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Heterogeneous clinical and functional features of GRIN2D-related developmental and epileptic encephalopathy.

XiangWei W, Kannan V, Xu Y, Kosobucki GJ, Schulien AJ, Kusumoto H, Moufawad El Achkar C, Bhattacharya S, Lesca G, Nguyen S, Helbig KL, Cuisset JM, Fenger CD, Marjanovic D, Schuler E, Wu Y, Bao X, Zhang Y, Dirkx N, Schoonjans AS, Syrbe S, Myers SJ, Poduri A, Aizenman E, Traynelis SF, Lemke JR, Yuan H, Jiang Y.

Brain. 2019 Oct 1;142(10):3009-3027. doi: 10.1093/brain/awz232.


Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.

Yeh CY, Ye Z, Moutal A, Gaur S, Henton AM, Kouvaros S, Saloman JL, Hartnett-Scott KA, Tzounopoulos T, Khanna R, Aizenman E, Camacho CJ.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15696-15705. doi: 10.1073/pnas.1903401116. Epub 2019 Jul 15.


Molecular Neuroprotection Induced by Zinc-Dependent Expression of Hepatitis C-Derived Protein NS5A Targeting Kv2.1 Potassium Channels.

Justice JA, Manjooran DT, Yeh CY, Hartnett-Scott KA, Schulien AJ, Kosobucki GJ, Mammen S, Palladino MJ, Aizenman E.

J Pharmacol Exp Ther. 2018 Nov;367(2):348-355. doi: 10.1124/jpet.118.252338. Epub 2018 Sep 6.


Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

Yeh CY, Bulas AM, Moutal A, Saloman JL, Hartnett KA, Anderson CT, Tzounopoulos T, Sun D, Khanna R, Aizenman E.

J Neurosci. 2017 Jun 7;37(23):5648-5658. doi: 10.1523/JNEUROSCI.3811-16.2017. Epub 2017 May 8.


Disruption of KV2.1 somato-dendritic clusters prevents the apoptogenic increase of potassium currents.

Justice JA, Schulien AJ, He K, Hartnett KA, Aizenman E, Shah NH.

Neuroscience. 2017 Jun 23;354:158-167. doi: 10.1016/j.neuroscience.2017.04.034. Epub 2017 Apr 28.


Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology.

Ogden KK, Chen W, Swanger SA, McDaniel MJ, Fan LZ, Hu C, Tankovic A, Kusumoto H, Kosobucki GJ, Schulien AJ, Su Z, Pecha J, Bhattacharya S, Petrovski S, Cohen AE, Aizenman E, Traynelis SF, Yuan H.

PLoS Genet. 2017 Jan 17;13(1):e1006536. doi: 10.1371/journal.pgen.1006536. eCollection 2017 Jan.


GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.

Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W, Schulien AJ, Chiavacci R, Tankovic A, Naase C, Brueckner F, von St├╝lpnagel-Steinbeis C, Hu C, Kusumoto H, Hedrich UB, Elsen G, H├Ârtnagel K, Aizenman E, Lemke JR, Hakonarson H, Traynelis SF, Falk MJ.

Am J Hum Genet. 2016 Oct 6;99(4):802-816. doi: 10.1016/j.ajhg.2016.07.013. Epub 2016 Sep 8.


Synthesis and Evaluation of Potent KCNQ2/3-Specific Channel Activators.

Kumar M, Reed N, Liu R, Aizenman E, Wipf P, Tzounopoulos T.

Mol Pharmacol. 2016 Jun;89(6):667-77. doi: 10.1124/mol.115.103200. Epub 2016 Mar 22.


Zn(2+) -induced Ca(2+) release via ryanodine receptors triggers calcineurin-dependent redistribution of cortical neuronal Kv2.1 K(+) channels.

Schulien AJ, Justice JA, Di Maio R, Wills ZP, Shah NH, Aizenman E.

J Physiol. 2016 May 15;594(10):2647-59. doi: 10.1113/JP272117.


Metals and neurodegeneration.

Aizenman E, Mastroberardino PG.

Neurobiol Dis. 2015 Sep;81:1-3. doi: 10.1016/j.nbd.2015.08.012. No abstract available.


Critical role of Casein kinase 2 in hepatitis C NS5A-mediated inhibition of Kv2.1 K(+) channel function.

Clemens K, Yeh CY, Aizenman E.

Neurosci Lett. 2015 Nov 16;609:48-52. doi: 10.1016/j.neulet.2015.10.021. Epub 2015 Oct 17.


Familial Dysautonomia (FD) Human Embryonic Stem Cell Derived PNS Neurons Reveal that Synaptic Vesicular and Neuronal Transport Genes Are Directly or Indirectly Affected by IKBKAP Downregulation.

Lefler S, Cohen MA, Kantor G, Cheishvili D, Even A, Birger A, Turetsky T, Gil Y, Even-Ram S, Aizenman E, Bashir N, Maayan C, Razin A, Reubinoff BE, Weil M.

PLoS One. 2015 Oct 5;10(10):e0138807. doi: 10.1371/journal.pone.0138807. eCollection 2015.


Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.

Ganay T, Asraf H, Aizenman E, Bogdanovic M, Sekler I, Hershfinkel M.

J Neurochem. 2015 Dec;135(5):897-907. doi: 10.1111/jnc.13367. Epub 2015 Oct 22.


Seashells by the zinc shore: a meeting report of the International Society for Zinc Biology, Asilomar, CA 2014.

Hershfinkel M, Ford D, Kelleher S, Aizenman E.

Metallomics. 2015 Sep;7(9):1299-304. doi: 10.1039/c5mt90029h. No abstract available.


Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels.

He K, McCord MC, Hartnett KA, Aizenman E.

PLoS One. 2015 Jun 26;10(6):e0129498. doi: 10.1371/journal.pone.0129498. eCollection 2015.


Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.

Gilad D, Shorer S, Ketzef M, Friedman A, Sekler I, Aizenman E, Hershfinkel M.

Neurobiol Dis. 2015 Sep;81:4-13. doi: 10.1016/j.nbd.2014.12.020. Epub 2015 Jan 3.


Frozen-Thawed Embryo Transfer Success Rate is Affected by Age and Ovarian Response at Oocyte Aspiration Regardless of Blastomere Survival Rate.

Bdolah Y, Zemet R, Aizenman E, Lossos F, Abram TB, Shufaro Y.

JBRA Assist Reprod. 2015 Nov 1;19(4):210-5. doi: 10.5935/1518-0557.20150041.


Syntaxin-binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents.

McCord MC, Kullmann PH, He K, Hartnett KA, Horn JP, Lotan I, Aizenman E.

J Physiol. 2014 Aug 15;592(16):3511-21. doi: 10.1113/jphysiol.2014.276964. Epub 2014 Jun 13.


The role of intracellular zinc release in aging, oxidative stress, and Alzheimer's disease.

McCord MC, Aizenman E.

Front Aging Neurosci. 2014 Apr 17;6:77. doi: 10.3389/fnagi.2014.00077. eCollection 2014. Review.


Zygote serine decreased uptake from the fertilization medium is associated with implantation and pregnancy.

Zivi E, Barash D, Aizenman E, Gibson D, Shufaro Y.

J Assist Reprod Genet. 2014 Jul;31(7):889-97. doi: 10.1007/s10815-014-0231-2. Epub 2014 May 2.


Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia.

Shah NH, Schulien AJ, Clemens K, Aizenman TD, Hageman TM, Wills ZP, Aizenman E.

J Neurosci. 2014 Mar 19;34(12):4326-31. doi: 10.1523/JNEUROSCI.5184-13.2014.


Voltage-gated potassium channels at the crossroads of neuronal function, ischemic tolerance, and neurodegeneration.

Shah NH, Aizenman E.

Transl Stroke Res. 2014 Feb;5(1):38-58. doi: 10.1007/s12975-013-0297-7. Epub 2013 Nov 19. Review.


Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents.

McCord MC, Aizenman E.

Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13988-93. doi: 10.1073/pnas.1306238110. Epub 2013 Aug 5.


Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid synthesis.

Perez-Rosello T, Anderson CT, Schopfer FJ, Zhao Y, Gilad D, Salvatore SR, Freeman BA, Hershfinkel M, Aizenman E, Tzounopoulos T.

J Neurosci. 2013 May 29;33(22):9259-72. doi: 10.1523/JNEUROSCI.0237-13.2013. Erratum in: J Neurosci. 2014 May 21;34(21):7394.


Glutamate transporter expression and function in a striatal neuronal model of Huntington's disease.

Petr GT, Bakradze E, Frederick NM, Wang J, Armsen W, Aizenman E, Rosenberg PA.

Neurochem Int. 2013 Jun;62(7):973-81. doi: 10.1016/j.neuint.2013.02.026. Epub 2013 Mar 15.


Targeted single-neuron infection with rabies virus for transneuronal multisynaptic tracing.

Nguyen TD, Wirblich C, Aizenman E, Schnell MJ, Strick PL, Kandler K.

J Neurosci Methods. 2012 Aug 15;209(2):367-70. doi: 10.1016/j.jneumeth.2012.06.019. Epub 2012 Jun 26.


Derivation of xeno-free and GMP-grade human embryonic stem cells--platforms for future clinical applications.

Tannenbaum SE, Turetsky TT, Singer O, Aizenman E, Kirshberg S, Ilouz N, Gil Y, Berman-Zaken Y, Perlman TS, Geva N, Levy O, Arbell D, Simon A, Ben-Meir A, Shufaro Y, Laufer N, Reubinoff BE.

PLoS One. 2012;7(6):e35325. doi: 10.1371/journal.pone.0035325. Epub 2012 Jun 20.


Regulation of neuronal proapoptotic potassium currents by the hepatitis C virus nonstructural protein 5A.

Norris CA, He K, Springer MG, Hartnett KA, Horn JP, Aizenman E.

J Neurosci. 2012 Jun 27;32(26):8865-70. doi: 10.1523/JNEUROSCI.0937-12.2012.


Human granulosa luteal cell oxidative phosphorylation function is not affected by age or ovarian response.

Shufaro Y, Lebovich M, Aizenman E, Miller C, Simon A, Laufer N, Saada A.

Fertil Steril. 2012 Jul;98(1):166-72. doi: 10.1016/j.fertnstert.2012.03.051. Epub 2012 May 10.


SNARE-dependent upregulation of potassium chloride co-transporter 2 activity after metabotropic zinc receptor activation in rat cortical neurons in vitro.

Saadi RA, He K, Hartnett KA, Kandler K, Hershfinkel M, Aizenman E.

Neuroscience. 2012 May 17;210:38-46. doi: 10.1016/j.neuroscience.2012.03.001. Epub 2012 Mar 7.


The neurophysiology and pathology of brain zinc.

Sensi SL, Paoletti P, Koh JY, Aizenman E, Bush AI, Hershfinkel M.

J Neurosci. 2011 Nov 9;31(45):16076-85. doi: 10.1523/JNEUROSCI.3454-11.2011. Review.


Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.

Chorin E, Vinograd O, Fleidervish I, Gilad D, Herrmann S, Sekler I, Aizenman E, Hershfinkel M.

J Neurosci. 2011 Sep 7;31(36):12916-26. doi: 10.1523/JNEUROSCI.2205-11.2011.


Inhibitory effects of chalcone glycosides isolated from Brassica rapa L. 'hidabeni' and their synthetic derivatives on LPS-induced NO production in microglia.

Hara H, Nakamura Y, Ninomiya M, Mochizuki R, Kamiya T, Aizenman E, Koketsu M, Adachi T.

Bioorg Med Chem. 2011 Sep 15;19(18):5559-68. doi: 10.1016/j.bmc.2011.07.036. Epub 2011 Jul 26.


Redox regulation of intracellular zinc: molecular signaling in the life and death of neurons.

Aras MA, Aizenman E.

Antioxid Redox Signal. 2011 Oct 15;15(8):2249-63. doi: 10.1089/ars.2010.3607. Epub 2011 Mar 31. Review.


Complex role of zinc in methamphetamine toxicity in vitro.

Aizenman E, McCord MC, Saadi RA, Hartnett KA, He K.

Neuroscience. 2010 Nov 24;171(1):31-9. doi: 10.1016/j.neuroscience.2010.08.049. Epub 2010 Aug 27.


Zinc bells rang in Jerusalem!

Hershfinkel M, Aizenman E, Andrews G, Sekler I.

Sci Signal. 2010 Jul 6;3(129):mr2. doi: 10.1126/scisignal.3129mr2.


ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity.

He K, Aizenman E.

J Neurochem. 2010 Jul;114(2):452-61. doi: 10.1111/j.1471-4159.2010.06762.x. Epub 2010 Apr 20.


Derivation, propagation and controlled differentiation of human embryonic stem cells in suspension.

Steiner D, Khaner H, Cohen M, Even-Ram S, Gil Y, Itsykson P, Turetsky T, Idelson M, Aizenman E, Ram R, Berman-Zaken Y, Reubinoff B.

Nat Biotechnol. 2010 Apr;28(4):361-4. doi: 10.1038/nbt.1616. Epub 2010 Mar 28.


Zn2+ regulates Kv2.1 voltage-dependent gating and localization following ischemia.

Aras MA, Saadi RA, Aizenman E.

Eur J Neurosci. 2009 Dec;30(12):2250-7. doi: 10.1111/j.1460-9568.2009.07026.x. Epub 2009 Dec 10.


Monozygotic multiple gestation after intracytoplasmic sperm injection and preimplantation genetic diagnosis.

Haimov-Kochman R, Daum H, Lossos F, Aizenman E, Werner M, Yagel S, Laufer N, Simon A, Hurwitz A.

Fertil Steril. 2009 Dec;92(6):2037.e11-7. doi: 10.1016/j.fertnstert.2009.09.002. Epub 2009 Oct 12.


Regulation of apoptotic potassium currents by coordinated zinc-dependent signalling.

Redman PT, Hartnett KA, Aras MA, Levitan ES, Aizenman E.

J Physiol. 2009 Sep 15;587(Pt 18):4393-404. doi: 10.1113/jphysiol.2009.176321. Epub 2009 Jul 21. Erratum in: J Physiol. 2009 Nov 1;587(Pt 21):5295.


Protein kinase C regulation of neuronal zinc signaling mediates survival during preconditioning.

Aras MA, Hara H, Hartnett KA, Kandler K, Aizenman E.

J Neurochem. 2009 Jul;110(1):106-17. doi: 10.1111/j.1471-4159.2009.06106.x. Epub 2009 Apr 22.


Intracellular zinc inhibits KCC2 transporter activity.

Hershfinkel M, Kandler K, Knoch ME, Dagan-Rabin M, Aras MA, Abramovitch-Dahan C, Sekler I, Aizenman E.

Nat Neurosci. 2009 Jun;12(6):725-7. doi: 10.1038/nn.2316. Epub 2009 May 10.


NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue.

Eisenman LN, Shu HJ, Wang C, Aizenman E, Covey DF, Zorumski CF, Mennerick S.

J Physiol. 2009 Jun 15;587(Pt 12):2937-47. doi: 10.1113/jphysiol.2009.172700. Epub 2009 Apr 29.


Preimplantation genetic diagnosis for BRCA1/2--a novel clinical experience.

Sagi M, Weinberg N, Eilat A, Aizenman E, Werner M, Girsh E, Siminovsky Y, Abeliovich D, Peretz T, Simon A, Laufer N.

Prenat Diagn. 2009 May;29(5):508-13. doi: 10.1002/pd.2232.


At what age can human oocytes be obtained?

Revel A, Revel-Vilk S, Aizenman E, Porat-Katz A, Safran A, Ben-Meir A, Weintraub M, Shapira M, Achache H, Laufer N.

Fertil Steril. 2009 Aug;92(2):458-63. doi: 10.1016/j.fertnstert.2008.07.013. Epub 2008 Oct 26.


Selective inhibition of mitogen-activated protein kinase phosphatases by zinc accounts for extracellular signal-regulated kinase 1/2-dependent oxidative neuronal cell death.

Ho Y, Samarasinghe R, Knoch ME, Lewis M, Aizenman E, DeFranco DB.

Mol Pharmacol. 2008 Oct;74(4):1141-51. doi: 10.1124/mol.108.049064. Epub 2008 Jul 17.


Assessment of cell viability in primary neuronal cultures.

Aras MA, Hartnett KA, Aizenman E.

Curr Protoc Neurosci. 2008 Jul;Chapter 7:Unit 7.18. doi: 10.1002/0471142301.ns0718s44.


Laser-assisted derivation of human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis.

Turetsky T, Aizenman E, Gil Y, Weinberg N, Shufaro Y, Revel A, Laufer N, Simon A, Abeliovich D, Reubinoff BE.

Hum Reprod. 2008 Jan;23(1):46-53. Epub 2007 Nov 7.


Microglia induce neurotoxicity via intraneuronal Zn(2+) release and a K(+) current surge.

Knoch ME, Hartnett KA, Hara H, Kandler K, Aizenman E.

Glia. 2008 Jan 1;56(1):89-96.

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