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Items: 1 to 50 of 88

1.

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

Santangelo AM, Sawiak SJ, Fryer T, Hong Y, Shiba Y, Clarke HF, Riss PJ, Ferrari V, Tait R, Suckling J, Aigbirhio FI, Roberts AC.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14761-14768. doi: 10.1073/pnas.1902087116. Epub 2019 Jul 2.

PMID:
31266890
2.

Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.

Mak E, Padilla C, Annus T, Wilson LR, Hong YT, Fryer TD, Coles JP, Aigbirhio FI, Menon DK, Nestor PJ, Zaman SH, Holland AJ.

Neurobiol Aging. 2019 Aug;80:196-202. doi: 10.1016/j.neurobiolaging.2019.02.018. Epub 2019 Mar 5.

PMID:
31207551
3.

Radiosynthesis of (R,S)-[18 F]GE387: A Potential PET Radiotracer for Imaging Translocator Protein 18 kDa (TSPO) with Low Binding Sensitivity to the Human Gene Polymorphism rs6971.

Qiao L, Fisher E, McMurray L, Milicevic Sephton S, Hird M, Kuzhuppilly-Ramakrishnan N, Williamson DJ, Zhou X, Werry E, Kassiou M, Luthra S, Trigg W, Aigbirhio FI.

ChemMedChem. 2019 May 6;14(9):982-993. doi: 10.1002/cmdc.201900023. Epub 2019 Apr 8.

4.

In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

Bevan-Jones WR, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer T, Arnold R, Coles JP, Aigbirhio FI, O'Brien JT, Rowe JB.

Ann Clin Transl Neurol. 2019 Jan 2;6(2):373-378. doi: 10.1002/acn3.683. eCollection 2019 Feb.

5.

In vivo coupling of tau pathology and cortical thinning in Alzheimer's disease.

Mak E, Bethlehem RAI, Romero-Garcia R, Cervenka S, Rittman T, Gabel S, Surendranathan A, Bevan-Jones RW, Passamonti L, Vázquez Rodríguez P, Su L, Arnold R, Williams GB, Hong YT, Fryer TD, Aigbirhio FI, Rowe JB, O'Brien JT.

Alzheimers Dement (Amst). 2018 Sep 17;10:678-687. doi: 10.1016/j.dadm.2018.08.005. eCollection 2018.

6.

Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

Surendranathan A, Su L, Mak E, Passamonti L, Hong YT, Arnold R, Vázquez Rodríguez P, Bevan-Jones WR, Brain SAE, Fryer TD, Aigbirhio FI, Rowe JB, O'Brien JT.

Brain. 2018 Dec 1;141(12):3415-3427. doi: 10.1093/brain/awy265.

7.

Synthesis, Radiolabelling and In Vitro Imaging of Multifunctional Nanoceramics.

Lledos M, Mirabello V, Sarpaki S, Ge H, Smugowski HJ, Carroll L, Aboagye EO, Aigbirhio FI, Botchway SW, Dilworth JR, Calatayud DG, Plucinski PK, Price GJ, Pascu SI.

ChemNanoMat. 2018 Apr;4(4):361-372. doi: 10.1002/cnma.201700378. Epub 2018 Feb 8.

8.

Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.

Morris RS, Simon Jones P, Alawneh JA, Hong YT, Fryer TD, Aigbirhio FI, Warburton EA, Baron JC.

Brain. 2018 Jul 1;141(7):2098-2111. doi: 10.1093/brain/awy121.

PMID:
29746644
9.

[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

Passamonti L, Rodríguez PV, Hong YT, Allinson KSJ, Bevan-Jones WR, Williamson D, Jones PS, Arnold R, Borchert RJ, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB.

Neurology. 2018 May 29;90(22):e1989-e1996. doi: 10.1212/WNL.0000000000005610. Epub 2018 Apr 27.

10.

[Carboxyl-11 C]Labelling of Four High-Affinity cPLA2α Inhibitors and Their Evaluation as Radioligands in Mice by Positron Emission Tomography.

Fisher MJ, McMurray L, Lu S, Morse CL, Liow JS, Zoghbi SS, Kowalski A, Tye GL, Innis RB, Aigbirhio FI, Pike VW.

ChemMedChem. 2018 Jan 22;13(2):138-146. doi: 10.1002/cmdc.201700697. Epub 2018 Jan 10.

11.

Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies.

Fryer TD, Ejaz S, Jensen-Kondering U, Williamson DJ, Sitnikov S, Sawiak SJ, Aigbirhio FI, Hong YT, Baron JC.

PLoS One. 2017 Nov 1;12(11):e0187087. doi: 10.1371/journal.pone.0187087. eCollection 2017.

12.

[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

Bevan-Jones WR, Cope TE, Jones PS, Passamonti L, Hong YT, Fryer TD, Arnold R, Allinson KSJ, Coles JP, Aigbirhio FI, Patterson K, O'Brien JT, Rowe JB.

J Neurol Neurosurg Psychiatry. 2018 Oct;89(10):1032-1037. doi: 10.1136/jnnp-2017-316402. Epub 2017 Sep 14.

13.

Detection and Characterization of Small Molecule Interactions with Fibrillar Protein Aggregates Using Microscale Thermophoresis.

Fisher E, Zhao Y, Richardson R, Janik M, Buell AK, Aigbirhio FI, Tóth G.

ACS Chem Neurosci. 2017 Sep 20;8(9):2088-2095. doi: 10.1021/acschemneuro.7b00228. Epub 2017 Jul 6.

PMID:
28640595
14.

Brain hypoxia mapping in acute stroke: Back-to-back T2' MR versus 18F-fluoromisonidazole PET in rodents.

Jensen-Kondering U, Manavaki R, Ejaz S, Sawiak SJ, Carpenter TA, Fryer TD, Aigbirhio FI, Williamson DJ, Baron JC.

Int J Stroke. 2017 Oct;12(7):752-760. doi: 10.1177/1747493017706221. Epub 2017 May 19.

PMID:
28523963
15.

Vascular Imaging With 18F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia.

Joshi FR, Manavaki R, Fryer TD, Figg NL, Sluimer JC, Aigbirhio FI, Davenport AP, Kirkpatrick PJ, Warburton EA, Rudd JH.

J Am Coll Cardiol. 2017 Apr 11;69(14):1873-1874. doi: 10.1016/j.jacc.2017.01.050. No abstract available.

16.

In vivo tau PET imaging in dementia: Pathophysiology, radiotracer quantification, and a systematic review of clinical findings.

Hall B, Mak E, Cervenka S, Aigbirhio FI, Rowe JB, O'Brien JT.

Ageing Res Rev. 2017 Jul;36:50-63. doi: 10.1016/j.arr.2017.03.002. Epub 2017 Mar 15. Review.

PMID:
28315409
17.

18F-AV-1451 positron emission tomography in Alzheimer's disease and progressive supranuclear palsy.

Passamonti L, Vázquez Rodríguez P, Hong YT, Allinson KS, Williamson D, Borchert RJ, Sami S, Cope TE, Bevan-Jones WR, Jones PS, Arnold R, Surendranathan A, Mak E, Su L, Fryer TD, Aigbirhio FI, O'Brien JT, Rowe JB.

Brain. 2017 Mar 1;140(3):781-791. doi: 10.1093/brain/aww340.

18.

Targeted Molecular Imaging in Adrenal Disease-An Emerging Role for Metomidate PET-CT.

Mendichovszky IA, Powlson AS, Manavaki R, Aigbirhio FI, Cheow H, Buscombe JR, Gurnell M, Gilbert FJ.

Diagnostics (Basel). 2016 Nov 18;6(4). pii: E42. Review.

19.

Synthesis, in Vitro Evaluation, and Radiolabeling of Fluorinated Puromycin Analogues: Potential Candidates for PET Imaging of Protein Synthesis.

Betts HM, Milicevic Sephton S, Tong C, Awais RO, Hill PJ, Perkins AC, Aigbirhio FI.

J Med Chem. 2016 Oct 27;59(20):9422-9430. Epub 2016 Oct 12.

PMID:
27690460
20.

Radiosynthesis of Carbon-11 Labeled Puromycin as a Potential PET Candidate for Imaging Protein Synthesis in Vivo.

Milicevic Sephton S, Aigbirhio FI.

ACS Med Chem Lett. 2016 Apr 12;7(6):647-51. doi: 10.1021/acsmedchemlett.6b00093. eCollection 2016 Jun 9.

21.

Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

Veenith TV, Carter EL, Geeraerts T, Grossac J, Newcombe VF, Outtrim J, Gee GS, Lupson V, Smith R, Aigbirhio FI, Fryer TD, Hong YT, Menon DK, Coles JP.

JAMA Neurol. 2016 May 1;73(5):542-50. doi: 10.1001/jamaneurol.2016.0091.

PMID:
27019039
22.

Abstracts of the 24th international isotope society (UK group) symposium: synthesis and applications of labelled compounds 2015.

Aigbirhio FI, Allwein S, Anwar A, Atzrodt J, Audisio D, Badman G, Bakale R, Berthon F, Bragg R, Brindle KM, Bushby N, Campos S, Cant AA, Chan MY, Colbon P, Cornelissen B, Czarny B, Derdau V, Dive V, Dunscombe M, Eggleston I, Ellis-Sawyer K, Elmore CS, Engstrom P, Ericsson C, Fairlamb IJ, Georgin D, Godfrey SP, He L, Hickey MJ, Huscroft IT, Kerr WJ, Lashford A, Lenz E, Lewinton S, L'Hermite MM, Lindelöf Å, Little G, Lockley WJ, Loreau O, Maddocks S, Marguerit M, Mirabello V, Mudd RJ, Nilsson GN, Owens PK, Pascu SI, Patriarche G, Pimlott SL, Pinault M, Plastow G, Racys DT, Reif J, Rossi J, Ruan J, Sarpaki S, Sephton SM, Simonsson R, Speed DJ, Sumal K, Sutherland A, Taran F, Thuleau A, Wang Y, Waring M, Watters WH, Wu J, Xiao J.

J Labelled Comp Radiopharm. 2016 Apr;59(4):175-86. doi: 10.1002/jlcr.3377. Epub 2016 Mar 18.

PMID:
26991121
23.

Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia.

Ejaz S, Emmrich JV, Sitnikov SL, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Williamson DJ, Baron JC.

Brain. 2016 Mar;139(Pt 3):751-64. doi: 10.1093/brain/awv391. Epub 2016 Jan 14.

PMID:
26767570
24.

Early-Phase 11C-PiB PET in Amyloid Angiopathy-Related Symptomatic Cerebral Hemorrhage: Potential Diagnostic Value?

Farid K, Hong YT, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Baron JC.

PLoS One. 2015 Oct 6;10(10):e0139926. doi: 10.1371/journal.pone.0139926. eCollection 2015.

25.

The pattern of amyloid accumulation in the brains of adults with Down syndrome.

Annus T, Wilson LR, Hong YT, Acosta-Cabronero J, Fryer TD, Cardenas-Blanco A, Smith R, Boros I, Coles JP, Aigbirhio FI, Menon DK, Zaman SH, Nestor PJ, Holland AJ.

Alzheimers Dement. 2016 May;12(5):538-45. doi: 10.1016/j.jalz.2015.07.490. Epub 2015 Sep 9.

26.

Synthesis and Initial in Vivo Studies with [(11)C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3.

Li L, Shao X, Cole EL, Ohnmacht SA, Ferrari V, Hong YT, Williamson DJ, Fryer TD, Quesada CA, Sherman P, Riss PJ, Scott PJ, Aigbirhio FI.

ACS Med Chem Lett. 2015 Mar 10;6(5):548-52. doi: 10.1021/acsmedchemlett.5b00044. eCollection 2015 May 14.

27.

White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden?

Charidimou A, Hong YT, Jäger HR, Fox Z, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Werring DJ, Baron JC.

Stroke. 2015 Jun;46(6):1707-9. doi: 10.1161/STROKEAHA.115.009090. Epub 2015 Apr 23.

PMID:
25908461
28.

Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.

Caprioli D, Jupp B, Hong YT, Sawiak SJ, Ferrari V, Wharton L, Williamson DJ, McNabb C, Berry D, Aigbirhio FI, Robbins TW, Fryer TD, Dalley JW.

J Neurosci. 2015 Mar 4;35(9):3747-55. doi: 10.1523/JNEUROSCI.3890-14.2015.

29.

Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.

Clarke HF, Cardinal RN, Rygula R, Hong YT, Fryer TD, Sawiak SJ, Ferrari V, Cockcroft G, Aigbirhio FI, Robbins TW, Roberts AC.

J Neurosci. 2014 May 28;34(22):7663-76. doi: 10.1523/JNEUROSCI.0718-14.2014.

30.

Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.

Baron JC, Farid K, Dolan E, Turc G, Marrapu ST, O'Brien E, Aigbirhio FI, Fryer TD, Menon DK, Warburton EA, Hong YT.

J Cereb Blood Flow Metab. 2014 May;34(5):753-8. doi: 10.1038/jcbfm.2014.43. Epub 2014 Mar 12.

31.

Radiosynthesis of 11-[(18) F]fluoroundecyltriphenylphosphonium (MitoF) as a potential mitochondria-specific positron emission tomography radiotracer.

Li L, Brichard L, Larsen L, Menon DK, Smith RA, Murphy MP, Aigbirhio FI.

J Labelled Comp Radiopharm. 2013 Dec;56(14):717-21. doi: 10.1002/jlcr.3109. Epub 2013 Sep 10.

PMID:
24339010
32.

Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.

Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK.

JAMA Neurol. 2014 Jan;71(1):23-31. doi: 10.1001/jamaneurol.2013.4847.

33.

A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.

del Campo N, Fryer TD, Hong YT, Smith R, Brichard L, Acosta-Cabronero J, Chamberlain SR, Tait R, Izquierdo D, Regenthal R, Dowson J, Suckling J, Baron JC, Aigbirhio FI, Robbins TW, Sahakian BJ, Müller U.

Brain. 2013 Nov;136(Pt 11):3252-70. doi: 10.1093/brain/awt263.

34.

Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study.

Alawneh JA, Moustafa RR, Marrapu ST, Jensen-Kondering U, Morris RS, Jones PS, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC.

Eur J Nucl Med Mol Imaging. 2014 Apr;41(4):736-44. doi: 10.1007/s00259-013-2581-x. Epub 2013 Oct 15.

PMID:
24126468
35.

Is neural activation within the rescued penumbra impeded by selective neuronal loss?

Carrera E, Jones PS, Morris RS, Alawneh J, Hong YT, Aigbirhio FI, Fryer TD, Carpenter TA, Warburton EA, Baron JC.

Brain. 2013 Jun;136(Pt 6):1816-29. doi: 10.1093/brain/awt112. Epub 2013 May 16.

PMID:
23682070
36.

Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls.

Caprioli D, Fryer TD, Sawiak SJ, Aigbirhio FI, Dalley JW.

Curr Opin Neurobiol. 2013 Aug;23(4):597-606. doi: 10.1016/j.conb.2013.04.003. Epub 2013 May 9. Review.

PMID:
23664005
37.

P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain.

Porteous CM, Menon DK, Aigbirhio FI, Smith RA, Murphy MP.

Biochim Biophys Acta. 2013 Jun;1830(6):3458-65. doi: 10.1016/j.bbagen.2013.02.005. Epub 2013 Feb 21.

38.

Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.

Caprioli D, Hong YT, Sawiak SJ, Ferrari V, Williamson DJ, Jupp B, Adrian Carpenter T, Aigbirhio FI, Everitt BJ, Robbins TW, Fryer TD, Dalley JW.

Neuropsychopharmacology. 2013 Jul;38(8):1460-71. doi: 10.1038/npp.2013.44. Epub 2013 Feb 11.

39.

Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging.

Riss PJ, Hong YT, Marton J, Caprioli D, Williamson DJ, Ferrari V, Saigal N, Roth BL, Henriksen G, Fryer TD, Dalley JW, Aigbirhio FI.

J Nucl Med. 2013 Feb;54(2):299-305. doi: 10.2967/jnumed.112.108688. Epub 2013 Jan 7.

40.

A comparison of four PET tracers for brain hypoxia mapping in a rodent model of stroke.

Williamson DJ, Ejaz S, Sitnikov S, Fryer TD, Sawiak SJ, Burke P, Baron JC, Aigbirhio FI.

Nucl Med Biol. 2013 Apr;40(3):338-44. doi: 10.1016/j.nucmedbio.2012.11.012. Epub 2013 Jan 5.

PMID:
23294900
41.

Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.

Ejaz S, Williamson DJ, Ahmed T, Sitnikov S, Hong YT, Sawiak SJ, Fryer TD, Aigbirhio FI, Baron JC.

Neurobiol Dis. 2013 Mar;51:120-32. doi: 10.1016/j.nbd.2012.11.002. Epub 2012 Nov 10.

PMID:
23146994
42.

Direct, nucleophilic radiosynthesis of [18F]trifluoroalkyl tosylates: improved labelling procedures.

Riss PJ, Ferrari V, Brichard L, Burke P, Smith R, Aigbirhio FI.

Org Biomol Chem. 2012 Sep 14;10(34):6980-6. doi: 10.1039/c2ob25802a. Epub 2012 Jul 26.

PMID:
22833145
43.

Positron emission tomography radiopharmaceutical studies in humans: a guide to regulations for academic researchers.

Fleming IN, Whelan M, Baxendale R, Gilbert FJ, Matthews PP, Aigbirhio FI.

Nucl Med Commun. 2012 Sep;33(9):899-906. doi: 10.1097/MNM.0b013e328356737f. Review.

PMID:
22773151
44.

Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.

Virdee K, Cumming P, Caprioli D, Jupp B, Rominger A, Aigbirhio FI, Fryer TD, Riss PJ, Dalley JW.

Neurosci Biobehav Rev. 2012 Apr;36(4):1188-216. doi: 10.1016/j.neubiorev.2012.01.009. Epub 2012 Feb 8. Review.

PMID:
22342372
45.

Cu(I)-catalyzed (11)C carboxylation of boronic acid esters: a rapid and convenient entry to (11)C-labeled carboxylic acids, esters, and amides.

Riss PJ, Lu S, Telu S, Aigbirhio FI, Pike VW.

Angew Chem Int Ed Engl. 2012 Mar 12;51(11):2698-702. doi: 10.1002/anie.201107263. Epub 2012 Feb 3.

46.

Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter.

Riss PJ, Hooker JM, Shea C, Xu Y, Carter P, Warner D, Ferrari V, Kim SW, Aigbirhio FI, Fowler JS, Roesch F.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):679-82. doi: 10.1016/j.bmcl.2011.10.053. Epub 2011 Oct 25.

PMID:
22082561
47.

A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation.

Hughes JL, Jones PS, Beech JS, Wang D, Menon DK, Aigbirhio FI, Fryer TD, Baron JC.

Neuroimage. 2012 Feb 1;59(3):2007-16. doi: 10.1016/j.neuroimage.2011.10.060. Epub 2011 Oct 25.

PMID:
22056528
48.

Probing small molecule binding to amyloid fibrils.

Buell AK, Esbjörner EK, Riss PJ, White DA, Aigbirhio FI, Toth G, Welland ME, Dobson CM, Knowles TP.

Phys Chem Chem Phys. 2011 Dec 7;13(45):20044-52. doi: 10.1039/c1cp22283j. Epub 2011 Oct 17. Review.

PMID:
22006124
49.

A simple, rapid procedure for nucleophilic radiosynthesis of aliphatic [18F]trifluoromethyl groups.

Riss PJ, Aigbirhio FI.

Chem Commun (Camb). 2011 Nov 21;47(43):11873-5. doi: 10.1039/c1cc15342k. Epub 2011 Oct 11.

PMID:
21987078
50.

Microembolism versus hemodynamic impairment in rosary-like deep watershed infarcts: a combined positron emission tomography and transcranial Doppler study.

Moustafa RR, Momjian-Mayor I, Jones PS, Morbelli S, Day DJ, Aigbirhio FI, Fryer TD, Warburton EA, Baron JC.

Stroke. 2011 Nov;42(11):3138-43. doi: 10.1161/STROKEAHA.111.616334. Epub 2011 Aug 18.

PMID:
21852602

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