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Engineered transfer RNAs for suppression of premature termination codons.

Lueck JD, Yoon JS, Perales-Puchalt A, Mackey AL, Infield DT, Behlke MA, Pope MR, Weiner DB, Skach WR, McCray PB Jr, Ahern CA.

Nat Commun. 2019 Feb 18;10(1):822. doi: 10.1038/s41467-019-08329-4.


Structural basis of α-scorpion toxin action on Nav channels.

Clairfeuille T, Cloake A, Infield DT, Llongueras JP, Arthur CP, Li ZR, Jian Y, Martin-Eauclaire MF, Bougis PE, Ciferri C, Ahern CA, Bosmans F, Hackos DH, Rohou A, Payandeh J.

Science. 2019 Feb 7. pii: eaav8573. doi: 10.1126/science.aav8573. [Epub ahead of print]


Automated data extraction and ensemble methods for predictive modeling of breast cancer outcomes after radiation therapy.

Lindsay WD, Ahern CA, Tobias JS, Berlind CG, Chinniah C, Gabriel PE, Gee JC, Simone CB 2nd.

Med Phys. 2019 Feb;46(2):1054-1063. doi: 10.1002/mp.13314. Epub 2018 Dec 28.


Main-chain mutagenesis reveals intrahelical coupling in an ion channel voltage-sensor.

Infield DT, Matulef K, Galpin JD, Lam K, Tajkhorshid E, Ahern CA, Valiyaveetil FI.

Nat Commun. 2018 Nov 29;9(1):5055. doi: 10.1038/s41467-018-07477-3.


Treatment of malignant pleural mesothelioma with chemotherapy preceding versus after surgical resection.

Verma V, Ahern CA, Berlind CG, Lindsay WD, Grover S, Friedberg JS, Simone CB 2nd.

J Thorac Cardiovasc Surg. 2019 Feb;157(2):758-766.e1. doi: 10.1016/j.jtcvs.2018.10.039. Epub 2018 Oct 22.


Survival by Histologic Subtype of Malignant Pleural Mesothelioma and the Impact of Surgical Resection on Overall Survival.

Verma V, Ahern CA, Berlind CG, Lindsay WD, Shabason J, Sharma S, Culligan MJ, Grover S, Friedberg JS, Simone CB 2nd.

Clin Lung Cancer. 2018 Nov;19(6):e901-e912. doi: 10.1016/j.cllc.2018.08.007. Epub 2018 Aug 29.


Replacing voltage sensor arginines with citrulline provides mechanistic insight into charge versus shape.

Infield DT, Lee EEL, Galpin JD, Galles GD, Bezanilla F, Ahern CA.

J Gen Physiol. 2018 Jul 2;150(7):1017-1024. doi: 10.1085/jgp.201812075. Epub 2018 Jun 4.


Facility volume and postoperative outcomes for malignant pleural mesothelioma: A National Cancer Data Base analysis.

Verma V, Ahern CA, Berlind CG, Lindsay WD, Grover S, Culligan MJ, Friedberg JS, Simone CB 2nd.

Lung Cancer. 2018 Jun;120:7-13. doi: 10.1016/j.lungcan.2018.03.019. Epub 2018 Mar 21.


Rapid evolution of a voltage-gated sodium channel gene in a lineage of electric fish leads to a persistent sodium current.

Thompson A, Infield DT, Smith AR, Smith GT, Ahern CA, Zakon HH.

PLoS Biol. 2018 Mar 27;16(3):e2004892. doi: 10.1371/journal.pbio.2004892. eCollection 2018 Mar.


Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte.

Infield DT, Lueck JD, Galpin JD, Galles GD, Ahern CA.

Sci Rep. 2018 Mar 26;8(1):5166. doi: 10.1038/s41598-018-23201-z.


Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits.

Molinarolo S, Granata D, Carnevale V, Ahern CA.

Handb Exp Pharmacol. 2018;246:33-49. doi: 10.1007/164_2017_75. Review.


Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel.

Molinarolo S, Lee S, Leisle L, Lueck JD, Granata D, Carnevale V, Ahern CA.

J Biol Chem. 2018 Apr 6;293(14):4981-4992. doi: 10.1074/jbc.RA117.000852. Epub 2018 Jan 25.


Conformational dynamics in TRPV1 channels reported by an encoded coumarin amino acid.

Steinberg X, Kasimova MA, Cabezas-Bratesco D, Galpin JD, Ladron-de-Guevara E, Villa F, Carnevale V, Islas L, Ahern CA, Brauchi SE.

Elife. 2017 Dec 5;6. pii: e28626. doi: 10.7554/eLife.28626.


Detecting evolutionary forces in language change.

Newberry MG, Ahern CA, Clark R, Plotkin JB.

Nature. 2017 Nov 9;551(7679):223-226. doi: 10.1038/nature24455. Epub 2017 Nov 1.


National Cancer Database Report on Pneumonectomy Versus Lung-Sparing Surgery for Malignant Pleural Mesothelioma.

Verma V, Ahern CA, Berlind CG, Lindsay WD, Sharma S, Shabason J, Culligan MJ, Grover S, Friedberg JS, Simone CB 2nd.

J Thorac Oncol. 2017 Nov;12(11):1704-1714. doi: 10.1016/j.jtho.2017.08.012. Epub 2017 Aug 24.


Cellular encoding of Cy dyes for single-molecule imaging.

Leisle L, Chadda R, Lueck JD, Infield DT, Galpin JD, Krishnamani V, Robertson JL, Ahern CA.

Elife. 2016 Dec 12;5. pii: e19088. doi: 10.7554/eLife.19088.


Atomic determinants of BK channel activation by polyunsaturated fatty acids.

Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13905-13910. Epub 2016 Nov 14.


Atomic mutagenesis in ion channels with engineered stoichiometry.

Lueck JD, Mackey AL, Infield DT, Galpin JD, Li J, Roux B, Ahern CA.

Elife. 2016 Oct 6;5. pii: e18976. doi: 10.7554/eLife.18976.


The hitchhiker's guide to the voltage-gated sodium channel galaxy.

Ahern CA, Payandeh J, Bosmans F, Chanda B.

J Gen Physiol. 2016 Jan;147(1):1-24. doi: 10.1085/jgp.201511492. Review.


Incorporation of Non-Canonical Amino Acids.

Leisle L, Valiyaveetil F, Mehl RA, Ahern CA.

Adv Exp Med Biol. 2015;869:119-51. doi: 10.1007/978-1-4939-2845-3_7. Review.


Introduction: Applying Chemical Biology to Ion Channels.

Pless SA, Ahern CA.

Adv Exp Med Biol. 2015;869:1-4. doi: 10.1007/978-1-4939-2845-3_1.


Atomic basis for therapeutic activation of neuronal potassium channels.

Kim RY, Yau MC, Galpin JD, Seebohm G, Ahern CA, Pless SA, Kurata HT.

Nat Commun. 2015 Sep 3;6:8116. doi: 10.1038/ncomms9116.


A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.

Zhang RS, Wright JD, Pless SA, Nunez JJ, Kim RY, Li JB, Yang R, Ahern CA, Kurata HT.

J Biol Chem. 2015 Jun 19;290(25):15450-61. doi: 10.1074/jbc.M114.631960. Epub 2015 May 1.


Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology.

Pless SA, Kim RY, Ahern CA, Kurata HT.

J Physiol. 2015 Jun 15;593(12):2627-34. doi: 10.1113/jphysiol.2014.287714. Epub 2015 Mar 13. Review.


Asymmetric functional contributions of acidic and aromatic side chains in sodium channel voltage-sensor domains.

Pless SA, Elstone FD, Niciforovic AP, Galpin JD, Yang R, Kurata HT, Ahern CA.

J Gen Physiol. 2014 May;143(5):645-56. doi: 10.1085/jgp.201311036.


Pharmacological insights and quirks of bacterial sodium channels.

Corry B, Lee S, Ahern CA.

Handb Exp Pharmacol. 2014;221:251-67. doi: 10.1007/978-3-642-41588-3_12. Review.


HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.

Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10.


Hydrogen bonds as molecular timers for slow inactivation in voltage-gated potassium channels.

Pless SA, Galpin JD, Niciforovic AP, Kurata HT, Ahern CA.

Elife. 2013 Dec 10;2:e01289. doi: 10.7554/eLife.01289.


What activates inactivation?

Ahern CA.

J Gen Physiol. 2013 Aug;142(2):97-100. doi: 10.1085/jgp.201311046. Epub 2013 Jul 15. No abstract available.


The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.

Leprivier G, Remke M, Rotblat B, Dubuc A, Mateo AR, Kool M, Agnihotri S, El-Naggar A, Yu B, Somasekharan SP, Faubert B, Bridon G, Tognon CE, Mathers J, Thomas R, Li A, Barokas A, Kwok B, Bowden M, Smith S, Wu X, Korshunov A, Hielscher T, Northcott PA, Galpin JD, Ahern CA, Wang Y, McCabe MG, Collins VP, Jones RG, Pollak M, Delattre O, Gleave ME, Jan E, Pfister SM, Proud CG, Derry WB, Taylor MD, Sorensen PH.

Cell. 2013 May 23;153(5):1064-79. doi: 10.1016/j.cell.2013.04.055.


A novel mechanism for fine-tuning open-state stability in a voltage-gated potassium channel.

Pless SA, Niciforovic AP, Galpin JD, Nunez JJ, Kurata HT, Ahern CA.

Nat Commun. 2013;4:1784. doi: 10.1038/ncomms2761.


Expression-dependent pharmacology of transient receptor potential vanilloid subtype 1 channels in Xenopus laevis oocytes.

Rivera-Acevedo RE, Pless SA, Schwarz SK, Ahern CA.

Channels (Austin). 2013 Jan 1;7(1):47-50. doi: 10.4161/chan.23105.


Unnatural amino acids as probes of ligand-receptor interactions and their conformational consequences.

Pless SA, Ahern CA.

Annu Rev Pharmacol Toxicol. 2013;53:211-29. doi: 10.1146/annurev-pharmtox-011112-140343. Review.


Seeing the forest through the trees: towards a unified view on physiological calcium regulation of voltage-gated sodium channels.

Van Petegem F, Lobo PA, Ahern CA.

Biophys J. 2012 Dec 5;103(11):2243-51. doi: 10.1016/j.bpj.2012.10.020. Review.


Intermediate state trapping of a voltage sensor.

Lacroix JJ, Pless SA, Maragliano L, Campos FV, Galpin JD, Ahern CA, Roux B, Bezanilla F.

J Gen Physiol. 2012 Dec;140(6):635-52. doi: 10.1085/jgp.201210827.


Basis for allosteric open-state stabilization of voltage-gated potassium channels by intracellular cations.

Goodchild SJ, Xu H, Es-Salah-Lamoureux Z, Ahern CA, Fedida D.

J Gen Physiol. 2012 Nov;140(5):495-511. doi: 10.1085/jgp.201210823. Epub 2012 Oct 15.


Molecular and functional determinants of local anesthetic inhibition of NaChBac.

Lee S, Goodchild SJ, Ahern CA.

Channels (Austin). 2012 Sep-Oct;6(5):403-6. doi: 10.4161/chan.21807. Epub 2012 Sep 1.


Identification and quantification of newly synthesized proteins translationally regulated by YB-1 using a novel Click-SILAC approach.

Somasekharan SP, Stoynov N, Rotblat B, Leprivier G, Galpin JD, Ahern CA, Foster LJ, Sorensen PH.

J Proteomics. 2012 Dec 21;77:e1-10. doi: 10.1016/j.jprot.2012.08.019. Epub 2012 Sep 5.


Extracellular quaternary ammonium blockade of transient receptor potential vanilloid subtype 1 channels expressed in Xenopus laevis oocytes.

Rivera-Acevedo RE, Pless SA, Schwarz SK, Ahern CA.

Mol Pharmacol. 2012 Dec;82(6):1129-35. doi: 10.1124/mol.112.079277. Epub 2012 Sep 6.


Local anesthetic inhibition of a bacterial sodium channel.

Lee S, Goodchild SJ, Ahern CA.

J Gen Physiol. 2012 Jun;139(6):507-16. doi: 10.1085/jgp.201210779.


Crystallographic basis for calcium regulation of sodium channels.

Sarhan MF, Tung CC, Van Petegem F, Ahern CA.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3558-63. doi: 10.1073/pnas.1114748109. Epub 2012 Feb 13.


Contributions of conserved residues at the gating interface of glycine receptors.

Pless SA, Leung AW, Galpin JD, Ahern CA.

J Biol Chem. 2011 Oct 7;286(40):35129-36. doi: 10.1074/jbc.M111.269027. Epub 2011 Aug 11.


Blockade of permeation by potassium but normal gating of the G628S nonconducting hERG channel mutant.

Es-Salah-Lamoureux Z, Xiong PY, Goodchild SJ, Ahern CA, Fedida D.

Biophys J. 2011 Aug 3;101(3):662-70. doi: 10.1016/j.bpj.2011.06.028.


Contributions of counter-charge in a potassium channel voltage-sensor domain.

Pless SA, Galpin JD, Niciforovic AP, Ahern CA.

Nat Chem Biol. 2011 Jul 24;7(9):617-23. doi: 10.1038/nchembio.622.


Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.

Pless SA, Galpin JD, Frankel A, Ahern CA.

Nat Commun. 2011 Jun 14;2:351. doi: 10.1038/ncomms1351.


The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro.

Rivera-Acevedo RE, Pless SA, Ahern CA, Schwarz SK.

Anesthesiology. 2011 Jun;114(6):1425-34. doi: 10.1097/ALN.0b013e318216ea0c. Erratum in: Anesthesiology. 2015 Aug;123(2):492.


Nη-substituted arginyl peptide inhibitors of protein arginine N-methyltransferases.

Lakowski TM, 't Hart P, Ahern CA, Martin NI, Frankel A.

ACS Chem Biol. 2010 Nov 19;5(11):1053-63. doi: 10.1021/cb100161u.


An electrostatic interaction between TEA and an introduced pore aromatic drives spring-in-the-door inactivation in Shaker potassium channels.

Ahern CA, Eastwood AL, Dougherty DA, Horn R.

J Gen Physiol. 2009 Dec;134(6):461-9. doi: 10.1085/jgp.200910260. Epub 2009 Nov 16.


A double tyrosine motif in the cardiac sodium channel domain III-IV linker couples calcium-dependent calmodulin binding to inactivation gating.

Sarhan MF, Van Petegem F, Ahern CA.

J Biol Chem. 2009 Nov 27;284(48):33265-74. doi: 10.1074/jbc.M109.052910. Epub 2009 Oct 5.


Chemical tools for K(+) channel biology.

Ahern CA, Kobertz WR.

Biochemistry. 2009 Jan 27;48(3):517-26. doi: 10.1021/bi8018515. Review.

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