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Items: 20


The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis.

Backe MB, Jin C, Andreone L, Sankar A, Agger K, Helin K, Madsen AN, Poulsen SS, Bysani M, Bacos K, Ling C, Perone MJ, Holst B, Mandrup-Poulsen T.

J Diabetes Res. 2019 Jul 28;2019:5451038. doi: 10.1155/2019/5451038. eCollection 2019.


The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance.

Agger K, Nishimura K, Miyagi S, Messling JE, Rasmussen KD, Helin K.

Blood. 2019 Oct 3;134(14):1154-1158. doi: 10.1182/blood.2019000855. Epub 2019 Aug 21.


Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova TB, Anil-Kirmizitas B, Bassett A, Kooistra SM, Agger K, Helin K, Heard E, Brockdorff N.

Nat Commun. 2016 Nov 28;7:13661. doi: 10.1038/ncomms13661.


Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.

Pedersen MT, Kooistra SM, Radzisheuskaya A, Laugesen A, Johansen JV, Hayward DG, Nilsson J, Agger K, Helin K.

EMBO J. 2016 Jul 15;35(14):1550-64. doi: 10.15252/embj.201593317. Epub 2016 Jun 6.


Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells.

Agger K, Miyagi S, Pedersen MT, Kooistra SM, Johansen JV, Helin K.

Genes Dev. 2016 Jun 1;30(11):1278-88. doi: 10.1101/gad.280495.116. Epub 2016 Jun 2.


The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development.

Pedersen MT, Agger K, Laugesen A, Johansen JV, Cloos PA, Christensen J, Helin K.

Mol Cell Biol. 2014 Mar;34(6):1031-45. doi: 10.1128/MCB.00864-13. Epub 2014 Jan 6.


Histone lysine demethylases as targets for anticancer therapy.

Højfeldt JW, Agger K, Helin K.

Nat Rev Drug Discov. 2013 Dec;12(12):917-30. doi: 10.1038/nrd4154. Epub 2013 Nov 15. Review.


Inhibitors of histone demethylases.

Lohse B, Kristensen JL, Kristensen LH, Agger K, Helin K, Gajhede M, Clausen RP.

Bioorg Med Chem. 2011 Jun 15;19(12):3625-36. doi: 10.1016/j.bmc.2011.01.046. Epub 2011 Feb 1. Review.


The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence.

Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K.

Genes Dev. 2009 May 15;23(10):1171-6. doi: 10.1101/gad.510809.


Regulation of stem cell differentiation by histone methyltransferases and demethylases.

Pasini D, Bracken AP, Agger K, Christensen J, Hansen K, Cloos PA, Helin K.

Cold Spring Harb Symp Quant Biol. 2008;73:253-63. doi: 10.1101/sqb.2008.73.009. Epub 2008 Nov 6. Review.


Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.

Pasini D, Hansen KH, Christensen J, Agger K, Cloos PA, Helin K.

Genes Dev. 2008 May 15;22(10):1345-55. doi: 10.1101/gad.470008.


Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease.

Cloos PA, Christensen J, Agger K, Helin K.

Genes Dev. 2008 May 1;22(9):1115-40. doi: 10.1101/gad.1652908. Review.


The emerging functions of histone demethylases.

Agger K, Christensen J, Cloos PA, Helin K.

Curr Opin Genet Dev. 2008 Apr;18(2):159-68. doi: 10.1016/j.gde.2007.12.003. Epub 2008 Feb 20. Review.


UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.

Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K.

Nature. 2007 Oct 11;449(7163):731-4. Epub 2007 Aug 22.


RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.

Christensen J, Agger K, Cloos PA, Pasini D, Rose S, Sennels L, Rappsilber J, Hansen KH, Salcini AE, Helin K.

Cell. 2007 Mar 23;128(6):1063-76. Epub 2007 Feb 22.


The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.

Cloos PA, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, Hansen KH, Helin K.

Nature. 2006 Jul 20;442(7100):307-11. Epub 2006 May 28.


A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.

Attwooll C, Oddi S, Cartwright P, Prosperini E, Agger K, Steensgaard P, Wagener C, Sardet C, Moroni MC, Helin K.

J Biol Chem. 2005 Jan 14;280(2):1199-208. Epub 2004 Nov 8.


Conditional E2F1 activation in transgenic mice causes testicular atrophy and dysplasia mimicking human CIS.

Agger K, Santoni-Rugiu E, Holmberg C, Karlström O, Helin K.

Oncogene. 2005 Jan 27;24(5):780-9.


[Trimethoprim-sulfamethoxazole as antibacterial prophylaxis during induction therapy of children with acute lymphatic leukemia].

Agger KE, Schrøder H, Rosthøj S, Carlsen NT, Schmiegelow K.

Ugeskr Laeger. 2002 Jan 21;164(4):488-92. Danish.


Antibacterial prophylaxis with trimethoprim-sulfamethoxazole during induction treatment for acute lymphoblastic leukemia.

Schrøder H, Agger KE, Rosthøj S, Carlsen NT, Schmiegelow K.

Dan Med Bull. 2001 Nov;48(4):275-7.


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