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Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.

Keller A, Nuvolone M, Abakumova I, Chincisan A, Reimann R, Avar M, Heinzer D, Hornemann S, Wagner J, Kirschenbaum D, Voigt FF, Zhu C, Regli L, Helmchen F, Aguzzi A.

PLoS Pathog. 2018 Nov 29;14(11):e1007424. doi: 10.1371/journal.ppat.1007424. eCollection 2018 Nov.


Genome-Wide Identification of microRNAs Regulating the Human Prion Protein.

Pease D, Scheckel C, Schaper E, Eckhardt V, Emmenegger M, Xenarios I, Aguzzi A.

Brain Pathol. 2018 Nov 19. doi: 10.1111/bpa.12679. [Epub ahead of print]


Toxic Protein Spread in Neurodegeneration: Reality versus Fantasy.

Kara E, Marks JD, Aguzzi A.

Trends Mol Med. 2018 Dec;24(12):1007-1020. doi: 10.1016/j.molmed.2018.09.004. Epub 2018 Nov 12. Review.


A Survey of Sodium Chloride Content in Italian Artisanal and Industrial Bread.

Carcea M, Narducci V, Turfani V, Aguzzi A.

Foods. 2018 Nov 5;7(11). pii: E181. doi: 10.3390/foods7110181.



Aguzzi A.

Nat Rev Mol Cell Biol. 2018 Oct 2. doi: 10.1038/s41580-018-0062-6. [Epub ahead of print] No abstract available.


Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression.

Liu Y, Sorce S, Nuvolone M, Domange J, Aguzzi A.

Sci Rep. 2018 Oct 2;8(1):14600. doi: 10.1038/s41598-018-32712-8.


A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity.

Bardelli M, Frontzek K, Simonelli L, Hornemann S, Pedotti M, Mazzola F, Carta M, Eckhardt V, D'Antuono R, Virgilio T, González SF, Aguzzi A, Varani L.

PLoS Pathog. 2018 Oct 1;14(10):e1007335. doi: 10.1371/journal.ppat.1007335. eCollection 2018 Oct.


Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.

Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU.

Nat Commun. 2018 Aug 13;9(1):3230. doi: 10.1038/s41467-018-05709-0.


From Plant Compounds to Botanicals and Back: A Current Snapshot.

Durazzo A, D'Addezio L, Camilli E, Piccinelli R, Turrini A, Marletta L, Marconi S, Lucarini M, Lisciani S, Gabrielli P, Gambelli L, Aguzzi A, Sette S.

Molecules. 2018 Jul 24;23(8). pii: E1844. doi: 10.3390/molecules23081844.


Intrinsic Toxicity of Antibodies to the Globular Domain of the Prion Protein.

Reimann RR, Aguzzi A.

Biol Psychiatry. 2018 Oct 1;84(7):e51-e52. doi: 10.1016/j.biopsych.2018.01.028. Epub 2018 Apr 12. No abstract available.


Prions, prionoids and protein misfolding disorders.

Scheckel C, Aguzzi A.

Nat Rev Genet. 2018 Jul;19(7):405-418. doi: 10.1038/s41576-018-0011-4. Review.


Infectious prions do not induce Aβ deposition in an in vivo seeding model.

Rasmussen J, Krasemann S, Altmeppen H, Schwarz P, Schelle J, Aguzzi A, Glatzel M, Jucker M.

Acta Neuropathol. 2018 Jun;135(6):965-967. doi: 10.1007/s00401-018-1848-5. Epub 2018 Apr 16. No abstract available.


Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion.

Baral PK, Swayampakula M, Aguzzi A, James MNG.

FEBS J. 2018 May;285(9):1701-1714. doi: 10.1111/febs.14438. Epub 2018 Apr 14.


Gastric metastasis from cervix carcer: a case report.

De Cicco L, Crivelli F, Beretta P, Gjoni E, Merlotti A, Starace A, Marzaroli G, Pasta F, Zurleni T, Aguzzi A, Calandra C, Bracelli S.

Pathologica. 2017 Dec;109(4):398-400.


GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.

Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D'Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR.

J Exp Med. 2018 Mar 5;215(3):941-961. doi: 10.1084/jem.20161714. Epub 2018 Jan 24.


Food Composition Databases: Considerations about Complex Food Matrices.

Marconi S, Durazzo A, Camilli E, Lisciani S, Gabrielli P, Aguzzi A, Gambelli L, Lucarini M, Marletta L.

Foods. 2018 Jan 1;7(1). pii: E2. doi: 10.3390/foods7010002.


Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice.

Kane SJ, Swanson E, Gordon EO, Rocha S, Bender HR, Donius LR, Aguzzi A, Hannan JP, Zabel MD.

mSphere. 2017 Nov 22;2(6). pii: e00493-17. doi: 10.1128/mSphereDirect.00493-17. eCollection 2017 Nov-Dec.


Binding of Polythiophenes to Amyloids: Structural Mapping of the Pharmacophore.

Schütz AK, Hornemann S, Wälti MA, Greuter L, Tiberi C, Cadalbert R, Gantner M, Riek R, Hammarström P, Nilsson KPR, Böckmann A, Aguzzi A, Meier BH.

ACS Chem Neurosci. 2018 Mar 21;9(3):475-481. doi: 10.1021/acschemneuro.7b00397. Epub 2017 Dec 4.


Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.

Goniotaki D, Lakkaraju AKK, Shrivastava AN, Bakirci P, Sorce S, Senatore A, Marpakwar R, Hornemann S, Gasparini F, Triller A, Aguzzi A.

PLoS Pathog. 2017 Nov 27;13(11):e1006733. doi: 10.1371/journal.ppat.1006733. eCollection 2017 Nov.


A role for astroglia in prion diseases.

Aguzzi A, Liu Y.

J Exp Med. 2017 Dec 4;214(12):3477-3479. doi: 10.1084/jem.20172045. Epub 2017 Nov 21.


Scaling behaviour and rate-determining steps in filamentous self-assembly.

Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ.

Chem Sci. 2017 Oct 1;8(10):7087-7097. doi: 10.1039/c7sc01965c. Epub 2017 Aug 31.


Strong, generous support for medical research emerges from a large cohort of Swiss patients.

Aguzzi A.

Swiss Med Wkly. 2017 Oct 22;147:w14537. doi: 10.4414/smw.2017.14537. eCollection 2017. No abstract available.


Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sánchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi A, Hornemann S.

Anal Chem. 2017 Nov 21;89(22):12306-12313. doi: 10.1021/acs.analchem.7b03279. Epub 2017 Nov 1.


Toward Therapy of Human Prion Diseases.

Aguzzi A, Lakkaraju AKK, Frontzek K.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:331-351. doi: 10.1146/annurev-pharmtox-010617-052745. Epub 2017 Sep 27.


NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?

Sorce S, Stocker R, Seredenina T, Holmdahl R, Aguzzi A, Chio A, Depaulis A, Heitz F, Olofsson P, Olsson T, Duveau V, Sanoudou D, Skosgater S, Vlahou A, Wasquel D, Krause KH, Jaquet V.

Free Radic Biol Med. 2017 Nov;112:387-396. doi: 10.1016/j.freeradbiomed.2017.08.006. Epub 2017 Aug 12. Review.


Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse.

Seredenina T, Sorce S, Herrmann FR, Ma Mulone XJ, Plastre O, Aguzzi A, Jaquet V, Krause KH.

Transl Psychiatry. 2017 Aug 15;7(8):e1206. doi: 10.1038/tp.2017.175.


Microglia in prion diseases.

Aguzzi A, Zhu C.

J Clin Invest. 2017 Sep 1;127(9):3230-3239. doi: 10.1172/JCI90605. Epub 2017 Jul 17. Review.


An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.

Bethge P, Carta S, Lorenzo DA, Egolf L, Goniotaki D, Madisen L, Voigt FF, Chen JL, Schneider B, Ohkura M, Nakai J, Zeng H, Aguzzi A, Helmchen F.

PLoS One. 2017 Jun 22;12(6):e0179460. doi: 10.1371/journal.pone.0179460. eCollection 2017.


Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling.

Nuvolone M, Paolucci M, Sorce S, Kana V, Moos R, Matozaki T, Aguzzi A.

PLoS One. 2017 May 17;12(5):e0177876. doi: 10.1371/journal.pone.0177876. eCollection 2017.


The biological function of the cellular prion protein: an update.

Wulf MA, Senatore A, Aguzzi A.

BMC Biol. 2017 May 2;15(1):34. doi: 10.1186/s12915-017-0375-5. Review.


Extended characterization of the novel co-isogenic C57BL/6J Prnp-/- mouse line.

Nuvolone M, Sorce S, Paolucci M, Aguzzi A.

Amyloid. 2017 Mar;24(sup1):36-37. doi: 10.1080/13506129.2017.1289913. No abstract available.


Regulated expression of amyloidogenic immunoglobulin light chains in mice.

Nuvolone M, Sorce S, Pelczar P, Rushing E, Lavatelli F, Rognoni P, Valentini V, Palladini G, Merlini G, Aguzzi A.

Amyloid. 2017 Mar;24(sup1):52-53. doi: 10.1080/13506129.2017.1289914. No abstract available.


Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay.

Ballmer BA, Moos R, Liberali P, Pelkmans L, Hornemann S, Aguzzi A.

J Biol Chem. 2017 May 19;292(20):8356-8368. doi: 10.1074/jbc.M116.773283. Epub 2017 Mar 24.


Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

Leske H, Hornemann S, Herrmann US, Zhu C, Dametto P, Li B, Laferriere F, Polymenidou M, Pelczar P, Reimann RR, Schwarz P, Rushing EJ, Wüthrich K, Aguzzi A.

PLoS One. 2017 Feb 16;12(2):e0170503. doi: 10.1371/journal.pone.0170503. eCollection 2017.


Cystatin F is a biomarker of prion pathogenesis in mice.

Nuvolone M, Schmid N, Miele G, Sorce S, Moos R, Schori C, Beerli RR, Bauer M, Saudan P, Dietmeier K, Lachmann I, Linnebank M, Martin R, Kallweit U, Kana V, Rushing EJ, Budka H, Aguzzi A.

PLoS One. 2017 Feb 8;12(2):e0171923. doi: 10.1371/journal.pone.0171923. eCollection 2017.


Correction: Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.

Kiessling MK, Curioni-Fontecedro A, Samaras P, Lang S, Scharl M, Aguzzi A, Oldridge DA, Maris JM, Rogler G.

PLoS One. 2017 Jan 20;12(1):e0170851. doi: 10.1371/journal.pone.0170851. eCollection 2017.


Nutritional composition and antioxidant properties of traditional Italian dishes.

Durazzo A, Lisciani S, Camilli E, Gabrielli P, Marconi S, Gambelli L, Aguzzi A, Lucarini M, Maiani G, Casale G, Marletta L.

Food Chem. 2017 Mar 1;218:70-77. doi: 10.1016/j.foodchem.2016.08.120. Epub 2016 Aug 31.


Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication.

Frontzek K, Pfammatter M, Sorce S, Senatore A, Schwarz P, Moos R, Frauenknecht K, Hornemann S, Aguzzi A.

PLoS One. 2016 Sep 29;11(9):e0163601. doi: 10.1371/journal.pone.0163601. eCollection 2016.


Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport.

Sherman MA, LaCroix M, Amar F, Larson ME, Forster C, Aguzzi A, Bennett DA, Ramsden M, Lesné SE.

J Neurosci. 2016 Sep 14;36(37):9647-58. doi: 10.1523/JNEUROSCI.1899-16.2016.


The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6.

Küffer A, Lakkaraju AK, Mogha A, Petersen SC, Airich K, Doucerain C, Marpakwar R, Bakirci P, Senatore A, Monnard A, Schiavi C, Nuvolone M, Grosshans B, Hornemann S, Bassilana F, Monk KR, Aguzzi A.

Nature. 2016 Aug 25;536(7617):464-8. Epub 2016 Aug 8.


The Priority position paper: Protecting Europe's food chain from prions.

Requena JR, Kristensson K, Korth C, Zurzolo C, Simmons M, Aguilar-Calvo P, Aguzzi A, Andreoletti O, Benestad SL, Böhm R, Brown K, Calgua B, Del Río JA, Espinosa JC, Girones R, Godsave S, Hoelzle LE, Knittler MR, Kuhn F, Legname G, Laeven P, Mabbott N, Mitrova E, Müller-Schiffmann A, Nuvolone M, Peters PJ, Raeber A, Roth K, Schmitz M, Schroeder B, Sonati T, Stitz L, Taraboulos A, Torres JM, Yan ZX, Zerr I.

Prion. 2016 May 3;10(3):165-81. doi: 10.1080/19336896.2016.1175801.


Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.

Seredenina T, Nayernia Z, Sorce S, Maghzal GJ, Filippova A, Ling SC, Basset O, Plastre O, Daali Y, Rushing EJ, Giordana MT, Cleveland DW, Aguzzi A, Stocker R, Krause KH, Jaquet V.

Free Radic Biol Med. 2016 Aug;97:95-108. doi: 10.1016/j.freeradbiomed.2016.05.016. Epub 2016 May 19.


A neuroprotective role for microglia in prion diseases.

Zhu C, Herrmann US, Falsig J, Abakumova I, Nuvolone M, Schwarz P, Frauenknecht K, Rushing EJ, Aguzzi A.

J Exp Med. 2016 May 30;213(6):1047-59. doi: 10.1084/jem.20151000. Epub 2016 May 16.


Phase Separation: Linking Cellular Compartmentalization to Disease.

Aguzzi A, Altmeyer M.

Trends Cell Biol. 2016 Jul;26(7):547-558. doi: 10.1016/j.tcb.2016.03.004. Epub 2016 Apr 1. Review.


Homozygous calreticulin mutations in patients with myelofibrosis lead to acquired myeloperoxidase deficiency.

Theocharides AP, Lundberg P, Lakkaraju AK, Lysenko V, Myburgh R, Aguzzi A, Skoda RC, Manz MG.

Blood. 2016 Jun 23;127(25):3253-9. doi: 10.1182/blood-2016-02-696310. Epub 2016 Mar 24.


Strictly co-isogenic C57BL/6J-Prnp-/- mice: A rigorous resource for prion science.

Nuvolone M, Hermann M, Sorce S, Russo G, Tiberi C, Schwarz P, Minikel E, Sanoudou D, Pelczar P, Aguzzi A.

J Exp Med. 2016 Mar 7;213(3):313-27. doi: 10.1084/jem.20151610. Epub 2016 Feb 29.


Correction: Aerosols transmit prions to immunocompetent and immunodeficient mice.

Haybaeck J, Heikenwalder M, Klevenz B, Schwarz P, Margalith I, Bridel C, Mertz K, Zirdum E, Petsch B, Fuchs TJ, Stitz L, Aguzzi A.

PLoS Pathog. 2016 Feb 12;12(2):e1005463. doi: 10.1371/journal.ppat.1005463. eCollection 2016 Feb. No abstract available.


Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.

Kiessling MK, Curioni-Fontecedro A, Samaras P, Lang S, Scharl M, Aguzzi A, Oldrige DA, Maris JM, Rogler G.

PLoS One. 2016 Jan 28;11(1):e0147682. doi: 10.1371/journal.pone.0147682. eCollection 2016. Erratum in: PLoS One. 2017 Jan 20;12 (1):e0170851.


Differential Toxicity of Antibodies to the Prion Protein.

Reimann RR, Sonati T, Hornemann S, Herrmann US, Arand M, Hawke S, Aguzzi A.

PLoS Pathog. 2016 Jan 28;12(1):e1005401. doi: 10.1371/journal.ppat.1005401. eCollection 2016 Jan.


Amyloid-β pathology and cerebral amyloid angiopathy are frequent in iatrogenic Creutzfeldt-Jakob disease after dural grafting.

Frontzek K, Lutz MI, Aguzzi A, Kovacs GG, Budka H.

Swiss Med Wkly. 2016 Jan 26;146:w14287. doi: 10.4414/smw.2016.14287. eCollection 2016.

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