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Items: 1 to 50 of 509

1.

Xenon modulates the GABA and glutamate responses at genuine synaptic levels in rat spinal neurons.

Kubota H, Akaike H, Okamitsu N, Jang IS, Nonaka K, Kotani N, Akaike N.

Brain Res Bull. 2020 Jan 24;157:51-60. doi: 10.1016/j.brainresbull.2020.01.016. [Epub ahead of print]

PMID:
31987927
2.

Xenon modulates synaptic transmission to rat hippocampal CA3 neurons at both pre- and postsynaptic sites.

Nonaka K, Kotani N, Akaike H, Shin MC, Yamaga T, Nagami H, Akaike N.

J Physiol. 2019 Dec;597(24):5915-5933. doi: 10.1113/JP278762. Epub 2019 Nov 8.

PMID:
31598974
3.

Intra-axonal Ca2+ mobilization contributes to triphenyltin-induced facilitation in glycinergic transmission of rat spinal neurons.

Noma K, Kurauchi Y, Katsuki H, Oyama Y, Akaike N.

Toxicol In Vitro. 2019 Mar;55:11-14. doi: 10.1016/j.tiv.2018.11.003. Epub 2018 Nov 12.

PMID:
30439410
4.

Comparison of efficacy and toxicity between botulinum toxin subtypes A1 and A2 in cynomolgus macaques.

Torii Y, Sasaki M, Shin MC, Akaike N, Kaji R.

Toxicon. 2018 Oct;153:114-119. doi: 10.1016/j.toxicon.2018.08.017. Epub 2018 Sep 5.

PMID:
30193802
5.

Calcium channel subtypes on glutamatergic mossy fiber terminals synapsing onto rat hippocampal CA3 neurons.

Shin MC, Nonaka K, Yamaga T, Wakita M, Akaike H, Akaike N.

J Neurophysiol. 2018 Sep 1;120(3):1264-1273. doi: 10.1152/jn.00571.2017. Epub 2018 Jun 13.

6.

Effects of triphenyltin on glycinergic transmission on rat spinal neurons.

Noma K, Akaike H, Kurauchi Y, Katsuki H, Oyama Y, Akaike N.

Environ Res. 2018 May;163:186-193. doi: 10.1016/j.envres.2018.02.005. Epub 2018 Feb 22.

PMID:
29453030
7.

4,5-Dichloro-2-octyl-4-isothiazolin-3-one (DCOIT) modifies synaptic transmission in hippocampal CA3 neurons of rats.

Wakita M, Shoudai K, Oyama Y, Akaike N.

Chemosphere. 2017 Oct;184:337-346. doi: 10.1016/j.chemosphere.2017.05.158. Epub 2017 May 29.

PMID:
28605704
8.

Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy.

Ievglevskyi O, Isaev D, Netsyk O, Romanov A, Fedoriuk M, Maximyuk O, Isaeva E, Akaike N, Krishtal O.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150431. doi: 10.1098/rstb.2015.0431.

9.

Effects of propofol on glycinergic neurotransmission in a single spinal nerve synapse preparation.

Wakita M, Kotani N, Akaike N.

Brain Res. 2016 Jan 15;1631:147-56. doi: 10.1016/j.brainres.2015.11.030. Epub 2015 Nov 23.

PMID:
26616339
10.

Nitrous oxide directly inhibits action potential-dependent neurotransmission from single presynaptic boutons adhering to rat hippocampal CA3 neurons.

Wakita M, Kotani N, Yamaga T, Akaike N.

Brain Res Bull. 2015 Sep;118:34-45. doi: 10.1016/j.brainresbull.2015.09.001. Epub 2015 Sep 4.

PMID:
26343381
11.

Modifications of excitatory and inhibitory transmission in rat hippocampal pyramidal neurons by acute lithium treatment.

Wakita M, Nagami H, Takase Y, Nakanishi R, Kotani N, Akaike N.

Brain Res Bull. 2015 Aug;117:39-44. doi: 10.1016/j.brainresbull.2015.07.009. Epub 2015 Aug 3.

PMID:
26247839
12.

Increase in intracellular Ca(2+) level by phenylsulfamide fungicides, tolylfluanid and dichlofluanid, in rat thymic lymphocytes.

Fukunaga E, Enma K, Saitoh S, Nishimura-Danjyobara Y, Oyama Y, Akaike N.

Environ Toxicol Pharmacol. 2015 Jul;40(1):149-55. doi: 10.1016/j.etap.2015.06.004. Epub 2015 Jun 5.

PMID:
26119233
13.

Modulation of inhibitory and excitatory fast neurotransmission in the rat CNS by heavy water (D2O).

Wakita M, Kotani N, Shoudai K, Yamaga T, Akaike N.

J Neurophysiol. 2015 Aug;114(2):1109-18. doi: 10.1152/jn.00801.2014. Epub 2015 May 27.

14.

Tetrodotoxin abruptly blocks excitatory neurotransmission in mammalian CNS.

Wakita M, Kotani N, Akaike N.

Toxicon. 2015 Sep;103:12-8. doi: 10.1016/j.toxicon.2015.05.003. Epub 2015 May 8.

PMID:
25959619
15.

Modulation of excitatory synaptic transmission in rat hippocampal CA3 neurons by triphenyltin, an environmental pollutant.

Wakita M, Oyama Y, Takase Y, Akaike N.

Chemosphere. 2015 Feb;120:598-607. doi: 10.1016/j.chemosphere.2014.09.073. Epub 2014 Oct 27.

PMID:
25462303
16.

Functional changes in piriform cortex pyramidal neurons in the chronic methamphetamine-treated rat.

Hori N, Kadota T, Akaike N.

Gen Physiol Biophys. 2015 Jan;34(1):5-12. doi: 10.4149/gpb_2014024. Epub 2014 Nov 4.

PMID:
25367761
17.

Spinal Central Effects of Peripherally Applied Botulinum Neurotoxin A in Comparison between Its Subtypes A1 and A2.

Koizumi H, Goto S, Okita S, Morigaki R, Akaike N, Torii Y, Harakawa T, Ginnaga A, Kaji R.

Front Neurol. 2014 Jun 23;5:98. doi: 10.3389/fneur.2014.00098. eCollection 2014.

18.

Hemodialysis restored iron distribution that was sequestered in the spleen by bilateral nephrectomy.

Kida A, Kuragano T, Furuta M, Otaki Y, Hasuike Y, Matsuda S, Akaike N, Kokuba Y, Nakanishi T.

Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1393-9. doi: 10.1152/ajprenal.00685.2012. Epub 2014 Apr 16.

19.

Potent cough suppression by physiologically active substance in human plasma.

Akaike N, Ito Y, Ogawa SK, Maeda M, Wakita M, Takahama K, Noguchi T, Kamei S, Hamamoto T, Umehashi M, Maeda H.

Gen Physiol Biophys. 2014;33(2):145-55. doi: 10.4149/gpb_2013083. Epub 2014 Jan 22.

PMID:
24448372
20.

Inhibition of excitatory synaptic transmission in hippocampal neurons by levetiracetam involves Zn²⁺-dependent GABA type A receptor-mediated presynaptic modulation.

Wakita M, Kotani N, Kogure K, Akaike N.

J Pharmacol Exp Ther. 2014 Feb;348(2):246-59. doi: 10.1124/jpet.113.208751. Epub 2013 Nov 20.

PMID:
24259680
21.

Potent and direct presynaptic modulation of glycinergic transmission in rat spinal neurons by atrial natriuretic peptide.

Maeda M, Mizuno Y, Wakita M, Yamaga T, Nonaka K, Shin MC, Shoudai K, Akaike N.

Brain Res Bull. 2013 Oct;99:19-26. doi: 10.1016/j.brainresbull.2013.09.003. Epub 2013 Sep 21.

PMID:
24060848
22.

Effects of propofol on GABAergic and glutamatergic transmission in isolated hippocampal single nerve-synapse preparations.

Wakita M, Kotani N, Nonaka K, Shin MC, Akaike N.

Eur J Pharmacol. 2013 Oct 15;718(1-3):63-73. doi: 10.1016/j.ejphar.2013.09.018. Epub 2013 Sep 17.

PMID:
24051267
23.

Botulinum neurotoxin A2 reduces incidence of seizures in mouse models of temporal lobe epilepsy.

Kato K, Akaike N, Kohda T, Torii Y, Goto Y, Harakawa T, Ginnaga A, Kaji R, Kozaki S.

Toxicon. 2013 Nov;74:109-15. doi: 10.1016/j.toxicon.2013.07.027. Epub 2013 Aug 15.

PMID:
23954512
24.

Effects of selenoprotein P on the contraction and relaxation of the airway smooth muscle.

Ogawa SK, Shin MC, Hirashima M, Akaike N, Ito Y.

Gen Physiol Biophys. 2013 Mar;32(1):47-54. doi: 10.4149/gpb_2013012.

PMID:
23531834
25.

Removal of toxin (tetrodotoxin) from puffer ovary by traditional fermentation.

Anraku K, Nonaka K, Yamaga T, Yamamoto T, Shin MC, Wakita M, Hamamoto A, Akaike N.

Toxins (Basel). 2013 Jan 18;5(1):193-202. doi: 10.3390/toxins5010193.

26.

Antinociceptive effects of A1 and A2 type botulinum toxins on carrageenan-induced hyperalgesia in rat.

Shin MC, Yukihira T, Ito Y, Akaike N.

Toxicon. 2013 Mar 15;64:12-9. doi: 10.1016/j.toxicon.2012.12.011. Epub 2012 Dec 24.

PMID:
23270755
27.

Modulation of allopregnanolone on excitatory transmitters release from single glutamatergic terminal.

Iwata S, Wakita M, Shin MC, Fukuda A, Akaike N.

Brain Res Bull. 2013 Apr;93:39-46. doi: 10.1016/j.brainresbull.2012.11.002. Epub 2012 Nov 19. Review.

PMID:
23174309
28.

Transsynaptic inhibition of spinal transmission by A2 botulinum toxin.

Akaike N, Shin MC, Wakita M, Torii Y, Harakawa T, Ginnaga A, Kato K, Kaji R, Kozaki S.

J Physiol. 2013 Feb 15;591(4):1031-43. doi: 10.1113/jphysiol.2012.242131. Epub 2012 Oct 29.

29.

Comparative effects of pentobarbital on spontaneous and evoked transmitter release from inhibitory and excitatory nerve terminals in rat CA3 neurons.

Shin MC, Wakita M, Iwata S, Nonaka K, Kotani N, Akaike N.

Brain Res Bull. 2013 Jan;90:10-8. doi: 10.1016/j.brainresbull.2012.09.013. Epub 2012 Sep 28.

PMID:
23026118
30.

The effects of volatile anesthetics on synaptic and extrasynaptic GABA-induced neurotransmission.

Kotani N, Akaike N.

Brain Res Bull. 2013 Apr;93:69-79. doi: 10.1016/j.brainresbull.2012.08.001. Epub 2012 Aug 17. Review.

PMID:
22925739
31.

Effects of halothane on GABAergic and glutamatergic transmission in isolated hippocampal nerve-synapse preparations.

Kotani N, Wakita M, Shin MC, Ogawa S, Nonaka K, Akaike N.

Brain Res. 2012 Sep 14;1473:9-18. doi: 10.1016/j.brainres.2012.07.035. Epub 2012 Jul 23.

PMID:
22836013
32.

Effects of ethanol on GABA(A) receptors in GABAergic and glutamatergic presynaptic nerve terminals.

Wakita M, Shin MC, Iwata S, Nonaka K, Akaike N.

J Pharmacol Exp Ther. 2012 Jun;341(3):809-19. doi: 10.1124/jpet.111.189126. Epub 2012 Mar 20.

PMID:
22434676
33.

Effects of tetanus toxin on spontaneous and evoked transmitter release at inhibitory and excitatory synapses in the rat SDCN neurons.

Shin MC, Nonaka K, Wakita M, Yamaga T, Torii Y, Harakawa T, Ginnaga A, Ito Y, Akaike N.

Toxicon. 2012 Mar 1;59(3):385-92. doi: 10.1016/j.toxicon.2011.12.009. Epub 2011 Dec 28.

PMID:
22227157
34.

Neurotoxin A2NTX blocks fast inhibitory and excitatory transmitter release from presynaptic terminals.

Yamaga T, Aou S, Shin MC, Wakita M, Akaike N.

J Pharmacol Sci. 2012;118(1):75-81. Epub 2011 Dec 23.

35.

Inhibition of membrane Na+ channels by A type botulinum toxin at femtomolar concentrations in central and peripheral neurons.

Shin MC, Wakita M, Xie DJ, Yamaga T, Iwata S, Torii Y, Harakawa T, Ginnaga A, Kozaki S, Akaike N.

J Pharmacol Sci. 2012;118(1):33-42. Epub 2011 Dec 10.

36.

Type A1 but not type A2 botulinum toxin decreases the grip strength of the contralateral foreleg through axonal transport from the toxin-treated foreleg of rats.

Torii Y, Akaike N, Harakawa T, Kato K, Sugimoto N, Goto Y, Nakahira S, Kohda T, Kozaki S, Kaji R, Ginnaga A.

J Pharmacol Sci. 2011;117(4):275-85. Epub 2011 Nov 26.

37.

Synergic effect of diazepam and muscimol via presynaptic GABA(A) receptors on glutamatergic evoked EPSCs.

Shin MC, Wakita M, Xie DJ, Iwata S, Akaike N.

Brain Res. 2011 Oct 6;1416:1-9. doi: 10.1016/j.brainres.2011.07.054. Epub 2011 Aug 2.

PMID:
21890116
38.

Different effects of α-chloralose on spontaneous and evoked GABA release in rat hippocampal CA1 neurons.

Matsuura T, Iwata S, Shin MC, Wakita M, Ogawa SK, Akaike N.

Brain Res Bull. 2011 May 30;85(3-4):180-8. doi: 10.1016/j.brainresbull.2011.03.022. Epub 2011 Mar 29.

PMID:
21453759
39.

Comparative study on the actions of toxin extracts from two different puffer fishes on I(Na) and respiratory N-M transmission in the rat.

Yamamoto S, Yoshimura M, Iwata S, Matsuura T, Shin MC, Yamaga T, Ito Y, Akaike N.

Fukuoka Igaku Zasshi. 2010 Aug;101(8):173-81.

PMID:
21171523
40.

Volatile anesthetic effects on isolated GABA synapses and extrasynaptic receptors.

Ogawa SK, Tanaka E, Shin MC, Kotani N, Akaike N.

Neuropharmacology. 2011 Mar;60(4):701-10. doi: 10.1016/j.neuropharm.2010.11.016. Epub 2010 Nov 25.

PMID:
21111749
41.

GABA(A) receptor-mediated presynaptic inhibition on glutamatergic transmission.

Yamamoto S, Yoshimura M, Shin MC, Wakita M, Nonaka K, Akaike N.

Brain Res Bull. 2011 Jan 15;84(1):22-30. doi: 10.1016/j.brainresbull.2010.10.007. Epub 2010 Oct 29.

PMID:
21044903
42.

Effects of A2 type botulinum toxin on spontaneous miniature and evoked transmitter release from the rat spinal excitatory and inhibitory synapses.

Akaike N, Ito Y, Shin MC, Nonaka K, Torii Y, Harakawa T, Ginnaga A, Kozaki S, Kaji R.

Toxicon. 2010 Dec;56(8):1315-26. doi: 10.1016/j.toxicon.2010.07.015. Epub 2010 Jul 30.

PMID:
20674584
43.

Inhibition of Na currents by the toxin extracts from puffer fishes captured in the sea coast of Japan.

Iwata S, Matsuura T, Yamamoto S, Tahara T, Shin MC, Ito Y, Akaike N.

Toxicon. 2010 Nov;56(6):999-1006. doi: 10.1016/j.toxicon.2010.07.004. Epub 2010 Jul 14.

PMID:
20637221
44.
45.

Neurotoxic effects of methamphetamine on rat hippocampus pyramidal neurons.

Hori N, Kadota MT, Watanabe M, Ito Y, Akaike N, Carpenter DO.

Cell Mol Neurobiol. 2010 Aug;30(6):849-56. doi: 10.1007/s10571-010-9512-1. Epub 2010 Mar 16.

PMID:
20232135
46.

P- and R-type Ca2+ channels regulating spinal glycinergic nerve terminals.

Nonaka K, Murayama N, Maeda M, Shoudai K, Shin MC, Akaike N.

Toxicon. 2010 Jun 15;55(7):1283-90. doi: 10.1016/j.toxicon.2010.01.020. Epub 2010 Feb 6.

PMID:
20144644
47.

Presynaptic effects of grayanotoxin III on excitatory and inhibitory nerve terminals in rat ventromedial hypothalamic neurons.

Kim SE, Shin MC, Akaike N, Kim CJ.

Neurotoxicology. 2010 Mar;31(2):230-8. doi: 10.1016/j.neuro.2009.12.006. Epub 2009 Dec 28.

PMID:
20038438
48.

Effects of scorpion toxin on excitatory and inhibitory presynaptic terminals.

Akaike H, Shin MC, Kubo C, Akaike N.

Toxicology. 2009 Oct 29;264(3):198-204. doi: 10.1016/j.tox.2009.08.010. Epub 2009 Aug 15.

PMID:
19686797
49.

Neuronal glutamate transporters regulate synaptic transmission in single synapses on CA1 hippocampal neurons.

Kondratskaya E, Shin MC, Akaike N.

Brain Res Bull. 2010 Jan 15;81(1):53-60. doi: 10.1016/j.brainresbull.2009.07.014.

PMID:
19665527
50.

Gastric relaxation induced by electrical and chemical stimulation of the area postrema in the rat.

Kawachi M, Hori N, Takei M, Kurimoto T, Akaike N, Ito Y.

Gen Physiol Biophys. 2008 Dec;27(4):243-52.

PMID:
19202197

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