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Items: 1 to 20 of 157

1.

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.

Hanniford D, Ulloa-Morales A, Karz A, Berzoti-Coelho MG, Moubarak RS, Sánchez-Sendra B, Kloetgen A, Davalos V, Imig J, Wu P, Vasudevaraja V, Argibay D, Lilja K, Tabaglio T, Monteagudo C, Guccione E, Tsirigos A, Osman I, Aifantis I, Hernando E.

Cancer Cell. 2020 Jan 13;37(1):55-70.e15. doi: 10.1016/j.ccell.2019.12.007.

PMID:
31935372
2.

Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML.

DiNardo CD, Tiong IS, Quaglieri A, MacRaild S, Loghavi S, Brown FC, Thijssen R, Pomilio G, Ivey A, Salmon J, Glytsou C, Fleming SA, Zhang Q, Ma H, Patel KP, Kornblau SM, Xu Z, Chua CC, Chen X, Blombery P, Flensburg C, Cummings N, Aifantis I, Kantarjian H, Huang DCS, Roberts AW, Majewski IJ, Konopleva M, Wei AH.

Blood. 2020 Jan 13. pii: blood.2019003988. doi: 10.1182/blood.2019003988. [Epub ahead of print]

PMID:
31932844
3.

Siah2 control of T-regulatory cells limits anti-tumor immunity.

Scortegagna M, Hockemeyer K, Dolgalev I, Poźniak J, Rambow F, Li Y, Feng Y, Tinoco R, Otero DC, Zhang T, Brown K, Bosenberg M, Bradley LM, Marine JC, Aifantis I, Ronai ZA.

Nat Commun. 2020 Jan 7;11(1):99. doi: 10.1038/s41467-019-13826-7.

4.

Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.

Papaioannou D, Petri A, Dovey OM, Terreri S, Wang E, Collins FA, Woodward LA, Walker AE, Nicolet D, Pepe F, Kumchala P, Bill M, Walker CJ, Karunasiri M, Mrózek K, Gardner ML, Camilotto V, Zitzer N, Cooper JL, Cai X, Rong-Mullins X, Kohlschmidt J, Archer KJ, Freitas MA, Zheng Y, Lee RJ, Aifantis I, Vassiliou G, Singh G, Kauppinen S, Bloomfield CD, Dorrance AM, Garzon R.

Nat Commun. 2020 Jan 7;11(1):204. doi: 10.1038/s41467-019-13969-7.

5.

Mapping and targeting of the leukemic microenvironment.

Witkowski MT, Kousteni S, Aifantis I.

J Exp Med. 2020 Feb 3;217(2). pii: e20190589. doi: 10.1084/jem.20190589.

PMID:
31873722
6.

A Deep Learning Framework for Predicting Response to Therapy in Cancer.

Sakellaropoulos T, Vougas K, Narang S, Koinis F, Kotsinas A, Polyzos A, Moss TJ, Piha-Paul S, Zhou H, Kardala E, Damianidou E, Alexopoulos LG, Aifantis I, Townsend PA, Panayiotidis MI, Sfikakis P, Bartek J, Fitzgerald RC, Thanos D, Mills Shaw KR, Petty R, Tsirigos A, Gorgoulis VG.

Cell Rep. 2019 Dec 10;29(11):3367-3373.e4. doi: 10.1016/j.celrep.2019.11.017.

7.

Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL.

Rodriguez S, Abundis C, Boccalatte F, Mehrotra P, Chiang MY, Yui MA, Wang L, Zhang H, Zollman A, Bonfim-Silva R, Kloetgen A, Palmer J, Sandusky G, Wunderlich M, Kaplan MH, Mulloy JC, Marcucci G, Aifantis I, Cardoso AA, Carlesso N.

Leukemia. 2019 Nov 26. doi: 10.1038/s41375-019-0653-z. [Epub ahead of print]

PMID:
31772299
8.

The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.

Papaioannou D, Petri A, Dovey OM, Terreri S, Wang E, Collins FA, Woodward LA, Walker AE, Nicolet D, Pepe F, Kumchala P, Bill M, Walker CJ, Karunasiri M, Mrózek K, Gardner ML, Camilotto V, Zitzer N, Cooper JL, Cai X, Rong-Mullins X, Kohlschmidt J, Archer KJ, Freitas MA, Zheng Y, Lee RJ, Aifantis I, Vassiliou G, Singh G, Kauppinen S, Bloomfield CD, Dorrance AM, Garzon R.

Nat Commun. 2019 Nov 25;10(1):5351. doi: 10.1038/s41467-019-13259-2. Erratum in: Nat Commun. 2020 Jan 7;11(1):204.

9.

Immune-Based Therapies in Acute Leukemia.

Witkowski MT, Lasry A, Carroll WL, Aifantis I.

Trends Cancer. 2019 Oct;5(10):604-618. doi: 10.1016/j.trecan.2019.07.009. Epub 2019 Aug 29. Review.

PMID:
31706508
10.

Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion.

Xiu Y, Dong Q, Fu L, Bossler A, Tang X, Boyce B, Borcherding N, Leidinger M, Sardina JL, Xue HH, Li Q, Feldman A, Aifantis I, Boccalatte F, Wang L, Jin M, Khoury J, Wang W, Hu S, Yuan Y, Wang E, Yuan J, Janz S, Colgan J, Habelhah H, Waldschmidt T, Müschen M, Bagg A, Darbro B, Zhao C.

Blood. 2020 Jan 9;135(2):108-120. doi: 10.1182/blood.2019001438.

PMID:
31697816
11.

CXCR4 signaling directs Igk recombination and the molecular mechanisms of late B lymphopoiesis.

Mandal M, Okoreeh MK, Kennedy DE, Maienschein-Cline M, Ai J, McLean KC, Kaverina N, Veselits M, Aifantis I, Gounari F, Clark MR.

Nat Immunol. 2019 Oct;20(10):1393-1403. doi: 10.1038/s41590-019-0468-0. Epub 2019 Sep 2.

PMID:
31477919
12.

Analysis of TET2 mutations in paroxysmal nocturnal hemoglobinuria (PNH).

Lobry C, Bains A, Zamechek LB, Ibrahim S, Aifantis I, Araten DJ.

Exp Hematol Oncol. 2019 Aug 21;8:17. doi: 10.1186/s40164-019-0142-0. eCollection 2019.

13.

3D Chromosomal Landscapes in Hematopoiesis and Immunity.

Kloetgen A, Thandapani P, Tsirigos A, Aifantis I.

Trends Immunol. 2019 Sep;40(9):809-824. doi: 10.1016/j.it.2019.07.003. Epub 2019 Aug 15. Review.

PMID:
31422902
14.

The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation.

Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I.

Nat Immunol. 2019 Sep;20(9):1196-1207. doi: 10.1038/s41590-019-0454-6. Epub 2019 Aug 12.

PMID:
31406379
15.

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining.

Vougas K, Sakellaropoulos T, Kotsinas A, Foukas GP, Ntargaras A, Koinis F, Polyzos A, Myrianthopoulos V, Zhou H, Narang S, Georgoulias V, Alexopoulos L, Aifantis I, Townsend PA, Sfikakis P, Fitzgerald R, Thanos D, Bartek J, Petty R, Tsirigos A, Gorgoulis VG.

Pharmacol Ther. 2019 Nov;203:107395. doi: 10.1016/j.pharmthera.2019.107395. Epub 2019 Jul 30. Review.

PMID:
31374225
16.

Author Correction: The bone marrow microenvironment at single-cell resolution.

Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I.

Nature. 2019 Aug;572(7767):E6. doi: 10.1038/s41586-019-1394-x.

PMID:
31296938
17.

Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment.

Chen X, Glytsou C, Zhou H, Narang S, Reyna DE, Lopez A, Sakellaropoulos T, Gong Y, Kloetgen A, Yap YS, Wang E, Gavathiotis E, Tsirigos A, Tibes R, Aifantis I.

Cancer Discov. 2019 Jul;9(7):890-909. doi: 10.1158/2159-8290.CD-19-0117. Epub 2019 May 2.

PMID:
31048321
18.

Cardiac myocyte KLF5 regulates body weight via alteration of cardiac FGF21.

Pol CJ, Pollak NM, Jurczak MJ, Zacharia E, Karagiannides I, Kyriazis ID, Ntziachristos P, Scerbo DA, Brown BR, Aifantis I, Shulman GI, Goldberg IJ, Drosatos K.

Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1;1865(9):2125-2137. doi: 10.1016/j.bbadis.2019.04.010. Epub 2019 Apr 26.

PMID:
31029826
19.

Splicing the innate immune signalling in leukaemia.

Guillamot M, Aifantis I.

Nat Cell Biol. 2019 May;21(5):536-537. doi: 10.1038/s41556-019-0323-4. No abstract available.

20.

The bone marrow microenvironment at single-cell resolution.

Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I.

Nature. 2019 May;569(7755):222-228. doi: 10.1038/s41586-019-1104-8. Epub 2019 Apr 10. Erratum in: Nature. 2019 Aug;572(7767):E6.

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