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Items: 13

1.

Progression of progenitor B cell leukemia is associated with alterations of the bone marrow micro-environment.

Ahsberg J, Xiao P, Okuyama K, Somasundaram R, Strid T, Qian H, Sigvardsson M.

Haematologica. 2019 Jul 11. pii: haematol.2018.214031. doi: 10.3324/haematol.2018.214031. [Epub ahead of print]

2.

Zinc Finger Protein 521 Regulates Early Hematopoiesis through Cell-Extrinsic Mechanisms in the Bone Marrow Microenvironment.

Fleenor CJ, Arends T, Lei H, Åhsberg J, Okuyama K, Kuruvilla J, Cristobal S, Rabe JL, Pandey A, Danhorn T, Straign D, Espinosa JM, Warming S, Pietras EM, Sigvardsson M, Hagman JR.

Mol Cell Biol. 2018 Aug 15;38(17). pii: e00603-17. doi: 10.1128/MCB.00603-17. Print 2018 Sep 1.

3.

Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.

Jensen CT, Åhsberg J, Sommarin MNE, Strid T, Somasundaram R, Okuyama K, Ungerbäck J, Kupari J, Airaksinen MS, Lang S, Bryder D, Soneji S, Karlsson G, Sigvardsson M.

J Exp Med. 2018 Jul 2;215(7):1947-1963. doi: 10.1084/jem.20171384. Epub 2018 Jun 13.

4.

Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states.

Somasundaram R, Åhsberg J, Okuyama K, Ungerbäck J, Lilljebjörn H, Fioretos T, Strid T, Sigvardsson M.

Genes Dev. 2016 Nov 15;30(22):2486-2499. Epub 2016 Dec 2.

5.

Combined heterozygous loss of Ebf1 and Pax5 allows for T-lineage conversion of B cell progenitors.

Ungerbäck J, Åhsberg J, Strid T, Somasundaram R, Sigvardsson M.

J Exp Med. 2015 Jun 29;212(7):1109-23. doi: 10.1084/jem.20132100. Epub 2015 Jun 8.

6.

Coexpression of hyperactivated AKT1 with additional genes activated in leukemia drives hematopoietic progenitor cells to cell cycle block and apoptosis.

Tang Y, Halvarsson C, Nordigården A, Kumar K, Åhsberg J, Rörby E, Wong WM, Jönsson JI.

Exp Hematol. 2015 Jul;43(7):554-64. doi: 10.1016/j.exphem.2015.04.007. Epub 2015 Apr 27.

7.

Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.

Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M.

Blood. 2015 Jun 25;125(26):4052-9. doi: 10.1182/blood-2014-12-617282. Epub 2015 Apr 2.

8.

Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.

Åhsberg J, Ungerbäck J, Strid T, Welinder E, Stjernberg J, Larsson M, Qian H, Sigvardsson M.

J Biol Chem. 2013 Nov 15;288(46):33449-61. doi: 10.1074/jbc.M113.506261. Epub 2013 Sep 27.

9.

Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate.

Mansson R, Welinder E, Åhsberg J, Lin YC, Benner C, Glass CK, Lucas JS, Sigvardsson M, Murre C.

Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21028-33. doi: 10.1073/pnas.1211427109. Epub 2012 Dec 4.

10.

Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.

Zandi S, Ahsberg J, Tsapogas P, Stjernberg J, Qian H, Sigvardsson M.

Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15871-6. Epub 2012 Sep 10.

11.

B-lymphocyte commitment: identifying the point of no return.

Welinder E, Ahsberg J, Sigvardsson M.

Semin Immunol. 2011 Oct;23(5):335-40. doi: 10.1016/j.smim.2011.08.005. Epub 2011 Sep 23. Review.

PMID:
21944938
12.

IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors.

Tsapogas P, Zandi S, Åhsberg J, Zetterblad J, Welinder E, Jönsson JI, Månsson R, Qian H, Sigvardsson M.

Blood. 2011 Aug 4;118(5):1283-90. doi: 10.1182/blood-2011-01-332189. Epub 2011 Jun 7.

13.

Interleukin-7-induced Stat-5 acts in synergy with Flt-3 signaling to stimulate expansion of hematopoietic progenitor cells.

Åhsberg J, Tsapogas P, Qian H, Zetterblad J, Zandi S, Månsson R, Jönsson JI, Sigvardsson M.

J Biol Chem. 2010 Nov 19;285(47):36275-84. doi: 10.1074/jbc.M110.155531. Epub 2010 Sep 9.

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