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MicroSPECT/CT Imaging of Cell-Line and Patient-Derived EGFR-Positive Tumor Xenografts in Mice with Panitumumab Fab Modified with Hexahistidine Peptides To Enable Labeling with 99mTc(I) Tricarbonyl Complex.

Ku A, Chan C, Aghevlian S, Cai Z, Cescon D, Bratman SV, Ailles L, Hedley DW, Reilly RM.

Mol Pharm. 2019 Jul 11. doi: 10.1021/acs.molpharmaceut.9b00422. [Epub ahead of print]


N-Glycoproteomics of Patient-Derived Xenografts: A Strategy to Discover Tumor-Associated Proteins in High-Grade Serous Ovarian Cancer.

Sinha A, Hussain A, Ignatchenko V, Ignatchenko A, Tang KH, Ho VWH, Neel BG, Clarke B, Bernardini MQ, Ailles L, Kislinger T.

Cell Syst. 2019 Apr 24;8(4):345-351.e4. doi: 10.1016/j.cels.2019.03.011. Epub 2019 Apr 10.


Cytometry of Reaction Rate Constant: Measuring Reaction Rate Constant in Individual Cells To Facilitate Robust and Accurate Analysis of Cell-Population Heterogeneity.

Koshkin V, Kochmann S, Sorupanathan A, Peng C, Ailles LE, Liu G, Krylov SN.

Anal Chem. 2019 Mar 19;91(6):4186-4194. doi: 10.1021/acs.analchem.9b00388. Epub 2019 Mar 4.


Patient-derived xenografts: a promising resource for preclinical cancer research.

Karamboulas C, Ailles L.

Mol Cell Oncol. 2019 Jan 8;6(1):1558684. doi: 10.1080/23723556.2018.1558684. eCollection 2019.


A controlled trial of HNSCC patient-derived xenografts reveals broad efficacy of PI3Kα inhibition in controlling tumor growth.

Ruicci KM, Meens J, Sun RX, Rizzo G, Pinto N, Yoo J, Fung K, MacNeil D, Mymryk JS, Barrett JW, Boutros PC, Ailles L, Nichols AC.

Int J Cancer. 2018 Nov 23. doi: 10.1002/ijc.32009. [Epub ahead of print]


Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma.

Karamboulas C, Bruce JP, Hope AJ, Meens J, Huang SH, Erdmann N, Hyatt E, Pereira K, Goldstein DP, Weinreb I, Su J, O'Sullivan B, Tiedemann R, Liu FF, Pugh TJ, Bratman SV, Xu W, Ailles L.

Cell Rep. 2018 Oct 30;25(5):1318-1331.e4. doi: 10.1016/j.celrep.2018.10.004.


High-throughput testing in head and neck squamous cell carcinoma identifies agents with preferential activity in human papillomavirus-positive or negative cell lines.

Ghasemi F, Black M, Sun RX, Vizeacoumar F, Pinto N, Ruicci KM, Yoo J, Fung K, MacNeil D, Palma DA, Winquist E, Mymryk JS, Ailles LA, Datti A, Barrett JW, Boutros PC, Nichols AC.

Oncotarget. 2018 May 25;9(40):26064-26071. doi: 10.18632/oncotarget.25436. eCollection 2018 May 25.


Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma.

Teichman J, Dodbiba L, Thai H, Fleet A, Morey T, Liu L, McGregor M, Cheng D, Chen Z, Darling G, Brhane Y, Song Y, Espin-Garcia O, Xu W, Girgis H, Schwock J, MacKay H, Bristow R, Ailles L, Liu G.

PLoS One. 2018 May 1;13(5):e0194809. doi: 10.1371/journal.pone.0194809. eCollection 2018.


Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma.

Principe S, Mejia-Guerrero S, Ignatchenko V, Sinha A, Ignatchenko A, Shi W, Pereira K, Su S, Huang SH, O'Sullivan B, Xu W, Goldstein DP, Weinreb I, Ailles L, Liu FF, Kislinger T.

J Proteome Res. 2018 Jun 1;17(6):2045-2059. doi: 10.1021/acs.jproteome.7b00925. Epub 2018 May 2.


A TRACER 3D Co-Culture tumour model for head and neck cancer.

Young M, Rodenhizer D, Dean T, D'Arcangelo E, Xu B, Ailles L, McGuigan AP.

Biomaterials. 2018 May;164:54-69. doi: 10.1016/j.biomaterials.2018.01.038. Epub 2018 Feb 19.


High Throughput Flow Cytometry for Cell Surface Profiling.

Paterson J, Ailles LE.

Methods Mol Biol. 2018;1678:111-138. doi: 10.1007/978-1-4939-7346-0_7.


Correction: Rapid determination of the tumour stroma ratio in squamous cell carcinomas with desorption electrospray ionization mass spectrometry (DESI-MS): a proof-of-concept demonstration.

Woolman M, Tata A, Dara D, Meens J, D'Arcangelo E, Perez CJ, Prova SS, Bluemke E, Ginsberg HJ, Ifa D, McGuigan A, Ailles L, Zarrine-Afsar A.

Analyst. 2017 Sep 8;142(18):3522. doi: 10.1039/c7an90066j.


Rapid determination of the tumour stroma ratio in squamous cell carcinomas with desorption electrospray ionization mass spectrometry (DESI-MS): a proof-of-concept demonstration.

Woolman M, Tata A, Dara D, Meens J, D'Arcangelo E, Perez CJ, Saiyara Prova S, Bluemke E, Ginsberg HJ, Ifa D, McGuigan A, Ailles L, Zarrine-Afsar A.

Analyst. 2017 Aug 21;142(17):3250-3260. doi: 10.1039/c7an00830a. Erratum in: Analyst. 2017 Sep 8;142(18):3522.


An Immune Atlas of Clear Cell Renal Cell Carcinoma.

Chevrier S, Levine JH, Zanotelli VRT, Silina K, Schulz D, Bacac M, Ries CH, Ailles L, Jewett MAS, Moch H, van den Broek M, Beisel C, Stadler MB, Gedye C, Reis B, Pe'er D, Bodenmiller B.

Cell. 2017 May 4;169(4):736-749.e18. doi: 10.1016/j.cell.2017.04.016.


Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer.

Medrano M, Communal L, Brown KR, Iwanicki M, Normand J, Paterson J, Sircoulomb F, Krzyzanowski P, Novak M, Doodnauth SA, Saiz FS, Cullis J, Al-Awar R, Neel BG, McPherson J, Drapkin R, Ailles L, Mes-Massons AM, Rottapel R.

Cell Rep. 2017 Mar 7;18(10):2343-2358. doi: 10.1016/j.celrep.2017.02.028.


Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

Papillon-Cavanagh S, Lu C, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu OM, Dhaliwal S, Stecho W, Howlett CJ, Mymryk JS, Barrett JW, Nichols AC, Allis CD, Majewski J, Jabado N.

Nat Genet. 2017 Feb;49(2):180-185. doi: 10.1038/ng.3757. Epub 2017 Jan 9.


Patterning cellular compartments within TRACER cultures using sacrificial gelatin printing.

Xu B, Rodenhizer D, Lakhani S, Zhang X, Soleas JP, Ailles L, McGuigan AP.

Biofabrication. 2016 Sep 15;8(3):035018. doi: 10.1088/1758-5090/8/3/035018.


Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine.

Lobo NC, Gedye C, Apostoli AJ, Brown KR, Paterson J, Stickle N, Robinette M, Fleshner N, Hamilton RJ, Kulkarni G, Zlotta A, Evans A, Finelli A, Moffat J, Jewett MA, Ailles L.

BMC Cancer. 2016 Jul 16;16:485. doi: 10.1186/s12885-016-2539-z.


Preservation of the 3D Phenotype Upon Dispersal of Cultured Cell Spheroids Into Monolayer Cultures.

Koshkin V, Ailles LE, Liu G, Krylov SN.

J Cell Biochem. 2017 Jan;118(1):154-162. doi: 10.1002/jcb.25621. Epub 2016 Jun 21.


Cancer stem cells are underestimated by standard experimental methods in clear cell renal cell carcinoma.

Gedye C, Sirskyj D, Lobo NC, Meens J, Hyatt E, Robinette M, Fleshner N, Hamilton RJ, Kulkarni G, Zlotta A, Evans A, Finelli A, Jewett MA, Ailles LE.

Sci Rep. 2016 Apr 28;6:25220. doi: 10.1038/srep25220.


Identification of CD146 as a marker enriched for tumor-propagating capacity reveals targetable pathways in primary human sarcoma.

Wei Q, Tang YJ, Voisin V, Sato S, Hirata M, Whetstone H, Han I, Ailles L, Bader GD, Wunder J, Alman BA.

Oncotarget. 2015 Nov 24;6(37):40283-94. doi: 10.18632/oncotarget.5375.


Clonal evolution and tumor-initiating cells: New dimensions in cancer patient treatment.

Apostoli AJ, Ailles L.

Crit Rev Clin Lab Sci. 2016;53(1):40-51. doi: 10.3109/10408363.2015.1083944. Epub 2015 Sep 23. Review.


Metabolic Suppression of a Drug-Resistant Subpopulation in Cancer Spheroid Cells.

Koshkin V, Ailles LE, Liu G, Krylov SN.

J Cell Biochem. 2016 Jan;117(1):59-65. doi: 10.1002/jcb.25247.


Appropriateness of using patient-derived xenograft models for pharmacologic evaluation of novel therapies for esophageal/gastro-esophageal junction cancers.

Dodbiba L, Teichman J, Fleet A, Thai H, Starmans MH, Navab R, Chen Z, Girgis H, Eng L, Espin-Garcia O, Shen X, Bandarchi B, Schwock J, Tsao MS, El-Zimaity H, Der SD, Xu W, Bristow RG, Darling GE, Boutros PC, Ailles LE, Liu G.

PLoS One. 2015 Mar 31;10(3):e0121872. doi: 10.1371/journal.pone.0121872. eCollection 2015.


Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas.

Van de Laar E, Clifford M, Hasenoeder S, Kim BR, Wang D, Lee S, Paterson J, Vu NM, Waddell TK, Keshavjee S, Tsao MS, Ailles L, Moghal N.

Respir Res. 2014 Dec 31;15:160. doi: 10.1186/s12931-014-0160-8.


Cell surface profiling using high-throughput flow cytometry: a platform for biomarker discovery and analysis of cellular heterogeneity.

Gedye CA, Hussain A, Paterson J, Smrke A, Saini H, Sirskyj D, Pereira K, Lobo N, Stewart J, Go C, Ho J, Medrano M, Hyatt E, Yuan J, Lauriault S, Meyer M, Kondratyev M, van den Beucken T, Jewett M, Dirks P, Guidos CJ, Danska J, Wang J, Wouters B, Neel B, Rottapel R, Ailles LE.

PLoS One. 2014 Aug 29;9(8):e105602. doi: 10.1371/journal.pone.0105602. eCollection 2014. Erratum in: PLoS One. 2014;9(11):e114354. Meyer, Mona [added].


Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.

Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, Wrana JL, Kislinger T, Khokha R.

Nat Cell Biol. 2014 Sep;16(9):889-901. doi: 10.1038/ncb3021. Epub 2014 Aug 24.


CD271 is a functional and targetable marker of tumor-initiating cells in head and neck squamous cell carcinoma.

Murillo-Sauca O, Chung MK, Shin JH, Karamboulas C, Kwok S, Jung YH, Oakley R, Tysome JR, Farnebo LO, Kaplan MJ, Sirjani D, Divi V, Holsinger FC, Tomeh C, Nichols A, Le QT, Colevas AD, Kong CS, Uppaluri R, Lewis JS Jr, Ailles LE, Sunwoo JB.

Oncotarget. 2014 Aug 30;5(16):6854-66.


Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment.

Dodbiba L, Teichman J, Fleet A, Thai H, Sun B, Panchal D, Patel D, Tse A, Chen Z, Faluyi OO, Renouf DJ, Girgis H, Bandarchi B, Schwock J, Xu W, Bristow RG, Tsao MS, Darling GE, Ailles LE, El-Zimaity H, Liu G.

Lab Invest. 2013 Apr;93(4):397-407. doi: 10.1038/labinvest.2013.8. Epub 2013 Feb 11.


Developmental signaling pathways in cancer stem cells of solid tumors.

Karamboulas C, Ailles L.

Biochim Biophys Acta. 2013 Feb;1830(2):2481-95. doi: 10.1016/j.bbagen.2012.11.008. Epub 2012 Nov 27.


Isolation and characterization of cancer stem cells in vitro.

Gedye C, Ailles L.

Methods Mol Biol. 2013;946:181-204. doi: 10.1007/978-1-62703-128-8_12.


Phenotypic heterogeneity and instability of human ovarian tumor-initiating cells.

Stewart JM, Shaw PA, Gedye C, Bernardini MQ, Neel BG, Ailles LE.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6468-73. doi: 10.1073/pnas.1005529108. Epub 2011 Mar 30.


Targeting the Hedgehog pathway in cancer: can the spines be smoothened?

Ailles L, Siu LL.

Clin Cancer Res. 2011 Apr 15;17(8):2071-3. doi: 10.1158/1078-0432.CCR-11-0211. Epub 2011 Mar 2.


Frequency of cells expressing CD44, a head and neck cancer stem cell marker: correlation with tumor aggressiveness.

Joshua B, Kaplan MJ, Doweck I, Pai R, Weissman IL, Prince ME, Ailles LE.

Head Neck. 2012 Jan;34(1):42-9. doi: 10.1002/hed.21699. Epub 2011 Feb 14.


Secretome-based identification and characterization of potential biomarkers in thyroid cancer.

Kashat L, So AK, Masui O, Wang XS, Cao J, Meng X, Macmillan C, Ailles LE, Siu KW, Ralhan R, Walfish PG.

J Proteome Res. 2010 Nov 5;9(11):5757-69. doi: 10.1021/pr100529t. Epub 2010 Oct 15.


Tumor-initiating cells are rare in many human tumors.

Ishizawa K, Rasheed ZA, Karisch R, Wang Q, Kowalski J, Susky E, Pereira K, Karamboulas C, Moghal N, Rajeshkumar NV, Hidalgo M, Tsao M, Ailles L, Waddell TK, Maitra A, Neel BG, Matsui W.

Cell Stem Cell. 2010 Sep 3;7(3):279-82. doi: 10.1016/j.stem.2010.08.009.


Oncolytic targeting of renal cell carcinoma via encephalomyocarditis virus.

Roos FC, Roberts AM, Hwang II, Moriyama EH, Evans AJ, Sybingco S, Watson IR, Carneiro LA, Gedye C, Girardin SE, Ailles LE, Jewett MA, Milosevic M, Wilson BC, Bell JC, Der SD, Ohh M.

EMBO Mol Med. 2010 Jul;2(7):275-88. doi: 10.1002/emmm.201000081.


Separating stem cells by flow cytometry: reducing variability for solid tissues.

Alexander CM, Puchalski J, Klos KS, Badders N, Ailles L, Kim CF, Dirks P, Smalley MJ.

Cell Stem Cell. 2009 Dec 4;5(6):579-83. doi: 10.1016/j.stem.2009.11.008.


Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells.

Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J Jr, Chang HY, van de Rijn M, Shortliffe L, Weissman IL.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14016-21. doi: 10.1073/pnas.0906549106. Epub 2009 Aug 4.


A neurosurgeon's guide to stem cells, cancer stem cells, and brain tumor stem cells.

Cheshier SH, Kalani MY, Lim M, Ailles L, Huhn SL, Weissman IL.

Neurosurgery. 2009 Aug;65(2):237-49; discussion 249-50; quiz N6. doi: 10.1227/01.NEU.0000349921.14519.2A. Review.


Cancer stem cells in head and neck squamous cell carcinoma.

Ailles L, Prince M.

Methods Mol Biol. 2009;568:175-93. doi: 10.1007/978-1-59745-280-9_11.


Association of reactive oxygen species levels and radioresistance in cancer stem cells.

Diehn M, Cho RW, Lobo NA, Kalisky T, Dorie MJ, Kulp AN, Qian D, Lam JS, Ailles LE, Wong M, Joshua B, Kaplan MJ, Wapnir I, Dirbas FM, Somlo G, Garberoglio C, Paz B, Shen J, Lau SK, Quake SR, Brown JM, Weissman IL, Clarke MF.

Nature. 2009 Apr 9;458(7239):780-3. doi: 10.1038/nature07733.


Cancer stem cells in head and neck squamous cell cancer.

Prince ME, Ailles LE.

J Clin Oncol. 2008 Jun 10;26(17):2871-5. doi: 10.1200/JCO.2007.15.1613. Review.


Cancer stem cells in solid tumors.

Ailles LE, Weissman IL.

Curr Opin Biotechnol. 2007 Oct;18(5):460-6. Review.


Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma.

Prince ME, Sivanandan R, Kaczorowski A, Wolf GT, Kaplan MJ, Dalerba P, Weissman IL, Clarke MF, Ailles LE.

Proc Natl Acad Sci U S A. 2007 Jan 16;104(3):973-8. Epub 2007 Jan 8.


The cancer stem cell hypothesis: a work in progress.

Tan BT, Park CY, Ailles LE, Weissman IL.

Lab Invest. 2006 Dec;86(12):1203-7. Epub 2006 Oct 30. Review.


Identification of phenotypic neural stem cells in a pediatric astroblastoma.

Huhn SL, Yung Y, Cheshier S, Harsh G, Ailles L, Weissman I, Vogel H, Tse V.

J Neurosurg. 2005 Nov;103(5 Suppl):446-50.


Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.

Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, Gotlib J, Li K, Manz MG, Keating A, Sawyers CL, Weissman IL.

N Engl J Med. 2004 Aug 12;351(7):657-67.


Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

Passegué E, Jamieson CH, Ailles LE, Weissman IL.

Proc Natl Acad Sci U S A. 2003 Sep 30;100 Suppl 1:11842-9. Epub 2003 Sep 22. Review.


A role for Wnt signalling in self-renewal of haematopoietic stem cells.

Reya T, Duncan AW, Ailles L, Domen J, Scherer DC, Willert K, Hintz L, Nusse R, Weissman IL.

Nature. 2003 May 22;423(6938):409-14. Epub 2003 Apr 27.


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