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Items: 1 to 50 of 555

1.

Transition of the prion protein from a structured cellular form (PrPC ) to the infectious scrapie agent (PrPSc ).

Baral PK, Yin J, Aguzzi A, James MNG.

Protein Sci. 2019 Oct 3. doi: 10.1002/pro.3735. [Epub ahead of print] Review.

PMID:
31583788
2.

The mesoSPIM initiative: open-source light-sheet microscopes for imaging cleared tissue.

Voigt FF, Kirschenbaum D, Platonova E, Pagès S, Campbell RAA, Kastli R, Schaettin M, Egolf L, van der Bourg A, Bethge P, Haenraets K, Frézel N, Topilko T, Perin P, Hillier D, Hildebrand S, Schueth A, Roebroeck A, Roska B, Stoeckli ET, Pizzala R, Renier N, Zeilhofer HU, Karayannis T, Ziegler U, Batti L, Holtmaat A, Lüscher C, Aguzzi A, Helmchen F.

Nat Methods. 2019 Sep 16. doi: 10.1038/s41592-019-0554-0. [Epub ahead of print]

PMID:
31527839
3.

Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention.

O'Connor T, Zhou X, Kosla J, Adili A, Garcia Beccaria M, Kotsiliti E, Pfister D, Johlke AL, Sinha A, Sankowski R, Schick M, Lewis R, Dokalis N, Seubert B, Höchst B, Inverso D, Heide D, Zhang W, Weihrich P, Manske K, Wohlleber D, Anton M, Hoellein A, Seleznik G, Bremer J, Bleul S, Augustin HG, Scherer F, Koedel U, Weber A, Protzer U, Förster R, Wirth T, Aguzzi A, Meissner F, Prinz M, Baumann B, Höpken UE, Knolle PA, von Baumgarten L, Keller U, Heikenwalder M.

Cancer Cell. 2019 Sep 16;36(3):250-267.e9. doi: 10.1016/j.ccell.2019.08.001.

PMID:
31526758
4.

NG2 glia are required for maintaining microglia homeostatic state.

Liu Y, Aguzzi A.

Glia. 2019 Sep 13. doi: 10.1002/glia.23721. [Epub ahead of print]

PMID:
31518022
5.

Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads.

Hornemann S, Schwarz P, Rushing EJ, Connolly MD, Zuckermann RN, Yam AY, Aguzzi A.

PLoS One. 2019 Sep 12;14(9):e0216013. doi: 10.1371/journal.pone.0216013. eCollection 2019.

6.

Prion protein deficiency impairs hematopoietic stem cells determination and sensitizes myeloid progenitors to irradiation.

Siberchicot C, Gault N, Déchamps N, Barroca V, Aguzzi A, Roméo PH, Radicella JP, Bravard A, Bernardino-Sgherri J.

Haematologica. 2019 Aug 1. pii: haematol.2018.205716. doi: 10.3324/haematol.2018.205716. [Epub ahead of print]

7.

'Broken access' publishing corrodes quality.

Aguzzi A.

Nature. 2019 Jun;570(7760):139. doi: 10.1038/d41586-019-01787-2. No abstract available.

PMID:
31190018
8.

A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.

Gerez JA, Prymaczok NC, Rockenstein E, Herrmann US, Schwarz P, Adame A, Enchev RI, Courtheoux T, Boersema PJ, Riek R, Peter M, Aguzzi A, Masliah E, Picotti P.

Sci Transl Med. 2019 Jun 5;11(495). pii: eaau6722. doi: 10.1126/scitranslmed.aau6722.

PMID:
31167929
9.

Antioxidant Properties of Four Commonly Consumed Popular Italian Dishes.

Durazzo A, Lucarini M, Santini A, Camilli E, Gabrielli P, Marconi S, Lisciani S, Aguzzi A, Gambelli L, Novellino E, Marletta L.

Molecules. 2019 Apr 19;24(8). pii: E1543. doi: 10.3390/molecules24081543.

10.

Immunotherapy for neurodegeneration?

Liu Y, Aguzzi A.

Science. 2019 Apr 12;364(6436):130-131. doi: 10.1126/science.aaw0685. No abstract available.

PMID:
30975878
11.

SARM1 deficiency up-regulates XAF1, promotes neuronal apoptosis, and accelerates prion disease.

Zhu C, Li B, Frontzek K, Liu Y, Aguzzi A.

J Exp Med. 2019 Apr 1;216(4):743-756. doi: 10.1084/jem.20171885. Epub 2019 Mar 6.

12.

Ossified blood vessels in primary familial brain calcification elicit a neurotoxic astrocyte response.

Zarb Y, Weber-Stadlbauer U, Kirschenbaum D, Kindler DR, Richetto J, Keller D, Rademakers R, Dickson DW, Pasch A, Byzova T, Nahar K, Voigt FF, Helmchen F, Boss A, Aguzzi A, Klohs J, Keller A.

Brain. 2019 Apr 1;142(4):885-902. doi: 10.1093/brain/awz032.

13.

Unaltered prion disease in mice lacking developmental endothelial locus-1.

Zhu C, Li Z, Li B, Pfammatter M, Hornemann S, Aguzzi A.

Neurobiol Aging. 2019 Apr;76:208-213. doi: 10.1016/j.neurobiolaging.2019.01.003. Epub 2019 Jan 11.

PMID:
30743056
14.

Dietary Lignans: Definition, Description and Research Trends in Databases Development.

Durazzo A, Lucarini M, Camilli E, Marconi S, Gabrielli P, Lisciani S, Gambelli L, Aguzzi A, Novellino E, Santini A, Turrini A, Marletta L.

Molecules. 2018 Dec 8;23(12). pii: E3251. doi: 10.3390/molecules23123251. Review.

15.

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.

Keller A, Nuvolone M, Abakumova I, Chincisan A, Reimann R, Avar M, Heinzer D, Hornemann S, Wagner J, Kirschenbaum D, Voigt FF, Zhu C, Regli L, Helmchen F, Aguzzi A.

PLoS Pathog. 2018 Nov 29;14(11):e1007424. doi: 10.1371/journal.ppat.1007424. eCollection 2018 Nov.

16.

Genome-wide identification of microRNAs regulating the human prion protein.

Pease D, Scheckel C, Schaper E, Eckhardt V, Emmenegger M, Xenarios I, Aguzzi A.

Brain Pathol. 2019 Mar;29(2):232-244. doi: 10.1111/bpa.12679. Epub 2018 Dec 21.

PMID:
30451334
17.

Toxic Protein Spread in Neurodegeneration: Reality versus Fantasy.

Kara E, Marks JD, Aguzzi A.

Trends Mol Med. 2018 Dec;24(12):1007-1020. doi: 10.1016/j.molmed.2018.09.004. Epub 2018 Nov 12. Review.

PMID:
30442495
18.

A Survey of Sodium Chloride Content in Italian Artisanal and Industrial Bread.

Carcea M, Narducci V, Turfani V, Aguzzi A.

Foods. 2018 Nov 5;7(11). pii: E181. doi: 10.3390/foods7110181.

19.

'Forward genetics' and the causes of ALS.

Aguzzi A.

Nat Rev Mol Cell Biol. 2019 Feb;20(2):67. doi: 10.1038/s41580-018-0062-6. No abstract available.

PMID:
30279566
20.

Lymphocyte activation gene 3 (Lag3) expression is increased in prion infections but does not modify disease progression.

Liu Y, Sorce S, Nuvolone M, Domange J, Aguzzi A.

Sci Rep. 2018 Oct 2;8(1):14600. doi: 10.1038/s41598-018-32712-8.

21.

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity.

Bardelli M, Frontzek K, Simonelli L, Hornemann S, Pedotti M, Mazzola F, Carta M, Eckhardt V, D'Antuono R, Virgilio T, González SF, Aguzzi A, Varani L.

PLoS Pathog. 2018 Oct 1;14(10):e1007335. doi: 10.1371/journal.ppat.1007335. eCollection 2018 Oct.

22.

Itch suppression in mice and dogs by modulation of spinal α2 and α3GABAA receptors.

Ralvenius WT, Neumann E, Pagani M, Acuña MA, Wildner H, Benke D, Fischer N, Rostaher A, Schwager S, Detmar M, Frauenknecht K, Aguzzi A, Hubbs JL, Rudolph U, Favrot C, Zeilhofer HU.

Nat Commun. 2018 Aug 13;9(1):3230. doi: 10.1038/s41467-018-05709-0.

23.

From Plant Compounds to Botanicals and Back: A Current Snapshot.

Durazzo A, D'Addezio L, Camilli E, Piccinelli R, Turrini A, Marletta L, Marconi S, Lucarini M, Lisciani S, Gabrielli P, Gambelli L, Aguzzi A, Sette S.

Molecules. 2018 Jul 24;23(8). pii: E1844. doi: 10.3390/molecules23081844.

24.

Intrinsic Toxicity of Antibodies to the Globular Domain of the Prion Protein.

Reimann RR, Aguzzi A.

Biol Psychiatry. 2018 Oct 1;84(7):e51-e52. doi: 10.1016/j.biopsych.2018.01.028. Epub 2018 Apr 12. No abstract available.

PMID:
29752074
25.

Prions, prionoids and protein misfolding disorders.

Scheckel C, Aguzzi A.

Nat Rev Genet. 2018 Jul;19(7):405-418. doi: 10.1038/s41576-018-0011-4. Review.

PMID:
29713012
26.

Infectious prions do not induce Aβ deposition in an in vivo seeding model.

Rasmussen J, Krasemann S, Altmeppen H, Schwarz P, Schelle J, Aguzzi A, Glatzel M, Jucker M.

Acta Neuropathol. 2018 Jun;135(6):965-967. doi: 10.1007/s00401-018-1848-5. Epub 2018 Apr 16. No abstract available.

PMID:
29663066
27.

Structural characterization of POM6 Fab and mouse prion protein complex identifies key regions for prions conformational conversion.

Baral PK, Swayampakula M, Aguzzi A, James MNG.

FEBS J. 2018 May;285(9):1701-1714. doi: 10.1111/febs.14438. Epub 2018 Apr 14.

28.

Gastric metastasis from cervix carcer: a case report.

De Cicco L, Crivelli F, Beretta P, Gjoni E, Merlotti A, Starace A, Marzaroli G, Pasta F, Zurleni T, Aguzzi A, Calandra C, Bracelli S.

Pathologica. 2017 Dec;109(4):398-400.

PMID:
29449732
29.

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin.

Ackerman SD, Luo R, Poitelon Y, Mogha A, Harty BL, D'Rozario M, Sanchez NE, Lakkaraju AKK, Gamble P, Li J, Qu J, MacEwan MR, Ray WZ, Aguzzi A, Feltri ML, Piao X, Monk KR.

J Exp Med. 2018 Mar 5;215(3):941-961. doi: 10.1084/jem.20161714. Epub 2018 Jan 24.

30.

Food Composition Databases: Considerations about Complex Food Matrices.

Marconi S, Durazzo A, Camilli E, Lisciani S, Gabrielli P, Aguzzi A, Gambelli L, Lucarini M, Marletta L.

Foods. 2018 Jan 1;7(1). pii: E2. doi: 10.3390/foods7010002.

31.

Relative Impact of Complement Receptors CD21/35 (Cr2/1) on Scrapie Pathogenesis in Mice.

Kane SJ, Swanson E, Gordon EO, Rocha S, Bender HR, Donius LR, Aguzzi A, Hannan JP, Zabel MD.

mSphere. 2017 Nov 22;2(6). pii: e00493-17. doi: 10.1128/mSphereDirect.00493-17. eCollection 2017 Nov-Dec.

32.

Binding of Polythiophenes to Amyloids: Structural Mapping of the Pharmacophore.

Schütz AK, Hornemann S, Wälti MA, Greuter L, Tiberi C, Cadalbert R, Gantner M, Riek R, Hammarström P, Nilsson KPR, Böckmann A, Aguzzi A, Meier BH.

ACS Chem Neurosci. 2018 Mar 21;9(3):475-481. doi: 10.1021/acschemneuro.7b00397. Epub 2017 Dec 4.

PMID:
29178774
33.

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.

Goniotaki D, Lakkaraju AKK, Shrivastava AN, Bakirci P, Sorce S, Senatore A, Marpakwar R, Hornemann S, Gasparini F, Triller A, Aguzzi A.

PLoS Pathog. 2017 Nov 27;13(11):e1006733. doi: 10.1371/journal.ppat.1006733. eCollection 2017 Nov.

34.

A role for astroglia in prion diseases.

Aguzzi A, Liu Y.

J Exp Med. 2017 Dec 4;214(12):3477-3479. doi: 10.1084/jem.20172045. Epub 2017 Nov 21.

35.

Scaling behaviour and rate-determining steps in filamentous self-assembly.

Meisl G, Rajah L, Cohen SAI, Pfammatter M, Šarić A, Hellstrand E, Buell AK, Aguzzi A, Linse S, Vendruscolo M, Dobson CM, Knowles TPJ.

Chem Sci. 2017 Oct 1;8(10):7087-7097. doi: 10.1039/c7sc01965c. Epub 2017 Aug 31.

36.

Strong, generous support for medical research emerges from a large cohort of Swiss patients.

Aguzzi A.

Swiss Med Wkly. 2017 Oct 22;147:w14537. doi: 10.4414/smw.2017.14537. eCollection 2017. No abstract available.

37.

Absolute Quantification of Amyloid Propagons by Digital Microfluidics.

Pfammatter M, Andreasen M, Meisl G, Taylor CG, Adamcik J, Bolisetty S, Sánchez-Ferrer A, Klenerman D, Dobson CM, Mezzenga R, Knowles TPJ, Aguzzi A, Hornemann S.

Anal Chem. 2017 Nov 21;89(22):12306-12313. doi: 10.1021/acs.analchem.7b03279. Epub 2017 Nov 1.

38.

Toward Therapy of Human Prion Diseases.

Aguzzi A, Lakkaraju AKK, Frontzek K.

Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:331-351. doi: 10.1146/annurev-pharmtox-010617-052745. Epub 2017 Sep 27. Review.

39.

NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?

Sorce S, Stocker R, Seredenina T, Holmdahl R, Aguzzi A, Chio A, Depaulis A, Heitz F, Olofsson P, Olsson T, Duveau V, Sanoudou D, Skosgater S, Vlahou A, Wasquel D, Krause KH, Jaquet V.

Free Radic Biol Med. 2017 Nov;112:387-396. doi: 10.1016/j.freeradbiomed.2017.08.006. Epub 2017 Aug 12. Review.

40.

Decreased NOX2 expression in the brain of patients with bipolar disorder: association with valproic acid prescription and substance abuse.

Seredenina T, Sorce S, Herrmann FR, Ma Mulone XJ, Plastre O, Aguzzi A, Jaquet V, Krause KH.

Transl Psychiatry. 2017 Aug 15;7(8):e1206. doi: 10.1038/tp.2017.175.

41.

Microglia in prion diseases.

Aguzzi A, Zhu C.

J Clin Invest. 2017 Sep 1;127(9):3230-3239. doi: 10.1172/JCI90605. Epub 2017 Jul 17. Review.

42.

An R-CaMP1.07 reporter mouse for cell-type-specific expression of a sensitive red fluorescent calcium indicator.

Bethge P, Carta S, Lorenzo DA, Egolf L, Goniotaki D, Madisen L, Voigt FF, Chen JL, Schneider B, Ohkura M, Nakai J, Zeng H, Aguzzi A, Helmchen F.

PLoS One. 2017 Jun 22;12(6):e0179460. doi: 10.1371/journal.pone.0179460. eCollection 2017.

43.

Prion pathogenesis is unaltered in the absence of SIRPα-mediated "don't-eat-me" signaling.

Nuvolone M, Paolucci M, Sorce S, Kana V, Moos R, Matozaki T, Aguzzi A.

PLoS One. 2017 May 17;12(5):e0177876. doi: 10.1371/journal.pone.0177876. eCollection 2017.

44.

The biological function of the cellular prion protein: an update.

Wulf MA, Senatore A, Aguzzi A.

BMC Biol. 2017 May 2;15(1):34. doi: 10.1186/s12915-017-0375-5. Review.

45.

Extended characterization of the novel co-isogenic C57BL/6J Prnp-/- mouse line.

Nuvolone M, Sorce S, Paolucci M, Aguzzi A.

Amyloid. 2017 Mar;24(sup1):36-37. doi: 10.1080/13506129.2017.1289913. No abstract available.

PMID:
28434290
46.

Regulated expression of amyloidogenic immunoglobulin light chains in mice.

Nuvolone M, Sorce S, Pelczar P, Rushing E, Lavatelli F, Rognoni P, Valentini V, Palladini G, Merlini G, Aguzzi A.

Amyloid. 2017 Mar;24(sup1):52-53. doi: 10.1080/13506129.2017.1289914. No abstract available.

PMID:
28434289
47.

Modifiers of prion protein biogenesis and recycling identified by a highly parallel endocytosis kinetics assay.

Ballmer BA, Moos R, Liberali P, Pelkmans L, Hornemann S, Aguzzi A.

J Biol Chem. 2017 May 19;292(20):8356-8368. doi: 10.1074/jbc.M116.773283. Epub 2017 Mar 24.

48.

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

Leske H, Hornemann S, Herrmann US, Zhu C, Dametto P, Li B, Laferriere F, Polymenidou M, Pelczar P, Reimann RR, Schwarz P, Rushing EJ, Wüthrich K, Aguzzi A.

PLoS One. 2017 Feb 16;12(2):e0170503. doi: 10.1371/journal.pone.0170503. eCollection 2017.

49.

Cystatin F is a biomarker of prion pathogenesis in mice.

Nuvolone M, Schmid N, Miele G, Sorce S, Moos R, Schori C, Beerli RR, Bauer M, Saudan P, Dietmeier K, Lachmann I, Linnebank M, Martin R, Kallweit U, Kana V, Rushing EJ, Budka H, Aguzzi A.

PLoS One. 2017 Feb 8;12(2):e0171923. doi: 10.1371/journal.pone.0171923. eCollection 2017.

50.

Correction: Targeting the mTOR Complex by Everolimus in NRAS Mutant Neuroblastoma.

Kiessling MK, Curioni-Fontecedro A, Samaras P, Lang S, Scharl M, Aguzzi A, Oldridge DA, Maris JM, Rogler G.

PLoS One. 2017 Jan 20;12(1):e0170851. doi: 10.1371/journal.pone.0170851. eCollection 2017.

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