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Eur Respir Rev. 2019 Oct 1;28(153). pii: 190061. doi: 10.1183/16000617.0061-2019. Print 2019 Sep 30.

Treating restless legs syndrome in the context of sleep disordered breathing comorbidity.

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Sleep Research Institute, Madrid, Spain.
Sleep Unit, Respiratory Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Sleep Research Institute, Madrid, Spain


Obstructive sleep apnoea (OSA) and restless legs syndrome (RLS) are two of the most prevalent sleep disorders and can coexist within the same patient. Nonetheless, the recognition of RLS among OSA patients has important clinical implications, since RLS can disrupt sleep despite adequate treatment of sleep disordered breathing and should be treated accordingly. Furthermore, the presence of OSA can also increase the severity of RLS. Therefore, it is important to be able to correctly identify both disorders and treat them effectively. The present article reviews our current knowledge on this comorbidity and discusses potential treatment options for RLS in the context of OSA.

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Conflict of interest statement

Conflict of interest: S. Romero-Peralta has nothing to disclose. Conflict of interest: I. Cano-Pumarega has nothing to disclose. Conflict of interest: C. Garcia-Malo has nothing to disclose. Conflict of interest: L. Agudelo Ramos has nothing to disclose. Conflict of interest: D. Garcia-Borreguero reports personal fees from American Regent and grants from Merck, during the conduct of the study.

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