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Items: 1 to 50 of 67

1.

Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions.

Canas PM, Porciúncula LO, Simões AP, Augusto E, Silva HB, Machado NJ, Gonçalves N, Alfaro TM, Gonçalves FQ, Araújo IM, Real JI, Coelho JE, Andrade GM, Almeida RD, Chen JF, Köfalvi A, Agostinho P, Cunha RA.

eNeuro. 2018 Dec 26;5(6). pii: ENEURO.0385-18.2018. doi: 10.1523/ENEURO.0385-18.2018. eCollection 2018 Nov-Dec.

2.

Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease.

Silva AC, Lemos C, Gonçalves FQ, Pliássova AV, Machado NJ, Silva HB, Canas PM, Cunha RA, Lopes JP, Agostinho P.

Neurobiol Dis. 2018 Sep;117:72-81. doi: 10.1016/j.nbd.2018.05.024. Epub 2018 May 31.

PMID:
29859867
3.

Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer's Disease.

Amorim JA, Canas PM, Tomé AR, Rolo AP, Agostinho P, Palmeira CM, Cunha RA.

J Alzheimers Dis. 2017;60(2):525-536. doi: 10.3233/JAD-170356.

PMID:
28869472
4.

Oncostatin M promotes excitotoxicity by inhibiting glutamate uptake in astrocytes: implications in HIV-associated neurotoxicity.

Moidunny S, Matos M, Wesseling E, Banerjee S, Volsky DJ, Cunha RA, Agostinho P, Boddeke HW, Roy S.

J Neuroinflammation. 2016 Jun 10;13(1):144. doi: 10.1186/s12974-016-0613-8.

5.

Low progesterone levels and ovulation by ultrasound assessment in infertile patients.

Sanchez EG, Giviziez CR, Sanchez HM, Agostinho PL, Barros PS, Approbato MS.

JBRA Assist Reprod. 2016 Mar 1;20(1):13-6. doi: 10.5935/1518-0557.20160004.

6.

Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide.

Carvalho FB, Gutierres JM, Bueno A, Agostinho P, Zago AM, Vieira J, Frühauf P, Cechella JL, Nogueira CW, Oliveira SM, Rizzi C, Spanevello RM, Duarte MMF, Duarte T, Dellagostin OA, Andrade CM.

Mol Neurobiol. 2017 Jul;54(5):3350-3367. doi: 10.1007/s12035-016-9900-8. Epub 2016 May 11.

PMID:
27167130
7.

Age-Related Changes in the Synaptic Density of Amyloid-β Protein Precursor and Secretases in the Human Cerebral Cortex.

Pliássova A, Canas PM, Xavier AC, da Silva BS, Cunha RA, Agostinho P.

J Alzheimers Dis. 2016 Apr 18;52(4):1209-14. doi: 10.3233/JAD-160213.

PMID:
27104908
8.

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease.

Köfalvi A, Lemos C, Martín-Moreno AM, Pinheiro BS, García-García L, Pozo MA, Valério-Fernandes Â, Beleza RO, Agostinho P, Rodrigues RJ, Pasquaré SJ, Cunha RA, de Ceballos ML.

Neuropharmacology. 2016 Nov;110(Pt A):519-529. doi: 10.1016/j.neuropharm.2016.03.015. Epub 2016 Mar 11.

9.

Caffeine Reverts Memory But Not Mood Impairment in a Depression-Prone Mouse Strain with Up-Regulated Adenosine A2A Receptor in Hippocampal Glutamate Synapses.

Machado NJ, Simões AP, Silva HB, Ardais AP, Kaster MP, Garção P, Rodrigues DI, Pochmann D, Santos AI, Araújo IM, Porciúncula LO, Tomé ÂR, Köfalvi A, Vaugeois JM, Agostinho P, El Yacoubi M, Cunha RA, Gomes CA.

Mol Neurobiol. 2017 Mar;54(2):1552-1563. doi: 10.1007/s12035-016-9774-9. Epub 2016 Feb 9.

PMID:
26860412
10.

Depression as a Glial-Based Synaptic Dysfunction.

Rial D, Lemos C, Pinheiro H, Duarte JM, Gonçalves FQ, Real JI, Prediger RD, Gonçalves N, Gomes CA, Canas PM, Agostinho P, Cunha RA.

Front Cell Neurosci. 2016 Jan 22;9:521. doi: 10.3389/fncel.2015.00521. eCollection 2015. Review.

11.

The Association of Amyloid-β Protein Precursor With α- and β-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.

Pliássova A, Lopes JP, Lemos C, Oliveira CR, Cunha RA, Agostinho P.

Mol Neurobiol. 2016 Oct;53(8):5710-21. doi: 10.1007/s12035-015-9491-9. Epub 2015 Oct 26.

PMID:
26497029
12.

Does Caffeine Consumption Modify Cerebrospinal Fluid Amyloid-β Levels in Patients with Alzheimer's Disease?

Travassos M, Santana I, Baldeiras I, Tsolaki M, Gkatzima O, Sermin G, Yener GG, Simonsen A, Hasselbalch SG, Kapaki E, Mara B, Cunha RA, Agostinho P, Blennow K, Zetterberg H, Mendes VM, Manadas B, de Mendon A.

J Alzheimers Dis. 2015;47(4):1069-78. doi: 10.3233/JAD-150374.

PMID:
26401784
13.

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress.

Kaster MP, Machado NJ, Silva HB, Nunes A, Ardais AP, Santana M, Baqi Y, Müller CE, Rodrigues AL, Porciúncula LO, Chen JF, Tomé ÂR, Agostinho P, Canas PM, Cunha RA.

Proc Natl Acad Sci U S A. 2015 Jun 23;112(25):7833-8. doi: 10.1073/pnas.1423088112. Epub 2015 Jun 8.

14.

Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia.

Matos M, Shen HY, Augusto E, Wang Y, Wei CJ, Wang YT, Agostinho P, Boison D, Cunha RA, Chen JF.

Biol Psychiatry. 2015 Dec 1;78(11):763-74. doi: 10.1016/j.biopsych.2015.02.026. Epub 2015 Feb 27.

15.

Localization and Trafficking of Amyloid-β Protein Precursor and Secretases: Impact on Alzheimer's Disease.

Agostinho P, Pliássova A, Oliveira CR, Cunha RA.

J Alzheimers Dis. 2015;45(2):329-47. doi: 10.3233/JAD-142730. Review.

PMID:
25589722
16.

Cellular prion protein is present in dopaminergic neurons and modulates the dopaminergic system.

Rial D, Pamplona FA, Moreira EL, Moreira KM, Hipolide D, Rodrigues DI, Dombrowski PA, Da Cunha C, Agostinho P, Takahashi RN, Walz R, Cunha RA, Prediger RD.

Eur J Neurosci. 2014 Aug;40(3):2479-86. doi: 10.1111/ejn.12600. Epub 2014 Apr 26.

PMID:
24766164
17.

Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum.

Garção P, Oliveira CR, Cunha RA, Agostinho P.

Neurosci Lett. 2014 Apr 30;566:106-10. doi: 10.1016/j.neulet.2014.02.018. Epub 2014 Mar 4.

PMID:
24607281
18.

Synaptic and sub-synaptic localization of amyloid-β protein precursor in the rat hippocampus.

Rodrigues DI, Gutierres J, Pliássova A, Oliveira CR, Cunha RA, Agostinho P.

J Alzheimers Dis. 2014;40(4):981-92. doi: 10.3233/JAD-132030.

PMID:
24531160
19.

Neuroprotective effect of anthocyanins on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia in rats.

Gutierres JM, Carvalho FB, Schetinger MR, Agostinho P, Marisco PC, Vieira JM, Rosa MM, Bohnert C, Rubin MA, Morsch VM, Spanevello R, Mazzanti CM.

Int J Dev Neurosci. 2014 Apr;33:88-97. doi: 10.1016/j.ijdevneu.2013.12.006. Epub 2013 Dec 24.

PMID:
24374256
20.

Prolonged nicotine exposure down-regulates presynaptic NMDA receptors in dopaminergic terminals of the rat nucleus accumbens.

Salamone A, Zappettini S, Grilli M, Olivero G, Agostinho P, Tomé AR, Chen J, Pittaluga A, Cunha RA, Marchi M.

Neuropharmacology. 2014 Apr;79:488-97. doi: 10.1016/j.neuropharm.2013.12.014. Epub 2013 Dec 25.

PMID:
24373903
21.

Anthocyanins restore behavioral and biochemical changes caused by streptozotocin-induced sporadic dementia of Alzheimer's type.

Gutierres JM, Carvalho FB, Schetinger MR, Marisco P, Agostinho P, Rodrigues M, Rubin MA, Schmatz R, da Silva CR, de P Cognato G, Farias JG, Signor C, Morsch VM, Mazzanti CM, Bogo M, Bonan CD, Spanevello R.

Life Sci. 2014 Feb 6;96(1-2):7-17. doi: 10.1016/j.lfs.2013.11.014. Epub 2013 Nov 28.

22.

Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes.

Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF.

J Neurosci. 2013 Nov 20;33(47):18492-502. doi: 10.1523/JNEUROSCI.1828-13.2013.

23.

Spatial memory impairments in a prediabetic rat model.

Soares E, Prediger RD, Nunes S, Castro AA, Viana SD, Lemos C, De Souza CM, Agostinho P, Cunha RA, Carvalho E, Fontes Ribeiro CA, Reis F, Pereira FC.

Neuroscience. 2013 Oct 10;250:565-77. doi: 10.1016/j.neuroscience.2013.07.055. Epub 2013 Jul 30.

PMID:
23912035
24.

Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum.

Garção P, Szabó EC, Wopereis S, Castro AA, Tomé ÂR, Prediger RD, Cunha RA, Agostinho P, Köfalvi A.

Br J Pharmacol. 2013 Aug;169(7):1600-11. doi: 10.1111/bph.12234.

25.

Synthesis, pharmacological assessment, and molecular modeling of acetylcholinesterase/butyrylcholinesterase inhibitors: effect against amyloid-β-induced neurotoxicity.

Silva D, Chioua M, Samadi A, Agostinho P, Garção P, Lajarín-Cuesta R, de Los Ríos C, Iriepa I, Moraleda I, Gonzalez-Lafuente L, Mendes E, Pérez C, Rodríguez-Franco MI, Marco-Contelles J, Carmo Carreiras M.

ACS Chem Neurosci. 2013 Apr 17;4(4):547-65. doi: 10.1021/cn300178k. Epub 2013 Feb 4.

26.

Blockade of adenosine A2A receptors prevents interleukin-1β-induced exacerbation of neuronal toxicity through a p38 mitogen-activated protein kinase pathway.

Simões AP, Duarte JA, Agasse F, Canas PM, Tomé AR, Agostinho P, Cunha RA.

J Neuroinflammation. 2012 Aug 20;9:204. doi: 10.1186/1742-2094-9-204.

27.

Astrocytic adenosine A2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake.

Matos M, Augusto E, Machado NJ, dos Santos-Rodrigues A, Cunha RA, Agostinho P.

J Alzheimers Dis. 2012;31(3):555-67. doi: 10.3233/JAD-2012-120469.

PMID:
22647260
28.

Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences.

Ferreira SG, Teixeira FM, Garção P, Agostinho P, Ledent C, Cortes L, Mackie K, Köfalvi A.

Neurochem Int. 2012 Jul;61(2):219-26. doi: 10.1016/j.neuint.2012.05.009. Epub 2012 May 17.

29.

Caffeine consumption prevents diabetes-induced memory impairment and synaptotoxicity in the hippocampus of NONcZNO10/LTJ mice.

Duarte JM, Agostinho PM, Carvalho RA, Cunha RA.

PLoS One. 2012;7(4):e21899. doi: 10.1371/journal.pone.0021899. Epub 2012 Apr 13.

30.

Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

Matos M, Augusto E, Santos-Rodrigues AD, Schwarzschild MA, Chen JF, Cunha RA, Agostinho P.

Glia. 2012 May;60(5):702-16. doi: 10.1002/glia.22290. Epub 2012 Feb 1.

PMID:
22298379
31.

Enhanced role of adenosine A(2A) receptors in the modulation of LTP in the rat hippocampus upon ageing.

Costenla AR, Diógenes MJ, Canas PM, Rodrigues RJ, Nogueira C, Maroco J, Agostinho PM, Ribeiro JA, Cunha RA, de Mendonça A.

Eur J Neurosci. 2011 Jul;34(1):12-21. doi: 10.1111/j.1460-9568.2011.07719.x. Epub 2011 May 25.

PMID:
21615561
32.

Cdk5: multitasking between physiological and pathological conditions.

Lopes JP, Agostinho P.

Prog Neurobiol. 2011 Jun;94(1):49-63. doi: 10.1016/j.pneurobio.2011.03.006. Epub 2011 Apr 5. Review.

PMID:
21473899
33.

Adenosine A2A receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.

Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA.

J Neurochem. 2011 Apr;117(1):100-11. doi: 10.1111/j.1471-4159.2011.07178.x. Epub 2011 Feb 9.

34.

Adenosine receptors and brain diseases: neuroprotection and neurodegeneration.

Gomes CV, Kaster MP, Tomé AR, Agostinho PM, Cunha RA.

Biochim Biophys Acta. 2011 May;1808(5):1380-99. doi: 10.1016/j.bbamem.2010.12.001. Epub 2010 Dec 9. Review.

35.

Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer's disease.

Agostinho P, Cunha RA, Oliveira C.

Curr Pharm Des. 2010;16(25):2766-78. Review.

PMID:
20698820
36.

Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline.

Cunha RA, Agostinho PM.

J Alzheimers Dis. 2010;20 Suppl 1:S95-116. doi: 10.3233/JAD-2010-1408. Review.

PMID:
20182043
37.

Neurodegeneration in an Abeta-induced model of Alzheimer's disease: the role of Cdk5.

Lopes JP, Oliveira CR, Agostinho P.

Aging Cell. 2010 Feb;9(1):64-77. doi: 10.1111/j.1474-9726.2009.00536.x. Epub 2009 Nov 6.

38.

Caffeine and an adenosine A(2A) receptor antagonist prevent memory impairment and synaptotoxicity in adult rats triggered by a convulsive episode in early life.

Cognato GP, Agostinho PM, Hockemeyer J, Müller CE, Souza DO, Cunha RA.

J Neurochem. 2010 Jan;112(2):453-62. doi: 10.1111/j.1471-4159.2009.06465.x. Epub 2009 Oct 30.

39.

Cell cycle re-entry in Alzheimer's disease: a major neuropathological characteristic?

Lopes JP, Oliveira CR, Agostinho P.

Curr Alzheimer Res. 2009 Jun;6(3):205-12. Review.

PMID:
19519302
40.

Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-beta and tau pathology.

Lopes JP, Blurton-Jones M, Yamasaki TR, Agostinho P, LaFerla FM.

J Alzheimers Dis. 2009;16(3):541-9. doi: 10.3233/JAD-2009-0993.

PMID:
19276549
41.

Galantamine protects against oxidative stress induced by amyloid-beta peptide in cortical neurons.

Melo JB, Sousa C, Garção P, Oliveira CR, Agostinho P.

Eur J Neurosci. 2009 Feb;29(3):455-64. doi: 10.1111/j.1460-9568.2009.06612.x.

PMID:
19222556
42.

Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-beta and prion peptides.

Lopes JP, Oliveira CR, Agostinho P.

Cell Cycle. 2009 Jan 1;8(1):97-104.

PMID:
19158499
43.

Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades.

Matos M, Augusto E, Oliveira CR, Agostinho P.

Neuroscience. 2008 Oct 28;156(4):898-910. doi: 10.1016/j.neuroscience.2008.08.022. Epub 2008 Aug 22.

PMID:
18790019
44.

Overactivation of calcineurin induced by amyloid-beta and prion proteins.

Agostinho P, Lopes JP, Velez Z, Oliveira CR.

Neurochem Int. 2008 May;52(6):1226-33. doi: 10.1016/j.neuint.2008.01.005. Epub 2008 Jan 16.

PMID:
18295934
45.
46.

Expression and subcellular localization of a novel nuclear acetylcholinesterase protein.

Santos SC, Vala I, Miguel C, Barata JT, Garção P, Agostinho P, Mendes M, Coelho AV, Calado A, Oliveira CR, e Silva JM, Saldanha C.

J Biol Chem. 2007 Aug 31;282(35):25597-603. Epub 2007 Jul 2.

47.

Prion protein aggregation and neurotoxicity in cortical neurons.

Melo JB, Agostinho P, Oliveira CR.

Ann N Y Acad Sci. 2007 Jan;1096:220-9.

PMID:
17405933
48.

Susceptibility of hippocampal neurons to Abeta peptide toxicity is associated with perturbation of Ca2+ homeostasis.

Resende R, Pereira C, Agostinho P, Vieira AP, Malva JO, Oliveira CR.

Brain Res. 2007 Apr 27;1143:11-21. Epub 2007 Jan 27.

PMID:
17336275
49.

Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration.

Garção P, Oliveira CR, Agostinho P.

J Neurosci Res. 2006 Jul;84(1):182-93.

PMID:
16634056
50.

Neurodegenerative pathways in Parkinson's disease: therapeutic strategies.

Cardoso SM, Moreira PI, Agostinho P, Pereira C, Oliveira CR.

Curr Drug Targets CNS Neurol Disord. 2005 Aug;4(4):405-19. Review.

PMID:
16101557

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