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Items: 43


Oscillatory shear potentiates latent TGF-β1 activation more than steady shear as demonstrated by a novel force generator.

Kouzbari K, Hossan MR, Arrizabalaga JH, Varshney R, Simmons AD, Gostynska S, Nollert MU, Ahamed J.

Sci Rep. 2019 Apr 15;9(1):6065. doi: 10.1038/s41598-019-42302-x.


Inactivation of platelet-derived TGF-β1 attenuates aortic stenosis progression in a robust murine model.

Varshney R, Murphy B, Woolington S, Ghafoory S, Chen S, Robison T, Ahamed J.

Blood Adv. 2019 Mar 12;3(5):777-788. doi: 10.1182/bloodadvances.2018025817.


Cooperative PSGL-1 and CXCR2 signaling in neutrophils promotes deep vein thrombosis in mice.

Yago T, Liu Z, Ahamed J, McEver RP.

Blood. 2018 Sep 27;132(13):1426-1437. doi: 10.1182/blood-2018-05-850859. Epub 2018 Aug 1.


HIV-associated cardiovascular disease: importance of platelet activation and cardiac fibrosis in the setting of specific antiretroviral therapies.

Laurence J, Elhadad S, Ahamed J.

Open Heart. 2018 Jul 11;5(2):e000823. doi: 10.1136/openhrt-2018-000823. eCollection 2018. Review.


Platelet TGF-β1 deficiency decreases liver fibrosis in a mouse model of liver injury.

Ghafoory S, Varshney R, Robison T, Kouzbari K, Woolington S, Murphy B, Xia L, Ahamed J.

Blood Adv. 2018 Mar 13;2(5):470-480. doi: 10.1182/bloodadvances.2017010868.


New methodologies to accurately assess circulating active transforming growth factor-β1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices.

Mancini D, Monteagudo J, Suárez-Fariñas M, Bander J, Varshney R, Gonzalez J, Coller BS, Ahamed J.

Transl Res. 2018 Feb;192:15-29. doi: 10.1016/j.trsl.2017.10.006. Epub 2017 Nov 5.


HIV protease inhibitor-induced cardiac dysfunction and fibrosis is mediated by platelet-derived TGF-β1 and can be suppressed by exogenous carbon monoxide.

Laurence J, Elhadad S, Robison T, Terry H, Varshney R, Woolington S, Ghafoory S, Choi ME, Ahamed J.

PLoS One. 2017 Oct 31;12(10):e0187185. doi: 10.1371/journal.pone.0187185. eCollection 2017.


Role of Platelet-Derived Transforming Growth Factor-β1 and Reactive Oxygen Species in Radiation-Induced Organ Fibrosis.

Ahamed J, Laurence J.

Antioxid Redox Signal. 2017 Nov 1;27(13):977-988. doi: 10.1089/ars.2017.7064. Epub 2017 Jul 5. Review.


Transforming growth factor-β1-mediated cardiac fibrosis: potential role in HIV and HIV/antiretroviral therapy-linked cardiovascular disease.

Ahamed J, Terry H, Choi ME, Laurence J.

AIDS. 2016 Feb 20;30(4):535-42. doi: 10.1097/QAD.0000000000000982. Review. No abstract available.


Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells.

Zhao M, Perry JM, Marshall H, Venkatraman A, Qian P, He XC, Ahamed J, Li L.

Nat Med. 2014 Nov;20(11):1321-6. doi: 10.1038/nm.3706. Epub 2014 Oct 19.


Granule cargo release from bone marrow-derived cells sustains cardiac hypertrophy.

Yang F, Dong A, Ahamed J, Sunkara M, Smyth SS.

Am J Physiol Heart Circ Physiol. 2014 Nov 15;307(10):H1529-38. doi: 10.1152/ajpheart.00951.2013. Epub 2014 Sep 19.


Association between shear stress and platelet-derived transforming growth factor-β1 release and activation in animal models of aortic valve stenosis.

Wang W, Vootukuri S, Meyer A, Ahamed J, Coller BS.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1924-32. doi: 10.1161/ATVBAHA.114.303852. Epub 2014 Jun 5.


Detection of tissue factor antigen and coagulation activity in coronary artery thrombi isolated from patients with ST-segment elevation acute myocardial infarction.

Palmerini T, Tomasi L, Barozzi C, Della Riva D, Mariani A, Taglieri N, Leone O, Ceccarelli C, De Servi S, Branzi A, Genereux P, Stone GW, Ahamed J.

PLoS One. 2013 Dec 11;8(12):e81501. doi: 10.1371/journal.pone.0081501. eCollection 2013.


Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor β1 (TGF-β1) activation.

Brophy TM, Coller BS, Ahamed J.

J Biol Chem. 2013 Apr 12;288(15):10628-39. doi: 10.1074/jbc.M112.439034. Epub 2013 Mar 5.


Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload.

Meyer A, Wang W, Qu J, Croft L, Degen JL, Coller BS, Ahamed J.

Blood. 2012 Jan 26;119(4):1064-74. doi: 10.1182/blood-2011-09-377648. Epub 2011 Dec 1.


Costimulatory role of CXCR4 with pre-TCR and its crosstalk with PI3K in beta-selection of thymocytes.

Ahamed JA, Madhivadhani P.

Sci Signal. 2010 Apr 27;3(119):jc4. doi: 10.1126/scisignal.3119jc4.


In vitro and in vivo evidence that thrombospondin-1 (TSP-1) contributes to stirring- and shear-dependent activation of platelet-derived TGF-beta1.

Ahamed J, Janczak CA, Wittkowski KM, Coller BS.

PLoS One. 2009 Aug 12;4(8):e6608. doi: 10.1371/journal.pone.0006608.


In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

Ahamed J, Burg N, Yoshinaga K, Janczak CA, Rifkin DB, Coller BS.

Blood. 2008 Nov 1;112(9):3650-60. doi: 10.1182/blood-2008-04-151753. Epub 2008 Jun 10.


Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1.

Bhattacharjee G, Ahamed J, Pawlinski R, Liu C, Mackman N, Ruf W, Edgington TS.

Circ Res. 2008 Feb 29;102(4):457-64. doi: 10.1161/CIRCRESAHA.107.167759. Epub 2008 Jan 3.


Inhibition of tissue factor signaling suppresses tumor growth.

Versteeg HH, Schaffner F, Kerver M, Petersen HH, Ahamed J, Felding-Habermann B, Takada Y, Mueller BM, Ruf W.

Blood. 2008 Jan 1;111(1):190-9. Epub 2007 Sep 27.


Inhibition of transmethylation down-regulates CD4 T cell activation and curtails development of autoimmunity in a model system.

Lawson BR, Manenkova Y, Ahamed J, Chen X, Zou JP, Baccala R, Theofilopoulos AN, Yuan C.

J Immunol. 2007 Apr 15;178(8):5366-74.


Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia.

Ahamed J, Niessen F, Kurokawa T, Lee YK, Bhattacharjee G, Morrissey JH, Ruf W.

Blood. 2007 Jun 15;109(12):5251-9. Epub 2007 Mar 1.


Evidence for activation of tissue factor by an allosteric disulfide bond.

Chen VM, Ahamed J, Versteeg HH, Berndt MC, Ruf W, Hogg PJ.

Biochemistry. 2006 Oct 3;45(39):12020-8.


Disulfide isomerization switches tissue factor from coagulation to cell signaling.

Ahamed J, Versteeg HH, Kerver M, Chen VM, Mueller BM, Hogg PJ, Ruf W.

Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13932-7. Epub 2006 Sep 7.


Regulation of tissue factor--mediated initiation of the coagulation cascade by cell surface grp78.

Bhattacharjee G, Ahamed J, Pedersen B, El-Sheikh A, Mackman N, Ruf W, Liu C, Edgington TS.

Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1737-43. Epub 2005 Jun 9.


Signaling of the tissue factor coagulation pathway in angiogenesis and cancer.

Belting M, Ahamed J, Ruf W.

Arterioscler Thromb Vasc Biol. 2005 Aug;25(8):1545-50. Epub 2005 May 19. Review.


Choice of drugs to manage anthrax.

Ahamed J.

Med Hypotheses. 2005;64(4):883-4. No abstract available.


Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor 1.

Ahamed J, Belting M, Ruf W.

Blood. 2005 Mar 15;105(6):2384-91. Epub 2004 Nov 18.


Regulation of inflammatory responses.

Krug A, Ahamed J, Ali H.

Penn Dent J (Phila). 2002;102:8-9.


C3a enhances nerve growth factor-induced NFAT activation and chemokine production in a human mast cell line, HMC-1.

Ahamed J, Venkatesha RT, Thangam EB, Ali H.

J Immunol. 2004 Jun 1;172(11):6961-8.


Regulation of angiogenesis by tissue factor cytoplasmic domain signaling.

Belting M, Dorrell MI, Sandgren S, Aguilar E, Ahamed J, Dorfleutner A, Carmeliet P, Mueller BM, Friedlander M, Ruf W.

Nat Med. 2004 May;10(5):502-9. Epub 2004 Apr 18.


Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain.

Ahamed J, Ruf W.

J Biol Chem. 2004 May 28;279(22):23038-44. Epub 2004 Mar 23.


Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms.

Subbarao K, Jala VR, Mathis S, Suttles J, Zacharias W, Ahamed J, Ali H, Tseng MT, Haribabu B.

Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):369-75. Epub 2003 Dec 1.


Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT.

Ali H, Ahamed J, Hernandez-Munain C, Baron JL, Krangel MS, Patel DD.

J Immunol. 2000 Dec 15;165(12):7215-23.


Caged chemotactic peptides.

Pirrung MC, Drabik SJ, Ahamed J, Ali H.

Bioconjug Chem. 2000 Sep-Oct;11(5):679-81.


Mechanisms of quinolone resistance in clinical isolates of Shigella dysenteriae.

Ahamed J, Gangopadhyay J, Kundu M, Sinha AK.

Antimicrob Agents Chemother. 1999 Sep;43(9):2333-4. No abstract available.


Molecular characterization of the SHV-11 beta-lactamase of Shigella dysenteriae.

Ahamed J, Kundu M.

Antimicrob Agents Chemother. 1999 Aug;43(8):2081-3.


Involvement of an efflux system in high-level fluoroquinolone resistance of Shigella dysenteriae.

Ghosh AS, Ahamed J, Chauhan KK, Kundu M.

Biochem Biophys Res Commun. 1998 Jan 6;242(1):54-6.


Involvement of a 43-kilodalton outer membrane protein in beta-lactam resistance of Shigella dysenteriae.

Kar AK, Ghosh AS, Chauhan K, Ahamed J, Basu J, Chakrabarti P, Kundu M.

Antimicrob Agents Chemother. 1997 Oct;41(10):2302-4.

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