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Items: 30


A New Series of Orally Bioavailable Chemokine Receptor 9 (CCR9) Antagonists; Possible Agents for the Treatment of Inflammatory Bowel Disease.

Kalindjian SB, Kadnur SV, Hewson CA, Venkateshappa C, Juluri S, Kristam R, Kulkarni B, Mohammed Z, Saxena R, Viswanadhan VN, Aiyar J, McVey D.

J Med Chem. 2016 Apr 14;59(7):3098-111. doi: 10.1021/acs.jmedchem.5b01840. Epub 2016 Mar 17.


Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation.

Witte LP, de Haas N, Mammen M, Stangeland EL, Steinfeld T, Aiyar J, Michel MC.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Dec;384(6):555-63. doi: 10.1007/s00210-011-0689-8. Epub 2011 Sep 24.


Expedited SAR study of high-affinity ligands to the alpha(2)delta subunit of voltage-gated calcium channels: Generation of a focused library using a solution-phase Sn2Ar coupling methodology.

Chen C, Stearns B, Hu T, Anker N, Santini A, Arruda JM, Campbell BT, Datta P, Aiyar J, Munoz B.

Bioorg Med Chem Lett. 2006 Feb;16(3):746-9.


Comparison of the antinociceptive profiles of gabapentin and 3-methylgabapentin in rat models of acute and persistent pain: implications for mechanism of action.

Urban MO, Ren K, Park KT, Campbell B, Anker N, Stearns B, Aiyar J, Belley M, Cohen C, Bristow L.

J Pharmacol Exp Ther. 2005 Jun;313(3):1209-16. Epub 2005 Feb 25.


Ric-3 promotes functional expression of the nicotinic acetylcholine receptor alpha7 subunit in mammalian cells.

Williams ME, Burton B, Urrutia A, Shcherbatko A, Chavez-Noriega LE, Cohen CJ, Aiyar J.

J Biol Chem. 2005 Jan 14;280(2):1257-63. Epub 2004 Oct 25.


Identification and synthesis of [1,2,4]triazolo[3,4-a]phthalazine derivatives as high-affinity ligands to the alpha 2 delta-1 subunit of voltage gated calcium channel.

Lebsack AD, Gunzner J, Wang B, Pracitto R, Schaffhauser H, Santini A, Aiyar J, Bezverkov R, Munoz B, Liu W, Venkatraman S.

Bioorg Med Chem Lett. 2004 May 17;14(10):2463-7.


Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives as high-affinity ligands of the alpha(2)delta subunit of voltage-gated calcium channels.

Hu T, Stearns BA, Campbell BT, Arruda JM, Chen C, Aiyar J, Bezverkov RE, Santini A, Schaffhauser H, Liu W, Venkatraman S, Munoz B.

Bioorg Med Chem Lett. 2004 May 3;14(9):2031-4.


N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the alpha2delta subunit of voltage gated calcium channels.

Lim J, Stock N, Pracitto R, Boueres JK, Munoz B, Chaudhary A, Santini AM, Orr K, Schaffhauser H, Bezverkov RE, Aiyar J, Venkatraman S.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1913-6.


International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS; International Union of Pharmacology.

Pharmacol Rev. 2003 Dec;55(4):583-6.


Differential expression of kcnq2 splice variants: implications to m current function during neuronal development.

Smith JS, Iannotti CA, Dargis P, Christian EP, Aiyar J.

J Neurosci. 2001 Feb 15;21(4):1096-103. Erratum in: J Neurosci 2001 Mar 15;21(6):1b.


Structure-guided transformation of charybdotoxin yields an analog that selectively targets Ca(2+)-activated over voltage-gated K(+) channels.

Rauer H, Lanigan MD, Pennington MW, Aiyar J, Ghanshani S, Cahalan MD, Norton RS, Chandy KG.

J Biol Chem. 2000 Jan 14;275(2):1201-8.


Interaction of calicheamicin gamma1(I) and its related carbohydrates with DNA-protein complexes.

Sissi C, Aiyar J, Boyer S, Depew K, Danishefsky S, Crothers DM.

Proc Natl Acad Sci U S A. 1999 Sep 14;96(19):10643-8.


Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1.

Fanger CM, Ghanshani S, Logsdon NJ, Rauer H, Kalman K, Zhou J, Beckingham K, Chandy KG, Cahalan MD, Aiyar J.

J Biol Chem. 1999 Feb 26;274(9):5746-54.


Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states.

J├Ąger H, Rauer H, Nguyen AN, Aiyar J, Chandy KG, Grissmer S.

J Physiol. 1998 Jan 15;506 ( Pt 2):291-301.


A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes.

Logsdon NJ, Kang J, Togo JA, Christian EP, Aiyar J.

J Biol Chem. 1997 Dec 26;272(52):32723-6.


Purification, visualization, and biophysical characterization of Kv1.3 tetramers.

Spencer RH, Sokolov Y, Li H, Takenaka B, Milici AJ, Aiyar J, Nguyen A, Park H, Jap BK, Hall JE, Gutman GA, Chandy KG.

J Biol Chem. 1997 Jan 24;272(4):2389-95.


The signature sequence of voltage-gated potassium channels projects into the external vestibule.

Aiyar J, Rizzi JP, Gutman GA, Chandy KG.

J Biol Chem. 1996 Dec 6;271(49):31013-6.


Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.

Nguyen A, Kath JC, Hanson DC, Biggers MS, Canniff PC, Donovan CB, Mather RJ, Bruns MJ, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG.

Mol Pharmacol. 1996 Dec;50(6):1672-9.


Characterization of the transcription unit of mouse Kv1.4, a voltage-gated potassium channel gene.

Wymore RS, Negulescu D, Kinoshita K, Kalman K, Aiyar J, Gutman GA, Chandy KG.

J Biol Chem. 1996 Jun 28;271(26):15629-34.


Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins.

Aiyar J, Withka JM, Rizzi JP, Singleton DH, Andrews GC, Lin W, Boyd J, Hanson DC, Simon M, Dethlefs B, et al.

Neuron. 1995 Nov;15(5):1169-81.


The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway.

Aiyar J, Nguyen AN, Chandy KG, Grissmer S.

Biophys J. 1994 Dec;67(6):2261-4.


Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.

Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG.

Mol Pharmacol. 1994 Jun;45(6):1227-34.


Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC.

Aiyar J, Grissmer S, Chandy KG.

Am J Physiol. 1993 Dec;265(6 Pt 1):C1571-8.


Reduction of chromium(VI) to chromium(V) by rat liver cytosolic and microsomal fractions: is DT-diaphorase involved?

Aiyar J, De Flora S, Wetterhahn KE.

Carcinogenesis. 1992 Jul;13(7):1159-66.


K+ channel expression in primary cell cultures mediated by vaccinia virus.

Karschin A, Aiyar J, Gouin A, Davidson N, Lester HA.

FEBS Lett. 1991 Jan 28;278(2):229-33.


Rotavirus-specific antibody response in saliva of infants with rotavirus diarrhea.

Aiyar J, Bhan MK, Bhandari N, Kumar R, Raj P, Sazawal S.

J Infect Dis. 1990 Dec;162(6):1383-4.


Reaction of chromium (VI) with hydrogen peroxide in the presence of glutathione: reactive intermediates and resulting DNA damage.

Aiyar J, Berkovits HJ, Floyd RA, Wetterhahn KE.

Chem Res Toxicol. 1990 Nov-Dec;3(6):595-603.


Mechanism of chromium(VI) carcinogenesis. Reactive intermediates and effect on gene expression.

Wetterhahn KE, Hamilton JW, Aiyar J, Borges KM, Floyd R.

Biol Trace Elem Res. 1989 Jul-Sep;21:405-11. Review.


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