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Items: 24


T Follicular Regulatory Cells Are Decreased in Patients With Established Treated Rheumatoid Arthritis With Active Disease: Comment on the Article by Liu et al.

Romão VC, Fonseca JE, Agua-Doce A, Graca L.

Arthritis Rheumatol. 2018 Nov;70(11):1893-1895. doi: 10.1002/art.40586. Epub 2018 Sep 3. No abstract available.



Fonseca VR, Romão VC, Fonseca JE, Agua-Doce A, Graca L.

Arthritis Rheumatol. 2018 Aug;70(8):1355-1356. doi: 10.1002/art.40487. Epub 2018 Jun 22. No abstract available.


The Ratio of Blood T Follicular Regulatory Cells to T Follicular Helper Cells Marks Ectopic Lymphoid Structure Formation While Activated Follicular Helper T Cells Indicate Disease Activity in Primary Sjögren's Syndrome.

Fonseca VR, Romão VC, Agua-Doce A, Santos M, López-Presa D, Ferreira AC, Fonseca JE, Graca L.

Arthritis Rheumatol. 2018 May;70(5):774-784. doi: 10.1002/art.40424. Epub 2018 Mar 25.


Route of Antigen Presentation Can Determine the Selection of Foxp3-Dependent or Foxp3-Independent Dominant Immune Tolerance.

Agua-Doce A, Caridade M, Oliveira VG, Bergman L, Lafaille MC, Lafaille JJ, Demengeot J, Graca L.

J Immunol. 2018 Jan 1;200(1):101-109. doi: 10.4049/jimmunol.1601886. Epub 2017 Nov 22.


Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function.

Fonseca VR, Agua-Doce A, Maceiras AR, Pierson W, Ribeiro F, Romão VC, Pires AR, da Silva SL, Fonseca JE, Sousa AE, Linterman MA, Graca L.

Sci Immunol. 2017 Aug 11;2(14). pii: eaan1487. doi: 10.1126/sciimmunol.aan1487.


T follicular regulatory cells in mice and men.

Maceiras AR, Fonseca VR, Agua-Doce A, Graca L.

Immunology. 2017 Sep;152(1):25-35. doi: 10.1111/imm.12774. Epub 2017 Jul 27. Review.


Umbilical cord tissue-derived mesenchymal stromal cells maintain immunomodulatory and angiogenic potencies after cryopreservation and subsequent thawing.

Bárcia RN, Santos JM, Teixeira M, Filipe M, Pereira ARS, Ministro A, Água-Doce A, Carvalheiro M, Gaspar MM, Miranda JP, Graça L, Simões S, Santos SCR, Cruz P, Cruz H.

Cytotherapy. 2017 Mar;19(3):360-370. doi: 10.1016/j.jcyt.2016.11.008. Epub 2016 Dec 28.


IL-9 Expression by Invariant NKT Cells Is Not Imprinted during Thymic Development.

Monteiro M, Agua-Doce A, Almeida CF, Fonseca-Pereira D, Veiga-Fernandes H, Graca L.

J Immunol. 2015 Oct 1;195(7):3463-71. doi: 10.4049/jimmunol.1403170. Epub 2015 Aug 21.


What Makes Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells Superior Immunomodulators When Compared to Bone Marrow Derived Mesenchymal Stromal Cells?

Bárcia RN, Santos JM, Filipe M, Teixeira M, Martins JP, Almeida J, Água-Doce A, Almeida SC, Varela A, Pohl S, Dittmar KE, Calado S, Simões SI, Gaspar MM, Cruz ME, Lindenmaier W, Graça L, Cruz H, Cruz PE.

Stem Cells Int. 2015;2015:583984. doi: 10.1155/2015/583984. Epub 2015 May 12.


Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.

Martins JP, Santos JM, de Almeida JM, Filipe MA, de Almeida MV, Almeida SC, Água-Doce A, Varela A, Gilljam M, Stellan B, Pohl S, Dittmar K, Lindenmaier W, Alici E, Graça L, Cruz PE, Cruz HJ, Bárcia RN.

Stem Cell Res Ther. 2014 Jan 17;5(1):9. doi: 10.1186/scrt398.


The fate of CD4+ T cells under tolerance-inducing stimulation: a modeling perspective.

Caridade M, Oliveira VG, Agua-Doce A, Graca L, Ribeiro RM.

Immunol Cell Biol. 2013 Nov-Dec;91(10):652-60. doi: 10.1038/icb.2013.63. Epub 2013 Oct 22.


Adjuvant facilitates tolerance induction to factor VIII in hemophilic mice through a Foxp3-independent mechanism that relies on IL-10.

Oliveira VG, Agua-Doce A, Curotto de Lafaille MA, Lafaille JJ, Graca L.

Blood. 2013 May 9;121(19):3936-45, S1. doi: 10.1182/blood-2012-09-457135. Epub 2013 Mar 26.


The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX®) in the treatment of inflammatory arthritis.

Santos JM, Bárcia RN, Simões SI, Gaspar MM, Calado S, Agua-Doce A, Almeida SC, Almeida J, Filipe M, Teixeira M, Martins JP, Graça L, Cruz ME, Cruz P, Cruz H.

J Transl Med. 2013 Jan 17;11:18. doi: 10.1186/1479-5876-11-18.


Induced IL-17-producing invariant NKT cells require activation in presence of TGF-β and IL-1β.

Monteiro M, Almeida CF, Agua-Doce A, Graca L.

J Immunol. 2013 Jan 15;190(2):805-11. doi: 10.4049/jimmunol.1201010.


Regulatory T cells and the control of the allergic response.

Agua-Doce A, Graca L.

J Allergy (Cairo). 2012;2012:948901. doi: 10.1155/2012/948901. Epub 2012 Sep 29.


T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis.

Duarte J, Carrié N, Oliveira VG, Almeida C, Agua-Doce A, Rodrigues L, Simas JP, Mars LT, Graca L.

J Immunol. 2012 Aug 15;189(4):1680-8. doi: 10.4049/jimmunol.1201269. Epub 2012 Jul 16.


Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells.

Wollenberg I, Agua-Doce A, Hernández A, Almeida C, Oliveira VG, Faro J, Graca L.

J Immunol. 2011 Nov 1;187(9):4553-60. doi: 10.4049/jimmunol.1101328. Epub 2011 Oct 7.


Prevention of house dust mite induced allergic airways disease in mice through immune tolerance.

Agua-Doce A, Graca L.

PLoS One. 2011;6(7):e22320. doi: 10.1371/journal.pone.0022320. Epub 2011 Jul 26.


Monoclonal anti-CD8 therapy induces disease amelioration in the K/BxN mouse model of spontaneous chronic polyarthritis.

Raposo BR, Rodrigues-Santos P, Carvalheiro H, Agua-Doce AM, Carvalho L, Pereira da Silva JA, Graça L, Souto-Carneiro MM.

Arthritis Rheum. 2010 Oct;62(10):2953-62. doi: 10.1002/art.27729.


Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-beta.

Monteiro M, Almeida CF, Caridade M, Ribot JC, Duarte J, Agua-Doce A, Wollenberg I, Silva-Santos B, Graca L.

J Immunol. 2010 Aug 15;185(4):2157-63. doi: 10.4049/jimmunol.1000359. Epub 2010 Jul 16.


Modulation of IL-17 and Foxp3 expression in the prevention of autoimmune arthritis in mice.

Duarte J, Agua-Doce A, Oliveira VG, Fonseca JE, Graca L.

PLoS One. 2010 May 10;5(5):e10558. doi: 10.1371/journal.pone.0010558.


B cells from the bench to the clinical practice.

Moura R, Agua-Doce A, Weinmann P, Graça L, Fonseca JE.

Acta Reumatol Port. 2008 Apr-Jun;33(2):137-54. Review.


Induction of dominant tolerance using monoclonal antibodies.

Agua-Doce A, Graça L.

Methods Mol Biol. 2007;380:405-29. Review.


Regulatory T cell maintenance of dominant tolerance: induction of tissue self-defense?

Oliveira V, Agua-Doce A, Duarte J, Soares MP, Graca L.

Transpl Immunol. 2006 Dec;17(1):7-10. Epub 2006 Oct 12. Review.


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