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Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.

Cantù C, Felker A, Zimmerli D, Prummel KD, Cabello EM, Chiavacci E, Méndez-Acevedo KM, Kirchgeorg L, Burger S, Ripoll J, Valenta T, Hausmann G, Vilain N, Aguet M, Burger A, Panáková D, Basler K, Mosimann C.

Genes Dev. 2018 Nov 1;32(21-22):1443-1458. doi: 10.1101/gad.315531.118. Epub 2018 Oct 26.


Cancer Metastasis: A Reappraisal of Its Underlying Mechanisms and Their Relevance to Treatment.

Riggi N, Aguet M, Stamenkovic I.

Annu Rev Pathol. 2018 Jan 24;13:117-140. doi: 10.1146/annurev-pathol-020117-044127. Epub 2017 Oct 25. Review.


The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34+ Stem/Progenitor Cells.

Murone M, Radpour R, Attinger A, Chessex AV, Huguenin AL, Schürch CM, Banz Y, Sengupta S, Aguet M, Rigotti S, Bachhav Y, Massière F, Ramachandra M, McAllister A, Riether C.

Mol Cancer Ther. 2017 Aug;16(8):1497-1510. doi: 10.1158/1535-7163.MCT-16-0889. Epub 2017 May 3.


Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases.

Murone M, Vaslin Chessex A, Attinger A, Ramachandra R, Shetty SJ, Daginakatte G, Sengupta S, Marappan S, Dhodheri S, Rigotti S, Bachhav Y, Brienza S, Traxler P, Lang M, Aguet M, Zoete V, Michielin O, Nicholas C, Johnson FM, Ramachandra M, McAllister A.

Mol Cancer Ther. 2016 Oct;15(10):2334-2343. Epub 2016 Jul 20.


Wnt Ligands Secreted by Subepithelial Mesenchymal Cells Are Essential for the Survival of Intestinal Stem Cells and Gut Homeostasis.

Valenta T, Degirmenci B, Moor AE, Herr P, Zimmerli D, Moor MB, Hausmann G, Cantù C, Aguet M, Basler K.

Cell Rep. 2016 May 3;15(5):911-918. doi: 10.1016/j.celrep.2016.03.088. Epub 2016 Apr 21.


The fusion protein SS18-SSX1 employs core Wnt pathway transcription factors to induce a partial Wnt signature in synovial sarcoma.

Cironi L, Petricevic T, Fernandes Vieira V, Provero P, Fusco C, Cornaz S, Fregni G, Letovanec I, Aguet M, Stamenkovic I.

Sci Rep. 2016 Feb 24;6:22113. doi: 10.1038/srep22113.


BCL9/9L-β-catenin Signaling is Associated With Poor Outcome in Colorectal Cancer.

Moor AE, Anderle P, Cantù C, Rodriguez P, Wiedemann N, Baruthio F, Deka J, André S, Valenta T, Moor MB, Győrffy B, Barras D, Delorenzi M, Basler K, Aguet M.

EBioMedicine. 2015 Oct 30;2(12):1932-43. doi: 10.1016/j.ebiom.2015.10.030. eCollection 2015 Dec.


Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.

Cantù C, Zimmerli D, Hausmann G, Valenta T, Moor A, Aguet M, Basler K.

Genes Dev. 2014 Sep 1;28(17):1879-84. doi: 10.1101/gad.246140.114.


The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription.

Cantù C, Valenta T, Hausmann G, Vilain N, Aguet M, Basler K.

Development. 2013 Jun;140(11):2377-86. doi: 10.1242/dev.093591. Epub 2013 May 1.


Defining new criteria for selection of cell-based intestinal models using publicly available databases.

Christensen J, El-Gebali S, Natoli M, Sengstag T, Delorenzi M, Bentz S, Bouzourene H, Rumbo M, Felsani A, Siissalo S, Hirvonen J, Vila MR, Saletti P, Aguet M, Anderle P.

BMC Genomics. 2012 Jun 22;13:274. doi: 10.1186/1471-2164-13-274.


Probing transcription-specific outputs of β-catenin in vivo.

Valenta T, Gay M, Steiner S, Draganova K, Zemke M, Hoffmans R, Cinelli P, Aguet M, Sommer L, Basler K.

Genes Dev. 2011 Dec 15;25(24):2631-43. doi: 10.1101/gad.181289.111.


Bcl9/Bcl9l are critical for Wnt-mediated regulation of stem cell traits in colon epithelium and adenocarcinomas.

Deka J, Wiedemann N, Anderle P, Murphy-Seiler F, Bultinck J, Eyckerman S, Stehle JC, André S, Vilain N, Zilian O, Robine S, Delorenzi M, Basler K, Aguet M.

Cancer Res. 2010 Aug 15;70(16):6619-28. doi: 10.1158/0008-5472.CAN-10-0148. Epub 2010 Aug 3.


BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.

Brack AS, Murphy-Seiler F, Hanifi J, Deka J, Eyckerman S, Keller C, Aguet M, Rando TA.

Dev Biol. 2009 Nov 1;335(1):93-105. doi: 10.1016/j.ydbio.2009.08.014. Epub 2009 Aug 21.


A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer.

Farmer P, Bonnefoi H, Anderle P, Cameron D, Wirapati P, Becette V, André S, Piccart M, Campone M, Brain E, Macgrogan G, Petit T, Jassem J, Bibeau F, Blot E, Bogaerts J, Aguet M, Bergh J, Iggo R, Delorenzi M.

Nat Med. 2009 Jan;15(1):68-74. doi: 10.1038/nm.1908. Epub 2009 Jan 4. Erratum in: Nat Med. 2009 Feb;15(2):220. Wirapati, Pratyakasha [corrected to Wirapati, Pratyaksha].


Normal hemopoiesis and lymphopoiesis in the combined absence of numb and numblike.

Wilson A, Ardiet DL, Saner C, Vilain N, Beermann F, Aguet M, Macdonald HR, Zilian O.

J Immunol. 2007 Jun 1;178(11):6746-51.


SOST expression is restricted to the great arteries during embryonic and neonatal cardiovascular development.

van Bezooijen RL, Deruiter MC, Vilain N, Monteiro RM, Visser A, van der Wee-Pals L, van Munsteren CJ, Hogendoorn PC, Aguet M, Mummery CL, Papapoulos SE, Ten Dijke P, Löwik CW.

Dev Dyn. 2007 Feb;236(2):606-12.


Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.

Wang XD, Leow CC, Zha J, Tang Z, Modrusan Z, Radtke F, Aguet M, de Sauvage FJ, Gao WQ.

Dev Biol. 2006 Feb 1;290(1):66-80. Epub 2005 Dec 15.


Notch1 control of oligodendrocyte differentiation in the spinal cord.

Genoud S, Lappe-Siefke C, Goebbels S, Radtke F, Aguet M, Scherer SS, Suter U, Nave KA, Mantei N.

J Cell Biol. 2002 Aug 19;158(4):709-18. Epub 2002 Aug 19.


Notch1 is required for neuronal and glial differentiation in the cerebellum.

Lütolf S, Radtke F, Aguet M, Suter U, Taylor V.

Development. 2002 Jan;129(2):373-85.


Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation.

Rangarajan A, Talora C, Okuyama R, Nicolas M, Mammucari C, Oh H, Aster JC, Krishna S, Metzger D, Chambon P, Miele L, Aguet M, Radtke F, Dotto GP.

EMBO J. 2001 Jul 2;20(13):3427-36.


Multiple roles of mouse Numb in tuning developmental cell fates.

Zilian O, Saner C, Hagedorn L, Lee HY, Säuberli E, Suter U, Sommer L, Aguet M.

Curr Biol. 2001 Apr 3;11(7):494-501.


Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.

Radtke F, Ferrero I, Wilson A, Lees R, Aguet M, MacDonald HR.

J Exp Med. 2000 Apr 3;191(7):1085-94.


Deficient T cell fate specification in mice with an induced inactivation of Notch1.

Radtke F, Wilson A, Stark G, Bauer M, van Meerwijk J, MacDonald HR, Aguet M.

Immunity. 1999 May;10(5):547-58.


VEGF is required for growth and survival in neonatal mice.

Gerber HP, Hillan KJ, Ryan AM, Kowalski J, Keller GA, Rangell L, Wright BD, Radtke F, Aguet M, Ferrara N.

Development. 1999 Mar;126(6):1149-59.


Demonstration of an interferon gamma-dependent tumor surveillance system in immunocompetent mice.

Kaplan DH, Shankaran V, Dighe AS, Stockert E, Aguet M, Old LJ, Schreiber RD.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7556-61.


The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor.

Spencer SD, Di Marco F, Hooley J, Pitts-Meek S, Bauer M, Ryan AM, Sordat B, Gibbs VC, Aguet M.

J Exp Med. 1998 Feb 16;187(4):571-8.


Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes.

Wang B, André I, Gonzalez A, Katz JD, Aguet M, Benoist C, Mathis D.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13844-9.


The role of antibody concentration and avidity in antiviral protection.

Bachmann MF, Kalinke U, Althage A, Freer G, Burkhart C, Roost H, Aguet M, Hengartner H, Zinkernagel RM.

Science. 1997 Jun 27;276(5321):2024-7.


The IFN gamma receptor: a paradigm for cytokine receptor signaling.

Bach EA, Aguet M, Schreiber RD.

Annu Rev Immunol. 1997;15:563-91. Review.


The gene for the ligand binding chain of the human interferon gamma receptor.

Merlin G, van der Leede BJ, McKune K, Knezevic N, Bannwarth W, Romquin N, Viegas-Pequignot E, Kiefer H, Aguet M, Dembic Z.

Immunogenetics. 1997;45(6):413-21.


A negative regulatory region in the intracellular domain of the human interferon-alpha receptor.

Gibbs VC, Takahashi M, Aguet M, Chuntharapai A.

J Biol Chem. 1996 Nov 8;271(45):28710-6.


Ligand-induced assembly and activation of the gamma interferon receptor in intact cells.

Bach EA, Tanner JW, Marsters S, Ashkenazi A, Aguet M, Shaw AS, Schreiber RD.

Mol Cell Biol. 1996 Jun;16(6):3214-21.


Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway.

Meraz MA, White JM, Sheehan KC, Bach EA, Rodig SJ, Dighe AS, Kaplan DH, Riley JK, Greenlund AC, Campbell D, Carver-Moore K, DuBois RN, Clark R, Aguet M, Schreiber RD.

Cell. 1996 Feb 9;84(3):431-42.


Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-alpha double-deficient mice.

Eugster HP, Muller M, Karrer U, Car BD, Schnyder B, Eng VM, Woerly G, Le Hir M, di Padova F, Aguet M, Zinkernagel R, Bluethmann H, Ryffel B.

Int Immunol. 1996 Jan;8(1):23-36.


Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

Yang YL, Reis LF, Pavlovic J, Aguzzi A, Schäfer R, Kumar A, Williams BR, Aguet M, Weissmann C.

EMBO J. 1995 Dec 15;14(24):6095-106.


Immune defence in mice lacking type I and/or type II interferon receptors.

van den Broek MF, Müller U, Huang S, Zinkernagel RM, Aguet M.

Immunol Rev. 1995 Dec;148:5-18. Review.


Variable region cDNA sequences and characterization of murine anti-human interferon gamma receptor monoclonal antibodies that inhibit receptor binding by interferon gamma.

Bridges A, Birch A, Williams G, Aguet M, Schlatter D, Huber W, Garotta G, Robinson JA.

Mol Immunol. 1995 Dec;32(17-18):1329-38.


Role of interferon-gamma in interleukin 12-induced pathology in mice.

Car BD, Eng VM, Schnyder B, LeHir M, Shakhov AN, Woerly G, Huang S, Aguet M, Anderson TD, Ryffel B.

Am J Pathol. 1995 Dec;147(6):1693-707.


The in vivo antiviral activity of interleukin-12 is mediated by gamma interferon.

Ozmen L, Aguet M, Trinchieri G, Garotta G.

J Virol. 1995 Dec;69(12):8147-50.


Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets.

Bach EA, Szabo SJ, Dighe AS, Ashkenazi A, Aguet M, Murphy KM, Schreiber RD.

Science. 1995 Nov 17;270(5239):1215-8.


IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide.

Matthys P, Froyen G, Verdot L, Huang S, Sobis H, Van Damme J, Vray B, Aguet M, Billiau A.

J Immunol. 1995 Oct 15;155(8):3823-9. Erratum in: J Immunol 1996 Apr 15;156(8):following 3088.


Role of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice.

Saulnier M, Huang S, Aguet M, Ryffel B.

Toxicology. 1995 Sep 18;102(3):301-12.


Inducible gene targeting in mice.

Kühn R, Schwenk F, Aguet M, Rajewsky K.

Science. 1995 Sep 8;269(5229):1427-9.


Antiviral activity of autocrine interferon-beta requires the presence of a functional interferon type I receptor.

Rousseau V, Cremer I, Lauret E, Rivière I, Aguet M, De Maeyer E.

J Interferon Cytokine Res. 1995 Sep;15(9):785-9.


Expansion of gamma delta+ T cells in BALB/c mice infected with Leishmania major is dependent upon Th2-type CD4+ T cells.

Rosat JP, Conceiçao-Silva F, Waanders GA, Beermann F, Wilson A, Owen MJ, Hayday AC, Huang S, Aguet M, MacDonald HR, et al.

Infect Immun. 1995 Aug;63(8):3000-4.


Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.

van den Broek MF, Müller U, Huang S, Aguet M, Zinkernagel RM.

J Virol. 1995 Aug;69(8):4792-6.


Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.

Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, Shih JC, et al.

Science. 1995 Jun 23;268(5218):1763-6.


Theiler's virus infection of 129Sv mice that lack the interferon alpha/beta or interferon gamma receptors.

Fiette L, Aubert C, Müller U, Huang S, Aguet M, Brahic M, Bureau JF.

J Exp Med. 1995 Jun 1;181(6):2069-76.

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