiura K, Nishida M, Watanabe Y, Sawa T, Akaike T, Ihara H.

Biochem Biophys Res Commun. 2018 Jan 15;495(3):2165-2170. doi: 10.1016/j.bbrc.2017.12.088. Epub 2017 Dec 16.

PMID:
29258821
21.

8-Nitro-cGMP is a promoter of osteoclast differentiation induced by RANKL.

Kaneko K, Miyamoto Y, Tsukuura R, Sasa K, Akaike T, Fujii S, Yoshimura K, Nagayama K, Hoshino M, Inoue S, Maki K, Baba K, Chikazu D, Kamijo R.

Nitric Oxide. 2018 Jan 30;72:46-51. doi: 10.1016/j.niox.2017.11.006. Epub 2017 Nov 26.

PMID:
29183803
22.

8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25.

Kishimoto Y, Kunieda K, Kitamura A, Kakihana Y, Akaike T, Ihara H.

ACS Chem Neurosci. 2018 Feb 21;9(2):217-223. doi: 10.1021/acschemneuro.7b00363. Epub 2017 Nov 10.

PMID:
29110463
23.

Important Role of Endothelial Caveolin-1 in the Protective Role of EDH against NO-mediated Nitrative Stress in Microcirculation in Mice.

Saito H, Godo S, Sato S, Ito A, Ikumi Y, Tanaka S, Ida T, Fujii S, Akaike T, Shimokawa H.

J Cardiovasc Pharmacol. 2017 Oct 27. doi: 10.1097/FJC.0000000000000552. [Epub ahead of print]

PMID:
29095792
24.

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.

Nat Commun. 2017 Oct 27;8(1):1177. doi: 10.1038/s41467-017-01311-y.

25.

A Sarcoplasmic Reticulum Localized Protein Phosphatase Regulates Phospholamban Phosphorylation and Promotes Ischemia Reperfusion Injury in the Heart.

Akaike T, Du N, Lu G, Minamisawa S, Wang Y, Ruan H.

JACC Basic Transl Sci. 2017 Mar;2(2):160-180. doi: 10.1016/j.jacbts.2016.12.002. Epub 2017 Apr 24.

26.

Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.

Redox Biol. 2018 Apr;14:379-385. doi: 10.1016/j.redox.2017.10.006. Epub 2017 Oct 9.

27.

Diversity and microevolution of CRISPR loci in Helicobacter cinaedi.

Tomida J, Morita Y, Shibayama K, Kikuchi K, Sawa T, Akaike T, Kawamura Y.

PLoS One. 2017 Oct 13;12(10):e0186241. doi: 10.1371/journal.pone.0186241. eCollection 2017.

28.

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

Ihara H, Kasamatsu S, Kitamura A, Nishimura A, Tsutsuki H, Ida T, Ishizaki K, Toyama T, Yoshida E, Abdul Hamid H, Jung M, Matsunaga T, Fujii S, Sawa T, Nishida M, Kumagai Y, Akaike T.

Chem Res Toxicol. 2017 Sep 18;30(9):1673-1684. doi: 10.1021/acs.chemrestox.7b00120. Epub 2017 Sep 7.

PMID:
28837763
29.

Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke.

Takamiya R, Uchida K, Shibata T, Maeno T, Kato M, Yamaguchi Y, Ariki S, Hasegawa Y, Saito A, Miwa S, Takahashi H, Akaike T, Kuroki Y, Takahashi M.

Sci Rep. 2017 Aug 16;7(1):8304. doi: 10.1038/s41598-017-08588-5.

30.

Pulmonary hypertension due to left heart disease causes intrapulmonary venous arterialization in rats.

Fujimoto Y, Urashima T, Kawachi F, Akaike T, Kusakari Y, Ida H, Minamisawa S.

J Thorac Cardiovasc Surg. 2017 Nov;154(5):1742-1753.e8. doi: 10.1016/j.jtcvs.2017.06.053. Epub 2017 Jul 5.

PMID:
28755882
31.

Production of reactive persulfide species in chronic obstructive pulmonary disease.

Numakura T, Sugiura H, Akaike T, Ida T, Fujii S, Koarai A, Yamada M, Onodera K, Hashimoto Y, Tanaka R, Sato K, Shishikura Y, Hirano T, Yanagisawa S, Fujino N, Okazaki T, Tamada T, Hoshikawa Y, Okada Y, Ichinose M.

Thorax. 2017 Dec;72(12):1074-1083. doi: 10.1136/thoraxjnl-2016-209359. Epub 2017 Jul 19.

PMID:
28724639
32.

Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue.

Takata T, Ihara H, Hatano N, Tsuchiya Y, Akaike T, Watanabe Y.

Biochem J. 2017 Jul 17;474(15):2547-2562. doi: 10.1042/BCJ20170092.

PMID:
28637792
33.

8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage.

Hoshino M, Kaneko K, Miyamoto Y, Yoshimura K, Suzuki D, Akaike T, Sawa T, Ida T, Fujii S, Ihara H, Tanaka J, Tsukuura R, Chikazu D, Mishima K, Baba K, Kamijo R.

Free Radic Biol Med. 2017 Sep;110:63-71. doi: 10.1016/j.freeradbiomed.2017.05.022. Epub 2017 May 27.

PMID:
28559051
34.

Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach.

Ikeda M, Ishima Y, Shibata A, Chuang VTG, Sawa T, Ihara H, Watanabe H, Xian M, Ouchi Y, Shimizu T, Ando H, Ukawa M, Ishida T, Akaike T, Otagiri M, Maruyama T.

Anal Chim Acta. 2017 May 29;969:18-25. doi: 10.1016/j.aca.2017.03.027. Epub 2017 Mar 22.

PMID:
28411626
35.

Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling.

Álvarez L, Bianco CL, Toscano JP, Lin J, Akaike T, Fukuto JM.

Antioxid Redox Signal. 2017 Oct 1;27(10):622-633. doi: 10.1089/ars.2017.7081. Epub 2017 Jun 13. Review.

PMID:
28398141
36.

Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments.

Kamei KI, Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Nakajima M, Shibata-Seki T, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Chen Y.

Small. 2017 May;13(18). doi: 10.1002/smll.201603104. Epub 2017 Mar 8.

PMID:
28272774
37.

Synthesis of l-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome.

Ono K, Jung M, Zhang T, Tsutsuki H, Sezaki H, Ihara H, Wei FY, Tomizawa K, Akaike T, Sawa T.

Free Radic Biol Med. 2017 May;106:69-79. doi: 10.1016/j.freeradbiomed.2017.02.023. Epub 2017 Feb 9.

PMID:
28189853
38.

Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors.

Kunikata H, Ida T, Sato K, Aizawa N, Sawa T, Tawarayama H, Murayama N, Fujii S, Akaike T, Nakazawa T.

Sci Rep. 2017 Feb 7;7:41984. doi: 10.1038/srep41984.

39.

Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation.

Ihara H, Kitamura A, Kasamatsu S, Ida T, Kakihana Y, Tsutsuki H, Sawa T, Watanabe Y, Akaike T.

Biochem J. 2017 Mar 15;474(7):1149-1162. doi: 10.1042/BCJ20160999.

PMID:
28126743
40.

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.

Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.

Free Radic Biol Med. 2017 Aug;109:132-140. doi: 10.1016/j.freeradbiomed.2017.01.024. Epub 2017 Jan 18. Review.

PMID:
28109891
41.

Impairment of Excitation-Contraction Coupling in Right Ventricular Hypertrophied Muscle with Fibrosis Induced by Pulmonary Artery Banding.

Kusakari Y, Urashima T, Shimura D, Amemiya E, Miyasaka G, Yokota S, Fujimoto Y, Akaike T, Inoue T, Minamisawa S.

PLoS One. 2017 Jan 9;12(1):e0169564. doi: 10.1371/journal.pone.0169564. eCollection 2017.

42.

1,4-Naphthoquinone activates the HSP90/HSF1 pathway through the S-arylation of HSP90 in A431 cells: Negative regulation of the redox signal transduction pathway by persulfides/polysulfides.

Abiko Y, Sha L, Shinkai Y, Unoki T, Luong NC, Tsuchiya Y, Watanabe Y, Hirose R, Akaike T, Kumagai Y.

Free Radic Biol Med. 2017 Mar;104:118-128. doi: 10.1016/j.freeradbiomed.2016.12.047. Epub 2016 Dec 31.

PMID:
28049024
43.

Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation.

Kasamatsu S, Nishimura A, Morita M, Matsunaga T, Abdul Hamid H, Akaike T.

Molecules. 2016 Dec 15;21(12). pii: E1721. Review.

44.

Synthesis and Characterization of 8-Nitroguanosine 3',5'-Cyclic Monophosphorothioate Rp-Isomer as a Potent Inhibitor of Protein Kinase G1α.

Ahmed KA, Zhang T, Ono K, Tsutsuki H, Ida T, Akashi S, Miyata K, Oike Y, Akaike T, Sawa T.

Biol Pharm Bull. 2017 Mar 1;40(3):365-374. doi: 10.1248/bpb.b16-00880. Epub 2016 Dec 16.

45.

Tissue thrombin is associated with the pathogenesis of dilated cardiomyopathy.

Ito K, Hongo K, Date T, Ikegami M, Hano H, Owada M, Morimoto S, Kashiwagi Y, Katoh D, Yoshino T, Yoshii A, Kimura H, Nagoshi T, Kajimura I, Kusakari Y, Akaike T, Minamisawa S, Ogawa K, Minai K, Ogawa T, Kawai M, Yajima J, Matsuo S, Yamane T, Taniguchi I, Morimoto S, Yoshimura M.

Int J Cardiol. 2017 Feb 1;228:821-827. doi: 10.1016/j.ijcard.2016.11.176. Epub 2016 Nov 9.

PMID:
27888761
46.

Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1.

Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Abdul Hamid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T.

Biochem Biophys Res Commun. 2016 Nov 11;480(2):180-186. doi: 10.1016/j.bbrc.2016.10.022. Epub 2016 Oct 11.

PMID:
27742479
47.
48.

Fabrication of 3D-culture platform with sandwich architecture for preserving liver-specific functions of hepatocytes using 3D bioprinter.

Arai K, Yoshida T, Okabe M, Goto M, Mir TA, Soko C, Tsukamoto Y, Akaike T, Nikaido T, Zhou K, Nakamura M.

J Biomed Mater Res A. 2017 Jun;105(6):1583-1592. doi: 10.1002/jbm.a.35905. Epub 2017 Mar 23.

PMID:
27643636
49.

Modification of Tau by 8-Nitroguanosine 3',5'-Cyclic Monophosphate (8-Nitro-cGMP): EFFECTS OF NITRIC OXIDE-LINKED CHEMICAL MODIFICATION ON TAU AGGREGATION.

Yoshitake J, Soeda Y, Ida T, Sumioka A, Yoshikawa M, Matsushita K, Akaike T, Takashima A.

J Biol Chem. 2016 Oct 21;291(43):22714-22720. Epub 2016 Sep 6.

50.

Reactive sulfur species regulate tRNA methylthiolation and contribute to insulin secretion.

Takahashi N, Wei FY, Watanabe S, Hirayama M, Ohuchi Y, Fujimura A, Kaitsuka T, Ishii I, Sawa T, Nakayama H, Akaike T, Tomizawa K.

Nucleic Acids Res. 2017 Jan 9;45(1):435-445. doi: 10.1093/nar/gkw745. Epub 2016 Aug 27.

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