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Electrospray for generation of drug delivery and vaccine particles applied in vitro and in vivo.

Steipel RT, Gallovic MD, Batty CJ, Bachelder EM, Ainslie KM.

Mater Sci Eng C Mater Biol Appl. 2019 Dec;105:110070. doi: 10.1016/j.msec.2019.110070. Epub 2019 Aug 9. Review.


Evaluation of synergy between host and pathogen-directed therapies against intracellular Leishmania donovani.

Zahid MSH, Johnson MM, Tokarski RJ 2nd, Satoskar AR, Fuchs JR, Bachelder EM, Ainslie KM.

Int J Parasitol Drugs Drug Resist. 2019 Aug;10:125-132. doi: 10.1016/j.ijpddr.2019.08.004. Epub 2019 Aug 21.


Flexible, microstructured surfaces using chitin-derived biopolymers.

Pradhan S, Moore KM, Ainslie KM, Yadavalli VK.

J Mater Chem B. 2019 Sep 11;7(35):5328-5335. doi: 10.1039/c9tb00965e.


Challenges in estimating influenza vaccine effectiveness.

Ainslie KEC, Haber M, Orenstein WA.

Expert Rev Vaccines. 2019 Jun;18(6):615-628. doi: 10.1080/14760584.2019.1622419. Epub 2019 May 31.


A microparticle platform for STING-targeted immunotherapy enhances natural killer cell- and CD8+ T cell-mediated anti-tumor immunity.

Watkins-Schulz R, Tiet P, Gallovic MD, Junkins RD, Batty C, Bachelder EM, Ainslie KM, Ting JPY.

Biomaterials. 2019 Jun;205:94-105. doi: 10.1016/j.biomaterials.2019.03.011. Epub 2019 Mar 14.


Bias of influenza vaccine effectiveness estimates from test-negative studies conducted during an influenza pandemic.

Ainslie KEC, Haber M, Orenstein WA.

Vaccine. 2019 Mar 28;37(14):1987-1993. doi: 10.1016/j.vaccine.2019.02.036. Epub 2019 Mar 2.


A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer.

Cheng N, Watkins-Schulz R, Junkins RD, David CN, Johnson BM, Montgomery SA, Peine KJ, Darr DB, Yuan H, McKinnon KP, Liu Q, Miao L, Huang L, Bachelder EM, Ainslie KM, Ting JP.

JCI Insight. 2018 Nov 15;3(22). pii: 120638. doi: 10.1172/jci.insight.120638.


A Dynamic Model for Evaluation of the Bias of Influenza Vaccine Effectiveness Estimates From Observational Studies.

Ainslie KEC, Shi M, Haber M, Orenstein WA.

Am J Epidemiol. 2019 Feb 1;188(2):451-460. doi: 10.1093/aje/kwy240.


Injectable long-acting human immunodeficiency virus antiretroviral prodrugs with improved pharmacokinetic profiles.

Krovi SA, Gallovic MD, Keller AM, Bhat M, Tiet P, Chen N, Collier MA, Gurysh EG, Pino EN, Johnson MM, Shamim Hasan Zahid M, Cottrell ML, Pirone JR, Kashuba AD, Kwiek JJ, Bachelder EM, Ainslie KM.

Int J Pharm. 2018 Dec 1;552(1-2):371-377. doi: 10.1016/j.ijpharm.2018.10.017. Epub 2018 Oct 8.


In Vivo and Cellular Trafficking of Acetalated Dextran Microparticles for Delivery of a Host-Directed Therapy for Salmonella enterica Serovar Typhi Infection.

Johnson MM, Collier MA, Hoang KV, Pino EN, Graham-Gurysh EG, Gallovic MD, Zahid MSH, Chen N, Schlesinger L, Gunn JS, Bachelder EM, Ainslie KM.

Mol Pharm. 2018 Nov 5;15(11):5336-5348. doi: 10.1021/acs.molpharmaceut.8b00802. Epub 2018 Oct 17.


Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists.

Collier MA, Junkins RD, Gallovic MD, Johnson BM, Johnson MM, Macintyre AN, Sempowski GD, Bachelder EM, Ting JP, Ainslie KM.

Mol Pharm. 2018 Nov 5;15(11):4933-4946. doi: 10.1021/acs.molpharmaceut.8b00579. Epub 2018 Oct 15.


Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy.

Chen N, Gallovic MD, Tiet P, Ting JP, Ainslie KM, Bachelder EM.

J Control Release. 2018 Nov 10;289:114-124. doi: 10.1016/j.jconrel.2018.09.020. Epub 2018 Sep 24.


Drug Delivery for Cancer Immunotherapy and Vaccines.

Batty CJ, Tiet P, Bachelder EM, Ainslie KM.

Pharm Nanotechnol. 2018;6(4):232-244. doi: 10.2174/2211738506666180918122337. Review.


Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31.

Chen N, Kroger CJ, Tisch RM, Bachelder EM, Ainslie KM.

Adv Healthc Mater. 2018 Sep;7(18):e1800341. doi: 10.1002/adhm.201800341. Epub 2018 Jul 26.


Identification of the effector domain of biglycan that facilitates BMP-2 osteogenic function.

Jongwattanapisan P, Terajima M, Miguez PA, Querido W, Nagaoka H, Sumida N, Gurysh EG, Ainslie KM, Pleshko N, Perera L, Yamauchi M.

Sci Rep. 2018 May 4;8(1):7022. doi: 10.1038/s41598-018-25279-x.


Tunable degradation of acetalated dextran microparticles enables controlled vaccine adjuvant and antigen delivery to modulate adaptive immune responses.

Chen N, Johnson MM, Collier MA, Gallovic MD, Bachelder EM, Ainslie KM.

J Control Release. 2018 Mar 10;273:147-159. doi: 10.1016/j.jconrel.2018.01.027. Epub 2018 Feb 2.


Sustained Delivery of Doxorubicin via Acetalated Dextran Scaffold Prevents Glioblastoma Recurrence after Surgical Resection.

Graham-Gurysh E, Moore KM, Satterlee AB, Sheets KT, Lin FC, Bachelder EM, Miller CR, Hingtgen SD, Ainslie KM.

Mol Pharm. 2018 Mar 5;15(3):1309-1318. doi: 10.1021/acs.molpharmaceut.7b01114. Epub 2018 Feb 2.


Vaccines for the Prevention of Melioidosis and Glanders.

Johnson MM, Ainslie KM.

Curr Trop Med Rep. 2017 Sep;4(3):136-145. doi: 10.1007/s40475-017-0121-7. Epub 2017 Jul 14.


A comparison of the test-negative and the traditional case-control study designs for estimation of influenza vaccine effectiveness under nonrandom vaccination.

Shi M, An Q, Ainslie KEC, Haber M, Orenstein WA.

BMC Infect Dis. 2017 Dec 8;17(1):757. doi: 10.1186/s12879-017-2838-2.


Maximum likelihood estimation of influenza vaccine effectiveness against transmission from the household and from the community.

Ainslie KEC, Haber MJ, Malosh RE, Petrie JG, Monto AS.

Stat Med. 2018 Mar 15;37(6):970-982. doi: 10.1002/sim.7558. Epub 2017 Nov 28.


A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination.

Junkins RD, Gallovic MD, Johnson BM, Collier MA, Watkins-Schulz R, Cheng N, David CN, McGee CE, Sempowski GD, Shterev I, McKinnon K, Bachelder EM, Ainslie KM, Ting JP.

J Control Release. 2018 Jan 28;270:1-13. doi: 10.1016/j.jconrel.2017.11.030. Epub 2017 Nov 21.


On the bias of estimates of influenza vaccine effectiveness from test-negative studies.

Ainslie KEC, Shi M, Haber M, Orenstein WA.

Vaccine. 2017 Dec 19;35(52):7297-7301. doi: 10.1016/j.vaccine.2017.10.107. Epub 2017 Nov 13.


Correction: PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis.

Webb LM, Amici SA, Jablonski KA, Savardekar H, Panfil AR, Li L, Zhou W, Peine K, Karkhanis V, Bachelder EM, Ainslie KM, Green PL, Li C, Baiocchi RA, Guerau-de-Arellano M.

J Immunol. 2017 Oct 15;199(8):3004. doi: 10.4049/jimmunol.1701237. No abstract available.


PRMT5-Selective Inhibitors Suppress Inflammatory T Cell Responses and Experimental Autoimmune Encephalomyelitis.

Webb LM, Amici SA, Jablonski KA, Savardekar H, Panfil AR, Li L, Zhou W, Peine K, Karkhanis V, Bachelder EM, Ainslie KM, Green PL, Li C, Baiocchi RA, Guerau-de-Arellano M.

J Immunol. 2017 Feb 15;198(4):1439-1451. doi: 10.4049/jimmunol.1601702. Epub 2017 Jan 13. Erratum in: J Immunol. 2017 Oct 15;199(8):3004.


Acetalated Dextran: A Tunable and Acid-Labile Biopolymer with Facile Synthesis and a Range of Applications.

Bachelder EM, Pino EN, Ainslie KM.

Chem Rev. 2017 Feb 8;117(3):1915-1926. doi: 10.1021/acs.chemrev.6b00532. Epub 2016 Dec 29. Review.


Electrosprayed Myocet-like Liposomes: An Alternative to Traditional Liposome Production.

Collier MA, Bachelder EM, Ainslie KM.

Pharm Res. 2017 Feb;34(2):419-426. doi: 10.1007/s11095-016-2072-4. Epub 2016 Nov 28.


Acetalated Dextran Microparticulate Vaccine Formulated via Coaxial Electrospray Preserves Toxin Neutralization and Enhances Murine Survival Following Inhalational Bacillus Anthracis Exposure.

Gallovic MD, Schully KL, Bell MG, Elberson MA, Palmer JR, Darko CA, Bachelder EM, Wyslouzil BE, Keane-Myers AM, Ainslie KM.

Adv Healthc Mater. 2016 Oct;5(20):2617-2627. doi: 10.1002/adhm.201600642. Epub 2016 Sep 5.


A Novel Sterol Isolated from a Plant Used by Mayan Traditional Healers Is Effective in Treatment of Visceral Leishmaniasis Caused by Leishmania donovani.

Gupta G, Peine KJ, Abdelhamid D, Snider H, Shelton AB, Rao L, Kotha SR, Huntsman AC, Varikuti S, Oghumu S, Naman CB, Pan L, Parinandi NL, Papenfuss TL, Kinghorn AD, Bachelder EM, Ainslie KM, Fuchs JR, Satoskar AR.

ACS Infect Dis. 2015 Oct 9;1(10):497-506. doi: 10.1021/acsinfecdis.5b00081. Epub 2015 Sep 21.


Degradation of acetalated dextran can be broadly tuned based on cyclic acetal coverage and molecular weight.

Chen N, Collier MA, Gallovic MD, Collins GC, Sanchez CC, Fernandes EQ, Bachelder EM, Ainslie KM.

Int J Pharm. 2016 Oct 15;512(1):147-157. doi: 10.1016/j.ijpharm.2016.08.031. Epub 2016 Aug 16.


Saquinavir Loaded Acetalated Dextran Microconfetti - a Long Acting Protease Inhibitor Injectable.

Collier MA, Gallovic MD, Bachelder EM, Sykes CD, Kashuba A, Ainslie KM.

Pharm Res. 2016 Aug;33(8):1998-2009. doi: 10.1007/s11095-016-1936-y. Epub 2016 May 6.


Gene integrated set profile analysis: a context-based approach for inferring biological endpoints.

Kowalski J, Dwivedi B, Newman S, Switchenko JM, Pauly R, Gutman DA, Arora J, Gandhi K, Ainslie K, Doho G, Qin Z, Moreno CS, Rossi MR, Vertino PM, Lonial S, Bernal-Mizrachi L, Boise LH.

Nucleic Acids Res. 2016 Apr 20;44(7):e69. doi: 10.1093/nar/gkv1503. Epub 2016 Jan 29.


Needle-Free Delivery of Acetalated Dextran-Encapsulated AR-12 Protects Mice from Francisella tularensis Lethal Challenge.

Hoang KV, Curry H, Collier MA, Borteh H, Bachelder EM, Schlesinger LS, Gunn JS, Ainslie KM.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2052-62. doi: 10.1128/AAC.02228-15. Print 2016 Apr.


Host-mediated Leishmania donovani treatment using AR-12 encapsulated in acetalated dextran microparticles.

Collier MA, Peine KJ, Gautam S, Oghumu S, Varikuti S, Borteh H, Papenfuss TL, Sataoskar AR, Bachelder EM, Ainslie KM.

Int J Pharm. 2016 Feb 29;499(1-2):186-194. doi: 10.1016/j.ijpharm.2016.01.004. Epub 2016 Jan 5.


Chemically modified inulin microparticles serving dual function as a protein antigen delivery vehicle and immunostimulatory adjuvant.

Gallovic MD, Montjoy DG, Collier MA, Do C, Wyslouzil BE, Bachelder EM, Ainslie KM.

Biomater Sci. 2016 Mar;4(3):483-93. doi: 10.1039/c5bm00451a.


One Step Encapsulation of Small Molecule Drugs in Liposomes via Electrospray-Remote Loading.

Duong AD, Collier MA, Bachelder EM, Wyslouzil BE, Ainslie KM.

Mol Pharm. 2016 Jan 4;13(1):92-9. doi: 10.1021/acs.molpharmaceut.5b00528. Epub 2015 Nov 30.


Evaluation of a biodegradable microparticulate polymer as a carrier for Burkholderia pseudomallei subunit vaccines in a mouse model of melioidosis.

Schully KL, Bell MG, Prouty AM, Gallovic MD, Gautam S, Peine KJ, Sharma S, Bachelder EM, Pesce JT, Elberson MA, Ainslie KM, Keane-Myers A.

Int J Pharm. 2015 Nov 30;495(2):849-61. doi: 10.1016/j.ijpharm.2015.09.059. Epub 2015 Sep 28.


Acetalated dextran encapsulated AR-12 as a host-directed therapy to control Salmonella infection.

Hoang KV, Borteh HM, Rajaram MV, Peine KJ, Curry H, Collier MA, Homsy ML, Bachelder EM, Gunn JS, Schlesinger LS, Ainslie KM.

Int J Pharm. 2014 Dec 30;477(1-2):334-43. doi: 10.1016/j.ijpharm.2014.10.022. Epub 2014 Oct 22.


Treatment of experimental autoimmune encephalomyelitis by codelivery of disease associated Peptide and dexamethasone in acetalated dextran microparticles.

Peine KJ, Guerau-de-Arellano M, Lee P, Kanthamneni N, Severin M, Probst GD, Peng H, Yang Y, Vangundy Z, Papenfuss TL, Lovett-Racke AE, Bachelder EM, Ainslie KM.

Mol Pharm. 2014 Mar 3;11(3):828-35. doi: 10.1021/mp4005172. Epub 2014 Feb 4.


Delivery of host cell-directed therapeutics for intracellular pathogen clearance.

Collier MA, Gallovic MD, Peine KJ, Duong AD, Bachelder EM, Gunn JS, Schlesinger LS, Ainslie KM.

Expert Rev Anti Infect Ther. 2013 Nov;11(11):1225-35. doi: 10.1586/14787210.2013.845524. Epub 2013 Oct 18. Review.


Liposomal resiquimod for the treatment of Leishmania donovani infection.

Peine KJ, Gupta G, Brackman DJ, Papenfuss TL, Ainslie KM, Satoskar AR, Bachelder EM.

J Antimicrob Chemother. 2014 Jan;69(1):168-75. doi: 10.1093/jac/dkt320. Epub 2013 Aug 16.


Efficient delivery of the toll-like receptor agonists polyinosinic:polycytidylic acid and CpG to macrophages by acetalated dextran microparticles.

Peine KJ, Bachelder EM, Vangundy Z, Papenfuss T, Brackman DJ, Gallovic MD, Schully K, Pesce J, Keane-Myers A, Ainslie KM.

Mol Pharm. 2013 Aug 5;10(8):2849-57. doi: 10.1021/mp300643d. Epub 2013 Jun 27.


Electrospun acetalated dextran scaffolds for temporal release of therapeutics.

Borteh HM, Gallovic MD, Sharma S, Peine KJ, Miao S, Brackman DJ, Gregg K, Xu Y, Guo X, Guan J, Bachelder EM, Ainslie KM.

Langmuir. 2013 Jun 25;29(25):7957-65. doi: 10.1021/la400541e. Epub 2013 Jun 11.


Rapid vaccination using an acetalated dextran microparticulate subunit vaccine confers protection against triplicate challenge by bacillus anthracis.

Schully KL, Sharma S, Peine KJ, Pesce J, Elberson MA, Fonseca ME, Prouty AM, Bell MG, Borteh H, Gallovic M, Bachelder EM, Keane-Myers A, Ainslie KM.

Pharm Res. 2013 May;30(5):1349-61. doi: 10.1007/s11095-013-0975-x. Epub 2013 Jan 25.


Electrospray encapsulation of toll-like receptor agonist resiquimod in polymer microparticles for the treatment of visceral leishmaniasis.

Duong AD, Sharma S, Peine KJ, Gupta G, Satoskar AR, Bachelder EM, Wyslouzil BE, Ainslie KM.

Mol Pharm. 2013 Mar 4;10(3):1045-55. doi: 10.1021/mp3005098. Epub 2013 Feb 12.


Synthesis and characterization of acetalated dextran polymer and microparticles with ethanol as a degradation product.

Kauffman KJ, Do C, Sharma S, Gallovic MD, Bachelder EM, Ainslie KM.

ACS Appl Mater Interfaces. 2012 Aug;4(8):4149-55. doi: 10.1021/am3008888. Epub 2012 Aug 2.


Enhanced stability of horseradish peroxidase encapsulated in acetalated dextran microparticles stored outside cold chain conditions.

Kanthamneni N, Sharma S, Meenach SA, Billet B, Zhao JC, Bachelder EM, Ainslie KM.

Int J Pharm. 2012 Jul 15;431(1-2):101-10. doi: 10.1016/j.ijpharm.2012.04.043. Epub 2012 Apr 22.


Synthesis, optimization, and characterization of camptothecin-loaded acetalated dextran porous microparticles for pulmonary delivery.

Meenach SA, Kim YJ, Kauffman KJ, Kanthamneni N, Bachelder EM, Ainslie KM.

Mol Pharm. 2012 Feb 6;9(2):290-8. doi: 10.1021/mp2003785. Epub 2012 Jan 13.


Optimization of rapamycin-loaded acetalated dextran microparticles for immunosuppression.

Kauffman KJ, Kanthamneni N, Meenach SA, Pierson BC, Bachelder EM, Ainslie KM.

Int J Pharm. 2012 Jan 17;422(1-2):356-63. doi: 10.1016/j.ijpharm.2011.10.034. Epub 2011 Oct 21.


Micrometer-sized iron oxide particle labeling of mesenchymal stem cells for magnetic resonance imaging-based monitoring of cartilage tissue engineering.

Saldanha KJ, Doan RP, Ainslie KM, Desai TA, Majumdar S.

Magn Reson Imaging. 2011 Jan;29(1):40-9. doi: 10.1016/j.mri.2010.07.015. Epub 2010 Sep 21.


In vitro analysis of acetalated dextran microparticles as a potent delivery platform for vaccine adjuvants.

Bachelder EM, Beaudette TT, Broaders KE, Fr├ęchet JM, Albrecht MT, Mateczun AJ, Ainslie KM, Pesce JT, Keane-Myers AM.

Mol Pharm. 2010 Jun 7;7(3):826-35. doi: 10.1021/mp900311x.

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