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Regenerative medicine and injection therapies in stress urinary incontinence.

Hillary CJ, Roman S, MacNeil S, Aicher WK, Stenzl A, Chapple CR.

Nat Rev Urol. 2020 Jan 23. doi: 10.1038/s41585-019-0273-4. [Epub ahead of print] Review.


A novel waterjet technology for transurethral cystoscopic injection of viable cells in the urethral sphincter complex.

Jäger L, Linzenbold W, Fech A, Enderle M, Abruzzese T, Stenzl A, Aicher WK.

Neurourol Urodyn. 2020 Feb;39(2):594-602. doi: 10.1002/nau.24261. Epub 2019 Dec 24.


A sensitive refining of in vitro and in vivo toxicological behavior of green synthesized ZnO nanoparticles from the shells of Jatropha curcas for multifunctional biomaterials development.

Suriyaprabha R, Balu KS, Karthik S, Prabhu M, Rajendran V, Aicher WK, Maaza M.

Ecotoxicol Environ Saf. 2019 Nov 30;184:109621. doi: 10.1016/j.ecoenv.2019.109621. Epub 2019 Sep 12.


Stress urinary incontinence and regenerative medicine: is injecting functional cells into the urethra feasible based on current knowledge and future prospects?

Aufderklamm S, Aicher WK, Amend B, Stenzl A.

Curr Opin Urol. 2019 Jul;29(4):394-399. doi: 10.1097/MOU.0000000000000624.


Establishing and monitoring of urethral sphincter deficiency in a large animal model.

Kelp A, Albrecht A, Amend B, Klünder M, Rapp P, Sawodny O, Stenzl A, Aicher WK.

World J Urol. 2017 Dec;35(12):1977-1986. doi: 10.1007/s00345-017-2088-3. Epub 2017 Sep 22.


The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces.

Uynuk-Ool T, Rothdiener M, Walters B, Hegemann M, Palm J, Nguyen P, Seeger T, Stöckle U, Stegemann JP, Aicher WK, Kurz B, Hart ML, Klein G, Rolauffs B.

J Tissue Eng Regen Med. 2017 Dec;11(12):3508-3522. doi: 10.1002/term.2263. Epub 2017 Mar 29.


Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells.

Hart ML, Rusch E, Kaupp M, Nieselt K, Aicher WK.

Stem Cell Rev Rep. 2017 Apr;13(2):258-266. doi: 10.1007/s12015-016-9710-4.


Precise injection of human mesenchymal stromal cells in the urethral sphincter complex of Göttingen minipigs without unspecific bulking effects.

Amend B, Kelp A, Vaegler M, Klünder M, Frajs V, Klein G, Sievert KD, Sawodny O, Stenzl A, Aicher WK.

Neurourol Urodyn. 2017 Sep;36(7):1723-1733. doi: 10.1002/nau.23182. Epub 2016 Dec 9.


Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

Rothdiener M, Hegemann M, Uynuk-Ool T, Walters B, Papugy P, Nguyen P, Claus V, Seeger T, Stoeckle U, Boehme KA, Aicher WK, Stegemann JP, Hart ML, Kurz B, Klein G, Rolauffs B.

Sci Rep. 2016 Oct 24;6:35840. doi: 10.1038/srep35840.


Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology.

Felka T, Rothdiener M, Bast S, Uynuk-Ool T, Zouhair S, Ochs BG, De Zwart P, Stoeckle U, Aicher WK, Hart ML, Shiozawa T, Grodzinsky AJ, Schenke-Layland K, Venkatesan JK, Cucchiarini M, Madry H, Kurz B, Rolauffs B.

Osteoarthritis Cartilage. 2016 Jul;24(7):1200-9. doi: 10.1016/j.joca.2016.02.001. Epub 2016 Feb 12.


Bone marrow-derived mesenchymal stromal cells differ in their attachment to fibronectin-derived peptides from term placenta-derived mesenchymal stromal cells.

Maerz JK, Roncoroni LP, Goldeck D, Abruzzese T, Kalbacher H, Rolauffs B, DeZwart P, Nieselt K, Hart ML, Klein G, Aicher WK.

Stem Cell Res Ther. 2016 Feb 11;7:29. doi: 10.1186/s13287-015-0243-6.


Choice of xenogenic-free expansion media significantly influences the myogenic differentiation potential of human bone marrow-derived mesenchymal stromal cells.

Brun J, Abruzzese T, Rolauffs B, Aicher WK, Hart ML.

Cytotherapy. 2016 Mar;18(3):344-59. doi: 10.1016/j.jcyt.2015.11.019.


Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture.

Schmal O, Seifert J, Schäffer TE, Walter CB, Aicher WK, Klein G.

Stem Cells Int. 2016;2016:4148093. doi: 10.1155/2016/4148093. Epub 2015 Dec 29.


Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns.

Elahi KC, Klein G, Avci-Adali M, Sievert KD, MacNeil S, Aicher WK.

Stem Cells Int. 2016;2016:5646384. doi: 10.1155/2016/5646384. Epub 2015 Dec 6. Review.


Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells.

Brun J, Lutz KA, Neumayer KM, Klein G, Seeger T, Uynuk-Ool T, Wörgötter K, Schmid S, Kraushaar U, Guenther E, Rolauffs B, Aicher WK, Hart ML.

PLoS One. 2015 Dec 16;10(12):e0145153. doi: 10.1371/journal.pone.0145153. eCollection 2015.


Mesenchymal Stromal Cells for Sphincter Regeneration: Role of Laminin Isoforms upon Myogenic Differentiation.

Seeger T, Hart M, Patarroyo M, Rolauffs B, Aicher WK, Klein G.

PLoS One. 2015 Sep 25;10(9):e0137419. doi: 10.1371/journal.pone.0137419. eCollection 2015.


Human Placenta-Derived CD146-Positive Mesenchymal Stromal Cells Display a Distinct Osteogenic Differentiation Potential.

Ulrich C, Abruzzese T, Maerz JK, Ruh M, Amend B, Benz K, Rolauffs B, Abele H, Hart ML, Aicher WK.

Stem Cells Dev. 2015 Jul 1;24(13):1558-69. doi: 10.1089/scd.2014.0465. Epub 2015 Apr 13.


Matrix metalloproteinases in stem cell mobilization.

Klein G, Schmal O, Aicher WK.

Matrix Biol. 2015 May-Jul;44-46:175-83. doi: 10.1016/j.matbio.2015.01.011. Epub 2015 Jan 21. Review.


Regeneration of degenerated urinary sphincter muscles: improved stem cell-based therapies and novel imaging technologies.

Amend B, Vaegler M, Fuchs K, Mannheim JG, Will S, Kramer U, Hart ML, Feitz W, Chapple C, Stenzl A, Aicher WK.

Cell Transplant. 2015;24(11):2171-83. doi: 10.3727/096368915X686229. Epub 2015 Jan 20. Review.


Mesenchymal stromal cells for sphincter regeneration.

Klein G, Hart ML, Brinchmann JE, Rolauffs B, Stenzl A, Sievert KD, Aicher WK.

Adv Drug Deliv Rev. 2015 Mar;82-83:123-36. doi: 10.1016/j.addr.2014.10.026. Epub 2014 Oct 27. Review.


Labelling and tracking of human mesenchymal stromal cells in preclinical studies and large animal models of degenerative diseases.

Vaegler M, Maerz JK, Amend B, da Silva LA, Mannheim JG, Fuchs K, Will S, Sievert KD, Stenzl A, Hart ML, Aicher WK.

Curr Stem Cell Res Ther. 2014;9(5):444-50. Review.


[Cell-based therapy to treat stress urinary incontinence: which cell type at what cost?].

Vaegler M, DaSilva LA, Benz K, Amend B, Mollenhauer J, Aicher WK, Stenzl A, Sievert KD.

Urologe A. 2014 Mar;53(3):354-61. doi: 10.1007/s00120-013-3353-8. German.


Towards a Treatment of Stress Urinary Incontinence: Application of Mesenchymal Stromal Cells for Regeneration of the Sphincter Muscle.

Aicher WK, Hart ML, Stallkamp J, Klünder M, Ederer M, Sawodny O, Vaegler M, Amend B, Sievert KD, Stenzl A.

J Clin Med. 2014 Feb 24;3(1):197-215. doi: 10.3390/jcm3010197. Review.


The spatial organisation of joint surface chondrocytes: review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis.

Aicher WK, Rolauffs B.

Ann Rheum Dis. 2014 Apr;73(4):645-53. doi: 10.1136/annrheumdis-2013-204308. Epub 2013 Dec 20. Review.


Cell-based therapy for the deficient urinary sphincter.

Hart ML, Neumayer KM, Vaegler M, Daum L, Amend B, Sievert KD, Di Giovanni S, Kraushaar U, Guenther E, Stenzl A, Aicher WK.

Curr Urol Rep. 2013 Oct;14(5):476-87. doi: 10.1007/s11934-013-0352-7. Review.


Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment.

Rolauffs B, Kurz B, Felka T, Rothdiener M, Uynuk-Ool T, Aurich M, Frank E, Bahrs C, Badke A, Stöckle U, Aicher WK, Grodzinsky AJ.

J Struct Biol. 2013 Sep;183(3):501-511. doi: 10.1016/j.jsb.2013.06.011. Epub 2013 Jun 28.


Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast cancer cells.

Kaiser T, Teufel I, Geiger K, Vater Y, Aicher WK, Klein G, Fehm T.

Breast Cancer Res Treat. 2013 Jul;140(1):35-48. doi: 10.1007/s10549-013-2613-z. Epub 2013 Jun 27.


Low osteogenic differentiation potential of placenta-derived mesenchymal stromal cells correlates with low expression of the transcription factors Runx2 and Twist2.

Ulrich C, Rolauffs B, Abele H, Bonin M, Nieselt K, Hart ML, Aicher WK.

Stem Cells Dev. 2013 Nov 1;22(21):2859-72. doi: 10.1089/scd.2012.0693. Epub 2013 Jul 20.


Laminin-5 and type I collagen promote adhesion and osteogenic differentiation of animal serum-free expanded human mesenchymal stromal cells.

Mittag F, Falkenberg EM, Janczyk A, Götze M, Felka T, Aicher WK, Kluba T.

Orthop Rev (Pavia). 2012 Dec 11;4(4):e36. doi: 10.4081/or.2012.e36. Print 2012 Nov 2.


Maintenance of "stem cell" features of cartilage cell sub-populations during in vitro propagation.

Benz K, Stippich C, Freudigmann C, Mollenhauer JA, Aicher WK.

J Transl Med. 2013 Jan 30;11:27. doi: 10.1186/1479-5876-11-27.


Identification of an aptamer binding to human osteogenic-induced progenitor cells.

Ardjomandi N, Niederlaender J, Aicher WK, Reinert S, Schweizer E, Wendel HP, Alexander D.

Nucleic Acid Ther. 2013 Feb;23(1):44-61. doi: 10.1089/nat.2012.0349. Epub 2013 Jan 4.


Release of matrix metalloproteinase-8 during physiological trafficking and induced mobilization of human hematopoietic stem cells.

Steinl C, Essl M, Schreiber TD, Geiger K, Prokop L, Stevanović S, Pötz O, Abele H, Wessels JT, Aicher WK, Klein G.

Stem Cells Dev. 2013 May 1;22(9):1307-18. doi: 10.1089/scd.2012.0063. Epub 2013 Feb 12.


Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets.

Sivasubramaniyan K, Lehnen D, Ghazanfari R, Sobiesiak M, Harichandan A, Mortha E, Petkova N, Grimm S, Cerabona F, de Zwart P, Abele H, Aicher WK, Faul C, Kanz L, Bühring HJ.

Ann N Y Acad Sci. 2012 Aug;1266:94-106. doi: 10.1111/j.1749-6632.2012.06551.x. Review.


Rheological and biological properties of a hydrogel support for cells intended for intervertebral disc repair.

Benz K, Stippich C, Osswald C, Gaissmaier C, Lembert N, Badke A, Steck E, Aicher WK, Mollenhauer JA.

BMC Musculoskelet Disord. 2012 Apr 10;13:54. doi: 10.1186/1471-2474-13-54.


Processing of CXCL12 by different osteoblast-secreted cathepsins.

Staudt ND, Maurer A, Spring B, Kalbacher H, Aicher WK, Klein G.

Stem Cells Dev. 2012 Jul 20;21(11):1924-35. doi: 10.1089/scd.2011.0307. Epub 2012 Jan 4.


Human mesenchymal stromal cells express CD14 cross-reactive epitopes.

Pilz GA, Braun J, Ulrich C, Felka T, Warstat K, Ruh M, Schewe B, Abele H, Larbi A, Aicher WK.

Cytometry A. 2011 Aug;79(8):635-45. doi: 10.1002/cyto.a.21073. Epub 2011 Jul 6.


Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis.

Rolauffs B, Rothdiener M, Bahrs C, Badke A, Weise K, Kuettner KE, Kurz B, Aurich M, Grodzinsky AJ, Aicher WK.

Arthritis Rheum. 2011 Jun;63(6):1637-47. doi: 10.1002/art.30217.


Osteoblast-secreted factors enhance the expression of dysadherin and CCL2-dependent migration of renal carcinoma cells.

Schüler Y, Lee-Thedieck C, Geiger K, Kaiser T, Ino Y, Aicher WK, Klein G.

Int J Cancer. 2012 Jan 15;130(2):288-99. doi: 10.1002/ijc.25981. Epub 2011 Apr 1.


Remodeling of articular cartilage and subchondral bone after bone grafting and matrix-associated autologous chondrocyte implantation for osteochondritis dissecans of the knee.

Ochs BG, Müller-Horvat C, Albrecht D, Schewe B, Weise K, Aicher WK, Rolauffs B.

Am J Sports Med. 2011 Apr;39(4):764-73. doi: 10.1177/0363546510388896. Epub 2010 Dec 30.


Regeneration of cartilage and bone by defined subsets of mesenchymal stromal cells--potential and pitfalls.

Aicher WK, Bühring HJ, Hart M, Rolauffs B, Badke A, Klein G.

Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):342-51. doi: 10.1016/j.addr.2010.12.004. Epub 2010 Dec 22. Review.


Transforming Growth Factor-β1 and Laminin-111 Cooperate in the Regulation of Expression of Interleukin-6 and Interleukin-8 in Synovial Fibroblasts.

Felka T, Warstat K, Kluba T, Mittag F, Hoberg M, Klein G, Aicher WK.

Int J Biomed Sci. 2010 Dec;6(4):289-93.


Human term placenta-derived mesenchymal stromal cells are less prone to osteogenic differentiation than bone marrow-derived mesenchymal stromal cells.

Pilz GA, Ulrich C, Ruh M, Abele H, Schäfer R, Kluba T, Bühring HJ, Rolauffs B, Aicher WK.

Stem Cells Dev. 2011 Apr;20(4):635-46. doi: 10.1089/scd.2010.0308. Epub 2011 Jan 27.


Evaluation of the osteogenic and chondrogenic differentiation capacities of equine adipose tissue-derived mesenchymal stem cells.

Braun J, Hack A, Weis-Klemm M, Conrad S, Treml S, Kohler K, Walliser U, Skutella T, Aicher WK.

Am J Vet Res. 2010 Oct;71(10):1228-36. doi: 10.2460/ajvr.71.10.1228.


Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts.

Staudt ND, Aicher WK, Kalbacher H, Stevanovic S, Carmona AK, Bogyo M, Klein G.

Haematologica. 2010 Sep;95(9):1452-60. doi: 10.3324/haematol.2009.018671. Epub 2010 May 21.


Animal serum-free expansion and differentiation of human mesenchymal stromal cells.

Felka T, Schäfer R, De Zwart P, Aicher WK.

Cytotherapy. 2010 Apr;12(2):143-53. doi: 10.3109/14653240903470647.


Cathepsin X is activated by cathepsin L, inactivates the chemokine SDF-1 and reduces adhesion of hematopoietic stem and progenitor cells to osteoblasts.

Staudt ND, Aicher WK, Kalbacher H, Stevanovic S, Carmona AK, Bogyo M, Klein G.

J Stem Cells Regen Med. 2010 Oct 23;6(2):70. eCollection 2010. No abstract available.


TGF-beta enhances the integrin alpha2beta1-mediated attachment of mesenchymal stem cells to type I collagen.

Warstat K, Meckbach D, Weis-Klemm M, Hack A, Klein G, de Zwart P, Aicher WK.

Stem Cells Dev. 2010 May;19(5):645-56. doi: 10.1089/scd.2009.0208.


The integrin {alpha}9{beta}1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.

Schreiber TD, Steinl C, Essl M, Abele H, Geiger K, Müller CA, Aicher WK, Klein G.

Haematologica. 2010 Feb 23. doi: 10.3324/haematol.006072. Epub 2010 Feb 23. No abstract available. Retraction in: Haematologica. 2010 Feb;95(2):344.


The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.

Schreiber TD, Steinl C, Essl M, Abele H, Geiger K, Müller CA, Aicher WK, Klein G.

Haematologica. 2009 Nov;94(11):1493-501. doi: 10.3324/haematol.2009.006072. Epub 2009 Jul 16.

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