Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 116

1.

Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury.

Zhuang Y, Xu HC, Shinde PV, Warfsmann J, Vasilevska J, Sundaram B, Behnke K, Huang J, Hoell JI, Borkhardt A, Pfeffer K, Taha MS, Herebian D, Mayatepek E, Brenner D, Ahmadian MR, Keitel V, Wieczorek D, Häussinger D, Pandyra AA, Lang KS, Lang PA.

Gut. 2019 Aug 13. pii: gutjnl-2019-318215. doi: 10.1136/gutjnl-2019-318215. [Epub ahead of print]

2.

Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome.

Capri Y, Flex E, Krumbach OHF, Carpentieri G, Cecchetti S, Lißewski C, Rezaei Adariani S, Schanze D, Brinkmann J, Piard J, Pantaleoni F, Lepri FR, Goh ES, Chong K, Stieglitz E, Meyer J, Kuechler A, Bramswig NC, Sacharow S, Strullu M, Vial Y, Vignal C, Kensah G, Cuturilo G, Kazemein Jasemi NS, Dvorsky R, Monaghan KG, Vincent LM, Cavé H, Verloes A, Ahmadian MR, Tartaglia M, Zenker M.

Am J Hum Genet. 2019 Jun 6;104(6):1223-1232. doi: 10.1016/j.ajhg.2019.04.013. Epub 2019 May 23.

PMID:
31130282
3.

Activating MRAS mutations cause Noonan syndrome associated with hypertrophic cardiomyopathy.

Motta M, Sagi-Dain L, Krumbach OHF, Hahn A, Peleg A, German A, Lissewski C, Coppola S, Pantaleoni F, Kocherscheid L, Altmüller F, Schanze D, Logeswaran T, Chahrokh-Zadeh S, Munzig A, Nakhaei-Rad S, Cavé H, Ahmadian MR, Tartaglia M, Zenker M.

Hum Mol Genet. 2019 May 21. pii: ddz108. doi: 10.1093/hmg/ddz108. [Epub ahead of print]

PMID:
31108500
4.

IL-6 Trans-signaling Controls Liver Regeneration After Partial Hepatectomy.

Fazel Modares N, Polz R, Haghighi F, Lamertz L, Behnke K, Zhuang Y, Kordes C, Häussinger D, Sorg UR, Pfeffer K, Floss DM, Moll JM, Piekorz RP, Ahmadian MR, Lang PA, Scheller J.

Hepatology. 2019 May 17. doi: 10.1002/hep.30774. [Epub ahead of print]

PMID:
31100194
5.

bFGF-mediated pluripotency maintenance in human induced pluripotent stem cells is associated with NRAS-MAPK signaling.

Haghighi F, Dahlmann J, Nakhaei-Rad S, Lang A, Kutschka I, Zenker M, Kensah G, Piekorz RP, Ahmadian MR.

Cell Commun Signal. 2018 Dec 5;16(1):96. doi: 10.1186/s12964-018-0307-1.

6.

Structural snapshots of RAF kinase interactions.

Rezaei Adariani S, Buchholzer M, Akbarzadeh M, Nakhaei-Rad S, Dvorsky R, Ahmadian MR.

Biochem Soc Trans. 2018 Dec 17;46(6):1393-1406. doi: 10.1042/BST20170528. Epub 2018 Oct 31. Review.

PMID:
30381334
7.

The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R), and IL-6·sIL-6R·sgp130 complexes allows simultaneous classic and trans-signaling.

Baran P, Hansen S, Waetzig GH, Akbarzadeh M, Lamertz L, Huber HJ, Ahmadian MR, Moll JM, Scheller J.

J Biol Chem. 2018 May 4;293(18):6762-6775. doi: 10.1074/jbc.RA117.001163. Epub 2018 Mar 20.

8.

Structural fingerprints, interactions, and signaling networks of RAS family proteins beyond RAS isoforms.

Nakhaei-Rad S, Haghighi F, Nouri P, Rezaei Adariani S, Lissy J, Kazemein Jasemi NS, Dvorsky R, Ahmadian MR.

Crit Rev Biochem Mol Biol. 2018 Apr;53(2):130-156. doi: 10.1080/10409238.2018.1431605. Epub 2018 Feb 19. Review. No abstract available.

PMID:
29457927
9.

IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells.

Hain A, Krämer M, Linka RM, Nakhaei-Rad S, Ahmadian MR, Häussinger D, Borkhardt A, Münk C.

Sci Rep. 2018 Feb 16;8(1):3217. doi: 10.1038/s41598-018-21344-7.

10.

Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes.

Martinelli S, Krumbach OHF, Pantaleoni F, Coppola S, Amin E, Pannone L, Nouri K, Farina L, Dvorsky R, Lepri F, Buchholzer M, Konopatzki R, Walsh L, Payne K, Pierpont ME, Vergano SS, Langley KG, Larsen D, Farwell KD, Tang S, Mroske C, Gallotta I, Di Schiavi E, Della Monica M, Lugli L, Rossi C, Seri M, Cocchi G, Henderson L, Baskin B, Alders M, Mendoza-Londono R, Dupuis L, Nickerson DA, Chong JX; University of Washington Center for Mendelian Genomics, Meeks N, Brown K, Causey T, Cho MT, Demuth S, Digilio MC, Gelb BD, Bamshad MJ, Zenker M, Ahmadian MR, Hennekam RC, Tartaglia M, Mirzaa GM.

Am J Hum Genet. 2018 Feb 1;102(2):309-320. doi: 10.1016/j.ajhg.2017.12.015. Epub 2018 Jan 25.

11.

Rho inhibition by lovastatin affects apoptosis and DSB repair of primary human lung cells in vitro and lung tissue in vivo following fractionated irradiation.

Ziegler V, Henninger C, Simiantonakis I, Buchholzer M, Ahmadian MR, Budach W, Fritz G.

Cell Death Dis. 2017 Aug 10;8(8):e2978. doi: 10.1038/cddis.2017.372.

12.

Correction: Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.

Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, Stork O, Zenker M, Fejtova A.

PLoS Genet. 2017 Jun 16;13(6):e1006843. doi: 10.1371/journal.pgen.1006843. eCollection 2017 Jun.

13.

New model for the interaction of IQGAP1 with CDC42 and RAC1.

Nouri K, Timson DJ, Ahmadian MR.

Small GTPases. 2017 Jun 16:1-7. doi: 10.1080/21541248.2017.1321169. [Epub ahead of print]

PMID:
28622072
14.

Genotype and phenotype spectrum of NRAS germline variants.

Altmüller F, Lissewski C, Bertola D, Flex E, Stark Z, Spranger S, Baynam G, Buscarilli M, Dyack S, Gillis J, Yntema HG, Pantaleoni F, van Loon RL, MacKay S, Mina K, Schanze I, Tan TY, Walsh M, White SM, Niewisch MR, García-Miñaúr S, Plaza D, Ahmadian MR, Cavé H, Tartaglia M, Zenker M.

Eur J Hum Genet. 2017 Jun;25(7):823-831. doi: 10.1038/ejhg.2017.65. Epub 2017 May 3.

15.

Aberrant HRAS transcript processing underlies a distinctive phenotype within the RASopathy clinical spectrum.

Pantaleoni F, Lev D, Cirstea IC, Motta M, Lepri FR, Bottero L, Cecchetti S, Linger I, Paolacci S, Flex E, Novelli A, Carè A, Ahmadian MR, Stellacci E, Tartaglia M.

Hum Mutat. 2017 Jul;38(7):798-804. doi: 10.1002/humu.23224. Epub 2017 May 3.

PMID:
28390077
16.

Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy.

Altmüller F, Pothula S, Annamneedi A, Nakhaei-Rad S, Montenegro-Venegas C, Pina-Fernández E, Marini C, Santos M, Schanze D, Montag D, Ahmadian MR, Stork O, Zenker M, Fejtova A.

PLoS Genet. 2017 Mar 27;13(3):e1006684. doi: 10.1371/journal.pgen.1006684. eCollection 2017 Mar. Erratum in: PLoS Genet. 2017 Jun 16;13(6):e1006843.

17.

The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions.

Nakhaeizadeh H, Amin E, Nakhaei-Rad S, Dvorsky R, Ahmadian MR.

PLoS One. 2016 Dec 9;11(12):e0167145. doi: 10.1371/journal.pone.0167145. eCollection 2016.

18.

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

Nouri K, Fansa EK, Amin E, Dvorsky R, Gremer L, Willbold D, Schmitt L, Timson DJ, Ahmadian MR.

J Biol Chem. 2016 Dec 16;291(51):26364-26376. Epub 2016 Nov 4.

19.

Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS.

Amin E, Jaiswal M, Derewenda U, Reis K, Nouri K, Koessmeier KT, Aspenström P, Somlyo AV, Dvorsky R, Ahmadian MR.

J Biol Chem. 2016 Sep 23;291(39):20353-71. doi: 10.1074/jbc.M116.736967. Epub 2016 Aug 1.

20.

The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.

Becker MS, Müller PM, Bajorat J, Schroeder A, Giaisi M, Amin E, Ahmadian MR, Rocks O, Köhler R, Krammer PH, Li-Weber M.

Oncotarget. 2016 Aug 9;7(32):51908-51921. doi: 10.18632/oncotarget.10188.

21.

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering.

Blaževitš O, Mideksa YG, Šolman M, Ligabue A, Ariotti N, Nakhaeizadeh H, Fansa EK, Papageorgiou AC, Wittinghofer A, Ahmadian MR, Abankwa D.

Sci Rep. 2016 Apr 18;6:24165. doi: 10.1038/srep24165.

22.

Specific mosaic KRAS mutations affecting codon 146 cause oculoectodermal syndrome and encephalocraniocutaneous lipomatosis.

Boppudi S, Bögershausen N, Hove HB, Percin EF, Aslan D, Dvorsky R, Kayhan G, Li Y, Cursiefen C, Tantcheva-Poor I, Toft PB, Bartsch O, Lissewski C, Wieland I, Jakubiczka S, Wollnik B, Ahmadian MR, Heindl LM, Zenker M.

Clin Genet. 2016 Oct;90(4):334-42. doi: 10.1111/cge.12775. Epub 2016 Apr 29.

PMID:
26970110
23.

The Role of Embryonic Stem Cell-expressed RAS (ERAS) in the Maintenance of Quiescent Hepatic Stellate Cells.

Nakhaei-Rad S, Nakhaeizadeh H, Götze S, Kordes C, Sawitza I, Hoffmann MJ, Franke M, Schulz WA, Scheller J, Piekorz RP, Häussinger D, Ahmadian MR.

J Biol Chem. 2016 Apr 15;291(16):8399-413. doi: 10.1074/jbc.M115.700088. Epub 2016 Feb 16.

24.

Biophysical Characterization of Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11.

Nouri K, Moll JM, Milroy LG, Hain A, Dvorsky R, Amin E, Lenders M, Nagel-Steger L, Howe S, Smits SH, Hengel H, Schmitt L, Münk C, Brunsveld L, Ahmadian MR.

PLoS One. 2015 Dec 1;10(12):e0143634. doi: 10.1371/journal.pone.0143634. eCollection 2015.

25.

Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network.

Caye A, Strullu M, Guidez F, Cassinat B, Gazal S, Fenneteau O, Lainey E, Nouri K, Nakhaei-Rad S, Dvorsky R, Lachenaud J, Pereira S, Vivent J, Verger E, Vidaud D, Galambrun C, Picard C, Petit A, Contet A, Poirée M, Sirvent N, Méchinaud F, Adjaoud D, Paillard C, Nelken B, Reguerre Y, Bertrand Y, Häussinger D, Dalle JH, Ahmadian MR, Baruchel A, Chomienne C, Cavé H.

Nat Genet. 2015 Nov;47(11):1334-40. doi: 10.1038/ng.3420. Epub 2015 Oct 12.

PMID:
26457648
26.

The Function of Embryonic Stem Cell-expressed RAS (E-RAS), a Unique RAS Family Member, Correlates with Its Additional Motifs and Its Structural Properties.

Nakhaei-Rad S, Nakhaeizadeh H, Kordes C, Cirstea IC, Schmick M, Dvorsky R, Bastiaens PI, Häussinger D, Ahmadian MR.

J Biol Chem. 2015 Jun 19;290(25):15892-903. doi: 10.1074/jbc.M115.640607. Epub 2015 May 4.

27.

Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets.

Dütting S, Heidenreich J, Cherpokova D, Amin E, Zhang SC, Ahmadian MR, Brakebusch C, Nieswandt B.

J Thromb Haemost. 2015 May;13(5):827-38. doi: 10.1111/jth.12861. Epub 2015 Feb 23.

28.

Liposome reconstitution and modulation of recombinant prenylated human Rac1 by GEFs, GDI1 and Pak1.

Zhang SC, Gremer L, Heise H, Janning P, Shymanets A, Cirstea IC, Krause E, Nürnberg B, Ahmadian MR.

PLoS One. 2014 Jul 11;9(7):e102425. doi: 10.1371/journal.pone.0102425. eCollection 2014.

29.

Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.

Flex E, Jaiswal M, Pantaleoni F, Martinelli S, Strullu M, Fansa EK, Caye A, De Luca A, Lepri F, Dvorsky R, Pannone L, Paolacci S, Zhang SC, Fodale V, Bocchinfuso G, Rossi C, Burkitt-Wright EM, Farrotti A, Stellacci E, Cecchetti S, Ferese R, Bottero L, Castro S, Fenneteau O, Brethon B, Sanchez M, Roberts AE, Yntema HG, Van Der Burgt I, Cianci P, Bondeson ML, Cristina Digilio M, Zampino G, Kerr B, Aoki Y, Loh ML, Palleschi A, Di Schiavi E, Carè A, Selicorni A, Dallapiccola B, Cirstea IC, Stella L, Zenker M, Gelb BD, Cavé H, Ahmadian MR, Tartaglia M.

Hum Mol Genet. 2014 Aug 15;23(16):4315-27. doi: 10.1093/hmg/ddu148. Epub 2014 Apr 4.

30.

Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin.

Taha MS, Nouri K, Milroy LG, Moll JM, Herrmann C, Brunsveld L, Piekorz RP, Ahmadian MR.

PLoS One. 2014 Mar 21;9(3):e91465. doi: 10.1371/journal.pone.0091465. eCollection 2014.

31.

Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger.

Jaiswal M, Dvorsky R, Amin E, Risse SL, Fansa EK, Zhang SC, Taha MS, Gauhar AR, Nakhaei-Rad S, Kordes C, Koessmeier KT, Cirstea IC, Olayioye MA, Häussinger D, Ahmadian MR.

J Biol Chem. 2014 Mar 7;289(10):6839-49. doi: 10.1074/jbc.M113.527655. Epub 2014 Jan 17.

32.

Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission.

Mayer S, Kumar R, Jaiswal M, Soykan T, Ahmadian MR, Brose N, Betz H, Rhee JS, Papadopoulos T.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20795-800. doi: 10.1073/pnas.1309078110. Epub 2013 Dec 2.

33.

The centrosomal adaptor TACC3 and the microtubule polymerase chTOG interact via defined C-terminal subdomains in an Aurora-A kinase-independent manner.

Thakur HC, Singh M, Nagel-Steger L, Kremer J, Prumbaum D, Fansa EK, Ezzahoini H, Nouri K, Gremer L, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.

J Biol Chem. 2014 Jan 3;289(1):74-88. doi: 10.1074/jbc.M113.532333. Epub 2013 Nov 22.

34.

Rho-kinase: regulation, (dys)function, and inhibition.

Amin E, Dubey BN, Zhang SC, Gremer L, Dvorsky R, Moll JM, Taha MS, Nagel-Steger L, Piekorz RP, Somlyo AV, Ahmadian MR.

Biol Chem. 2013 Nov;394(11):1399-410. doi: 10.1515/hsz-2013-0181. Review.

35.

Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division.

Thakur HC, Singh M, Nagel-Steger L, Prumbaum D, Fansa EK, Gremer L, Ezzahoini H, Abts A, Schmitt L, Raunser S, Ahmadian MR, Piekorz RP.

Biol Chem. 2013 Nov;394(11):1411-23. doi: 10.1515/hsz-2013-0184. Review.

PMID:
23787465
36.

Interaction characteristics of Plexin-B1 with Rho family proteins.

Fansa EK, Dvorsky R, Zhang SC, Fiegen D, Ahmadian MR.

Biochem Biophys Res Commun. 2013 May 17;434(4):785-90. doi: 10.1016/j.bbrc.2013.04.012. Epub 2013 Apr 17.

PMID:
23603360
37.

Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins.

Jaiswal M, Dvorsky R, Ahmadian MR.

J Biol Chem. 2013 Feb 8;288(6):4486-500. doi: 10.1074/jbc.M112.429746. Epub 2012 Dec 19.

38.

SH3-mediated targeting of Wrch1/RhoU by multiple adaptor proteins.

Risse SL, Vaz B, Burton MF, Aspenström P, Piekorz RP, Brunsveld L, Ahmadian MR.

Biol Chem. 2013 Mar;394(3):421-32. doi: 10.1515/hsz-2012-0246.

PMID:
23183748
39.

New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm.

Jaiswal M, Fansa EK, Dvorsky R, Ahmadian MR.

Biol Chem. 2013 Jan;394(1):89-95. doi: 10.1515/hsz-2012-0207.

PMID:
23096567
40.

Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and cardio-facio-cutaneous syndromes.

Cirstea IC, Gremer L, Dvorsky R, Zhang SC, Piekorz RP, Zenker M, Ahmadian MR.

Hum Mol Genet. 2013 Jan 15;22(2):262-70. doi: 10.1093/hmg/dds426. Epub 2012 Oct 11.

PMID:
23059812
41.

Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases.

Linka RM, Risse SL, Bienemann K, Werner M, Linka Y, Krux F, Synaeve C, Deenen R, Ginzel S, Dvorsky R, Gombert M, Halenius A, Hartig R, Helminen M, Fischer A, Stepensky P, Vettenranta K, Köhrer K, Ahmadian MR, Laws HJ, Fleckenstein B, Jumaa H, Latour S, Schraven B, Borkhardt A.

Leukemia. 2012 May;26(5):963-71. doi: 10.1038/leu.2011.371. Epub 2012 Jan 6.

PMID:
22289921
42.

Illuminating the functional and structural repertoire of human TBC/RABGAPs.

Frasa MA, Koessmeier KT, Ahmadian MR, Braga VM.

Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):67-73. doi: 10.1038/nrm3267. Review. Erratum in: Nat Rev Mol Cell Biol. 2012 Jul;13(7):476.

PMID:
22251903
43.

Biochemical assays to characterize Rho GTPases.

Jaiswal M, Dubey BN, Koessmeier KT, Gremer L, Ahmadian MR.

Methods Mol Biol. 2012;827:37-58. doi: 10.1007/978-1-61779-442-1_3.

PMID:
22144266
44.

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.

Shymanets A, Ahmadian MR, Kössmeier KT, Wetzker R, Harteneck C, Nürnberg B.

Biochem J. 2012 Feb 1;441(3):851-8. doi: 10.1042/BJ20111664.

PMID:
22054284
45.

Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.

Kraft M, Cirstea IC, Voss AK, Thomas T, Goehring I, Sheikh BN, Gordon L, Scott H, Smyth GK, Ahmadian MR, Trautmann U, Zenker M, Tartaglia M, Ekici A, Reis A, Dörr HG, Rauch A, Thiel CT.

J Clin Invest. 2011 Sep;121(9):3479-91. doi: 10.1172/JCI43428. Epub 2011 Aug 1.

46.

Two novel germline KRAS mutations: expanding the molecular and clinical phenotype.

Stark Z, Gillessen-Kaesbach G, Ryan MM, Cirstea IC, Gremer L, Ahmadian MR, Savarirayan R, Zenker M.

Clin Genet. 2012 Jun;81(6):590-4. doi: 10.1111/j.1399-0004.2011.01754.x. Epub 2011 Aug 18.

PMID:
21797849
47.

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR.

J Biol Chem. 2011 May 20;286(20):18202-12. doi: 10.1074/jbc.M111.226431. Epub 2011 Mar 28.

48.

The centrosome and mitotic spindle apparatus in cancer and senescence.

Schmidt S, Essmann F, Cirstea IC, Kuck F, Thakur HC, Singh M, Kletke A, Jänicke RU, Wiek C, Hanenberg H, Ahmadian MR, Schulze-Osthoff K, Nürnberg B, Piekorz RP.

Cell Cycle. 2010 Nov 15;9(22):4469-73.

PMID:
21088502
49.

The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.

Scholz RP, Gustafsson JO, Hoffmann P, Jaiswal M, Ahmadian MR, Eisler SA, Erlmann P, Schmid S, Hausser A, Olayioye MA.

Exp Cell Res. 2011 Feb 15;317(4):496-503. doi: 10.1016/j.yexcr.2010.11.003. Epub 2010 Nov 16.

PMID:
21087603
50.

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

Gremer L, Merbitz-Zahradnik T, Dvorsky R, Cirstea IC, Kratz CP, Zenker M, Wittinghofer A, Ahmadian MR.

Hum Mutat. 2011 Jan;32(1):33-43. doi: 10.1002/humu.21377. Epub 2010 Dec 9.

Supplemental Content

Loading ...
Support Center