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Items: 1 to 50 of 72

1.

Epigenetic reprogramming of primary pancreatic cancer cells counteracts their in vivo tumourigenicity.

Khoshchehreh R, Totonchi M, Carlos Ramirez J, Torres R, Baharvand H, Aicher A, Ebrahimi M, Heeschen C.

Oncogene. 2019 Aug;38(34):6226-6239. doi: 10.1038/s41388-019-0871-x. Epub 2019 Jul 15.

2.

Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma.

Raj D, Yang MH, Rodgers D, Hampton EN, Begum J, Mustafa A, Lorizio D, Garces I, Propper D, Kench JG, Kocher HM, Young TS, Aicher A, Heeschen C.

Gut. 2019 Jun;68(6):1052-1064. doi: 10.1136/gutjnl-2018-316595. Epub 2018 Aug 18.

3.

The VAR2CSA malaria protein efficiently retrieves circulating tumor cells in an EpCAM-independent manner.

Agerbæk MØ, Bang-Christensen SR, Yang MH, Clausen TM, Pereira MA, Sharma S, Ditlev SB, Nielsen MA, Choudhary S, Gustavsson T, Sorensen PH, Meyer T, Propper D, Shamash J, Theander TG, Aicher A, Daugaard M, Heeschen C, Salanti A.

Nat Commun. 2018 Aug 16;9(1):3279. doi: 10.1038/s41467-018-05793-2.

4.

Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase: Implications for striatal energy metabolism.

Warren EB, Aicher AE, Fessel JP, Konradi C.

PLoS One. 2017 Dec 29;12(12):e0190456. doi: 10.1371/journal.pone.0190456. eCollection 2017.

5.

The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1.

Cioffi M, Trabulo SM, Vallespinos M, Raj D, Kheir TB, Lin ML, Begum J, Baker AM, Amgheib A, Saif J, Perez M, Soriano J, Desco M, Gomez-Gaviro MV, Cusso L, Megias D, Aicher A, Heeschen C.

Oncotarget. 2017 Mar 28;8(13):21609-21625. doi: 10.18632/oncotarget.15450.

6.

Multifunctionalized iron oxide nanoparticles for selective targeting of pancreatic cancer cells.

Trabulo S, Aires A, Aicher A, Heeschen C, Cortajarena AL.

Biochim Biophys Acta Gen Subj. 2017 Jun;1861(6):1597-1605. doi: 10.1016/j.bbagen.2017.01.035. Epub 2017 Feb 1.

PMID:
28161480
7.

DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster.

Zagorac S, Alcala S, Fernandez Bayon G, Bou Kheir T, Schoenhals M, González-Neira A, Fernandez Fraga M, Aicher A, Heeschen C, Sainz B Jr.

Cancer Res. 2016 Aug 1;76(15):4546-58. doi: 10.1158/0008-5472.CAN-15-3268. Epub 2016 Jun 3.

8.

Methanol Production by a Broad Phylogenetic Array of Marine Phytoplankton.

Mincer TJ, Aicher AC.

PLoS One. 2016 Mar 10;11(3):e0150820. doi: 10.1371/journal.pone.0150820. eCollection 2016.

9.

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.

Cioffi M, Vallespinos-Serrano M, Trabulo SM, Fernandez-Marcos PJ, Firment AN, Vazquez BN, Vieira CR, Mulero F, Camara JA, Cronin UP, Perez M, Soriano J, G Galvez B, Castells-Garcia A, Haage V, Raj D, Megias D, Hahn S, Serrano L, Moon A, Aicher A, Heeschen C.

Cell Rep. 2015 Sep 8;12(10):1594-605. doi: 10.1016/j.celrep.2015.08.006. Epub 2015 Aug 28.

10.

Concise Review: Stem Cells in Pancreatic Cancer: From Concept to Translation.

Raj D, Aicher A, Heeschen C.

Stem Cells. 2015 Oct;33(10):2893-902. doi: 10.1002/stem.2114. Epub 2015 Aug 14. Review.

11.

The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells.

Cioffi M, Trabulo SM, Sanchez-Ripoll Y, Miranda-Lorenzo I, Lonardo E, Dorado J, Reis Vieira C, Ramirez JC, Hidalgo M, Aicher A, Hahn S, Sainz B Jr, Heeschen C.

Gut. 2015 Dec;64(12):1936-48. doi: 10.1136/gutjnl-2014-308470. Epub 2015 Apr 17. Erratum in: Gut. 2016 Jul;65(7):1224.

12.

K-RasV14I recapitulates Noonan syndrome in mice.

Hernández-Porras I, Fabbiano S, Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, Cussó L, Desco M, Heeschen C, Mulero F, Bustelo XR, Guerra C, Barbacid M.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16395-400. doi: 10.1073/pnas.1418126111. Epub 2014 Oct 30.

13.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.

PMID:
25127677
14.

Vascular incorporation of endothelial colony-forming cells is essential for functional recovery of murine ischemic tissue following cell therapy.

Schwarz TM, Leicht SF, Radic T, Rodriguez-Arabaolaza I, Hermann PC, Berger F, Saif J, Böcker W, Ellwart JW, Aicher A, Heeschen C.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):e13-21. doi: 10.1161/ATVBAHA.111.239822. Epub 2011 Dec 22. Erratum in: Arterioscler Thromb Vasc Biol. 2015 Aug;35(8):e36.

PMID:
22199368
15.

Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.

Lonardo E, Hermann PC, Mueller MT, Huber S, Balic A, Miranda-Lorenzo I, Zagorac S, Alcala S, Rodriguez-Arabaolaza I, Ramirez JC, Torres-Ruíz R, Garcia E, Hidalgo M, Cebrián DÁ, Heuchel R, Löhr M, Berger F, Bartenstein P, Aicher A, Heeschen C.

Cell Stem Cell. 2011 Nov 4;9(5):433-46. doi: 10.1016/j.stem.2011.10.001. Erratum in: Cell Stem Cell. 2012 Jan 6;10(1):104.

16.

Adiponectin pretreatment counteracts the detrimental effect of a diabetic environment on endothelial progenitors.

Leicht SF, Schwarz TM, Hermann PC, Seissler J, Aicher A, Heeschen C.

Diabetes. 2011 Feb;60(2):652-61. doi: 10.2337/db10-0240.

17.

Quantification of circulating endothelial progenitor cells using the modified ISHAGE protocol.

Schmidt-Lucke C, Fichtlscherer S, Aicher A, Tschöpe C, Schultheiss HP, Zeiher AM, Dimmeler S.

PLoS One. 2010 Nov 3;5(11):e13790. doi: 10.1371/journal.pone.0013790.

18.

Combination of injectable multiple growth factor-releasing scaffolds and cell therapy as an advanced modality to enhance tissue neovascularization.

Saif J, Schwarz TM, Chau DY, Henstock J, Sami P, Leicht SF, Hermann PC, Alcala S, Mulero F, Shakesheff KM, Heeschen C, Aicher A.

Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1897-904. doi: 10.1161/ATVBAHA.110.207928. Epub 2010 Aug 5.

PMID:
20689075
19.

Accelerated telomere shortening in leukocyte subpopulations of patients with coronary heart disease: role of cytomegalovirus seropositivity.

Spyridopoulos I, Hoffmann J, Aicher A, Brümmendorf TH, Doerr HW, Zeiher AM, Dimmeler S.

Circulation. 2009 Oct 6;120(14):1364-72. doi: 10.1161/CIRCULATIONAHA.109.854299. Epub 2009 Sep 21.

PMID:
19770396
20.

NADPH oxidase Nox2 is required for hypoxia-induced mobilization of endothelial progenitor cells.

Schröder K, Kohnen A, Aicher A, Liehn EA, Büchse T, Stein S, Weber C, Dimmeler S, Brandes RP.

Circ Res. 2009 Sep 11;105(6):537-44. doi: 10.1161/CIRCRESAHA.109.205138. Epub 2009 Aug 13.

PMID:
19679834
21.

Add some fat to vascular progenitor cell therapy.

Saif J, Heeschen C, Aicher A.

Circ Res. 2009 Jun 19;104(12):1330-2. doi: 10.1161/CIRCRESAHA.109.200469. No abstract available.

PMID:
19542018
22.

cGMP-dependent protein kinase I is crucial for angiogenesis and postnatal vasculogenesis.

Aicher A, Heeschen C, Feil S, Hofmann F, Mendelsohn ME, Feil R, Dimmeler S.

PLoS One. 2009;4(3):e4879. doi: 10.1371/journal.pone.0004879. Epub 2009 Mar 16.

23.

Downregulation of ETS rescues diabetes-induced reduction of endothelial progenitor cells.

Seeger FH, Chen L, Spyridopoulos I, Altschmied J, Aicher A, Haendeler J.

PLoS One. 2009;4(2):e4529. doi: 10.1371/journal.pone.0004529. Epub 2009 Feb 19.

24.

Pilot trial on determinants of progenitor cell recruitment to the infarcted human myocardium.

Schächinger V, Aicher A, Döbert N, Röver R, Diener J, Fichtlscherer S, Assmus B, Seeger FH, Menzel C, Brenner W, Dimmeler S, Zeiher AM.

Circulation. 2008 Sep 30;118(14):1425-32. doi: 10.1161/CIRCULATIONAHA.108.777102. Epub 2008 Sep 15.

PMID:
18794392
25.

The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche.

Aicher A, Kollet O, Heeschen C, Liebner S, Urbich C, Ihling C, Orlandi A, Lapidot T, Zeiher AM, Dimmeler S.

Circ Res. 2008 Oct 10;103(8):796-803. doi: 10.1161/CIRCRESAHA.107.172718. Epub 2008 Sep 5.

PMID:
18776043
26.

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer.

Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ, Heeschen C.

Cell Stem Cell. 2007 Sep 13;1(3):313-23. doi: 10.1016/j.stem.2007.06.002.

27.

Nonbone marrow-derived endothelial progenitor cells: what is their exact location?

Aicher A, Heeschen C.

Circ Res. 2007 Oct 26;101(9):e102. No abstract available.

PMID:
17967790
28.

Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure.

Kissel CK, Lehmann R, Assmus B, Aicher A, Honold J, Fischer-Rasokat U, Heeschen C, Spyridopoulos I, Dimmeler S, Zeiher AM.

J Am Coll Cardiol. 2007 Jun 19;49(24):2341-9. Epub 2007 Jun 4.

29.

Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia.

Aicher A, Rentsch M, Sasaki K, Ellwart JW, Fändrich F, Siebert R, Cooke JP, Dimmeler S, Heeschen C.

Circ Res. 2007 Mar 2;100(4):581-9. Epub 2007 Feb 1.

PMID:
17272807
30.

Specific recruitment of CD4+CD25++ regulatory T cells into the allograft in heart transplant recipients.

Schmidt-Lucke C, Aicher A, Romagnani P, Gareis B, Romagnani S, Zeiher AM, Dimmeler S.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2425-31. Epub 2007 Jan 19.

31.

Endothelial progenitor cells participate in nicotine-mediated angiogenesis.

Heeschen C, Chang E, Aicher A, Cooke JP.

J Am Coll Cardiol. 2006 Dec 19;48(12):2553-60. Epub 2006 Nov 28.

32.

Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor.

Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J.

Arterioscler Thromb Vasc Biol. 2007 Feb;27(2):275-82. Epub 2006 Dec 7.

PMID:
17158356
33.

Low-energy shock wave for enhancing recruitment of endothelial progenitor cells: a new modality to increase efficacy of cell therapy in chronic hind limb ischemia.

Aicher A, Heeschen C, Sasaki K, Urbich C, Zeiher AM, Dimmeler S.

Circulation. 2006 Dec 19;114(25):2823-30. Epub 2006 Dec 4.

PMID:
17145991
34.

Ex vivo pretreatment of bone marrow mononuclear cells with endothelial NO synthase enhancer AVE9488 enhances their functional activity for cell therapy.

Sasaki K, Heeschen C, Aicher A, Ziebart T, Honold J, Urbich C, Rossig L, Koehl U, Koyanagi M, Mohamed A, Brandes RP, Martin H, Zeiher AM, Dimmeler S.

Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14537-41. Epub 2006 Sep 18.

35.

Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease.

Walter DH, Haendeler J, Reinhold J, Rochwalsky U, Seeger F, Honold J, Hoffmann J, Urbich C, Lehmann R, Arenzana-Seisdesdos F, Aicher A, Heeschen C, Fichtlscherer S, Zeiher AM, Dimmeler S.

Circ Res. 2005 Nov 25;97(11):1142-51. Epub 2005 Oct 27.

PMID:
16254213
36.

Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells.

Urbich C, Aicher A, Heeschen C, Dernbach E, Hofmann WK, Zeiher AM, Dimmeler S.

J Mol Cell Cardiol. 2005 Nov;39(5):733-42. Epub 2005 Sep 29.

PMID:
16199052
37.

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization.

Potente M, Urbich C, Sasaki K, Hofmann WK, Heeschen C, Aicher A, Kollipara R, DePinho RA, Zeiher AM, Dimmeler S.

J Clin Invest. 2005 Sep;115(9):2382-92. Epub 2005 Aug 11.

38.

Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells.

Rössig L, Urbich C, Brühl T, Dernbach E, Heeschen C, Chavakis E, Sasaki K, Aicher D, Diehl F, Seeger F, Potente M, Aicher A, Zanetta L, Dejana E, Zeiher AM, Dimmeler S.

J Exp Med. 2005 Jun 6;201(11):1825-35. Epub 2005 May 31.

39.

Cathepsin L is required for endothelial progenitor cell-induced neovascularization.

Urbich C, Heeschen C, Aicher A, Sasaki K, Bruhl T, Farhadi MR, Vajkoczy P, Hofmann WK, Peters C, Pennacchio LA, Abolmaali ND, Chavakis E, Reinheckel T, Zeiher AM, Dimmeler S.

Nat Med. 2005 Feb;11(2):206-13. Epub 2005 Jan 23.

PMID:
15665831
40.

Mobilizing endothelial progenitor cells.

Aicher A, Zeiher AM, Dimmeler S.

Hypertension. 2005 Mar;45(3):321-5. Epub 2005 Jan 17. Review.

PMID:
15655116
41.

Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells.

Chavakis E, Aicher A, Heeschen C, Sasaki K, Kaiser R, El Makhfi N, Urbich C, Peters T, Scharffetter-Kochanek K, Zeiher AM, Chavakis T, Dimmeler S.

J Exp Med. 2005 Jan 3;201(1):63-72. Epub 2004 Dec 28.

42.

The role of NOS3 in stem cell mobilization.

Aicher A, Heeschen C, Dimmeler S.

Trends Mol Med. 2004 Sep;10(9):421-5. Review. No abstract available.

PMID:
15350893
43.

Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease.

Heeschen C, Lehmann R, Honold J, Assmus B, Aicher A, Walter DH, Martin H, Zeiher AM, Dimmeler S.

Circulation. 2004 Apr 6;109(13):1615-22. Epub 2004 Mar 22.

PMID:
15037527
44.

111In-labeled CD34+ hematopoietic progenitor cells in a rat myocardial infarction model.

Brenner W, Aicher A, Eckey T, Massoudi S, Zuhayra M, Koehl U, Heeschen C, Kampen WU, Zeiher AM, Dimmeler S, Henze E.

J Nucl Med. 2004 Mar;45(3):512-8.

45.

p21Cip1 levels differentially regulate turnover of mature endothelial cells, endothelial progenitor cells, and in vivo neovascularization.

Brühl T, Heeschen C, Aicher A, Jadidi AS, Haendeler J, Hoffmann J, Schneider MD, Zeiher AM, Dimmeler S, Rössig L.

Circ Res. 2004 Mar 19;94(5):686-92. Epub 2004 Jan 29.

PMID:
14752032
46.

Statin therapy in patients with coronary artery disease improves the impaired endothelial progenitor cell differentiation into cardiomyogenic cells.

Rupp S, Badorff C, Koyanagi M, Urbich C, Fichtlscherer S, Aicher A, Zeiher AM, Dimmeler S.

Basic Res Cardiol. 2004 Jan;99(1):61-8. Epub 2003 Oct 14.

PMID:
14685707
47.

Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells.

Urbich C, Heeschen C, Aicher A, Dernbach E, Zeiher AM, Dimmeler S.

Circulation. 2003 Nov 18;108(20):2511-6. Epub 2003 Oct 27. Erratum in: Circulation. 2005 Apr 5;111(13):1718.

PMID:
14581410
48.

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells.

Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, Zeiher AM, Dimmeler S.

Nat Med. 2003 Nov;9(11):1370-6. Epub 2003 Oct 12. Erratum in: Nat Med. 2004 Sep;10(9):999.

PMID:
14556003
49.

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization.

Heeschen C, Aicher A, Lehmann R, Fichtlscherer S, Vasa M, Urbich C, Mildner-Rihm C, Martin H, Zeiher AM, Dimmeler S.

Blood. 2003 Aug 15;102(4):1340-6. Epub 2003 Apr 17. Erratum in: Blood. 2004 Jun 15;103(12):4388.

PMID:
12702503
50.

Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling.

Aicher A, Brenner W, Zuhayra M, Badorff C, Massoudi S, Assmus B, Eckey T, Henze E, Zeiher AM, Dimmeler S.

Circulation. 2003 Apr 29;107(16):2134-9. Epub 2003 Apr 14.

PMID:
12695305

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