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Chronic Airway Diseases Early Stratification (CADSET): a new ERS Clinical Research Collaboration.

Agusti A, Faner R, Donaldson G, Heuvelin E, Breyer-Kohansal R, Melén E, Maitland-van der Zee AH, Vestbo J, Allinson JP, Vanfleteren LEGW, van den Berge M, Adcock IM, Lahousse L, Brusselle G, Wedzicha JA; on behalf of the CADSET Clinical Research Collaboration; Current members of the CADSET Clinical Research Collaboration.

Eur Respir J. 2019 Mar 18;53(3). pii: 1900217. doi: 10.1183/13993003.00217-2019. Print 2019 Mar. No abstract available.


Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease: The GOLD Science Committee Report 2019.

Singh D, Agusti A, Anzueto A, Barnes PJ, Bourbeau J, Celli BR, Criner GJ, Frith P, Halpin DMG, Han M, López Varela MV, Martinez F, Montes de Oca M, Papi A, Pavord ID, Roche N, Sin DD, Stockley R, Vestbo J, Wedzicha JA, Vogelmeier C.

Eur Respir J. 2019 Mar 7. pii: 1900164. doi: 10.1183/13993003.00164-2019. [Epub ahead of print] Review.


Treatable Traits: a new paradigm for 21st century management of chronic airway diseases.

McDonald VM, Fingleton J, Agusti A, Hiles SA, Clark VL, Holland AE, Marks GB, Bardin PP, Beasley R, Pavord ID, Wark PAB, Gibson PG; all the participants in the seminar.

Eur Respir J. 2019 Mar 7. pii: 1802058. doi: 10.1183/13993003.02058-2018. [Epub ahead of print] Review.


Lung function trajectories in health and disease.

Agusti A, Faner R.

Lancet Respir Med. 2019 Feb 11. pii: S2213-2600(18)30529-0. doi: 10.1016/S2213-2600(18)30529-0. [Epub ahead of print] Review.


Arterial Vascular Pruning, Right Ventricular Size and Clinical Outcomes in COPD.

Washko GR, Nardelli P, Ash SY, Vegas Sanchez-Ferrero G, Rahaghi FN, Come CE, Dransfield MT, Kalhan R, Han MK, Bhatt S, Wells JM, Aaron CP, Diaz AA, Ross JC, Cuttica MJ, Labaki WW, Querejeta Roca G, Shah AM, Young K, Kinney GL, Hokanson JE, Agusti A, San José Estépar R; COPDGene Investigators.

Am J Respir Crit Care Med. 2019 Feb 13. doi: 10.1164/rccm.201811-2063OC. [Epub ahead of print]


Prospective observational study in patients with obstructive lung disease: NOVELTY design.

Reddel HK, Gerhardsson de Verdier M, Agustí A, Anderson G, Beasley R, Bel EH, Janson C, Make B, Martin RJ, Pavord I, Price D, Keen C, Gardev A, Rennard S, Sveréus A, Bansal AT, Brannman L, Karlsson N, Nuevo J, Nyberg F, Young SS, Vestbo J.

ERJ Open Res. 2019 Feb 1;5(1). pii: 00036-2018. doi: 10.1183/23120541.00036-2018. eCollection 2019 Feb.


The rationale, design, and methods of a randomized, controlled trial to evaluate the efficacy and safety of an active strategy for the diagnosis and treatment of acute pulmonary embolism during exacerbations of chronic obstructive pulmonary disease.

Jiménez D, Agustí A, Monreal M, Otero R, Huisman MV, Lobo JL, Quezada A, Jara-Palomares L, Hernando A, Tabernero E, Marcos P, Ruiz-Artacho P, Ballaz A, Bertoletti L, Couturaud F, Yusen R; SLICE investigators.

Clin Cardiol. 2019 Mar;42(3):346-351. doi: 10.1002/clc.23161. Epub 2019 Feb 25.


Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis.

Faner R, Morrow JD, Casas-Recasens S, Cloonan SM, Noell G, López-Giraldo A, Tal-Singer R, Miller BE, Silverman EK, Agustí A, Hersh CP.

Respir Res. 2019 Jan 8;20(1):5. doi: 10.1186/s12931-018-0965-y.


Development of a pharmaceutical care program in progressive stages in geriatric institutions.

Mestres C, Hernandez M, Agustí A, Puerta L, Llagostera B, Amorós P.

BMC Geriatr. 2018 Dec 19;18(1):316. doi: 10.1186/s12877-018-1002-1.


Early Life Origins of Asthma: A Review of Potential Effectors.

Bobolea I, Arismendi E, Valero A, Agustí A.

J Investig Allergol Clin Immunol. 2018 Dec 18:0. doi: 10.18176/jiaci.0361. [Epub ahead of print] Review.


Are semantic and episodic autobiographical memories influenced by the life period remembered? Comparison of young and older adults.

Meléndez JC, Agusti AI, Satorres E, Pitarque A.

Eur J Ageing. 2018 Jan 19;15(4):417-424. doi: 10.1007/s10433-018-0457-4. eCollection 2018 Dec.


Physical Activity Is Associated with Attenuated Disease Progression in COPD.

Demeyer H, Donaire-Gonzalez D, Gimeno-Santos E, Ramon MA, de Batlle J, Benet M, Serra I, Guerra S, Farrero E, Rodriguez E, Ferrer J, Sauleda J, Monso E, Gea J, Rodriguez-Roisin R, Agusti A, Antó JM, Garcia-Aymerich J.

Med Sci Sports Exerc. 2018 Dec 7. doi: 10.1249/MSS.0000000000001859. [Epub ahead of print]


Heterogeneity and complexity in bronchiectasis: A pending challenge.

Martinez-Garcia MA, Agustí A.

Arch Bronconeumol. 2018 Nov 20. pii: S0300-2896(18)30344-2. doi: 10.1016/j.arbres.2018.09.010. [Epub ahead of print] English, Spanish. No abstract available.


Determinants of the Appearance and Progression of Early-Onset Chronic Obstructive Pulmonary Disease in Young Adults. A Case-Control Study with Follow-up.

Borràs-Santos A, Garcia-Aymerich J, Soler-Cataluña JJ, Vigil Giménez L, Gea Guiral J, Rodríguez Chiaradía D, Pascual-Guardia S, Marcos Rodríguez PJ, Alvarez Martinez CJ, Casanova Macario C, López-Campos JL, Carrasco Hernández L, Martínez-González C, Santos-Pérez S, Peces-Barba G, Molina Paris J, Román Rodríguez M, Barberà JA, Faner R, Agustí A, Cosío BG; en representación del Grupo Investigador del estudio EARLY COPD.

Arch Bronconeumol. 2018 Nov 11. pii: S0300-2896(18)30341-7. doi: 10.1016/j.arbres.2018.09.007. [Epub ahead of print] English, Spanish.


Current Controversies in Chronic Obstructive Pulmonary Disease. A Report from the Global Initiative for Chronic Obstructive Lung Disease Scientific Committee.

Criner GJ, Martinez FJ, Aaron S, Agusti A, Anzueto A, Bafadhel M, Barnes PJ, Bourbeau J, Chen R, Ewig J, Fabbri LM, Frith P, Halpin DMG, Han M, Montes de Oca M, Nishimura M, O'Donnell D, Papi A, Pavord I, Roche N, Rodriguez-Roisin R, Salvi S, Singh D, Sin DD, Stockley R, López Varela MV, Vestbo J, Vogelmeier CF, Washko G, Wedzicha JA, Celli BR.

Ann Am Thorac Soc. 2019 Jan;16(1):29-39. doi: 10.1513/AnnalsATS.201808-557PS. No abstract available.


Do we really need a new classification of airway diseases?

Agusti A, Pavord ID.

Lancet Respir Med. 2018 Dec;6(12):891-893. doi: 10.1016/S2213-2600(18)30386-2. Epub 2018 Nov 9. No abstract available.


Lessons from a Life: The Manuel Tapia Lecture 2018.

Agusti A.

Arch Bronconeumol. 2019 Mar;55(3):177-180. doi: 10.1016/j.arbres.2018.09.003. Epub 2018 Nov 2. English, Spanish. No abstract available.


The LEAD (Lung, Heart, Social, Body) Study: Objectives, Methodology, and External Validity of the Population-Based Cohort Study.

Breyer-Kohansal R, Hartl S, Burghuber OC, Urban M, Schrott A, Agusti A, Sigsgaard T, Vogelmeier C, Wouters E, Studnicka M, Breyer MK.

J Epidemiol. 2018 Oct 20. doi: 10.2188/jea.JE20180039. [Epub ahead of print]


The BIOMEPOC Project: Personalized Biomarkers and Clinical Profiles in Chronic Obstructive Pulmonary Disease.

Gea J, Pascual S, Castro-Acosta A, Hernández-Carcereny C, Castelo R, Márquez-Martín E, Montón C, Palou A, Faner R, Furlong LI, Seijo L, Sanz F, Torà M, Vilaplana C, Casadevall C, López-Campos JL, Monsó E, Peces-Barba G, Cosío BG, Agustí A; en representación del grupo BIOMEPOC; Anexo. Miembros del grupo BIOMEPOC.

Arch Bronconeumol. 2019 Feb;55(2):93-99. doi: 10.1016/j.arbres.2018.07.026. Epub 2018 Oct 19. English, Spanish.


INTEND II randomized clinical trial of intraoperative duct endoscopy in pathological nipple discharge.

Gui G, Agusti A, Twelves D, Tang S, Kabir M, Montgomery C, Nerurkar A, Osin P, Isacke C.

Br J Surg. 2018 Nov;105(12):1583-1590. doi: 10.1002/bjs.10990. Epub 2018 Sep 20.


Inhaled corticosteroids in COPD: friend or foe?

Agusti A, Fabbri LM, Singh D, Vestbo J, Celli B, Franssen FME, Rabe KF, Papi A.

Eur Respir J. 2018 Dec 13;52(6). pii: 1801219. doi: 10.1183/13993003.01219-2018. Print 2018 Dec. Review.


Treatable traits in bronchiectasis.

Boaventura R, Sibila O, Agusti A, Chalmers JD.

Eur Respir J. 2018 Sep 6;52(3). pii: 1801269. doi: 10.1183/13993003.01269-2018. Print 2018 Sep. No abstract available.


The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD.

Obeidat M, Dvorkin-Gheva A, Li X, Bossé Y, Brandsma CA, Nickle DC, Hansbro PM, Faner R, Agusti A, Paré PD, Stampfli MR, Sin DD.

Sci Rep. 2018 Aug 8;8(1):11881. doi: 10.1038/s41598-018-30313-z.


Circulating eosinophil levels do not predict severe exacerbations in COPD: a retrospective study.

Adir Y, Hakrush O, Shteinberg M, Schneer S, Agusti A.

ERJ Open Res. 2018 Aug 3;4(3). pii: 00022-2018. doi: 10.1183/23120541.00022-2018. eCollection 2018 Jul.


The dyspnoea-inactivity vicious circle in COPD: development and external validation of a conceptual model.

Ramon MA, Ter Riet G, Carsin AE, Gimeno-Santos E, Agustí A, Antó JM, Donaire-Gonzalez D, Ferrer J, Rodríguez E, Rodriguez-Roisin R, Puhan MA, Garcia-Aymerich J; and the PAC-COPD Study Group.

Eur Respir J. 2018 Sep 15;52(3). pii: 1800079. doi: 10.1183/13993003.00079-2018. Print 2018 Sep.


Characterization, localization and comparison of c-Kit+ lung cells in never smokers and smokers with and without COPD.

López-Giraldo A, Cruz T, Molins L, Guirao Á, Saco A, Cuerpo S, Ramirez J, Agustí Á, Faner R.

BMC Pulm Med. 2018 Jul 31;18(1):123. doi: 10.1186/s12890-018-0688-3.


Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.

Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH.

Hum Mol Genet. 2018 Nov 1;27(21):3801-3812. doi: 10.1093/hmg/ddy269.


Distribution, temporal stability and association with all-cause mortality of the 2017 GOLD groups in the ECLIPSE cohort.

Faner R, Noell G, Badia JR, López-Giraldo A, Bakke P, Silverman EK, Tal-Singer R, Agustí A.

Respir Med. 2018 Aug;141:14-19. doi: 10.1016/j.rmed.2018.06.015. Epub 2018 Jun 19.


Precision medicine in COPD exacerbations.

Agusti A, Faner R, Celli B, Rodriguez-Roisin R.

Lancet Respir Med. 2018 Sep;6(9):657-659. doi: 10.1016/S2213-2600(18)30296-0. Epub 2018 Jul 18. No abstract available.


How to Define Early Chronic Obstructive Pulmonary Disease.

Agusti A, Faner R.

Am J Respir Crit Care Med. 2018 Oct 1;198(7):973. doi: 10.1164/rccm.201805-0880LE. No abstract available.


Bone marrow characterization in COPD: a multi-level network analysis.

Toledo-Pons N, Noell G, Jahn A, Iglesias A, Duran MA, Iglesias J, Rios A, Scrimini S, Faner R, Gigirey O, Agustí A, Cosío BG.

Respir Res. 2018 Jun 15;19(1):118. doi: 10.1186/s12931-018-0824-x.


Pulmonary Vascular Involvement in Chronic Obstructive Pulmonary Disease. Is There a Pulmonary Vascular Phenotype?

Kovacs G, Agusti A, Barberà JA, Celli B, Criner G, Humbert M, Sin DD, Voelkel N, Olschewski H.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1000-1011. doi: 10.1164/rccm.201801-0095PP. No abstract available.


Correction to: Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both.

Olloquequi J, Jaime S, Parra V, Cornejo-Córdova E, Valdivia G, Agustí À, Silva RO.

Respir Res. 2018 Apr 30;19(1):77. doi: 10.1186/s12931-018-0765-4.


COPD: time to improve its taxonomy?

Celli BR, Agustí A.

ERJ Open Res. 2018 Feb 16;4(1). pii: 00132-2017. doi: 10.1183/23120541.00132-2017. eCollection 2018 Jan.


The Changing Landscape of Chronic Obstructive Pulmonary Disease.

Agustí A, Faner R.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):978-981. doi: 10.1164/rccm.201804-0714ED. No abstract available.


Hepatopulmonary Disorders: Gas Exchange and Vascular Manifestations in Chronic Liver Disease.

Rodríguez-Roisin R, Krowka MJ, Agustí A.

Compr Physiol. 2018 Mar 25;8(2):711-729. doi: 10.1002/cphy.c170020.


Pharmacological treatment of COPD: the devil is always in the detail.

Singh D, Barnes PJ, Stockley R, Lopez Valera MV, Vogelmeier C, Agusti A.

Eur Respir J. 2018 Apr 19;51(4). pii: 1800263. doi: 10.1183/13993003.00263-2018. Print 2018 Apr. No abstract available.


The disease model: implications for clinical practice.

Agusti A.

Eur Respir J. 2018 Apr 12;51(4). pii: 1800188. doi: 10.1183/13993003.00188-2018. Print 2018 Apr. No abstract available.


Interplay Between the Gut-Brain Axis, Obesity and Cognitive Function.

Agustí A, García-Pardo MP, López-Almela I, Campillo I, Maes M, Romaní-Pérez M, Sanz Y.

Front Neurosci. 2018 Mar 16;12:155. doi: 10.3389/fnins.2018.00155. eCollection 2018. Review.


COPD beyond smoking: new paradigm, novel opportunities.

Agustí A, Faner R.

Lancet Respir Med. 2018 May;6(5):324-326. doi: 10.1016/S2213-2600(18)30060-2. Epub 2018 Feb 26. No abstract available.


Non-commercial vs. commercial clinical trials: a retrospective study of the applications submitted to a research ethics committee.

Fuentes Camps I, Rodríguez A, Agustí A.

Br J Clin Pharmacol. 2018 Jun;84(6):1384-1388. doi: 10.1111/bcp.13555. Epub 2018 Mar 22.


Emphysema and extrapulmonary tissue loss in COPD: a multi-organ loss of tissue phenotype.

Celli BR, Locantore N, Tal-Singer R, Riley J, Miller B, Vestbo J, Yates JC, Silverman EK, Owen CA, Divo M, Pinto-Plata V, Wouters EFM, Faner R, Agusti A; ECLIPSE Study Investigators.

Eur Respir J. 2018 Feb 7;51(2). pii: 1702146. doi: 10.1183/13993003.02146-2017. Print 2018 Feb.


From systems biology to P4 medicine: applications in respiratory medicine.

Noell G, Faner R, Agustí A.

Eur Respir Rev. 2018 Feb 7;27(147). pii: 170110. doi: 10.1183/16000617.0110-2017. Print 2018 Mar 31. Review.


Filling the gaps in COPD: the TRIBUTE study.

Agusti A.

Lancet. 2018 Mar 17;391(10125):1004-1006. doi: 10.1016/S0140-6736(18)30252-6. Epub 2018 Feb 9. No abstract available. Erratum in: Lancet. 2018 Feb 14;:.


Pulmonary function predicts mortality and hospitalizations in outpatients with heart failure and preserved ejection fraction.

Andrea R, López-Giraldo A, Falces C, López T, Sanchis L, Gistau C, Sabaté M, Sitges M, Brugada J, Agustí À.

Respir Med. 2018 Jan;134:124-129. doi: 10.1016/j.rmed.2017.12.004. Epub 2017 Dec 6.


Hospitalizations due to exacerbations of COPD: A big data perspective.

Serra-Picamal X, Roman R, Escarrabill J, García-Altés A, Argimón JM, Soler N, Faner R, Carbonell EM, Trilla A, Agusti A.

Respir Med. 2018 Dec;145:219-225. doi: 10.1016/j.rmed.2018.01.008. Epub 2018 Jan 16.


Persistently elevated exhaled nitric oxide fraction is associated with increased risk of exacerbation in COPD.

Alcázar-Navarrete B, Ruiz Rodríguez O, Conde Baena P, Romero Palacios PJ, Agusti A.

Eur Respir J. 2018 Jan 18;51(1). pii: 1701457. doi: 10.1183/13993003.01457-2017. Print 2018 Jan.


Comparative analysis of COPD associated with tobacco smoking, biomass smoke exposure or both.

Olloquequi J, Jaime S, Parra V, Cornejo-Córdova E, Valdivia G, Agustí À, Silva O R.

Respir Res. 2018 Jan 18;19(1):13. doi: 10.1186/s12931-018-0718-y. Erratum in: Respir Res. 2018 Apr 30;19(1):77.


Clinical News.

Hosgood S, Williams R, Brugada J, Agusti A, Faner R, Noell G.

Br J Hosp Med (Lond). 2018 Jan 2;79(1):8-11. doi: 10.12968/hmed.2018.79.1.8. No abstract available.


Cirrhotic patients with minimal hepatic encephalopathy have increased capacity to eliminate superoxide and peroxynitrite in lymphocytes, associated with cognitive impairment.

Giménez-Garzó C, Urios A, Agustí A, Mangas-Losada A, García-García R, Escudero-García D, Kosenko E, Ordoño JF, Tosca J, Giner-Durán R, Serra MA, Felipo V, Montoliu C.

Free Radic Res. 2018 Jan;52(1):118-133. doi: 10.1080/10715762.2017.1420183.


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