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Calcimimetics maintain bone turnover in uremic rats despite the concomitant decrease in parathyroid hormone concentration.

Díaz-Tocados JM, Rodríguez-Ortiz ME, Almadén Y, Pineda C, Martínez-Moreno JM, Herencia C, Vergara N, Pendón-Ruiz de Mier MV, Santamaría R, Rodelo-Haad C, Casado-Díaz A, Lorenzo V, Carvalho C, Frazão JM, Felsenfeld AJ, Richards WG, Aguilera-Tejero E, Rodríguez M, López I, Muñoz-Castañeda JR.

Kidney Int. 2019 May;95(5):1064-1078. doi: 10.1016/j.kint.2018.12.015. Epub 2019 Mar 12.


Energy-Dense Diets and Mineral Metabolism in the Context of Chronic Kidney Disease⁻Metabolic Bone Disease (CKD-MBD).

Rodriguez M, Aguilera-Tejero E.

Nutrients. 2018 Dec 1;10(12). pii: E1840. doi: 10.3390/nu10121840. Review.


Hypocaloric Diet Prevents the Decrease in FGF21 Elicited by High Phosphorus Intake.

Pineda C, Rios R, Raya AI, Rodriguez M, Aguilera-Tejero E, Lopez I.

Nutrients. 2018 Oct 13;10(10). pii: E1496. doi: 10.3390/nu10101496.


Increased Phosphaturia Accelerates The Decline in Renal Function: A Search for Mechanisms.

Santamaría R, Díaz-Tocados JM, Pendón-Ruiz de Mier MV, Robles A, Salmerón-Rodríguez MD, Ruiz E, Vergara N, Aguilera-Tejero E, Raya A, Ortega R, Felsenfeld A, Muñoz-Castañeda JR, Martín-Malo A, Aljama P, Rodríguez M.

Sci Rep. 2018 Sep 12;8(1):13701. doi: 10.1038/s41598-018-32065-2.


Phosphorus restriction does not prevent the increase in fibroblast growth factor 23 elicited by high fat diet.

Rios R, Pineda C, Lopez I, Muñoz-Castañeda J, Rodriguez M, Aguilera-Tejero E, Raya AI.

PLoS One. 2018 Jun 1;13(6):e0198481. doi: 10.1371/journal.pone.0198481. eCollection 2018.


Vitamin E protects against extraskeletal calcification in uremic rats fed high fat diets.

Rios R, Raya AI, Pineda C, Rodriguez M, Lopez I, Aguilera-Tejero E.

BMC Nephrol. 2017 Dec 28;18(1):374. doi: 10.1186/s12882-017-0790-4.


Treatment of canine leishmaniasis with marbofloxacin in dogs with renal disease.

Pineda C, Aguilera-Tejero E, Morales MC, Belinchon-Lorenzo S, Gomez-Nieto LC, Garcia P, Martinez-Moreno JM, Rodriguez-Ortiz ME, Lopez I.

PLoS One. 2017 Oct 5;12(10):e0185981. doi: 10.1371/journal.pone.0185981. eCollection 2017.


Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats.

Diaz-Tocados JM, Peralta-Ramirez A, Rodríguez-Ortiz ME, Raya AI, Lopez I, Pineda C, Herencia C, Montes de Oca A, Vergara N, Steppan S, Pendon-Ruiz de Mier MV, Buendía P, Carmona A, Carracedo J, Alcalá-Díaz JF, Frazao J, Martínez-Moreno JM, Canalejo A, Felsenfeld A, Rodriguez M, Aguilera-Tejero E, Almadén Y, Muñoz-Castañeda JR.

Kidney Int. 2017 Nov;92(5):1084-1099. doi: 10.1016/j.kint.2017.04.011. Epub 2017 Jul 29.


Obesity-induced discrepancy between contractile and metabolic phenotypes in slow- and fast-twitch skeletal muscles of female obese Zucker rats.

Acevedo LM, Raya AI, Ríos R, Aguilera-Tejero E, Rivero JL.

J Appl Physiol (1985). 2017 Jul 1;123(1):249-259. doi: 10.1152/japplphysiol.00282.2017. Epub 2017 May 18.


Mangiferin protects against adverse skeletal muscle changes and enhances muscle oxidative capacity in obese rats.

Acevedo LM, Raya AI, Martínez-Moreno JM, Aguilera-Tejero E, Rivero JL.

PLoS One. 2017 Mar 2;12(3):e0173028. doi: 10.1371/journal.pone.0173028. eCollection 2017.


Leptin directly stimulates parathyroid hormone secretion.

Lopez I, Pineda C, Raya AI, Rodriguez-Ortiz ME, Diaz-Tocados JM, Rios R, Rodriguez JM, Aguilera-Tejero E, Almaden Y.

Endocrine. 2017 Jun;56(3):675-678. doi: 10.1007/s12020-016-1207-z. Epub 2016 Dec 16. No abstract available.


Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats.

Raya AI, Rios R, Pineda C, Rodriguez-Ortiz ME, Diez E, Almaden Y, Muñoz-Castañeda JR, Rodriguez M, Aguilera-Tejero E, Lopez I.

Sci Rep. 2016 Nov 14;6:36881. doi: 10.1038/srep36881.


Chronic Vitamin D Intoxication in Captive Iberian Lynx (Lynx pardinus).

Lopez I, Pineda C, Muñoz L, Raya A, Lopez G, Aguilera-Tejero E.

PLoS One. 2016 May 31;11(5):e0156331. doi: 10.1371/journal.pone.0156331. eCollection 2016.


Endocrine, morphometric, and ultrasonographic characterization of neck adiposity in Andalusian horses.

Martin-Gimenez T, de Blas I, Aguilera-Tejero E, Diez de Castro E, Aguirre-Pascasio CN.

Domest Anim Endocrinol. 2016 Jul;56:57-62. doi: 10.1016/j.domaniend.2016.02.003. Epub 2016 Feb 26.


Eosinophilic Enteritis in Horses with Motor Neuron Disease.

Díez de Castro E, Zafra R, Acevedo LM, Pérez J, Acosta I, Rivero JL, Aguilera-Tejero E.

J Vet Intern Med. 2016 May;30(3):873-9. doi: 10.1111/jvim.13944. Epub 2016 Mar 26.


High-phosphorus diet maximizes and low-dose calcitriol attenuates skeletal muscle changes in long-term uremic rats.

Acevedo LM, López I, Peralta-Ramírez A, Pineda C, Chamizo VE, Rodríguez M, Aguilera-Tejero E, Rivero JL.

J Appl Physiol (1985). 2016 May 1;120(9):1059-69. doi: 10.1152/japplphysiol.00957.2015. Epub 2016 Feb 11.


Dissolution of Urinary Bladder Clots in a Dog with Alteplase.

Pineda C, Guisado A, Aguilera-Tejero E, Lopez I.

J Vet Intern Med. 2015 Nov-Dec;29(6):1627-8. doi: 10.1111/jvim.13637. Epub 2015 Oct 12. No abstract available.


Slow- and fast-twitch hindlimb skeletal muscle phenotypes 12 wk after ⅚ nephrectomy in Wistar rats of both sexes.

Acevedo LM, Peralta-Ramírez A, López I, Chamizo VE, Pineda C, Rodríguez-Ortiz ME, Rodríguez M, Aguilera-Tejero E, Rivero JL.

Am J Physiol Renal Physiol. 2015 Oct 1;309(7):F638-47. doi: 10.1152/ajprenal.00195.2015. Epub 2015 Aug 5.


Effects of two calculolytic diets on parameters of feline mineral metabolism.

Pineda C, Aguilera-Tejero E, Raya AI, Montes de Oca A, Rodriguez M, Lopez I.

J Small Anim Pract. 2015 Aug;56(8):499-504. doi: 10.1111/jsap.12368. Epub 2015 May 26.


Repeated measurements of P retention in ponies fed rations with various Ca:P ratios.

van Doorn DA, Schaafstra FJ, Wouterse H, Everts H, Estepa JC, Aguilera-Tejero E, Beynen AC.

J Anim Sci. 2014 Nov;92(11):4981-90. doi: 10.2527/jas.2014-7632.


Acid-base balance in uremic rats with vascular calcification.

Peralta-Ramírez A, Raya AI, Pineda C, Rodríguez M, Aguilera-Tejero E, López I.

Nephron Extra. 2014 Jul 2;4(2):89-94. doi: 10.1159/000363298. eCollection 2014 Jan.


Influence of feeding status, time of the day, and season on baseline adrenocorticotropic hormone and the response to thyrotropin releasing hormone-stimulation test in healthy horses.

Diez de Castro E, Lopez I, Cortes B, Pineda C, Garfia B, Aguilera-Tejero E.

Domest Anim Endocrinol. 2014 Jul;48:77-83. doi: 10.1016/j.domaniend.2014.02.004. Epub 2014 Mar 5.


Magnesium inhibits Wnt/β-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells.

Montes de Oca A, Guerrero F, Martinez-Moreno JM, Madueño JA, Herencia C, Peralta A, Almaden Y, Lopez I, Aguilera-Tejero E, Gundlach K, Büchel J, Peter ME, Passlick-Deetjen J, Rodriguez M, Muñoz-Castañeda JR.

PLoS One. 2014 Feb 25;9(2):e89525. doi: 10.1371/journal.pone.0089525. eCollection 2014.


TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathways.

Guerrero F, Herencia C, Almadén Y, Martínez-Moreno JM, Montes de Oca A, Rodriguez-Ortiz ME, Diaz-Tocados JM, Canalejo A, Florio M, López I, Richards WG, Rodriguez M, Aguilera-Tejero E, Muñoz-Castañeda JR.

PLoS One. 2014 Feb 27;9(2):e89179. doi: 10.1371/journal.pone.0089179. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e101910.


Vitamin E protection of obesity-enhanced vascular calcification in uremic rats.

Peralta-Ramírez A, Montes de Oca A, Raya AI, Pineda C, López I, Guerrero F, Diez E, Muñoz-Castañeda JR, Martinez J, Almaden Y, Rodríguez M, Aguilera-Tejero E.

Am J Physiol Renal Physiol. 2014 Feb 15;306(4):F422-9. doi: 10.1152/ajprenal.00355.2013. Epub 2013 Dec 26.


Assessment of calcitonin response to experimentally induced hypercalcemia in cats.

Pineda C, Aguilera-Tejero E, Raya AI, Guerrero F, Rodriguez M, Lopez I.

Am J Vet Res. 2013 Dec;74(12):1514-21. doi: 10.2460/ajvr.74.12.1514.


Mineral metabolism in growing cats: changes in the values of blood parameters with age.

Pineda C, Aguilera-Tejero E, Guerrero F, Raya AI, Rodriguez M, Lopez I.

J Feline Med Surg. 2013 Oct;15(10):866-71. doi: 10.1177/1098612X13478264. Epub 2013 Feb 14.


Comparison of different treatments for oestrous induction in seasonally anovulatory mares.

Vizuete G, Diez E, Galisteo J, Agüera E, Aguilera-Tejero E, Perez-Marín CC.

Reprod Domest Anim. 2013 Jun;48(3):463-9. doi: 10.1111/rda.12098. Epub 2012 Nov 9.


In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation.

Martínez-Moreno JM, Muñoz-Castañeda JR, Herencia C, Oca AM, Estepa JC, Canalejo R, Rodríguez-Ortiz ME, Perez-Martinez P, Aguilera-Tejero E, Canalejo A, Rodríguez M, Almadén Y.

Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1136-44. doi: 10.1152/ajprenal.00684.2011. Epub 2012 Aug 8.


FGF23 and mineral metabolism, implications in CKD-MBD.

Rodríguez M, López I, Muñoz J, Aguilera-Tejero E, Almaden Y.

Nefrologia. 2012 May 14;32(3):275-8. doi: 10.3265/Nefrologia.pre2012.Mar.11415. Review. No abstract available.


Calcium deficiency reduces circulating levels of FGF23.

Rodriguez-Ortiz ME, Lopez I, Muñoz-Castañeda JR, Martinez-Moreno JM, Ramírez AP, Pineda C, Canalejo A, Jaeger P, Aguilera-Tejero E, Rodriguez M, Felsenfeld A, Almaden Y.

J Am Soc Nephrol. 2012 Jul;23(7):1190-7. doi: 10.1681/ASN.2011101006. Epub 2012 May 10.


Plasma leptin concentration in donkeys.

Díez E, López I, Pérez C, Pineda C, Aguilera-Tejero E.

Vet Q. 2012;32(1):13-6. doi: 10.1080/01652176.2012.677867. Epub 2012 Apr 11.


Feline parathyroid hormone: validation of hormonal assays and dynamics of secretion.

Pineda C, Aguilera-Tejero E, Raya AI, Diez E, Rodriguez M, Lopez I.

Domest Anim Endocrinol. 2012 May;42(4):256-64. doi: 10.1016/j.domaniend.2012.01.003. Epub 2012 Feb 8.


The effect of vitamin D derivatives on vascular calcification associated with inflammation.

Guerrero F, Montes de Oca A, Aguilera-Tejero E, Zafra R, Rodríguez M, López I.

Nephrol Dial Transplant. 2012 Jun;27(6):2206-12. doi: 10.1093/ndt/gfr555. Epub 2011 Oct 24.


Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo.

López I, Rodríguez-Ortiz ME, Almadén Y, Guerrero F, de Oca AM, Pineda C, Shalhoub V, Rodríguez M, Aguilera-Tejero E.

Kidney Int. 2011 Sep;80(5):475-82. doi: 10.1038/ki.2011.107. Epub 2011 Apr 27.


Localization, distribution, and function of the calcium-sensing receptor in sperm.

Mendoza FJ, Perez-Marin CC, Garcia-Marin L, Madueño JA, Henley C, Aguilera-Tejero E, Rodriguez M.

J Androl. 2012 Jan-Feb;33(1):96-104. doi: 10.2164/jandrol.110.011254. Epub 2011 Mar 10.


Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells.

Mendoza FJ, Martinez-Moreno J, Almaden Y, Rodriguez-Ortiz ME, Lopez I, Estepa JC, Henley C, Rodriguez M, Aguilera-Tejero E.

Calcif Tissue Int. 2011 Mar;88(3):169-78. doi: 10.1007/s00223-010-9442-4. Epub 2010 Dec 15.


High-phosphate-induced calcification is related to SM22α promoter methylation in vascular smooth muscle cells.

Montes de Oca A, Madueño JA, Martinez-Moreno JM, Guerrero F, Muñoz-Castañeda J, Rodriguez-Ortiz ME, Mendoza FJ, Almaden Y, Lopez I, Rodriguez M, Aguilera-Tejero E.

J Bone Miner Res. 2010 Sep;25(9):1996-2005. doi: 10.1002/jbmr.93.


ECG of the month. Atrial premature complexes in a horse.

Diez E, Estepa JC, Aguilera-Tejero E.

J Am Vet Med Assoc. 2009 Dec 1;235(11):1288-9. doi: 10.2460/javma.235.11.1288. No abstract available.


Calcimimetics normalize the phosphate-induced stimulation of PTH secretion in vivo and in vitro.

Almaden Y, Rodriguez-Ortiz ME, Canalejo A, Cañadillas S, Canalejo R, Martin D, Aguilera-Tejero E, Rodríguez M.

J Nephrol. 2009 Mar-Apr;22(2):281-8.


The calcimimetic AMG 641 accelerates regression of extraosseous calcification in uremic rats.

Lopez I, Mendoza FJ, Guerrero F, Almaden Y, Henley C, Aguilera-Tejero E, Rodriguez M.

Am J Physiol Renal Physiol. 2009 Jun;296(6):F1376-85. doi: 10.1152/ajprenal.90737.2008. Epub 2009 Mar 25.


Clinical, pathological and immunohistochemical features of a pulmonary blastoma in a horse.

Pérez-Ecija RA, Mendoza FJ, Zafra R, Estepa JC, Aguilera-Tejero E, Mozos E, Pérez J.

Vet Rec. 2009 Feb 7;164(6):182-3. No abstract available.


Direct upregulation of parathyroid calcium-sensing receptor and vitamin D receptor by calcimimetics in uremic rats.

Mendoza FJ, Lopez I, Canalejo R, Almaden Y, Martin D, Aguilera-Tejero E, Rodriguez M.

Am J Physiol Renal Physiol. 2009 Mar;296(3):F605-13. doi: 10.1152/ajprenal.90272.2008. Epub 2008 Dec 17.


Effects of calcimimetics on extraskeletal calcifications in chronic kidney disease.

Rodríguez M, Aguilera-Tejero E, Mendoza FJ, Guerrero F, López I.

Kidney Int Suppl. 2008 Dec;(111):S50-4. doi: 10.1038/ki.2008.546. Review.


Circadian variation of the Ca2+ -PTH curve during hypercalcaemia in dogs.

Domingo V, López I, Mendoza FJ, Rodríguez M, Aguilera-Tejero E, Estepa JC.

J Vet Med A Physiol Pathol Clin Med. 2007 Dec;54(10):545-8.


The effect of calcitriol, paricalcitol, and a calcimimetic on extraosseous calcifications in uremic rats.

Lopez I, Mendoza FJ, Aguilera-Tejero E, Perez J, Guerrero F, Martin D, Rodriguez M.

Kidney Int. 2008 Feb;73(3):300-7. Epub 2007 Nov 14.


Metabolic acidosis inhibits soft tissue calcification in uremic rats.

Mendoza FJ, Lopez I, Montes de Oca A, Perez J, Rodriguez M, Aguilera-Tejero E.

Kidney Int. 2008 Feb;73(4):407-14. Epub 2007 Nov 7.


Dynamics of parathyroid hormone secretion in health and secondary hyperparathyroidism.

Felsenfeld AJ, Rodríguez M, Aguilera-Tejero E.

Clin J Am Soc Nephrol. 2007 Nov;2(6):1283-305. Epub 2007 Oct 17. Review.


Effects of intensity and duration of exercise on muscular responses to training of thoroughbred racehorses.

Rivero JL, Ruz A, Martí-Korff S, Estepa JC, Aguilera-Tejero E, Werkman J, Sobotta M, Lindner A.

J Appl Physiol (1985). 2007 May;102(5):1871-82. Epub 2007 Jan 25.


The calcimimetic R-568 increases vitamin D receptor expression in rat parathyroid glands.

Rodriguez ME, Almaden Y, Cañadillas S, Canalejo A, Siendones E, Lopez I, Aguilera-Tejero E, Martin D, Rodriguez M.

Am J Physiol Renal Physiol. 2007 May;292(5):F1390-5. Epub 2007 Jan 2.

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