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Items: 38

1.

Identification and structural characterization of LytU, a unique peptidoglycan endopeptidase from the lysostaphin family.

Raulinaitis V, Tossavainen H, Aitio O, Juuti JT, Hiramatsu K, Kontinen V, Permi P.

Sci Rep. 2017 Jul 20;7(1):6020. doi: 10.1038/s41598-017-06135-w.

2.

1H, 13C and 15N resonance assignments of the new lysostaphin family endopeptidase catalytic domain from Staphylococcus aureus.

Raulinaitis V, Tossavainen H, Aitio O, Seppala R, Permi P.

Biomol NMR Assign. 2017 Apr;11(1):69-73. doi: 10.1007/s12104-016-9722-7. Epub 2016 Dec 9.

PMID:
27943001
3.

Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2.

Tossavainen H, Aitio O, Hellman M, Saksela K, Permi P.

J Biol Chem. 2016 Jul 29;291(31):16307-17. doi: 10.1074/jbc.M116.732412. Epub 2016 Jun 6.

4.

Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway.

Vestola J, Shishido TK, Jokela J, Fewer DP, Aitio O, Permi P, Wahlsten M, Wang H, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1909-17. doi: 10.1073/pnas.1320913111. Epub 2014 Apr 17.

5.

New structural variants of aeruginosin produced by the toxic bloom forming cyanobacterium Nodularia spumigena.

Fewer DP, Jokela J, Paukku E, Österholm J, Wahlsten M, Permi P, Aitio O, Rouhiainen L, Gomez-Saez GV, Sivonen K.

PLoS One. 2013 Sep 6;8(9):e73618. doi: 10.1371/journal.pone.0073618. eCollection 2013.

6.

Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

Aitio O, Hellman M, Skehan B, Kesti T, Leong JM, Saksela K, Permi P.

Structure. 2012 Oct 10;20(10):1692-703. doi: 10.1016/j.str.2012.07.015. Epub 2012 Aug 23.

7.

Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid.

Kandiba L, Aitio O, Helin J, Guan Z, Permi P, Bamford DH, Eichler J, Roine E.

Mol Microbiol. 2012 May;84(3):578-93. doi: 10.1111/j.1365-2958.2012.08045.x. Epub 2012 Apr 11.

8.

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.

Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21743-8. doi: 10.1073/pnas.1010243107. Epub 2010 Nov 22.

9.

Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol.

Lehtonen P, Sten T, Aitio O, Kurkela M, Vuorensola K, Finel M, Kostiainen R.

Eur J Pharm Sci. 2010 Nov 20;41(3-4):523-30. doi: 10.1016/j.ejps.2010.08.005. Epub 2010 Aug 24.

PMID:
20797434
10.

HA-detected experiments for the backbone assignment of intrinsically disordered proteins.

Mäntylahti S, Aitio O, Hellman M, Permi P.

J Biomol NMR. 2010 Jul;47(3):171-81. doi: 10.1007/s10858-010-9421-0. Epub 2010 May 1.

PMID:
20437194
11.

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.

Ekokoski E, Aitio O, Törnquist K, Yli-Kauhaluoma J, Tuominen RK.

Eur J Pharm Sci. 2010 Aug 11;40(5):404-11. doi: 10.1016/j.ejps.2010.04.013. Epub 2010 Apr 28.

PMID:
20433920
12.

The N-glycome of human embryonic stem cells.

Satomaa T, Heiskanen A, Mikkola M, Olsson C, Blomqvist M, Tiittanen M, Jaatinen T, Aitio O, Olonen A, Helin J, Hiltunen J, Natunen J, Tuuri T, Otonkoski T, Saarinen J, Laine J.

BMC Cell Biol. 2009 Jun 2;10:42. doi: 10.1186/1471-2121-10-42.

13.

Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides.

Alonen A, Gartman M, Aitio O, Finel M, Yli-Kauhaluoma J, Kostiainen R.

Eur J Pharm Sci. 2009 Jul 12;37(5):581-7. doi: 10.1016/j.ejps.2009.05.003. Epub 2009 May 15.

PMID:
19447177
14.

Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.

Boije af Gennäs G, Talman V, Aitio O, Ekokoski E, Finel M, Tuominen RK, Yli-Kauhaluoma J.

J Med Chem. 2009 Jul 9;52(13):3969-81. doi: 10.1021/jm900229p.

PMID:
19438240
15.

Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage.

Heiskanen A, Hirvonen T, Salo H, Impola U, Olonen A, Laitinen A, Tiitinen S, Natunen S, Aitio O, Miller-Podraza H, Wuhrer M, Deelder AM, Natunen J, Laine J, Lehenkari P, Saarinen J, Satomaa T, Valmu L.

Glycoconj J. 2009 Apr;26(3):367-84. doi: 10.1007/s10719-008-9217-6. Epub 2008 Nov 27.

PMID:
19037724
16.

Structural basis of PxxDY motif recognition in SH3 binding.

Aitio O, Hellman M, Kesti T, Kleino I, Samuilova O, Pääkkönen K, Tossavainen H, Saksela K, Permi P.

J Mol Biol. 2008 Sep 26;382(1):167-78. doi: 10.1016/j.jmb.2008.07.008. Epub 2008 Jul 11.

PMID:
18644376
17.

Acyl group migration and cleavage in selectively protected beta-d-galactopyranosides as studied by NMR spectroscopy and kinetic calculations.

Roslund MU, Aitio O, Wärnå J, Maaheimo H, Murzin DY, Leino R.

J Am Chem Soc. 2008 Jul 9;130(27):8769-72. doi: 10.1021/ja801177s. Epub 2008 Jun 11.

PMID:
18543925
18.

Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes.

Kaivosaari S, Toivonen P, Aitio O, Sipilä J, Koskinen M, Salonen JS, Finel M.

Drug Metab Dispos. 2008 Aug;36(8):1529-37. doi: 10.1124/dmd.108.021709. Epub 2008 May 12.

PMID:
18474681
19.

Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan.

Alonen A, Jansson J, Kallonen S, Kiriazis A, Aitio O, Finel M, Kostiainen R.

Bioorg Chem. 2008 Jun;36(3):148-55. doi: 10.1016/j.bioorg.2008.02.004. Epub 2008 Apr 1.

PMID:
18378273
20.

Enzyme-assisted synthesis and structure characterization of glucuronide conjugates of eleven anabolic steroid metabolites.

Hintikka L, Kuuranne T, Aitio O, Thevis M, Schänzer W, Kostiainen R.

Steroids. 2008 Mar;73(3):257-65. Epub 2007 Oct 26.

PMID:
18082235
21.

Simultaneous detection of amide and methyl correlations using a time shared NMR experiment: application to binding epitope mapping.

Würtz P, Aitio O, Hellman M, Permi P.

J Biomol NMR. 2007 Oct;39(2):97-105. Epub 2007 Aug 24.

PMID:
17717630
22.

Redox-dependent sodium binding by the Na(+)-translocating NADH:quinone oxidoreductase from Vibrio harveyi.

Bogachev AV, Bertsova YV, Aitio O, Permi P, Verkhovsky MI.

Biochemistry. 2007 Sep 4;46(35):10186-91. Epub 2007 Aug 15.

PMID:
17696408
23.

N-glycan structures and associated gene expression reflect the characteristic N-glycosylation pattern of human hematopoietic stem and progenitor cells.

Hemmoranta H, Satomaa T, Blomqvist M, Heiskanen A, Aitio O, Saarinen J, Natunen J, Partanen J, Laine J, Jaatinen T.

Exp Hematol. 2007 Aug;35(8):1279-92.

PMID:
17662891
24.

Conjugation of oligosaccharides by reductive amination to amine modified chondroitin oligomer and gamma-cyclodextrin.

Weikkolainen K, Aitio O, Blomqvist M, Natunen J, Helin J.

Glycoconj J. 2007 Apr;24(2-3):157-65. Epub 2007 Feb 1.

PMID:
17268859
25.

Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins.

Riihimäki L, Aitio O, Vahermo M, Heikura J, Valkonen K, Virtanen V, Yli-Kauhaluoma J, Vuorela P.

J Biochem Biophys Methods. 2006 Aug 31;68(2):75-85.

PMID:
16766039
26.

Peptide binding and NMR analysis of the interaction between SAP97 PDZ2 and GluR-A: potential involvement of a disulfide bond.

von Ossowski L, Tossavainen H, von Ossowski I, Cai C, Aitio O, Fredriksson K, Permi P, Annila A, Keinänen K.

Biochemistry. 2006 May 2;45(17):5567-75.

PMID:
16634638
27.

Stabilization of the activated alphaMbeta2 integrin by a small molecule inhibits leukocyte migration and recruitment.

Björklund M, Aitio O, Stefanidakis M, Suojanen J, Salo T, Sorsa T, Koivunen E.

Biochemistry. 2006 Mar 7;45(9):2862-71.

PMID:
16503641
28.

Biosynthesis of dobutamine monoglucuronides and glucuronidation of dobutamine by recombinant human UDP-glucuronosyltransferases.

Alonen A, Aitio O, Hakala K, Luukkanen L, Finel M, Kostiainen R.

Drug Metab Dispos. 2005 May;33(5):657-63. Epub 2005 Feb 2.

PMID:
15689500
29.

Several polylactosamine-modifying glycosyltransferases also use internal GalNAcbeta1-4GlcNAc units of synthetic saccharides as acceptors.

Salo H, Aitio O, Ilves K, Bencomo E, Toivonen S, Penttilä L, Niemelä R, Salminen H, Grabenhorst E, Renkonen R, Renkonen O.

Glycobiology. 2002 Mar;12(3):217-28.

PMID:
11971866
31.

Vilsmeier formylation of 2-carboxyindoles and preparation of O-benzylhydroxyureas on solid phase.

Tois J, Franzèn R, Aitio O, Laakso I, Kylänlahti I.

J Comb Chem. 2001 Nov-Dec;3(6):542-5.

PMID:
11703149
32.

Solid-phase bromination and Suzuki coupling of 2-carboxyindoles.

Tois J, Franzén R, Aitio O, Laakso I, Huuskonen J, Taskinen J.

Comb Chem High Throughput Screen. 2001 Sep;4(6):521-4.

PMID:
11562256
34.

Human alpha3-fucosyltransferases convert chitin oligosaccharides to products containing a GlcNAcbeta1-4(Fucalpha1-3)GlcNAcbeta1-4R determinant at the nonreducing terminus.

Natunen J, Aitio O, Helin J, Maaheimo H, Niemelä R, Heikkinen S, Renkonen O.

Glycobiology. 2001 Mar;11(3):209-16.

PMID:
11320059
35.

The acceptor and site specificity of alpha 3-fucosyltransferase V. High reactivity of the proximal and low of the distal galbeta 1-4GlcNAc unit in i-type polylactosamines.

Pykäri M, Toivonen S, Natunen J, Niemela R, Salminen H, Aitio O, Ekström M, Parmanne P, Välimäki M, Alais J, Augé C, Lowe JB, Renkonen O, Renkonen R.

J Biol Chem. 2000 Dec 22;275(51):40057-63.

36.
37.

Purification and characterization of UDP-GlcNAc:Galbeta1-4GlcNAcbeta1-3*Galbeta1-4Glc(NAc)-R(GlcNAc to *Gal) beta1,6N-acetylglucosaminyltransferase from hog small intestine.

Sakamoto Y, Taguchi T, Tano Y, Ogawa T, Leppänen A, Kinnunen M, Aitio O, Parmanne P, Renkonen O, Taniguchi N.

J Biol Chem. 1998 Oct 16;273(42):27625-32.

38.

Enzymatic synthesis of site-specifically (alpha 1-3)-fucosylated polylactosamines containing either a sialyl Lewis (x), a VIM-2, or a sialylated and internally difucosylated sequence.

Räbinä J, Natunen J, Niemelä R, Salminen H, Ilves K, Aitio O, Maaheimo H, Helin J, Renkonen O.

Carbohydr Res. 1997 Dec;305(3-4):491-9.

PMID:
9648266

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