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Items: 35


Orai1 Channel Inhibition Preserves Left Ventricular Systolic Function and Normal Ca2+ Handling After Pressure Overload.

Bartoli F, Bailey MA, Rode B, Mateo P, Antigny F, Bedouet K, Gerbaud P, Gosain R, Plante J, Norman K, Gomez S, Lefebvre F, Rucker-Martin C, Ainscough JFX, Kearney MT, Bruns AF, Shi J, Appleby HL, Young RS, Shawer HM, Debant M, Gomez AM, Beech DJ, Foster R, Benitah JP, Sabourin J.

Circulation. 2020 Jan 21;141(3):199-216. doi: 10.1161/CIRCULATIONAHA.118.038891. Epub 2020 Jan 7.


Fibroblast-specific deletion of interleukin-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction.

Bageghni SA, Hemmings KE, Yuldasheva NY, Maqbool A, Gamboa-Esteves FO, Humphreys NE, Jackson MS, Denton CP, Francis S, Porter KE, Ainscough JF, Pinteaux E, Drinkhill MJ, Turner NA.

JCI Insight. 2019 Aug 8;5. pii: 125074. doi: 10.1172/jci.insight.125074.


TRPC5 ion channel permeation promotes weight gain in hypercholesterolaemic mice.

Rode B, Yuldasheva NY, Baxter PD, Sedo A, Ainscough JF, Shires M, Kearney MT, Bailey MA, Wheatcroft SB, Beech DJ.

Sci Rep. 2019 Jan 28;9(1):773. doi: 10.1038/s41598-018-37299-8.


Maintenance of epigenetic landscape requires CIZ1 and is corrupted in differentiated fibroblasts in long-term culture.

Stewart ER, Turner RML, Newling K, Ridings-Figueroa R, Scott V, Ashton PD, Ainscough JFX, Coverley D.

Nat Commun. 2019 Jan 28;10(1):460. doi: 10.1038/s41467-018-08072-2.


Cardiac fibroblast-specific p38α MAP kinase promotes cardiac hypertrophy via a putative paracrine interleukin-6 signaling mechanism.

Bageghni SA, Hemmings KE, Zava N, Denton CP, Porter KE, Ainscough JFX, Drinkhill MJ, Turner NA.

FASEB J. 2018 Sep;32(9):4941-4954. doi: 10.1096/fj.201701455RR. Epub 2018 Mar 30.


The nuclear matrix protein CIZ1 facilitates localization of Xist RNA to the inactive X-chromosome territory.

Ridings-Figueroa R, Stewart ER, Nesterova TB, Coker H, Pintacuda G, Godwin J, Wilson R, Haslam A, Lilley F, Ruigrok R, Bageghni SA, Albadrani G, Mansfield W, Roulson JA, Brockdorff N, Ainscough JFX, Coverley D.

Genes Dev. 2017 May 1;31(9):876-888. doi: 10.1101/gad.295907.117. Epub 2017 May 25.


Cardiomyocyte--specific expression of the nuclear matrix protein, CIZ1, stimulates production of mono-nucleated cells with an extended window of proliferation in the postnatal mouse heart.

Bageghni SA, Frentzou GA, Drinkhill MJ, Mansfield W, Coverley D, Ainscough JF.

Biol Open. 2017 Jan 15;6(1):92-99. doi: 10.1242/bio.021550.


A state of reversible compensated ventricular dysfunction precedes pathological remodelling in response to cardiomyocyte-specific activity of angiotensin II type-1 receptor in mice.

Frentzou GA, Drinkhill MJ, Turner NA, Ball SG, Ainscough JF.

Dis Model Mech. 2015 Aug 1;8(8):783-94. doi: 10.1242/dmm.019174. Epub 2015 Jun 18.


TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia.

Ye M, Yang W, Ainscough JF, Hu XP, Li X, Sedo A, Zhang XH, Zhang X, Chen Z, Li XM, Beech DJ, Sivaprasadarao A, Luo JH, Jiang LH.

Cell Death Dis. 2014 Nov 27;5:e1541. doi: 10.1038/cddis.2014.494.


Piezo1 integration of vascular architecture with physiological force.

Li J, Hou B, Tumova S, Muraki K, Bruns A, Ludlow MJ, Sedo A, Hyman AJ, McKeown L, Young RS, Yuldasheva NY, Majeed Y, Wilson LA, Rode B, Bailey MA, Kim HR, Fu Z, Carter DA, Bilton J, Imrie H, Ajuh P, Dear TN, Cubbon RM, Kearney MT, Prasad RK, Evans PC, Ainscough JF, Beech DJ.

Nature. 2014 Nov 13;515(7526):279-282. doi: 10.1038/nature13701. Epub 2014 Aug 10.


A differential role of macrophage TRPM2 channels in Ca²⁺ signaling and cell death in early responses to H₂O₂.

Zou J, Ainscough JF, Yang W, Sedo A, Yu SP, Mei ZZ, Sivaprasadarao A, Beech DJ, Jiang LH.

Am J Physiol Cell Physiol. 2013 Jul 1;305(1):C61-9. doi: 10.1152/ajpcell.00390.2012. Epub 2013 Apr 17.


Variant Ciz1 is a circulating biomarker for early-stage lung cancer.

Higgins G, Roper KM, Watson IJ, Blackhall FH, Rom WN, Pass HI, Ainscough JF, Coverley D.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):E3128-35. doi: 10.1073/pnas.1210107109. Epub 2012 Oct 16.


Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin.

Sukumar P, Sedo A, Li J, Wilson LA, O'Regan D, Lippiat JD, Porter KE, Kearney MT, Ainscough JF, Beech DJ.

Circ Res. 2012 Jul 6;111(2):191-200. doi: 10.1161/CIRCRESAHA.112.270751. Epub 2012 Jun 5.


Cancer-associated variant expression and interaction of CIZ1 with cyclin A1 in differentiating male germ cells.

Greaves EA, Copeland NA, Coverley D, Ainscough JF.

J Cell Sci. 2012 May 15;125(Pt 10):2466-77. doi: 10.1242/jcs.101097. Epub 2012 Feb 24.


Cyclin E is recruited to the nuclear matrix during differentiation, but is not recruited in cancer cells.

Munkley J, Copeland NA, Moignard V, Knight JR, Greaves E, Ramsbottom SA, Pownall ME, Southgate J, Ainscough JF, Coverley D.

Nucleic Acids Res. 2011 Apr;39(7):2671-7. doi: 10.1093/nar/gkq1190. Epub 2010 Nov 24.


Ciz1 cooperates with cyclin-A-CDK2 to activate mammalian DNA replication in vitro.

Copeland NA, Sercombe HE, Ainscough JF, Coverley D.

J Cell Sci. 2010 Apr 1;123(Pt 7):1108-15. doi: 10.1242/jcs.059345. Epub 2010 Mar 9.


H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.

Gabory A, Ripoche MA, Le Digarcher A, Watrin F, Ziyyat A, Forné T, Jammes H, Ainscough JF, Surani MA, Journot L, Dandolo L.

Development. 2009 Oct;136(20):3413-21. doi: 10.1242/dev.036061. Epub 2009 Sep 17.


Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction.

Ainscough JF, Drinkhill MJ, Sedo A, Turner NA, Brooke DA, Balmforth AJ, Ball SG.

Cardiovasc Res. 2009 Feb 15;81(3):592-600. doi: 10.1093/cvr/cvn230. Epub 2008 Aug 14.


Cancer-associated missplicing of exon 4 influences the subnuclear distribution of the DNA replication factor CIZ1.

Rahman F, Ainscough JF, Copeland N, Coverley D.

Hum Mutat. 2007 Oct;28(10):993-1004.


Human menopausal and pregnant mare serum gonadotrophins in murine superovulation regimens for transgenic applications.

Brooke DA, Orsi NM, Ainscough JF, Holwell SE, Markham AF, Coletta PL.

Theriogenology. 2007 May;67(8):1409-13. Epub 2007 Apr 8.


C-terminal domains deliver the DNA replication factor Ciz1 to the nuclear matrix.

Ainscough JF, Rahman FA, Sercombe H, Sedo A, Gerlach B, Coverley D.

J Cell Sci. 2007 Jan 1;120(Pt 1):115-24.


Pluripotency of reprogrammed somatic genomes in embryonic stem hybrid cells.

Tada M, Morizane A, Kimura H, Kawasaki H, Ainscough JF, Sasai Y, Nakatsuji N, Tada T.

Dev Dyn. 2003 Aug;227(4):504-10.


A transgenic approach to studying imprinted genes: modified BACs and PACs.

John RM, Ainscough JF, Barton SC.

Methods Mol Biol. 2001;181:67-81.


Production of YAC transgenic mice by pronuclear injection.

Ainscough JF, John RM, Barton SC.

Methods Mol Biol. 2001;181:55-65.


Polycomb-group proteins are involved in silencing processes caused by a transgenic element from the murine imprinted H19/Igf2 region in Drosophila.

Erhardt S, Lyko F, Ainscough JF, Surani MA, Paro R.

Dev Genes Evol. 2003 Jul;213(7):336-44. Epub 2003 May 15.


Imprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers.

John RM, Aparicio SA, Ainscough JF, Arney KL, Khosla S, Hawker K, Hilton KJ, Barton SC, Surani MA.

Dev Biol. 2001 Aug 15;236(2):387-99.


A skeletal muscle-specific mouse Igf2 repressor lies 40 kb downstream of the gene.

Ainscough JF, John RM, Barton SC, Surani MA.

Development. 2000 Sep;127(18):3923-30.


Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch.

Drewell RA, Brenton JD, Ainscough JF, Barton SC, Hilton KJ, Arney KL, Dandolo L, Surani MA.

Development. 2000 Aug;127(16):3419-28.


A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice.

Brenton JD, Drewell RA, Viville S, Hilton KJ, Barton SC, Ainscough JF, Surani MA.

Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9242-7.


Mechanism of imprinting on mouse distal chromosome 7.

Ainscough JF, John RM, Surani MA.

Genet Res. 1998 Dec;72(3):237-45.


Imprinting and gene silencing in mice and Drosophila.

Brenton JD, Ainscough JF, Lyko F, Paro R, Surani MA.

Novartis Found Symp. 1998;214:233-44; discussion 244-50. Review.


Imprinting of Igf2 and H19 from a 130 kb YAC transgene.

Ainscough JF, Koide T, Tada M, Barton S, Surani MA.

Development. 1997 Sep;124(18):3621-32.


Clonal analysis of the late flowering fca mutant of Arabidopsis thaliana: cell fate and cell autonomy.

Furner IJ, Ainscough JF, Pumfrey JA, Petty LM.

Development. 1996 Mar;122(3):1041-50.

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