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Imaging Biomarkers in Translational Small Animal Models.

Aguiar P, Fernández-Ferreiro A, Galli F, Tsoumpas C.

Contrast Media Mol Imaging. 2019 Feb 4;2019:9469041. doi: 10.1155/2019/9469041. eCollection 2019. No abstract available.


Back to the Future: In the Era of Cost-Effectiveness Analysis, Affordability Is a Limiting Factor for Patients' Access to Innovative Cancer Treatments.

Aguiar PN Jr, Roitberg F, Noia Barreto CM, Adashek JJ, Del Giglio A, Lopes GL Jr.

Value Health Reg Issues. 2019 Mar 8;20:47-50. doi: 10.1016/j.vhri.2018.12.003. [Epub ahead of print]


Cost-effectiveness analysis of abiraterone, docetaxel or placebo plus androgen deprivation therapy for hormone-sensitive advanced prostate cancer.

Aguiar PN Jr, Tan PS, Simko S, Barreto CMN, Gutierres BS, Giglio AD, Lopes GL Jr.

Einstein (Sao Paulo). 2019 Mar 7;17(2):eGS4414. doi: 10.31744/einstein_journal/2019GS4414. English, Portuguese.


Improved in vitro electrophysiology using 3D-structured microelectrode arrays with a micro-mushrooms islets architecture capable of promoting topotaxis.

Mateus J, Lopes C, Cerquido M, Leitão L, Leitao DC, Cardoso S, Ventura J, Aguiar P.

J Neural Eng. 2019 Feb 28. doi: 10.1088/1741-2552/ab0b86. [Epub ahead of print]


[Multimorbidity and Disease Severity Measured by the Charlson Index in Portuguese Hospitalised Patients During the Year 2015: A Cross-Sectional Study].

Broeiro-Gonçalves P, Nogueira P, Aguiar P.

Acta Med Port. 2019 Feb 1;32(1):38-46. doi: 10.20344/amp.9728. Epub 2019 Feb 1. Portuguese.


Albendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism.

Furtado LFV, de Aguiar PHN, Zuccherato LW, Teixeira TTG, Alves WP, da Silva VJ, Gasser RB, Rabelo ÉML.

Parasitol Res. 2019 Mar;118(3):837-849. doi: 10.1007/s00436-019-06218-9. Epub 2019 Jan 29.


Porphyromonas gingivalis lipopolysaccharide-induced periodontitis and serum amyloid-beta peptides.

Leira Y, Iglesias-Rey R, Gómez-Lado N, Aguiar P, Campos F, D'Aiuto F, Castillo J, Blanco J, Sobrino T.

Arch Oral Biol. 2019 Mar;99:120-125. doi: 10.1016/j.archoralbio.2019.01.008. Epub 2019 Jan 16.


Pharmacist-participated medication review in different practice settings: Service or intervention? An overview of systematic reviews.

Silva ROS, Macêdo LA, Santos GAD Júnior, Aguiar PM, de Lyra DP Júnior.

PLoS One. 2019 Jan 10;14(1):e0210312. doi: 10.1371/journal.pone.0210312. eCollection 2019.


Monopolar 250-500 Hz language mapping: Results of 41 patients.

Verst SM, de Aguiar PHP, Joaquim MAS, Vieira VG, Sucena ABC, Maldaun MVC.

Clin Neurophysiol Pract. 2018 Dec 10;4:1-8. doi: 10.1016/j.cnp.2018.11.002. eCollection 2019.


Reduction of βN-alkanoyl-5-hydroxytryptamides and diterpenes by yeast supplementation to green coffee during wet processing.

Tinoco NAB, Pacheco S, Godoy RLO, Bizzo HR, de Aguiar PF, Leite SGF, Rezende CM.

Food Res Int. 2019 Jan;115:487-492. doi: 10.1016/j.foodres.2018.10.007. Epub 2018 Oct 3.


Interfacing Microfluidics with Microelectrode Arrays for Studying Neuronal Communication and Axonal Signal Propagation.

Lopes CDF, Mateus JC, Aguiar P.

J Vis Exp. 2018 Dec 8;(142). doi: 10.3791/58878.


Post-exercise cold-water immersion improves the performance in a subsequent 5-km running trial.

De Paula F, Escobar K, Ottone V, Aguiar P, Aguiar de Matos M, Duarte T, Araújo T, Costa K, Magalhães F, Rocha-Vieira E, Amorim F.

Temperature (Austin). 2018 Sep 12;5(4):359-370. doi: 10.1080/23328940.2018.1495023. eCollection 2018.


Dressing Tool Condition Monitoring through Impedance-Based Sensors: Part 1-PZT Diaphragm Transducer Response and EMI Sensing Technique.

Junior P, D'Addona DM, Aguiar PR.

Sensors (Basel). 2018 Dec 16;18(12). pii: E4455. doi: 10.3390/s18124455.


Dressing Tool Condition Monitoring through Impedance-Based Sensors: Part 2-Neural Networks and K-Nearest Neighbor Classifier Approach.

Junior P, D'Addona DM, Aguiar P, Teti R.

Sensors (Basel). 2018 Dec 16;18(12). pii: E4453. doi: 10.3390/s18124453.


Reply to the letter to the editor 'Response to the effect of PD-L1 testing on the cost-effectiveness of immune checkpoint inhibitors' by Ogale.

de Lima Lopes G, Aguiar P Jr.

Ann Oncol. 2019 Jan 1;30(1):149-150. doi: 10.1093/annonc/mdy501. No abstract available.


Vaginal residence and pharmacokinetic preclinical study of topical vaginal mucoadhesive W/S emulsions containing ciprofloxacin.

Campaña-Seoane M, Pérez-Gago A, Vázquez G, Conde N, González P, Martinez A, Martínez X, García Varela L, Herranz M, Aguiar P, Fernández-Ferreiro A, Laguna R, Otero-Espinar FJ.

Int J Pharm. 2019 Jan 10;554:276-283. doi: 10.1016/j.ijpharm.2018.11.022. Epub 2018 Nov 10.


Optogenetics: the new molecular approach to control functions of neural cells in epilepsy, depression and tumors of the central nervous system.

Camporeze B, Manica BA, Bonafé GA, Ferreira JJC, Diniz AL, de Oliveira CTP, Mathias Junior LR, de Aguiar PHP, Ortega MM.

Am J Cancer Res. 2018 Oct 1;8(10):1900-1918. eCollection 2018. Review.


A paradigm shift for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer: a review of CDK inhibitors.

Fernandes MT, Adashek JJ, Barreto CMN, Spinosa ACB, de Souza Gutierres B, Lopes G, Del Giglio A, Aguiar PN Jr.

Drugs Context. 2018 Nov 5;7:212555. doi: 10.7573/dic.212555. eCollection 2018. Review.


Configurationally flexible zinc complexes as catalysts for rac-lactide polymerisation.

Daneshmand P, Michalsky I, Aguiar PM, Schaper F.

Dalton Trans. 2018 Nov 22;47(45):16279-16291. doi: 10.1039/c8dt02562b.


[Reply to the Letter Regarding the Article: "Oral Health - Factors of Non-Adherence to Dental Vouchers: A Case- Control Study" by Rita Filipe and Pedro Aguiar].

Filipe R, Aguiar P.

Acta Med Port. 2018 Sep 28;31(9):518-519. doi: 10.20344/amp.11241. Epub 2018 Sep 28. Portuguese. No abstract available.


Validation of the Skindex-29 Questionnaire: Portuguese Version (Portugal).

Carvalho D, Aguiar P, Palma-Carlos A.

Acta Med Port. 2018 Sep 28;31(9):463-469. doi: 10.20344/amp.9850. Epub 2018 Sep 28.


Cost-effectiveness of pembrolizumab as first-line therapy for advanced non-small cell lung cancer.

Georgieva M, da Silveira Nogueira Lima JP, Aguiar P Jr, de Lima Lopes G Jr, Haaland B.

Lung Cancer. 2018 Oct;124:248-254. doi: 10.1016/j.lungcan.2018.08.018. Epub 2018 Aug 22.


Development and validation of key performance indicators for medication management services provided for outpatients.

Lima TM, Aguiar PM, Storpirtis S.

Res Social Adm Pharm. 2018 Sep 22. pii: S1551-7411(18)30376-0. doi: 10.1016/j.sapharm.2018.09.010. [Epub ahead of print]


The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi.

Alves CL, Repolês BM, da Silva MS, Mendes IC, Marin PA, Aguiar PHN, Santos SDS, Franco GR, Macedo AM, Pena SDJ, Andrade LO, Guarneri AA, Tahara EB, Elias MC, Machado CR.

Sci Rep. 2018 Sep 6;8(1):13335. doi: 10.1038/s41598-018-31541-z.


Natural history of intraventricular meningiomas: systematic review.

Pereira BJA, de Almeida AN, Paiva WS, de Aguiar PHP, Teixeira MJ, Marie SKN.

Neurosurg Rev. 2018 Aug 15. doi: 10.1007/s10143-018-1019-0. [Epub ahead of print] Review.


Longitudinal PET/CT evaluation of TNBS-induced inflammatory bowel disease rat model.

Seoane-Viaño I, Gómez-Lado N, Lázare-Iglesias H, Barreiro-de Acosta M, Silva-Rodríguez J, Luzardo-Álvarez A, Herranz M, Otero-Espinar F, Antúnez-López JR, Lamas MJ, Aguiar P, Fernández-Ferreiro A, Ruibal Á.

Int J Pharm. 2018 Oct 5;549(1-2):335-342. doi: 10.1016/j.ijpharm.2018.08.005. Epub 2018 Aug 3.


Cost-effectiveness and budget impact of lung cancer immunotherapy in South America: strategies to improve access.

Aguiar P Jr, Giglio AD, Perry LA, Penny-Dimri J, Babiker H, Tadokoro H, Lopes G Jr, De Mello RA.

Immunotherapy. 2018 Aug;10(10):887-897. doi: 10.2217/imt-2017-0183.


Efficacy of physical therapy associated with botulinum toxin type A on functional performance in post-stroke spasticity: A randomized, double-blinded, placebo-controlled trial.

Prazeres A, Lira M, Aguiar P, Monteiro L, Vilasbôas Í, Melo A.

Neurol Int. 2018 Jul 4;10(2):7385. doi: 10.4081/ni.2018.7385. eCollection 2018 May 24.


Bone marrow cell response after injury and during early stage of regeneration is independent of the tissue-of-injury in 2 injury models.

Leitão L, Alves CJ, Alencastre IS, Sousa DM, Neto E, Conceição F, Leitão C, Aguiar P, Almeida-Porada G, Lamghari M.

FASEB J. 2019 Jan;33(1):857-872. doi: 10.1096/fj.201800610RR. Epub 2018 Jul 25.


MetaLanc9 as a novel biomarker for non-small cell lung cancer: promising treatments via a PGK1-activated AKT/mTOR pathway.

De Mello RA, Aguiar PN, Tadokoro H, Farias-Vieira TM, Castelo-Branco P, de Lima Lopes G, Pozza DH.

J Thorac Dis. 2018 Jun;10(Suppl 17):S2076-S2078. doi: 10.21037/jtd.2018.04.122. No abstract available.


[Oral Health - Factors of Non-Adherence to Dental Vouchers: A Case-Control Study].

Filipe R, Aguiar P.

Acta Med Port. 2018 Jun 29;31(6):303-311. doi: 10.20344/amp.9640. Epub 2018 Jun 29. Portuguese.


Efficacy and safety of aripiprazole for the treatment of schizophrenia: an overview of systematic reviews.

Ribeiro ELA, de Mendonça Lima T, Vieira MEB, Storpirtis S, Aguiar PM.

Eur J Clin Pharmacol. 2018 Oct;74(10):1215-1233. doi: 10.1007/s00228-018-2498-1. Epub 2018 Jun 15. Review.


Vaccination With Recombinant Filamentous fd Phages Against Parasite Infection Requires TLR9 Expression.

Gomes-Neto JF, Sartorius R, Canto FB, Almeida TS, Dias AA, Barbosa CD, Melo GA, Oliveira AC, Aguiar PN, Machado CR, de Matos Guedes HL, Santiago MF, Nóbrega A, De Berardinis P, Bellio M.

Front Immunol. 2018 May 29;9:1173. doi: 10.3389/fimmu.2018.01173. eCollection 2018.


Addition of abiraterone, docetaxel, bisphosphonate, celecoxib or combinations to androgen-deprivation therapy (ADT) for metastatic hormone-sensitive prostate cancer (mHSPC): a network meta-analysis.

Tan PS, Aguiar P Jr, Haaland B, Lopes G.

Prostate Cancer Prostatic Dis. 2018 Nov;21(4):516-523. doi: 10.1038/s41391-018-0055-8. Epub 2018 Jun 6.


Cost-effectiveness of Osimertinib in the First-Line Treatment of Patients With EGFR-Mutated Advanced Non-Small Cell Lung Cancer.

Aguiar PN Jr, Haaland B, Park W, San Tan P, Del Giglio A, de Lima Lopes G Jr.

JAMA Oncol. 2018 Aug 1;4(8):1080-1084. doi: 10.1001/jamaoncol.2018.1395.


Self-complementary nickel halides enable multifaceted comparisons of intermolecular halogen bonds: fluoride ligands vs. other halides.

Thangavadivale V, Aguiar PM, Jasim NA, Pike SJ, Smith DA, Whitwood AC, Brammer L, Perutz RN.

Chem Sci. 2018 Mar 23;9(15):3767-3781. doi: 10.1039/c8sc00890f. eCollection 2018 Apr 21.


Chromosome Segregation Is Biased by Kinetochore Size.

Drpic D, Almeida AC, Aguiar P, Renda F, Damas J, Lewin HA, Larkin DM, Khodjakov A, Maiato H.

Curr Biol. 2018 May 7;28(9):1344-1356.e5. doi: 10.1016/j.cub.2018.03.023. Epub 2018 Apr 26.


Preclinical characterization and clinical evaluation of tacrolimus eye drops.

Luaces-Rodríguez A, Touriño-Peralba R, Alonso-Rodríguez I, García-Otero X, González-Barcia M, Rodríguez-Ares MT, Martínez-Pérez L, Aguiar P, Gómez-Lado N, Silva-Rodríguez J, Herranz M, Ruibal-Morell Á, Lamas MJ, Otero-Espinar FJ, Fernández-Ferreiro A.

Eur J Pharm Sci. 2018 Jul 30;120:152-161. doi: 10.1016/j.ejps.2018.04.038. Epub 2018 Apr 26.


Individualized threshold for tumor segmentation in 18F-FDG PET/CT imaging: The key for response evaluation of neoadjuvant chemoradiation therapy in patients with rectal cancer?

Fagundes TC, Mafra A, Silva RG, Castro ACG, Silva LC, Aguiar PT, Silva JA, P Junior E, Machado AM, Mamede M.

Rev Assoc Med Bras (1992). 2018 Feb;64(2):119-126. doi: 10.1590/1806-9282.64.02.119.


Enrichment of Probiotic Fermented Milk with Green Banana Pulp: Characterization Microbiological, Physicochemical and Sensory.

Vogado CO, Leandro EDS, Zandonadi RP, de Alencar ER, Ginani VC, Nakano EY, Habú S, Aguiar PA.

Nutrients. 2018 Mar 29;10(4). pii: E427. doi: 10.3390/nu10040427.


Optimization of the reconstruction parameters in [123I]FP-CIT SPECT.

Niñerola-Baizán A, Gallego J, Cot A, Aguiar P, Lomeña F, Pavía J, Ros D.

Phys Med Biol. 2018 Apr 13;63(8):085009. doi: 10.1088/1361-6560/aab799.


Automatic classification of tissue malignancy for breast carcinoma diagnosis.

Fondón I, Sarmiento A, García AI, Silvestre M, Eloy C, Polónia A, Aguiar P.

Comput Biol Med. 2018 May 1;96:41-51. doi: 10.1016/j.compbiomed.2018.03.003. Epub 2018 Mar 8.


Biomarkers of Myocardial Fibrosis: Revealing the Natural History of Fibrogenesis in Fabry Disease Cardiomyopathy.

Aguiar P, Azevedo O, Pinto R, Marino J, Cardoso C, Sousa N, Cunha D, Hughes D, Ducla Soares JL.

J Am Heart Assoc. 2018 Mar 13;7(6). pii: e007124. doi: 10.1161/JAHA.117.007124.


NAD+ analog reveals PARP-1 substrate-blocking mechanism and allosteric communication from catalytic center to DNA-binding domains.

Langelier MF, Zandarashvili L, Aguiar PM, Black BE, Pascal JM.

Nat Commun. 2018 Feb 27;9(1):844. doi: 10.1038/s41467-018-03234-8.


Association of metreleptin treatment and dietary intervention with neurological outcomes in Celia's encephalopathy.

Araújo-Vilar D, Domingo-Jiménez R, Ruibal Á, Aguiar P, Ibáñez-Micó S, Garrido-Pumar M, Martínez-Olmos MÁ, López-Soler C, Guillín-Amarelle C, González-Rodríguez M, Rodríguez-Núñez A, Álvarez-Escudero J, Liñares-Paz M, González-Méndez B, Rodríguez-García S, Sánchez-Iglesias S.

Eur J Hum Genet. 2018 Mar;26(3):396-406. doi: 10.1038/s41431-017-0052-8. Epub 2018 Jan 24.


Optimization of Aqueous Extraction from Kalanchoe pinnata Leaves to Obtain the Highest Content of an Anti-inflammatory Flavonoid using a Response Surface Model.

Dos Santos Nascimento LB, de Aguiar PF, Leal-Costa MV, Coutinho MAS, Borsodi MPG, Rossi-Bergmann B, Tavares ES, Costa SS.

Phytochem Anal. 2018 May;29(3):308-315. doi: 10.1002/pca.2744. Epub 2018 Jan 19.


A Novel System for Assessing Facial Muscle Movements: The Facegram 3D.

Horta R, Nascimento R, Gerós A, Aguiar P, Silva A, Amarante J.

Surg Innov. 2018 Feb;25(1):90-92. doi: 10.1177/1553350617753227. No abstract available.


Comparative effectiveness of immune-checkpoint inhibitors for previously treated advanced non-small cell lung cancer - A systematic review and network meta-analysis of 3024 participants.

Tan PS, Aguiar P Jr, Haaland B, Lopes G.

Lung Cancer. 2018 Jan;115:84-88. doi: 10.1016/j.lungcan.2017.11.017. Epub 2017 Nov 22.


The effect of PD-L1 testing on the cost-effectiveness and economic impact of immune checkpoint inhibitors for the second-line treatment of NSCLC.

Aguiar PN Jr, Perry LA, Penny-Dimri J, Babiker H, Tadokoro H, de Mello RA, Lopes GL Jr.

Ann Oncol. 2018 Apr 1;29(4):1078. doi: 10.1093/annonc/mdx478. No abstract available.


Linkage to HIV care and its determinants in the late HAART era: a systematic review and meta-analysis.

Perelman J, Rosado R, Ferro A, Aguiar P.

AIDS Care. 2018 Jun;30(6):672-687. doi: 10.1080/09540121.2017.1417537. Epub 2017 Dec 19.


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