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Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.

Pegram LM, Liddle JC, Xiao Y, Hoh M, Rudolph J, Iverson DB, Vigers GP, Smith D, Zhang H, Wang W, Moffat JG, Ahn NG.

Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15463-15468. doi: 10.1073/pnas.1906824116. Epub 2019 Jul 16.


Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.

Masson GR, Burke JE, Ahn NG, Anand GS, Borchers C, Brier S, Bou-Assaf GM, Engen JR, Englander SW, Faber J, Garlish R, Griffin PR, Gross ML, Guttman M, Hamuro Y, Heck AJR, Houde D, Iacob RE, Jørgensen TJD, Kaltashov IA, Klinman JP, Konermann L, Man P, Mayne L, Pascal BD, Reichmann D, Skehel M, Snijder J, Strutzenberg TS, Underbakke ES, Wagner C, Wales TE, Walters BT, Weis DD, Wilson DJ, Wintrode PL, Zhang Z, Zheng J, Schriemer DC, Rand KD.

Nat Methods. 2019 Jul;16(7):595-602. doi: 10.1038/s41592-019-0459-y. Epub 2019 Jun 27. Review.


Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells.

Basken J, Stuart SA, Kavran AJ, Lee T, Ebmeier CC, Old WM, Ahn NG.

Mol Cell Proteomics. 2018 Apr;17(4):550-564. doi: 10.1074/mcp.RA117.000335. Epub 2017 Dec 18.


Gamma-irradiated black ginseng extract inhibits mast cell degranulation and suppresses atopic dermatitis-like skin lesions in mice.

Kang JA, Song HY, Byun EH, Ahn NG, Kim HM, Nam YR, Lee GH, Jang BS, Choi DS, Lee DE, Byun EB.

Food Chem Toxicol. 2018 Jan;111:133-143. doi: 10.1016/j.fct.2017.11.006. Epub 2017 Nov 7.


Structure of histone-based chromatin in Archaea.

Mattiroli F, Bhattacharyya S, Dyer PN, White AE, Sandman K, Burkhart BW, Byrne KR, Lee T, Ahn NG, Santangelo TJ, Reeve JN, Luger K.

Science. 2017 Aug 11;357(6351):609-612. doi: 10.1126/science.aaj1849.


In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng.

In G, Ahn NG, Bae BS, Lee MW, Park HW, Jang KH, Cho BG, Han CK, Park CK, Kwak YS.

J Ginseng Res. 2017 Jul;41(3):361-369. doi: 10.1016/j.jgr.2016.07.004. Epub 2016 Jul 20.


Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration.

Connacher MK, Tay JW, Ahn NG.

Mol Biol Cell. 2017 Jul 7;28(14):1924-1936. doi: 10.1091/mbc.E16-12-0875. Epub 2017 Jun 7.


The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1.

Mattiroli F, Gu Y, Balsbaugh JL, Ahn NG, Luger K.

Sci Rep. 2017 Apr 18;7:46274. doi: 10.1038/srep46274.


DNA-mediated association of two histone-bound complexes of yeast Chromatin Assembly Factor-1 (CAF-1) drives tetrasome assembly in the wake of DNA replication.

Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K.

Elife. 2017 Mar 18;6. pii: e22799. doi: 10.7554/eLife.22799.


The Cac1 subunit of histone chaperone CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones.

Liu WH, Roemer SC, Zhou Y, Shen ZJ, Dennehey BK, Balsbaugh JL, Liddle JC, Nemkov T, Ahn NG, Hansen KC, Tyler JK, Churchill ME.

Elife. 2016 Sep 30;5. pii: e18023. doi: 10.7554/eLife.18023.


Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation.

Goshen-Lago T, Goldberg-Carp A, Melamed D, Darlyuk-Saadon I, Bai C, Ahn NG, Admon A, Engelberg D.

Mol Biol Cell. 2016 Sep 1;27(17):2771-83. doi: 10.1091/mbc.E16-03-0167. Epub 2016 Jul 13.


p38β Mitogen-Activated Protein Kinase Modulates Its Own Basal Activity by Autophosphorylation of the Activating Residue Thr180 and the Inhibitory Residues Thr241 and Ser261.

Beenstock J, Melamed D, Mooshayef N, Mordechay D, Garfinkel BP, Ahn NG, Admon A, Engelberg D.

Mol Cell Biol. 2016 May 2;36(10):1540-54. doi: 10.1128/MCB.01105-15. Print 2016 May 15.


Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition.

Lee SM, Bae BS, Park HW, Ahn NG, Cho BG, Cho YL, Kwak YS.

J Ginseng Res. 2015 Oct;39(4):384-91. doi: 10.1016/j.jgr.2015.04.009. Epub 2015 May 11. Review.


Intrinsically active variants of Erk oncogenically transform cells and disclose unexpected autophosphorylation capability that is independent of TEY phosphorylation.

Smorodinsky-Atias K, Goshen-Lago T, Goldberg-Carp A, Melamed D, Shir A, Mooshayef N, Beenstock J, Karamansha Y, Darlyuk-Saadon I, Livnah O, Ahn NG, Admon A, Engelberg D.

Mol Biol Cell. 2016 Mar 15;27(6):1026-39. doi: 10.1091/mbc.E15-07-0521. Epub 2015 Dec 10.


A synthetic modular approach for modeling the role of the 3D microenvironment in tumor progression.

Singh SP, Schwartz MP, Tokuda EY, Luo Y, Rogers RE, Fujita M, Ahn NG, Anseth KS.

Sci Rep. 2015 Dec 7;5:17814. doi: 10.1038/srep17814.


Erratum to: Large-Scale Examination of Factors Influencing Phosphopeptide Neutral Loss During Collision Induced Dissociation.

Brown R, Stuart SA, Houel S, Ahn NG, Old WM.

J Am Soc Mass Spectrom. 2015 Oct;26(10):1796. doi: 10.1007/s13361-015-1222-y. No abstract available.


Structure-Based Assignment of Ile, Leu, and Val Methyl Groups in the Active and Inactive Forms of the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 2.

Xiao Y, Warner LR, Latham MP, Ahn NG, Pardi A.

Biochemistry. 2015 Jul 21;54(28):4307-19. doi: 10.1021/acs.biochem.5b00506. Epub 2015 Jul 13.


Large-Scale Examination of Factors Influencing Phosphopeptide Neutral Loss during Collision Induced Dissociation.

Brown R, Stuart SA, Houel S, Ahn NG, Old WM.

J Am Soc Mass Spectrom. 2015 Jul;26(7):1128-42. doi: 10.1007/s13361-015-1109-y. Epub 2015 Apr 8. Erratum in: J Am Soc Mass Spectrom. 2015 Oct;26(10):1796. Stuart, Scott S [corrected to Stuart, Scott A].


A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells.

Stuart SA, Houel S, Lee T, Wang N, Old WM, Ahn NG.

Mol Cell Proteomics. 2015 Jun;14(6):1599-615. doi: 10.1074/mcp.M114.047233. Epub 2015 Apr 7.


Dynamics of protein kinases: insights from nuclear magnetic resonance.

Xiao Y, Liddle JC, Pardi A, Ahn NG.

Acc Chem Res. 2015 Apr 21;48(4):1106-14. doi: 10.1021/acs.accounts.5b00001. Epub 2015 Mar 24.


Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties.

Long J, Tokhunts R, Old WM, Houel S, Rodgriguez-Blanco J, Singh S, Schilling N, J Capobianco A, Ahn NG, Robbins DJ.

Cell Rep. 2015 Mar 3;10(8):1280-1287. doi: 10.1016/j.celrep.2015.01.058. Epub 2015 Feb 26.


Slow inhibition and conformation selective properties of extracellular signal-regulated kinase 1 and 2 inhibitors.

Rudolph J, Xiao Y, Pardi A, Ahn NG.

Biochemistry. 2015 Jan 13;54(1):22-31. doi: 10.1021/bi501101v. Epub 2014 Dec 4.


The p38β mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the α-G helix and MAPK insert.

Beenstock J, Ben-Yehuda S, Melamed D, Admon A, Livnah O, Ahn NG, Engelberg D.

J Biol Chem. 2014 Aug 22;289(34):23546-56. doi: 10.1074/jbc.M114.578237. Epub 2014 Jul 8.


Phosphorylation releases constraints to domain motion in ERK2.

Xiao Y, Lee T, Latham MP, Warner LR, Tanimoto A, Pardi A, Ahn NG.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2506-11. doi: 10.1073/pnas.1318899111. Epub 2014 Feb 3.


Extracellular-regulated kinase 2 is activated by the enhancement of hinge flexibility.

Sours KM, Xiao Y, Ahn NG.

J Mol Biol. 2014 May 1;426(9):1925-35. doi: 10.1016/j.jmb.2014.02.011. Epub 2014 Feb 15.


Programmed cell death protein 5 interacts with the cytosolic chaperonin containing tailless complex polypeptide 1 (CCT) to regulate β-tubulin folding.

Tracy CM, Gray AJ, Cuéllar J, Shaw TS, Howlett AC, Taylor RM, Prince JT, Ahn NG, Valpuesta JM, Willardson BM.

J Biol Chem. 2014 Feb 14;289(7):4490-502. doi: 10.1074/jbc.M113.542159. Epub 2013 Dec 27.


A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype.

Schwartz MP, Rogers RE, Singh SP, Lee JY, Loveland SG, Koepsel JT, Witze ES, Montanez-Sauri SI, Sung KE, Tokuda EY, Sharma Y, Everhart LM, Nguyen EH, Zaman MH, Beebe DJ, Ahn NG, Murphy WL, Anseth KS.

PLoS One. 2013 Dec 3;8(12):e81689. doi: 10.1371/journal.pone.0081689. eCollection 2013.


Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge.

Witze ES, Connacher MK, Houel S, Schwartz MP, Morphew MK, Reid L, Sacks DB, Anseth KS, Ahn NG.

Dev Cell. 2013 Sep 30;26(6):645-57. doi: 10.1016/j.devcel.2013.08.019.


Structure of mediator of RhoA-dependent invasion (MRDI) explains its dual function as a metabolic enzyme and a mediator of cell invasion.

Templeton PD, Litman ES, Metzner SI, Ahn NG, Sousa MC.

Biochemistry. 2013 Aug 20;52(33):5675-84. doi: 10.1021/bi400556e. Epub 2013 Jul 31.


New Method for Simultaneous Quantification of 12 Ginsenosides in Red Ginseng Powder and Extract: In-house Method Validation.

In G, Ahn NG, Bae BS, Han ST, Noh KB, Kim CS.

J Ginseng Res. 2012 Apr;36(2):205-10. doi: 10.5142/jgr.2012.36.2.205.


The non-coding B2 RNA binds to the DNA cleft and active-site region of RNA polymerase II.

Ponicsan SL, Houel S, Old WM, Ahn NG, Goodrich JA, Kugel JF.

J Mol Biol. 2013 Oct 9;425(19):3625-38. doi: 10.1016/j.jmb.2013.01.035. Epub 2013 Feb 8.


Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions.

Couts KL, Anderson EM, Gross MM, Sullivan K, Ahn NG.

Oncogene. 2013 Apr 11;32(15):1959-70. doi: 10.1038/onc.2012.209. Epub 2012 Jul 2.


Side population cells from human melanoma tumors reveal diverse mechanisms for chemoresistance.

Luo Y, Ellis LZ, Dallaglio K, Takeda M, Robinson WA, Robinson SE, Liu W, Lewis KD, McCarter MD, Gonzalez R, Norris DA, Roop DR, Spritz RA, Ahn NG, Fujita M.

J Invest Dermatol. 2012 Oct;132(10):2440-2450. doi: 10.1038/jid.2012.161. Epub 2012 May 24.


Quantitative functions of Argonaute proteins in mammalian development.

Wang D, Zhang Z, O'Loughlin E, Lee T, Houel S, O'Carroll D, Tarakhovsky A, Ahn NG, Yi R.

Genes Dev. 2012 Apr 1;26(7):693-704. doi: 10.1101/gad.182758.111.


Comparative hydrogen-deuterium exchange for a mesophilic vs thermophilic dihydrofolate reductase at 25 °C: identification of a single active site region with enhanced flexibility in the mesophilic protein.

Oyeyemi OA, Sours KM, Lee T, Kohen A, Resing KA, Ahn NG, Klinman JP.

Biochemistry. 2011 Sep 27;50(38):8251-60. doi: 10.1021/bi200640s. Epub 2011 Aug 30.


Distinct patterns of activation-dependent changes in conformational mobility between ERK1 and ERK2.

Ring AY, Sours KM, Lee T, Ahn NG.

Int J Mass Spectrom. 2011 Apr;302(1-3):101-109.


IsoformResolver: A peptide-centric algorithm for protein inference.

Meyer-Arendt K, Old WM, Houel S, Renganathan K, Eichelberger B, Resing KA, Ahn NG.

J Proteome Res. 2011 Jul 1;10(7):3060-75. doi: 10.1021/pr200039p. Epub 2011 Jun 7.


Spectrum-to-spectrum searching using a proteome-wide spectral library.

Yen CY, Houel S, Ahn NG, Old WM.

Mol Cell Proteomics. 2011 Jul;10(7):M111.007666. doi: 10.1074/mcp.M111.007666. Epub 2011 Apr 30.


Analysis of MAP kinases by hydrogen exchange mass spectrometry.

Sours KM, Ahn NG.

Methods Mol Biol. 2010;661:239-55. doi: 10.1007/978-1-60761-795-2_14.


Quantifying the impact of chimera MS/MS spectra on peptide identification in large-scale proteomics studies.

Houel S, Abernathy R, Renganathan K, Meyer-Arendt K, Ahn NG, Old WM.

J Proteome Res. 2010 Aug 6;9(8):4152-60. doi: 10.1021/pr1003856.


Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency.

Oyeyemi OA, Sours KM, Lee T, Resing KA, Ahn NG, Klinman JP.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10074-9. doi: 10.1073/pnas.1003678107. Epub 2010 May 13.


The case of the disappearing drug target.

Prince JT, Ahn NG.

Mol Cell. 2010 Feb 26;37(4):455-6. doi: 10.1016/j.molcel.2010.02.010.


PORE-ing over ERK substrates.

Ahn NG.

Nat Struct Mol Biol. 2009 Oct;16(10):1004-5. doi: 10.1038/nsmb1009-1004. No abstract available.


A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme.

Kabuyama Y, Litman ES, Templeton PD, Metzner SI, Witze ES, Argast GM, Langer SJ, Polvinen K, Shellman Y, Chan D, Shabb JB, Fitzpatrick JE, Resing KA, Sousa MC, Ahn NG.

Mol Cell Proteomics. 2009 Oct;8(10):2308-20. doi: 10.1074/mcp.M900178-MCP200. Epub 2009 Jul 20.


Plexin B1 is repressed by oncogenic B-Raf signaling and functions as a tumor suppressor in melanoma cells.

Argast GM, Croy CH, Couts KL, Zhang Z, Litman E, Chan DC, Ahn NG.

Oncogene. 2009 Jul 30;28(30):2697-709. doi: 10.1038/onc.2009.133. Epub 2009 Jun 1.


Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma.

Old WM, Shabb JB, Houel S, Wang H, Couts KL, Yen CY, Litman ES, Croy CH, Meyer-Arendt K, Miranda JG, Brown RA, Witze ES, Schweppe RE, Resing KA, Ahn NG.

Mol Cell. 2009 Apr 10;34(1):115-31. doi: 10.1016/j.molcel.2009.03.007.


A simulated MS/MS library for spectrum-to-spectrum searching in large scale identification of proteins.

Yen CY, Meyer-Arendt K, Eichelberger B, Sun S, Houel S, Old WM, Knight R, Ahn NG, Hunter LE, Resing KA.

Mol Cell Proteomics. 2009 Apr;8(4):857-69. doi: 10.1074/mcp.M800384-MCP200. Epub 2008 Dec 22.


Isolation of intrinsically active (MEK-independent) variants of the ERK family of mitogen-activated protein (MAP) kinases.

Levin-Salomon V, Kogan K, Ahn NG, Livnah O, Engelberg D.

J Biol Chem. 2008 Dec 12;283(50):34500-10. doi: 10.1074/jbc.M806443200. Epub 2008 Oct 1.


Hydrogen-exchange mass spectrometry reveals activation-induced changes in the conformational mobility of p38alpha MAP kinase.

Sours KM, Kwok SC, Rachidi T, Lee T, Ring A, Hoofnagle AN, Resing KA, Ahn NG.

J Mol Biol. 2008 Jun 20;379(5):1075-93. doi: 10.1016/j.jmb.2008.04.044. Epub 2008 Apr 25.


Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.

Witze ES, Litman ES, Argast GM, Moon RT, Ahn NG.

Science. 2008 Apr 18;320(5874):365-9. doi: 10.1126/science.1151250.

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