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Epigenetic Modifications in Stress Response Genes Associated With Childhood Trauma.

Jiang S, Postovit L, Cattaneo A, Binder EB, Aitchison KJ.

Front Psychiatry. 2019 Nov 8;10:808. doi: 10.3389/fpsyt.2019.00808. eCollection 2019. Review.


Prediction and Understanding of Resilience in Albertan Families: Longitudinal Study of Disaster Responses (PURLS) - Protocol.

Kingston D, Mughal MK, Arshad M, Kovalchuk I, Metz GAS, Wynne-Edwards K, King S, Jiang S, Postovit L, Wajid A, McDonald S, Slater DM, Tough SC, Aitchison K, Arnold P.

Front Psychiatry. 2019 Oct 31;10:729. doi: 10.3389/fpsyt.2019.00729. eCollection 2019.


The neuronal ceroid lipofuscinosis protein Cln7 functions in the postsynaptic cell to regulate synapse development.

Connolly KJ, O'Hare MB, Mohammed A, Aitchison KM, Anthoney NC, Taylor MJ, Stewart BA, Tuxworth RI, Tear G.

Sci Rep. 2019 Oct 30;9(1):15592. doi: 10.1038/s41598-019-51588-w.


Proteomic characterisation of the Chlamydia abortus outer membrane complex (COMC) using combined rapid monolithic column liquid chromatography and fast MS/MS scanning.

Longbottom D, Livingstone M, Aitchison KD, Imrie L, Manson E, Wheelhouse N, Inglis NF.

PLoS One. 2019 Oct 24;14(10):e0224070. doi: 10.1371/journal.pone.0224070. eCollection 2019.


Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis.

Lodhi RJ, Wang Y, Macintyre G, Crocker C, Loverock A, Henriques BC, Heywood B, Sivapalan S, Bowker A, Majeau B, Bolt C, Bugbee D, Newton V, Tibbo P, Purdon SE, Aitchison KJ.

Psychiatry Res. 2019 Oct;280:112500. doi: 10.1016/j.psychres.2019.112500. Epub 2019 Aug 8.


Teaching best practice in hand hygiene: student use and performance with a gamified gesture recognition system.

Mosley C, Mosley JR, Bell C, Aitchison K, Rhind SM, MacKay J.

Vet Rec. 2019 Oct 12;185(14):444. doi: 10.1136/vr.105338. Epub 2019 Aug 23.


Trajectories of Suicidal Ideation During 12 Weeks of Escitalopram or Nortriptyline Antidepressant Treatment Among 811 Patients With Major Depressive Disorder.

Madsen T, Buttenschøn HN, Uher R, Behrendt-Møller I, Perroud N, Maier W, Hauser J, Dernovsek MZ, Henigsberg N, Souery D, Rietschel M, McGuffin P, Aitchison KJ, Mors O, Köhler-Forsberg O.

J Clin Psychiatry. 2019 Jul 16;80(4). pii: 18m12575. doi: 10.4088/JCP.18m12575.


Differential gene expression analysis in blood of first episode psychosis patients.

Leirer DJ, Iyegbe CO, Di Forti M, Patel H, Carra E, Fraietta S, Colizzi M, Mondelli V, Quattrone D, Lally J, Ajnakina O, Lee SH, Curtis CJ, Breen G, Pariante C, Aitchison K, Dazzan P, Murray RM, Dobson RJB, Newhouse SJ.

Schizophr Res. 2019 Jul;209:88-97. doi: 10.1016/j.schres.2019.05.011. Epub 2019 May 19.


A functional variant in the serotonin receptor 7 gene (HTR7), rs7905446, is associated with good response to SSRIs in bipolar and unipolar depression.

Wei YB, McCarthy M, Ren H, Carrillo-Roa T, Shekhtman T, DeModena A, Liu JJ, Leckband SG, Mors O, Rietschel M, Henigsberg N, Cattaneo A, Binder EB, Aitchison KJ, Kelsoe JR.

Mol Psychiatry. 2019 Mar 15. doi: 10.1038/s41380-019-0397-1. [Epub ahead of print]


Effect of antidepressant switching between nortriptyline and escitalopram after a failed first antidepressant treatment among patients with major depressive disorder.

Köhler-Forsberg O, Larsen ER, Buttenschøn HN, Rietschel M, Hauser J, Souery D, Maier W, Farmer A, McGuffin P, Aitchison KJ, Uher R, Mors O.

Br J Psychiatry. 2019 Aug;215(2):494-501. doi: 10.1192/bjp.2018.302. Epub 2019 Jan 30.


Associations between the LEP -2548G/A Promoter and Baseline Weight and between LEPR Gln223Arg and Lys656Asn Variants and Change in BMI z Scores in Arab Children and Adolescents Treated with Risperidone.

Almandil NB, Lodhi RJ, Ren H, Besag FMC, Rossolatos D, Ohlsen R, Slomp C, Lapetina DL, Plazzotta G, Murray ML, Al-Sulaiman AA, Gringras P, Wong ICK, Aitchison KJ.

Mol Neuropsychiatry. 2018 Oct;4(2):111-117. doi: 10.1159/000490463. Epub 2018 Oct 5.


Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

Lodhi RJ, Wang Y, Rossolatos D, MacIntyre G, Bowker A, Crocker C, Ren H, Dimitrijevic A, Bugbee DA, Loverock A, Majeau B, Sivapalan S, Newton VM, Tibbo P, Purdon SE, Aitchison KJ.

Brain Behav. 2018 Sep;8(9):e01120. doi: 10.1002/brb3.1120. No abstract available.


Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies.

Fabbri C, Tansey KE, Perlis RH, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Breen G, Curtis C, Lee SH, Newhouse S, Patel H, O'Donovan M, Lewis G, Jenkins G, Weinshilboum RM, Farmer A, Aitchison KJ, Craig I, McGuffin P, Schruers K, Biernacka JM, Uher R, Lewis CM.

Eur Neuropsychopharmacol. 2018 Aug;28(8):945-954. doi: 10.1016/j.euroneuro.2018.05.009. Epub 2018 Jun 28.


Genetic disposition to inflammation and response to antidepressants in major depressive disorder.

Zwicker A, Fabbri C, Rietschel M, Hauser J, Mors O, Maier W, Zobel A, Farmer A, Aitchison KJ, McGuffin P, Lewis CM, Uher R.

J Psychiatr Res. 2018 Oct;105:17-22. doi: 10.1016/j.jpsychires.2018.08.011. Epub 2018 Aug 7.


Genes associated with anhedonia: a new analysis in a large clinical trial (GENDEP).

Ren H, Fabbri C, Uher R, Rietschel M, Mors O, Henigsberg N, Hauser J, Zobel A, Maier W, Dernovsek MZ, Souery D, Cattaneo A, Breen G, Craig IW, Farmer AE, McGuffin P, Lewis CM, Aitchison KJ.

Transl Psychiatry. 2018 Aug 13;8(1):150. doi: 10.1038/s41398-018-0198-3.


Antidepressant drug-specific prediction of depression treatment outcomes from genetic and clinical variables.

Iniesta R, Hodgson K, Stahl D, Malki K, Maier W, Rietschel M, Mors O, Hauser J, Henigsberg N, Dernovsek MZ, Souery D, Dobson R, Aitchison KJ, Farmer A, McGuffin P, Lewis CM, Uher R.

Sci Rep. 2018 Apr 3;8(1):5530. doi: 10.1038/s41598-018-23584-z.


Implications of Cannabis Legalization on Youth and Young Adults.

Tibbo P, Crocker CE, Lam RW, Meyer J, Sareen J, Aitchison KJ.

Can J Psychiatry. 2018 Jan;63(1):65-71. doi: 10.1177/0706743718759031. No abstract available.


Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use.

Lodhi RJ, Wang Y, Rossolatos D, MacIntyre G, Bowker A, Crocker C, Ren H, Dimitrijevic A, Bugbee DA, Loverock A, Majeau B, Sivapalan S, Newton VM, Tibbo P, Purdon SE, Aitchison KJ.

Brain Behav. 2017 Oct 6;7(11):e00850. doi: 10.1002/brb3.850. eCollection 2017 Nov. Erratum in: Brain Behav. 2018 Sep;8(9):e01120.


New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation.

Fabbri C, Tansey KE, Perlis RH, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Breen G, Curtis C, Sang-Hyuk L, Newhouse S, Patel H, Guipponi M, Perroud N, Bondolfi G, O'Donovan M, Lewis G, Biernacka JM, Weinshilboum RM, Farmer A, Aitchison KJ, Craig I, McGuffin P, Uher R, Lewis CM.

Pharmacogenomics J. 2018 May 22;18(3):413-421. doi: 10.1038/tpj.2017.44. Epub 2017 Nov 21.


Contribution of genes in the GABAergic pathway to bipolar disorder and its executive function deficit in the Chinese Han population.

Ren H, Guan L, Zhao L, Lin Y, Wang Y, Yang Z, Li X, Ma X, Cheng X, Deng W, Aitchison KJ, Cao L, Li T.

Am J Med Genet B Neuropsychiatr Genet. 2018 Jan;177(1):50-67. doi: 10.1002/ajmg.b.32601. Epub 2017 Nov 14.


Interaction between the FTO gene, body mass index and depression: meta-analysis of 13701 individuals.

Rivera M, Locke AE, Corre T, Czamara D, Wolf C, Ching-Lopez A, Milaneschi Y, Kloiber S, Cohen-Woods S, Rucker J, Aitchison KJ, Bergmann S, Boomsma DI, Craddock N, Gill M, Holsboer F, Hottenga JJ, Korszun A, Kutalik Z, Lucae S, Maier W, Mors O, Müller-Myhsok B, Owen MJ, Penninx BWJH, Preisig M, Rice J, Rietschel M, Tozzi F, Uher R, Vollenweider P, Waeber G, Willemsen G, Craig IW, Farmer AE, Lewis CM, Breen G, McGuffin P.

Br J Psychiatry. 2017 Aug;211(2):70-76. doi: 10.1192/bjp.bp.116.183475. Epub 2017 Jun 22. Review. Erratum in: Br J Psychiatry. 2017 Dec;211(6):401.


MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.

Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C, Han MH, Foster J, Frey BN, Soares CN, Müller DJ, Farzan F, Leri F, MacQueen GM, Feilotter H, Tyryshkin K, Evans KR, Giacobbe P, Blier P, Lam RW, Milev R, Parikh SV, Rotzinger S, Strother SC, Lewis CM, Aitchison KJ, Wittenberg GM, Mechawar N, Nestler EJ, Uher R, Kennedy SH, Turecki G.

Nat Commun. 2017 May 22;8:15497. doi: 10.1038/ncomms15497.


Pathogenic outcome following experimental infection of sheep with Chlamydia abortus variant strains LLG and POS.

Livingstone M, Wheelhouse N, Ensor H, Rocchi M, Maley S, Aitchison K, Wattegedera S, Wilson K, Sait M, Siarkou V, Vretou E, Entrican G, Dagleish M, Longbottom D.

PLoS One. 2017 May 11;12(5):e0177653. doi: 10.1371/journal.pone.0177653. eCollection 2017.


European Chlamydia abortus livestock isolate genomes reveal unusual stability and limited diversity, reflected in geographical signatures.

Seth-Smith HMB, Busó LS, Livingstone M, Sait M, Harris SR, Aitchison KD, Vretou E, Siarkou VI, Laroucau K, Sachse K, Longbottom D, Thomson NR.

BMC Genomics. 2017 May 4;18(1):344. doi: 10.1186/s12864-017-3657-y.


Association between C-reactive protein (CRP) with depression symptom severity and specific depressive symptoms in major depression.

Köhler-Forsberg O, Buttenschøn HN, Tansey KE, Maier W, Hauser J, Dernovsek MZ, Henigsberg N, Souery D, Farmer A, Rietschel M, McGuffin P, Aitchison KJ, Uher R, Mors O.

Brain Behav Immun. 2017 May;62:344-350. doi: 10.1016/j.bbi.2017.02.020. Epub 2017 Mar 1.


Pharmacogenetics of antidepressant response: A polygenic approach.

García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K; Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium, Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:128-134. doi: 10.1016/j.pnpbp.2017.01.011. Epub 2017 Jan 31.


Experimental challenge of pregnant cattle with the putative abortifacient Waddlia chondrophila.

Wheelhouse N, Flockhart A, Aitchison K, Livingstone M, Finlayson J, Flachon V, Sellal E, Dagleish MP, Longbottom D.

Sci Rep. 2016 Nov 14;6:37150. doi: 10.1038/srep37150.


An Examination of Polygenic Score Risk Prediction in Individuals With First-Episode Psychosis.

Vassos E, Di Forti M, Coleman J, Iyegbe C, Prata D, Euesden J, O'Reilly P, Curtis C, Kolliakou A, Patel H, Newhouse S, Traylor M, Ajnakina O, Mondelli V, Marques TR, Gardner-Sood P, Aitchison KJ, Powell J, Atakan Z, Greenwood KE, Smith S, Ismail K, Pariante C, Gaughran F, Dazzan P, Markus HS, David AS, Lewis CM, Murray RM, Breen G.

Biol Psychiatry. 2017 Mar 15;81(6):470-477. doi: 10.1016/j.biopsych.2016.06.028. Epub 2016 Aug 6.


Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study.

Trotta A, Iyegbe C, Di Forti M, Sham PC, Campbell DD, Cherny SS, Mondelli V, Aitchison KJ, Murray RM, Vassos E, Fisher HL.

PLoS One. 2016 Sep 20;11(9):e0163319. doi: 10.1371/journal.pone.0163319. eCollection 2016.


Combining clinical variables to optimize prediction of antidepressant treatment outcomes.

Iniesta R, Malki K, Maier W, Rietschel M, Mors O, Hauser J, Henigsberg N, Dernovsek MZ, Souery D, Stahl D, Dobson R, Aitchison KJ, Farmer A, Lewis CM, McGuffin P, Uher R.

J Psychiatr Res. 2016 Jul;78:94-102. doi: 10.1016/j.jpsychires.2016.03.016. Epub 2016 Apr 1.


Changes in biomarkers of bone turnover in an aripiprazole add-on or switching study.

Lodhi RJ, Masand S, Malik A, Shivakumar K, McAllister VD, O'Keane V, Young LC, Heald AH, Sherwood RA, Aitchison KJ.

Schizophr Res. 2016 Feb;170(2-3):245-51. doi: 10.1016/j.schres.2015.12.007. Epub 2016 Jan 12.


Transcriptomics and the mechanisms of antidepressant efficacy.

Hodgson K, Tansey KE, Powell TR, Coppola G, Uher R, Zvezdana Dernovšek M, Mors O, Hauser J, Souery D, Maier W, Henigsberg N, Rietschel M, Placentino A, Aitchison KJ, Craig IW, Farmer AE, Breen G, McGuffin P, Dobson R.

Eur Neuropsychopharmacol. 2016 Jan;26(1):105-112. doi: 10.1016/j.euroneuro.2015.10.009. Epub 2015 Nov 12.


Authors' reply.

Fu CH, Legge RM, Cohen-Woods S, Cole JH, Aitchison KJ, McGuffin P.

Br J Psychiatry. 2015 Oct;207(4):363-4. doi: 10.1192/bjp.207.4.363a. No abstract available.


Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder.

Rucker JJ, Tansey KE, Rivera M, Pinto D, Cohen-Woods S, Uher R, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Barnes MR, Preisig M, Mors O, Maier W, Rice J, Rietschel M, Holsboer F, Farmer AE, Craig IW, Scherer SW, McGuffin P, Breen G.

Biol Psychiatry. 2016 Feb 15;79(4):329-36. doi: 10.1016/j.biopsych.2015.02.025. Epub 2015 Feb 25.


Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis.

Colizzi M, Iyegbe C, Powell J, Ursini G, Porcelli A, Bonvino A, Taurisano P, Romano R, Masellis R, Blasi G, Morgan C, Aitchison K, Mondelli V, Luzi S, Kolliakou A, David A, Murray RM, Bertolino A, Di Forti M.

Schizophr Bull. 2015 Sep;41(5):1171-82. doi: 10.1093/schbul/sbv032. Epub 2015 Mar 31.


Exploring the role of drug-metabolising enzymes in antidepressant side effects.

Hodgson K, Tansey KE, Uher R, Dernovšek MZ, Mors O, Hauser J, Souery D, Maier W, Henigsberg N, Rietschel M, Placentino A, Craig IW, Aitchison KJ, Farmer AE, Dobson RJ, McGuffin P.

Psychopharmacology (Berl). 2015 Jul;232(14):2609-17. doi: 10.1007/s00213-015-3898-x. Epub 2015 Mar 12.


Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.

Legge RM, Sendi S, Cole JH, Cohen-Woods S, Costafreda SG, Simmons A, Farmer AE, Aitchison KJ, McGuffin P, Fu CH.

Br J Psychiatry. 2015 May;206(5):379-84. doi: 10.1192/bjp.bp.113.143529. Epub 2015 Mar 5.


Familiality and SNP heritability of age at onset and episodicity in major depressive disorder.

Ferentinos P, Koukounari A, Power R, Rivera M, Uher R, Craddock N, Owen MJ, Korszun A, Jones L, Jones I, Gill M, Rice JP, Ising M, Maier W, Mors O, Rietschel M, Preisig M, Binder EB, Aitchison KJ, Mendlewicz J, Souery D, Hauser J, Henigsberg N, Breen G, Craig IW, Farmer AE, Müller-Myhsok B, McGuffin P, Lewis CM.

Psychol Med. 2015 Jul;45(10):2215-25. doi: 10.1017/S0033291715000215. Epub 2015 Feb 20.


Role of a Combination of Seven Micronutrients in the Management of Glioblastoma Multiforme.

Rooprai HK, Ashkan K, Brazil L, Selway RP, Lodhi R, Aitchison KJ, Gullan RW, Beaney R.

Clin Oncol (R Coll Radiol). 2015 Jun;27(6):370-1. doi: 10.1016/j.clon.2015.01.010. Epub 2015 Feb 12. No abstract available.


Investigation of blood mRNA biomarkers for suicidality in an independent sample.

Mullins N, Hodgson K, Tansey KE, Perroud N, Maier W, Mors O, Rietschel M, Hauser J, Henigsberg N, Souery D, Aitchison K, Farmer A, McGuffin P, Breen G, Uher R, Lewis CM.

Transl Psychiatry. 2014 Oct 28;4:e474. doi: 10.1038/tp.2014.112.


Association of KIBRA rs17070145 polymorphism with episodic memory in the early stages of a human neurodevelopmental disorder.

Vyas NS, Ahn K, Stahl DR, Caviston P, Simic M, Netherwood S, Puri BK, Lee Y, Aitchison KJ.

Psychiatry Res. 2014 Dec 15;220(1-2):37-43. doi: 10.1016/j.psychres.2014.07.024. Epub 2014 Jul 19.


The effect of age on DNA concentration from whole saliva: implications for the standard isolation method.

Gassó P, Pagerols M, Flamarique I, Castro-Fornieles J, Rodriguez N, Mas S, Curran S, Aitchison K, Santosh P, Lafuente A; Stop Consortium.

Am J Hum Biol. 2014 Nov-Dec;26(6):859-62. doi: 10.1002/ajhb.22593. Epub 2014 Jul 28.


Abortion in flocks vaccinated against enzootic abortion.

Livingstone M, Aitchison K, Longbottom D.

Vet Rec. 2014 Jun 14;174(24):613-4. doi: 10.1136/vr.g3833. No abstract available.


Potential role of the combination of galantamine and memantine to improve cognition in schizophrenia.

Koola MM, Buchanan RW, Pillai A, Aitchison KJ, Weinberger DR, Aaronson ST, Dickerson FB.

Schizophr Res. 2014 Aug;157(1-3):84-9. doi: 10.1016/j.schres.2014.04.037. Epub 2014 May 28. Review.


The 12th Annual Pharmacogenetics in Psychiatry meeting report.

Zhang JP, Aitchison KJ, Malhotra AK.

Psychiatr Genet. 2014 Oct;24(5):218-20. doi: 10.1097/YPG.0000000000000041.


Relationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.

Hung CF, Rivera M, Craddock N, Owen MJ, Gill M, Korszun A, Maier W, Mors O, Preisig M, Rice JP, Rietschel M, Jones L, Middleton L, Aitchison KJ, Davis OS, Breen G, Lewis C, Farmer A, McGuffin P.

Br J Psychiatry. 2014 Jul;205(1):24-8. doi: 10.1192/bjp.bp.113.130419. Epub 2014 May 8.


NPAS3 variants in schizophrenia: a neuroimaging study.

Bernier D, Macintyre G, Bartha R, Hanstock CC, McAllindon D, Cox D, Purdon S, Aitchison KJ, Rusak B, Tibbo PG.

BMC Med Genet. 2014 Mar 27;15:37. doi: 10.1186/1471-2350-15-37.


Association of tardive dyskinesia with variation in CYP2D6: Is there a role for active metabolites?

Koola MM, Tsapakis EM, Wright P, Smith S, Kerwin Rip RW, Nugent KL, Aitchison KJ.

J Psychopharmacol. 2014 Jul;28(7):665-70. doi: 10.1177/0269881114523861. Epub 2014 Mar 4.


Genomics for clinical utility: the future is near.

Rossolatos D, Aitchison KJ.

Genome Med. 2014 Jan 28;6(1):3. doi: 10.1186/gm522. eCollection 2014.


Effects of antidepressant drug exposure on gene expression in the developing cerebral cortex.

Tsapakis EM, Fernandes C, Moran-Gates T, Basu A, Sugden K, Aitchison KJ, Tarazi FI.

Synapse. 2014 May;68(5):209-20. doi: 10.1002/syn.21732. Epub 2014 Feb 13.


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