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Deficient Active Transport Activity in Healing Mucosa After Mild Gastric Epithelial Damage.

Matthis AL, Kaji I, Engevik KA, Akiba Y, Kaunitz JD, Montrose MH, Aihara E.

Dig Dis Sci. 2019 Sep 12. doi: 10.1007/s10620-019-05825-x. [Epub ahead of print]


Helicobacter pylori Uses the TlpB Receptor To Sense Sites of Gastric Injury.

Hanyu H, Engevik KA, Matthis AL, Ottemann KM, Montrose MH, Aihara E.

Infect Immun. 2019 Aug 21;87(9). pii: e00202-19. doi: 10.1128/IAI.00202-19. Print 2019 Sep.


Transient receptor potential vanilloid 4 mediates sour taste sensing via type III taste cell differentiation.

Matsumoto K, Ohishi A, Iwatsuki K, Yamazaki K, Takayanagi S, Tsuji M, Aihara E, Utsumi D, Tsukahara T, Tominaga M, Nagasawa K, Kato S.

Sci Rep. 2019 Apr 30;9(1):6686. doi: 10.1038/s41598-019-43254-y.


Trefoil factor 2 activation of CXCR4 requires calcium mobilization to drive epithelial repair in gastric organoids.

Engevik KA, Hanyu H, Matthis AL, Zhang T, Frey MR, Oshima Y, Aihara E, Montrose MH.

J Physiol. 2019 May;597(10):2673-2690. doi: 10.1113/JP277259. Epub 2019 Apr 14.


Cell injury triggers actin polymerization to initiate epithelial restitution.

Aihara E, Medina-Candelaria NM, Hanyu H, Matthis AL, Engevik KA, Gurniak CB, Witke W, Turner JR, Zhang T, Montrose MH.

J Cell Sci. 2018 Aug 20;131(16). pii: jcs216317. doi: 10.1242/jcs.216317.


Organoids as a Model to Study Infectious Disease.

Engevik KA, Matthis AL, Montrose MH, Aihara E.

Methods Mol Biol. 2018;1734:71-81. doi: 10.1007/978-1-4939-7604-1_8.


Multiscale positive feedbacks contribute to unidirectional gastric disease progression induced by helicobacter pylori infection.

Ballweg R, Schozer F, Elliott K, Kuhn A, Spotts L, Aihara E, Zhang T.

BMC Syst Biol. 2017 Nov 22;11(1):111. doi: 10.1186/s12918-017-0497-y.


Transcriptome analyses of taste organoids reveal multiple pathways involved in taste cell generation.

Ren W, Aihara E, Lei W, Gheewala N, Uchiyama H, Margolskee RF, Iwatsuki K, Jiang P.

Sci Rep. 2017 Jun 21;7(1):4004. doi: 10.1038/s41598-017-04099-5.


Effect of essential amino acids on enteroids: Methionine deprivation suppresses proliferation and affects differentiation in enteroid stem cells.

Saito Y, Iwatsuki K, Hanyu H, Maruyama N, Aihara E, Tadaishi M, Shimizu M, Kobayashi-Hattori K.

Biochem Biophys Res Commun. 2017 Jun 17;488(1):171-176. doi: 10.1016/j.bbrc.2017.05.029. Epub 2017 May 5.


Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells.

Asai A, Aihara E, Watson C, Mourya R, Mizuochi T, Shivakumar P, Phelan K, Mayhew C, Helmrath M, Takebe T, Wells J, Bezerra JA.

Development. 2017 Mar 15;144(6):1056-1064. doi: 10.1242/dev.142794.


Erratum: Wnt/β-catenin promotes gastric fundus specification in mice and humans.

McCracken KW, Aihara E, Martin B, Crawford CM, Broda T, Treguier J, Zhang X, Shannon JM, Montrose MH, Wells JM.

Nature. 2017 Mar 2;543(7643):136. doi: 10.1038/nature21381. Epub 2017 Jan 25. No abstract available.


Wnt/β-catenin promotes gastric fundus specification in mice and humans.

McCracken KW, Aihara E, Martin B, Crawford CM, Broda T, Treguier J, Zhang X, Shannon JM, Montrose MH, Wells JM.

Nature. 2017 Jan 12;541(7636):182-187. doi: 10.1038/nature21021. Epub 2017 Jan 4. Erratum in: Nature. 2017 Mar 2;543(7643):136.


Trefoil Factor Peptides and Gastrointestinal Function.

Aihara E, Engevik KA, Montrose MH.

Annu Rev Physiol. 2017 Feb 10;79:357-380. doi: 10.1146/annurev-physiol-021115-105447. Epub 2016 Dec 15. Review.


The Development of Spasmolytic Polypeptide/TFF2-Expressing Metaplasia (SPEM) During Gastric Repair Is Absent in the Aged Stomach.

Engevik AC, Feng R, Choi E, White S, Bertaux-Skeirik N, Li J, Mahe MM, Aihara E, Yang L, DiPasquale B, Oh S, Engevik KA, Giraud AS, Montrose MH, Medvedovic M, Helmrath MA, Goldenring JR, Zavros Y.

Cell Mol Gastroenterol Hepatol. 2016 May 17;2(5):605-624. eCollection 2016 Sep.


Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture.

Matsu-Ura T, Dovzhenok A, Aihara E, Rood J, Le H, Ren Y, Rosselot AE, Zhang T, Lee C, Obrietan K, Montrose MH, Lim S, Moore SR, Hong CI.

Mol Cell. 2016 Dec 1;64(5):900-912. doi: 10.1016/j.molcel.2016.10.015. Epub 2016 Nov 17.


Epithelial Regeneration After Gastric Ulceration Causes Prolonged Cell-Type Alterations.

Aihara E, Matthis AL, Karns RA, Engevik KA, Jiang P, Wang J, Yacyshyn BR, Montrose MH.

Cell Mol Gastroenterol Hepatol. 2016 May 17;2(5):625-647. eCollection 2016 Sep.


Importance of the Evaluation of N-Acetyltransferase Enzyme Activity Prior to 5-Aminosalicylic Acid Medication for Ulcerative Colitis.

Matthis AL, Zhang B, Denson LA, Yacyshyn BR, Aihara E, Montrose MH.

Inflamm Bowel Dis. 2016 Aug;22(8):1793-802. doi: 10.1097/MIB.0000000000000823.


Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid.

Aihara E, Mahe MM, Schumacher MA, Matthis AL, Feng R, Ren W, Noah TK, Matsu-ura T, Moore SR, Hong CI, Zavros Y, Herness S, Shroyer NF, Iwatsuki K, Jiang P, Helmrath MA, Montrose MH.

Sci Rep. 2015 Nov 24;5:17185. doi: 10.1038/srep17185.


Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids.

Moore SR, Guedes MM, Costa TB, Vallance J, Maier EA, Betz KJ, Aihara E, Mahe MM, Lima AA, Oriá RB, Shroyer NF.

Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G831-9. doi: 10.1152/ajpgi.00422.2014. Epub 2015 Mar 19.


The use of murine-derived fundic organoids in studies of gastric physiology.

Schumacher MA, Aihara E, Feng R, Engevik A, Shroyer NF, Ottemann KM, Worrell RT, Montrose MH, Shivdasani RA, Zavros Y.

J Physiol. 2015 Apr 15;593(8):1809-27. doi: 10.1113/jphysiol.2014.283028. Epub 2015 Feb 19.


Helicobacter pylori-induced Sonic Hedgehog expression is regulated by NFκB pathway activation: the use of a novel in vitro model to study epithelial response to infection.

Schumacher MA, Feng R, Aihara E, Engevik AC, Montrose MH, Ottemann KM, Zavros Y.

Helicobacter. 2015 Feb;20(1):19-28. doi: 10.1111/hel.12152. Epub 2014 Dec 11.


H2S-induced HCO3- secretion in the rat stomach--involvement of nitric oxide, prostaglandins, and capsaicin-sensitive sensory neurons.

Takeuchi K, Ise F, Takahashi K, Aihara E, Hayashi S.

Nitric Oxide. 2015 Apr 30;46:157-64. doi: 10.1016/j.niox.2014.11.001. Epub 2014 Nov 7.


Single Lgr5- or Lgr6-expressing taste stem/progenitor cells generate taste bud cells ex vivo.

Ren W, Lewandowski BC, Watson J, Aihara E, Iwatsuki K, Bachmanov AA, Margolskee RF, Jiang P.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16401-6. doi: 10.1073/pnas.1409064111. Epub 2014 Nov 3.


Helicobacter pylori targets cancer-associated apical-junctional constituents in gastroids and gastric epithelial cells.

Wroblewski LE, Piazuelo MB, Chaturvedi R, Schumacher M, Aihara E, Feng R, Noto JM, Delgado A, Israel DA, Zavros Y, Montrose MH, Shroyer N, Correa P, Wilson KT, Peek RM Jr.

Gut. 2015 May;64(5):720-30. doi: 10.1136/gutjnl-2014-307650. Epub 2014 Aug 14.


Importance of Ca(2+) in gastric epithelial restitution-new views revealed by real-time in vivo measurements.

Aihara E, Montrose MH.

Curr Opin Pharmacol. 2014 Dec;19:76-83. doi: 10.1016/j.coph.2014.07.012. Epub 2014 Aug 9. Review.


Establishment of Gastrointestinal Epithelial Organoids.

Mahe MM, Aihara E, Schumacher MA, Zavros Y, Montrose MH, Helmrath MA, Sato T, Shroyer NF.

Curr Protoc Mouse Biol. 2013 Dec 19;3(4):217-40. doi: 10.1002/9780470942390.mo130179.


Motility and chemotaxis mediate the preferential colonization of gastric injury sites by Helicobacter pylori.

Aihara E, Closson C, Matthis AL, Schumacher MA, Engevik AC, Zavros Y, Ottemann KM, Montrose MH.

PLoS Pathog. 2014 Jul 17;10(7):e1004275. doi: 10.1371/journal.ppat.1004275. eCollection 2014 Jul.


Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine.

Moore SR, Pruszka J, Vallance J, Aihara E, Matsuura T, Montrose MH, Shroyer NF, Hong CI.

Dis Model Mech. 2014 Sep;7(9):1123-30. doi: 10.1242/dmm.014399. Epub 2014 Jul 4.


Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.

Feng R, Aihara E, Kenny S, Yang L, Li J, Varro A, Montrose MH, Shroyer NF, Wang TC, Shivdasani RA, Zavros Y.

Gastroenterology. 2014 Sep;147(3):655-666.e9. doi: 10.1053/j.gastro.2014.05.006. Epub 2014 May 20.


In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium.

Aihara E, Hentz CL, Korman AM, Perry NP, Prasad V, Shull GE, Montrose MH.

J Biol Chem. 2013 Nov 22;288(47):33585-97. doi: 10.1074/jbc.M113.488098. Epub 2013 Oct 11.


Loss of NHE3 alters gut microbiota composition and influences Bacteroides thetaiotaomicron growth.

Engevik MA, Aihara E, Montrose MH, Shull GE, Hassett DJ, Worrell RT.

Am J Physiol Gastrointest Liver Physiol. 2013 Nov 15;305(10):G697-711. doi: 10.1152/ajpgi.00184.2013. Epub 2013 Sep 26.


Gas mediators involved in modulating duodenal HCO3(-) secretion.

Takeuchi K, Aihara E, Kimura M, Dogishi K, Hara T, Hayashi S.

Curr Med Chem. 2012;19(1):43-54. Review.


Inhibitors of acid secretion can benefit gastric wound repair independent of luminal pH effects on the site of damage.

Demitrack ES, Aihara E, Kenny S, Varro A, Montrose MH.

Gut. 2012 Jun;61(6):804-11. doi: 10.1136/gutjnl-2011-300420. Epub 2011 Oct 13.


Trefoil factor 2 requires Na/H exchanger 2 activity to enhance mouse gastric epithelial repair.

Xue L, Aihara E, Wang TC, Montrose MH.

J Biol Chem. 2011 Nov 4;286(44):38375-82. doi: 10.1074/jbc.M111.268219. Epub 2011 Sep 7.


Carbon monoxide involved in modulating HCO3- secretion in rat duodenum.

Takasuka H, Hayashi S, Koyama M, Yasuda M, Aihara E, Amagase K, Takeuchi K.

J Pharmacol Exp Ther. 2011 Apr;337(1):293-300. doi: 10.1124/jpet.110.175216. Epub 2011 Jan 19.


Regulatory mechanism of duodenal bicarbonate secretion: Roles of endogenous prostaglandins and nitric oxide.

Takeuchi K, Kita K, Hayashi S, Aihara E.

Pharmacol Ther. 2011 Apr;130(1):59-70. doi: 10.1016/j.pharmthera.2010.12.006. Epub 2010 Dec 24. Review.


In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase.

Xue L, Aihara E, Podolsky DK, Wang TC, Montrose MH.

Gut. 2010 Sep;59(9):1184-91. doi: 10.1136/gut.2009.205625. Epub 2010 Jun 29.


Stimulation of duodenal HCO₃⁻ secretion by hydrogen sulphide in rats: relation to prostaglandins, nitric oxide and sensory neurones.

Ise F, Takasuka H, Hayashi S, Takahashi K, Koyama M, Aihara E, Takeuchi K.

Acta Physiol (Oxf). 2011 Jan;201(1):117-26. doi: 10.1111/j.1748-1716.2010.02152.x.


Phosphodiesterase isozymes involved in regulating acid secretion in the isolated mouse stomach.

Okuda S, Honda M, Ito Y, Aihara E, Kato S, Mitsufuji S, Yoshikawa T, Takeuchi K.

J Physiol Pharmacol. 2009 Dec;60 Suppl 7:183-90.


Prostaglandin EP receptor subtypes involved in regulating HCO(3)(-) secretion from gastroduodenal mucosa.

Takeuchi K, Koyama M, Hayashi S, Aihara E.

Curr Pharm Des. 2010;16(10):1241-51. Review.


Stimulation by sparkling water of gastroduodenal HCO3- secretion in rats.

Sasaki Y, Aihara E, Ohashi Y, Okuda S, Takasuka H, Takahashi K, Takeuchi K.

Med Sci Monit. 2009 Dec;15(12):BR349-56.


Antral ulcers induced by alendronate, a nitrogen-containing biphophonate, in rat stomachs - prophylactic effect of rebamipide.

Ohashi Y, Aihara E, Takasuka H, Takahashi K, Takeuchi K.

J Physiol Pharmacol. 2009 Sep;60(3):85-93.


Phosphodiesterase isozymes involved in regulation of formula secretion in isolated mouse stomach in vitro.

Kita K, Takahashi K, Ohashi Y, Takasuka H, Aihara E, Takeuchi K.

J Pharmacol Exp Ther. 2008 Sep;326(3):889-96. doi: 10.1124/jpet.108.138941. Epub 2008 Jun 12.


Inhibition of Ca2+-signal-dependent growth regulation by radicicol in budding yeast.

Chanklan R, Aihara E, Koga S, Takahashi H, Mizunuma M, Miyakawa T.

Biosci Biotechnol Biochem. 2008 Jan;72(1):132-8. Epub 2008 Jan 7.


Stimulatory effect of Coca-Cola on gastroduodenal HCO3- secretion in rats.

Sasaki Y, Aihara E, Ise F, Kita K, Takeuchi K.

Inflammopharmacology. 2007 Oct;15(5):223-8.


Prophylactic effect of rebamipide against the irritative and healing impairment actions of alendronate in rat stomachs.

Aihara E, Hayashi S, Amagase K, Kato S, Takeuchi K.

Inflammopharmacology. 2007 Oct;15(5):196-202.


Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.

Nishio H, Terashima S, Nakashima M, Aihara E, Takeuchi K.

J Physiol Pharmacol. 2007 Sep;58(3):407-21.


Phosphodiesterase isozymes involved in regulation of HCO3- secretion in isolated mouse duodenum in vitro.

Hayashi M, Kita K, Ohashi Y, Aihara E, Takeuchi K.

Biochem Pharmacol. 2007 Nov 15;74(10):1507-13. Epub 2007 Jul 26.


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