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Modified sialic acids on mucus and erythrocytes inhibit influenza A HA and NA functions.

Barnard KN, Alford-Lawrence BK, Buchholz DW, Wasik BR, LaClair JR, Yu H, Honce R, Ruhl S, Pajic P, Daugherity EK, Chen X, Schultz-Cherry SL, Aguilar HC, Varki A, Parrish CR.

J Virol. 2020 Feb 12. pii: JVI.01567-19. doi: 10.1128/JVI.01567-19. [Epub ahead of print]


Expression of 9-O- and 7,9-O-Acetyl Modified Sialic Acid in Cells and Their Effects on Influenza Viruses.

Barnard KN, Wasik BR, LaClair JR, Buchholz DW, Weichert WS, Alford-Lawrence BK, Aguilar HC, Parrish CR.

mBio. 2019 Dec 3;10(6). pii: e02490-19. doi: 10.1128/mBio.02490-19.


Nipah Virus-Like Particle Egress Is Modulated by Cytoskeletal and Vesicular Trafficking Pathways: a Validated Particle Proteomics Analysis.

Johnston GP, Bradel-Tretheway B, Piehowski PD, Brewer HM, Lee BNR, Usher NT, Zamora JLR, Ortega V, Contreras EM, Teuton JR, Wendler JP, Matz KM, Adkins JN, Aguilar HC.

mSystems. 2019 Sep 24;4(5). pii: e00194-19. doi: 10.1128/mSystems.00194-19.


Nipah and Hendra Virus Glycoproteins Induce Comparable Homologous but Distinct Heterologous Fusion Phenotypes.

Bradel-Tretheway BG, Zamora JLR, Stone JA, Liu Q, Li J, Aguilar HC.

J Virol. 2019 Jun 14;93(13). pii: e00577-19. doi: 10.1128/JVI.00577-19. Print 2019 Jul 1.


Broad-spectrum antiviral JL122 blocks infection and inhibits transmission of aquatic rhabdoviruses.

Balmer BF, Getchell RG, Powers RL, Lee J, Zhang T, Jung ME, Purcell MK, Snekvik K, Aguilar HC.

Virology. 2018 Dec;525:143-149. doi: 10.1016/j.virol.2018.09.009. Epub 2018 Oct 1.


A stochastic assembly model for Nipah virus revealed by super-resolution microscopy.

Liu Q, Chen L, Aguilar HC, Chou KC.

Nat Commun. 2018 Aug 3;9(1):3050. doi: 10.1038/s41467-018-05480-2.


Addicted to sugar: roles of glycans in the order Mononegavirales.

Ortega V, Stone JA, Contreras EM, Iorio RM, Aguilar HC.

Glycobiology. 2019 Jan 1;29(1):2-21. doi: 10.1093/glycob/cwy053.


Flow virometry as a tool to study viruses.

Zamora JLR, Aguilar HC.

Methods. 2018 Feb 1;134-135:87-97. doi: 10.1016/j.ymeth.2017.12.011. Epub 2017 Dec 16. Review.


Cytoplasmic Motifs in the Nipah Virus Fusion Protein Modulate Virus Particle Assembly and Egress.

Johnston GP, Contreras EM, Dabundo J, Henderson BA, Matz KM, Ortega V, Ramirez A, Park A, Aguilar HC.

J Virol. 2017 Apr 28;91(10). pii: e02150-16. doi: 10.1128/JVI.02150-16. Print 2017 May 15.


Paramyxovirus Glycoproteins and the Membrane Fusion Process.

Aguilar HC, Henderson BA, Zamora JL, Johnston GP.

Curr Clin Microbiol Rep. 2016 Sep;3(3):142-154. doi: 10.1007/s40588-016-0040-8. Epub 2016 Jul 5.


Ovine Herpesvirus 2 Glycoproteins B, H, and L Are Sufficient for, and Viral Glycoprotein Ov8 Can Enhance, Cell-Cell Membrane Fusion.

AlHajri SM, Cunha CW, Nicola AV, Aguilar HC, Li H, Taus NS.

J Virol. 2017 Feb 28;91(6). pii: e02454-16. doi: 10.1128/JVI.02454-16. Print 2017 Mar 15.


Mildly Acidic pH Triggers an Irreversible Conformational Change in the Fusion Domain of Herpes Simplex Virus 1 Glycoprotein B and Inactivation of Viral Entry.

Weed DJ, Pritchard SM, Gonzalez F, Aguilar HC, Nicola AV.

J Virol. 2017 Feb 14;91(5). pii: e02123-16. doi: 10.1128/JVI.02123-16. Print 2017 Mar 1.


Inhibition of an Aquatic Rhabdovirus Demonstrates Promise of a Broad-Spectrum Antiviral for Use in Aquaculture.

Balmer BF, Powers RL, Zhang TH, Lee J, Vigant F, Lee B, Jung ME, Purcell MK, Snekvik K, Aguilar HC.

J Virol. 2017 Jan 31;91(4). pii: e02181-16. doi: 10.1128/JVI.02181-16. Print 2017 Feb 15.


Multiple Strategies Reveal a Bidentate Interaction between the Nipah Virus Attachment and Fusion Glycoproteins.

Stone JA, Vemulapati BM, Bradel-Tretheway B, Aguilar HC.

J Virol. 2016 Nov 14;90(23):10762-10773. doi: 10.1128/JVI.01469-16. Print 2016 Dec 1.


Measles Virus Fusion Protein: Structure, Function and Inhibition.

Plattet P, Alves L, Herren M, Aguilar HC.

Viruses. 2016 Apr 21;8(4):112. doi: 10.3390/v8040112. Review.


Multiple Novel Functions of Henipavirus O-glycans: The First O-glycan Functions Identified in the Paramyxovirus Family.

Stone JA, Nicola AV, Baum LG, Aguilar HC.

PLoS Pathog. 2016 Feb 11;12(2):e1005445. doi: 10.1371/journal.ppat.1005445. eCollection 2016 Feb.


Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly.

Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB.

PLoS Pathog. 2015 Dec 8;11(12):e1005322. doi: 10.1371/journal.ppat.1005322. eCollection 2015 Dec.


Polyethylene glycol-mediated fusion of herpes simplex type 1 virions with the plasma membrane of cells that support endocytic entry.

Walker EB, Pritchard SM, Cunha CW, Aguilar HC, Nicola AV.

Virol J. 2015 Nov 16;12:190. doi: 10.1186/s12985-015-0423-0.


Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors.

Zhao Y, Yang C, Organ C, Li Z, Bhushan S, Otsuka H, Pacheco A, Kang J, Aguilar HC, Lefer DJ, Xian M.

J Med Chem. 2015 Sep 24;58(18):7501-11. doi: 10.1021/acs.jmedchem.5b01033. Epub 2015 Sep 4.


Widely Used Herpes Simplex Virus 1 ICP0 Deletion Mutant Strain dl1403 and Its Derivative Viruses Do Not Express Glycoprotein C Due to a Secondary Mutation in the gC Gene.

Cunha CW, Taylor KE, Pritchard SM, Delboy MG, Komala Sari T, Aguilar HC, Mossman KL, Nicola AV.

PLoS One. 2015 Jul 17;10(7):e0131129. doi: 10.1371/journal.pone.0131129. eCollection 2015.


Novel Functions of Hendra Virus G N-Glycans and Comparisons to Nipah Virus.

Bradel-Tretheway BG, Liu Q, Stone JA, McInally S, Aguilar HC.

J Virol. 2015 Jul;89(14):7235-47. doi: 10.1128/JVI.00773-15. Epub 2015 May 6.


Branched dimerization of Tat peptide improves permeability to HeLa and hippocampal neuronal cells.

Monreal IA, Liu Q, Tyson K, Bland T, Dalisay DS, Adams EV, Wayman GA, Aguilar HC, Saludes JP.

Chem Commun (Camb). 2015 Mar 28;51(25):5463-6. doi: 10.1039/c5cc00882d.


Antibodies to ovine herpesvirus 2 glycoproteins decrease virus infectivity and prevent malignant catarrhal fever in rabbits.

Cunha CW, Knowles DP, Taus NS, O'Toole D, Nicola AV, Aguilar HC, Li H.

Vet Microbiol. 2015 Feb 25;175(2-4):349-55. doi: 10.1016/j.vetmic.2014.11.026. Epub 2014 Dec 9.


Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytium formation in endothelial cells.

Garner OB, Yun T, Pernet O, Aguilar HC, Park A, Bowden TA, Freiberg AN, Lee B, Baum LG.

J Virol. 2015 Mar;89(5):2520-9. doi: 10.1128/JVI.02435-14. Epub 2014 Dec 10.


Nipah virus attachment glycoprotein stalk C-terminal region links receptor binding to fusion triggering.

Liu Q, Bradel-Tretheway B, Monreal AI, Saludes JP, Lu X, Nicola AV, Aguilar HC.

J Virol. 2015 Feb;89(3):1838-50. doi: 10.1128/JVI.02277-14. Epub 2014 Nov 26.


Nipah virion entry kinetics, composition, and conformational changes determined by enzymatic virus-like particles and new flow virometry tools.

Landowski M, Dabundo J, Liu Q, Nicola AV, Aguilar HC.

J Virol. 2014 Dec;88(24):14197-206. doi: 10.1128/JVI.01632-14. Epub 2014 Oct 1.


Molecular requirement for sterols in herpes simplex virus entry and infectivity.

Wudiri GA, Pritchard SM, Li H, Liu J, Aguilar HC, Gilk SD, Nicola AV.

J Virol. 2014 Dec;88(23):13918-22. doi: 10.1128/JVI.01615-14. Epub 2014 Sep 17.


Fluorescent probes based on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging.

Peng B, Chen W, Liu C, Rosser EW, Pacheco A, Zhao Y, Aguilar HC, Xian M.

Chemistry. 2014 Jan 20;20(4):1010-6. doi: 10.1002/chem.201303757. Epub 2013 Dec 11.


Unraveling a three-step spatiotemporal mechanism of triggering of receptor-induced Nipah virus fusion and cell entry.

Liu Q, Stone JA, Bradel-Tretheway B, Dabundo J, Benavides Montano JA, Santos-Montanez J, Biering SB, Nicola AV, Iorio RM, Lu X, Aguilar HC.

PLoS Pathog. 2013;9(11):e1003770. doi: 10.1371/journal.ppat.1003770. Epub 2013 Nov 21.


Contributions of herpes simplex virus 1 envelope proteins to entry by endocytosis.

Komala Sari T, Pritchard SM, Cunha CW, Wudiri GA, Laws EI, Aguilar HC, Taus NS, Nicola AV.

J Virol. 2013 Dec;87(24):13922-6. doi: 10.1128/JVI.02500-13. Epub 2013 Oct 9.


Virus entry by endocytosis.

Nicola AV, Aguilar HC, Mercer J, Ryckman B, Wiethoff CM.

Adv Virol. 2013;2013:469538. doi: 10.1155/2013/469538. Epub 2013 Apr 21. No abstract available.


A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion.

Vigant F, Lee J, Hollmann A, Tanner LB, Akyol Ataman Z, Yun T, Shui G, Aguilar HC, Zhang D, Meriwether D, Roman-Sosa G, Robinson LR, Juelich TL, Buczkowski H, Chou S, Castanho MA, Wolf MC, Smith JK, Banyard A, Kielian M, Reddy S, Wenk MR, Selke M, Santos NC, Freiberg AN, Jung ME, Lee B.

PLoS Pathog. 2013;9(4):e1003297. doi: 10.1371/journal.ppat.1003297. Epub 2013 Apr 18.


Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury.

Zhao Y, Bhushan S, Yang C, Otsuka H, Stein JD, Pacheco A, Peng B, Devarie-Baez NO, Aguilar HC, Lefer DJ, Xian M.

ACS Chem Biol. 2013;8(6):1283-90. doi: 10.1021/cb400090d. Epub 2013 Apr 16.


Individual N-glycans added at intervals along the stalk of the Nipah virus G protein prevent fusion but do not block the interaction with the homologous F protein.

Zhu Q, Biering SB, Mirza AM, Grasseschi BA, Mahon PJ, Lee B, Aguilar HC, Iorio RM.

J Virol. 2013 Mar;87(6):3119-29. doi: 10.1128/JVI.03084-12. Epub 2013 Jan 2.


Detection of receptor-induced glycoprotein conformational changes on enveloped virions by using confocal micro-Raman spectroscopy.

Lu X, Liu Q, Benavides-Montano JA, Nicola AV, Aston DE, Rasco BA, Aguilar HC.

J Virol. 2013 Mar;87(6):3130-42. doi: 10.1128/JVI.03220-12. Epub 2013 Jan 2.


N-Glycans on the Nipah virus attachment glycoprotein modulate fusion and viral entry as they protect against antibody neutralization.

Biering SB, Huang A, Vu AT, Robinson LR, Bradel-Tretheway B, Choi E, Lee B, Aguilar HC.

J Virol. 2012 Nov;86(22):11991-2002. doi: 10.1128/JVI.01304-12. Epub 2012 Aug 22.


Cysteines in the stalk of the nipah virus G glycoprotein are located in a distinct subdomain critical for fusion activation.

Maar D, Harmon B, Chu D, Schulz B, Aguilar HC, Lee B, Negrete OA.

J Virol. 2012 Jun;86(12):6632-42. doi: 10.1128/JVI.00076-12. Epub 2012 Apr 11.


Henipavirus membrane fusion and viral entry.

Aguilar HC, Iorio RM.

Curr Top Microbiol Immunol. 2012;359:79-94. doi: 10.1007/82_2012_200. Review.


Triggering of the newcastle disease virus fusion protein by a chimeric attachment protein that binds to Nipah virus receptors.

Mirza AM, Aguilar HC, Zhu Q, Mahon PJ, Rota PA, Lee B, Iorio RM.

J Biol Chem. 2011 May 20;286(20):17851-60. doi: 10.1074/jbc.M111.233965. Epub 2011 Apr 1.


Interactions of human complement with virus particles containing the Nipah virus glycoproteins.

Johnson JB, Aguilar HC, Lee B, Parks GD.

J Virol. 2011 Jun;85(12):5940-8. doi: 10.1128/JVI.00193-11. Epub 2011 Mar 30.


Emerging paramyxoviruses: molecular mechanisms and antiviral strategies.

Aguilar HC, Lee B.

Expert Rev Mol Med. 2011 Feb 24;13:e6. doi: 10.1017/S1462399410001754. Review.


Endothelial galectin-1 binds to specific glycans on nipah virus fusion protein and inhibits maturation, mobility, and function to block syncytia formation.

Garner OB, Aguilar HC, Fulcher JA, Levroney EL, Harrison R, Wright L, Robinson LR, Aspericueta V, Panico M, Haslam SM, Morris HR, Dell A, Lee B, Baum LG.

PLoS Pathog. 2010 Jul 15;6(7):e1000993. doi: 10.1371/journal.ppat.1000993.


A quantitative and kinetic fusion protein-triggering assay can discern distinct steps in the nipah virus membrane fusion cascade.

Aguilar HC, Aspericueta V, Robinson LR, Aanensen KE, Lee B.

J Virol. 2010 Aug;84(16):8033-41. doi: 10.1128/JVI.00469-10. Epub 2010 Jun 2.


A broad-spectrum antiviral targeting entry of enveloped viruses.

Wolf MC, Freiberg AN, Zhang T, Akyol-Ataman Z, Grock A, Hong PW, Li J, Watson NF, Fang AQ, Aguilar HC, Porotto M, Honko AN, Damoiseaux R, Miller JP, Woodson SE, Chantasirivisal S, Fontanes V, Negrete OA, Krogstad P, Dasgupta A, Moscona A, Hensley LE, Whelan SP, Faull KF, Holbrook MR, Jung ME, Lee B.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3157-62. doi: 10.1073/pnas.0909587107. Epub 2010 Jan 28.


A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F).

Aguilar HC, Ataman ZA, Aspericueta V, Fang AQ, Stroud M, Negrete OA, Kammerer RA, Lee B.

J Biol Chem. 2009 Jan 16;284(3):1628-35. doi: 10.1074/jbc.M807469200. Epub 2008 Nov 19.


Single amino acid changes in the Nipah and Hendra virus attachment glycoproteins distinguish ephrinB2 from ephrinB3 usage.

Negrete OA, Chu D, Aguilar HC, Lee B.

J Virol. 2007 Oct;81(19):10804-14. Epub 2007 Jul 25.


Polybasic KKR motif in the cytoplasmic tail of Nipah virus fusion protein modulates membrane fusion by inside-out signaling.

Aguilar HC, Matreyek KA, Choi DY, Filone CM, Young S, Lee B.

J Virol. 2007 May;81(9):4520-32. Epub 2007 Feb 14.


N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry.

Aguilar HC, Matreyek KA, Filone CM, Hashimi ST, Levroney EL, Negrete OA, Bertolotti-Ciarlet A, Choi DY, McHardy I, Fulcher JA, Su SV, Wolf MC, Kohatsu L, Baum LG, Lee B.

J Virol. 2006 May;80(10):4878-89.


Rho GTPase activity modulates paramyxovirus fusion protein-mediated cell-cell fusion.

Schowalter RM, Wurth MA, Aguilar HC, Lee B, Moncman CL, McCann RO, Dutch RE.

Virology. 2006 Jul 5;350(2):323-34. Epub 2006 Feb 28.

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