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Items: 1 to 50 of 607

1.

Is curcumin bioavailability a problem in humans: lessons from clinical trials.

Kunnumakkara AB, Harsha C, Banik K, Vikkurthi R, Sailo BL, Bordoloi D, Gupta SC, Aggarwal BB.

Expert Opin Drug Metab Toxicol. 2019 Sep;15(9):705-733. doi: 10.1080/17425255.2019.1650914. Epub 2019 Aug 29.

PMID:
31361978
2.

Cancer drug development: The missing links.

Kunnumakkara AB, Bordoloi D, Sailo BL, Roy NK, Thakur KK, Banik K, Shakibaei M, Gupta SC, Aggarwal BB.

Exp Biol Med (Maywood). 2019 May;244(8):663-689. doi: 10.1177/1535370219839163. Epub 2019 Apr 8.

PMID:
30961357
3.

Induction of the Epithelial-to-Mesenchymal Transition of Human Colorectal Cancer by Human TNF-β (Lymphotoxin) and its Reversal by Resveratrol.

Buhrmann C, Yazdi M, Popper B, Kunnumakkara AB, Aggarwal BB, Shakibaei M.

Nutrients. 2019 Mar 26;11(3). pii: E704. doi: 10.3390/nu11030704.

4.

Correction: Celastrol Suppresses Angiogenesis-Mediated Tumor Growth through Inhibition of AKT/Mammalian Target of Rapamycin Pathway.

Pang X, Yi Z, Zhang J, Lu B, Sung B, Qu W, Aggarwal BB, Liu M.

Cancer Res. 2019 Feb 1;79(3):685. doi: 10.1158/0008-5472.CAN-18-3859. No abstract available.

PMID:
30709873
5.

Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it.

Buhrmann C, Yazdi M, Popper B, Shayan P, Goel A, Aggarwal BB, Shakibaei M.

Exp Biol Med (Maywood). 2019 Jan;244(1):1-12. doi: 10.1177/1535370218824538. Epub 2019 Jan 19.

PMID:
30661394
6.

Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.

Gupta SC, Kunnumakkara AB, Aggarwal S, Aggarwal BB.

Front Immunol. 2018 Sep 27;9:2160. doi: 10.3389/fimmu.2018.02160. eCollection 2018. Review.

7.

Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases.

Kunnumakkara AB, Banik K, Bordoloi D, Harsha C, Sailo BL, Padmavathi G, Roy NK, Gupta SC, Aggarwal BB.

Front Pharmacol. 2018 Aug 6;9:686. doi: 10.3389/fphar.2018.00686. eCollection 2018. Review.

8.

Resveratrol Chemosensitizes TNF-β-Induced Survival of 5-FU-Treated Colorectal Cancer Cells.

Buhrmann C, Yazdi M, Popper B, Shayan P, Goel A, Aggarwal BB, Shakibaei M.

Nutrients. 2018 Jul 12;10(7). pii: E888. doi: 10.3390/nu10070888.

9.

Dietary nutraceuticals as backbone for bone health.

Pandey MK, Gupta SC, Karelia D, Gilhooley PJ, Shakibaei M, Aggarwal BB.

Biotechnol Adv. 2018 Nov 1;36(6):1633-1648. doi: 10.1016/j.biotechadv.2018.03.014. Epub 2018 Mar 27. Review.

PMID:
29597029
10.

Chronic diseases, inflammation, and spices: how are they linked?

Kunnumakkara AB, Sailo BL, Banik K, Harsha C, Prasad S, Gupta SC, Bharti AC, Aggarwal BB.

J Transl Med. 2018 Jan 25;16(1):14. doi: 10.1186/s12967-018-1381-2. Review.

11.

Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric.

Prasad S, Tyagi AK, Siddik ZH, Aggarwal BB.

Front Pharmacol. 2017 Dec 12;8:871. doi: 10.3389/fphar.2017.00871. eCollection 2017. Retraction in: Front Pharmacol. 2018 Apr 16;9:400.

12.

Resveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: Comparison with TNF-α.

Buhrmann C, Popper B, Aggarwal BB, Shakibaei M.

PLoS One. 2017 Nov 2;12(11):e0186993. doi: 10.1371/journal.pone.0186993. eCollection 2017.

13.

Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention.

Griffiths K, Aggarwal BB, Singh RB, Buttar HS, Wilson D, De Meester F.

Diseases. 2016 Aug 1;4(3). pii: E28. doi: 10.3390/diseases4030028. Review.

14.

Calebin A, a novel component of turmeric, suppresses NF-κB regulated cell survival and inflammatory gene products leading to inhibition of cell growth and chemosensitization.

Tyagi AK, Prasad S, Majeed M, Aggarwal BB.

Phytomedicine. 2017 Oct 15;34:171-181. doi: 10.1016/j.phymed.2017.08.021. Epub 2017 Aug 31.

PMID:
28899500
15.

Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis.

Gupta SC, Prasad S, Tyagi AK, Kunnumakkara AB, Aggarwal BB.

Phytomedicine. 2017 Oct 15;34:14-20. doi: 10.1016/j.phymed.2017.07.001. Epub 2017 Jul 3. Review.

PMID:
28899496
16.

Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment.

Pandey MK, Gupta SC, Nabavizadeh A, Aggarwal BB.

Semin Cancer Biol. 2017 Oct;46:158-181. doi: 10.1016/j.semcancer.2017.07.002. Epub 2017 Aug 16. Review.

PMID:
28823533
17.

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.

Kunnumakkara AB, Bordoloi D, Harsha C, Banik K, Gupta SC, Aggarwal BB.

Clin Sci (Lond). 2017 Jul 5;131(15):1781-1799. doi: 10.1042/CS20160935. Print 2017 Aug 1. Review.

PMID:
28679846
18.

Curcumin, the golden nutraceutical: multitargeting for multiple chronic diseases.

Kunnumakkara AB, Bordoloi D, Padmavathi G, Monisha J, Roy NK, Prasad S, Aggarwal BB.

Br J Pharmacol. 2017 Jun;174(11):1325-1348. doi: 10.1111/bph.13621. Epub 2016 Oct 21. Review.

19.

Prevention and Treatment of Cancer: Hypes and Hopes 6th International Translational Cancer Research Conference.

Patel P, Vora H, Aggarwal BB, Gandhi V, Mehta K, Pathak S.

Anticancer Res. 2016 Sep;36(9):4971-5.

PMID:
27630358
20.

γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules.

Prasad S, Gupta SC, Tyagi AK, Aggarwal BB.

Br J Cancer. 2016 Sep 27;115(7):814-24. doi: 10.1038/bjc.2016.257. Epub 2016 Aug 30.

21.

3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cells.

Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16926. doi: 10.1074/jbc.A111.274613. No abstract available.

22.

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.

Gupta SC, Reuter S, Phromnoi K, Park B, Hema PS, Nair M, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16925. doi: 10.1074/jbc.A110.191379. No abstract available.

23.

Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors. EVIDENCE FOR THE ROLE OF REACTIVE OXYGEN SPECIES AND JNK.

Prasad S, Yadav VR, Kannappan R, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16924. doi: 10.1074/jbc.A110.183699. No abstract available.

24.

Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.

Sung B, Ravindran J, Prasad S, Pandey MK, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16923. doi: 10.1074/jbc.A110.172767. No abstract available.

25.
26.

Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway.

Prasad S, Yadav VR, Sundaram C, Reuter S, Hema PS, Nair MS, Chaturvedi MM, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16921. doi: 10.1074/jbc.A110.121061. No abstract available.

27.

Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.

Sung B, Park B, Yadav VR, Aggarwal BB.

J Biol Chem. 2016 Aug 5;291(32):16920. doi: 10.1074/jbc.A109.090209. No abstract available.

28.

Serendipity in Cancer Drug Discovery: Rational or Coincidence?

Prasad S, Gupta SC, Aggarwal BB.

Trends Pharmacol Sci. 2016 Jun;37(6):435-450. doi: 10.1016/j.tips.2016.03.004. Epub 2016 Apr 12. Review.

PMID:
27083322
29.

Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials.

Sahebkar A, Cicero AFG, Simental-Mendía LE, Aggarwal BB, Gupta SC.

Pharmacol Res. 2016 May;107:234-242. doi: 10.1016/j.phrs.2016.03.026. Epub 2016 Mar 26. Review.

PMID:
27025786
30.

Detection of inflammatory biomarkers in saliva and urine: Potential in diagnosis, prevention, and treatment for chronic diseases.

Prasad S, Tyagi AK, Aggarwal BB.

Exp Biol Med (Maywood). 2016 Apr;241(8):783-99. doi: 10.1177/1535370216638770. Epub 2016 Mar 24. Review.

31.

Targeting Cell Survival Proteins for Cancer Cell Death.

Pandey MK, Prasad S, Tyagi AK, Deb L, Huang J, Karelia DN, Amin SG, Aggarwal BB.

Pharmaceuticals (Basel). 2016 Feb 25;9(1). pii: E11. doi: 10.3390/ph9010011. Review.

32.
33.

Calebin A downregulates osteoclastogenesis through suppression of RANKL signalling.

Tyagi AK, Prasad S, Majeed M, Aggarwal BB.

Arch Biochem Biophys. 2016 Mar 1;593:80-9. doi: 10.1016/j.abb.2016.02.013. Epub 2016 Feb 11.

PMID:
26874195
34.

Curcumin hormesis mediates a cross-talk between autophagy and cell death.

Rainey N, Motte L, Aggarwal BB, Petit PX.

Cell Death Dis. 2015 Dec 3;6:e2003. doi: 10.1038/cddis.2015.343. No abstract available.

35.

Identification of a novel compound (β-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin.

Tyagi AK, Prasad S, Yuan W, Li S, Aggarwal BB.

Invest New Drugs. 2015 Dec;33(6):1175-86. doi: 10.1007/s10637-015-0296-5. Epub 2015 Nov 2.

PMID:
26521943
36.

Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα.

Sethi G, Ahn KS, Chaturvedi MM, Aggarwal BB.

Oncogene. 2015 Oct 16;34(42):5407. doi: 10.1038/onc.2015.313. No abstract available.

PMID:
26473948
37.

Natural Compounds Targeting STAT3 Mediated Inflammation.

Morales EE, Aggarwal BB, Kamat AM.

Eur Urol. 2016 Mar;69(3):405-6. doi: 10.1016/j.eururo.2015.09.033. Epub 2015 Oct 9. No abstract available.

PMID:
26454706
38.

Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses.

Aggarwal BB, Deb L, Prasad S.

Molecules. 2014 Dec 24;20(1):185-205. doi: 10.3390/molecules20010185. Review.

39.

Multi-targeted approach to cancer treatment: an international translational cancer research symposium.

Mehta K, Gandhi V, Pathak S, Aggarwal BB, Grover RK.

Anticancer Res. 2014 Nov;34(11):6791-5.

PMID:
25368293
40.

Synthesis, characterization and in vitro anticancer activity of C-5 curcumin analogues with potential to inhibit TNF-α-induced NF-κB activation.

Anthwal A, Thakur BK, Rawat MS, Rawat DS, Tyagi AK, Aggarwal BB.

Biomed Res Int. 2014;2014:524161. doi: 10.1155/2014/524161. Epub 2014 Jul 24.

41.

Forecasting nutrition research in 2020.

Hackman RM, Aggarwal BB, Applebaum RS, deVere White RW, Dubick MA, Heber D, Ito T, Johnson GH, Keen CL, Winters BL, Stohs SJ.

J Am Coll Nutr. 2014;33(4):340-6. doi: 10.1080/07315724.2014.943113. Epub 2014 Aug 21. No abstract available.

PMID:
25144361
42.

Targeting death receptors for TRAIL by agents designed by Mother Nature.

Prasad S, Kim JH, Gupta SC, Aggarwal BB.

Trends Pharmacol Sci. 2014 Oct;35(10):520-36. doi: 10.1016/j.tips.2014.07.004. Epub 2014 Aug 14. Review.

PMID:
25128958
43.

Piperlongumine chemosensitizes tumor cells through interaction with cysteine 179 of IκBα kinase, leading to suppression of NF-κB-regulated gene products.

Han JG, Gupta SC, Prasad S, Aggarwal BB.

Mol Cancer Ther. 2014 Oct;13(10):2422-35. doi: 10.1158/1535-7163.MCT-14-0171. Epub 2014 Jul 31.

44.

Editorial: Balancing tumor necrosis factor receptor I and tumor necrosis factor receptor II jointly for joint inflammation.

Aggarwal BB.

Arthritis Rheumatol. 2014 Oct;66(10):2657-60. doi: 10.1002/art.38753. No abstract available.

45.

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols.

Gupta SC, Tyagi AK, Deshmukh-Taskar P, Hinojosa M, Prasad S, Aggarwal BB.

Arch Biochem Biophys. 2014 Oct 1;559:91-9. doi: 10.1016/j.abb.2014.06.006. Epub 2014 Jun 16. Review.

PMID:
24946050
46.

History and current status of evidence-based korean medicine.

Ko SG, Aggarwal BB, Liu M, Yin CS, Jin DH, Jang BH.

Evid Based Complement Alternat Med. 2014;2014:503867. doi: 10.1155/2014/503867. Epub 2014 Apr 15. No abstract available.

47.

Curcumin, a component of golden spice: from bedside to bench and back.

Prasad S, Gupta SC, Tyagi AK, Aggarwal BB.

Biotechnol Adv. 2014 Nov 1;32(6):1053-64. doi: 10.1016/j.biotechadv.2014.04.004. Epub 2014 Apr 30. Review.

PMID:
24793420
48.

Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice.

Prasad S, Tyagi AK, Aggarwal BB.

Cancer Res Treat. 2014 Jan;46(1):2-18. doi: 10.4143/crt.2014.46.1.2. Epub 2014 Jan 15. Review.

49.

Evidence that TNF-β (lymphotoxin α) can activate the inflammatory environment in human chondrocytes.

Buhrmann C, Shayan P, Aggarwal BB, Shakibaei M.

Arthritis Res Ther. 2013;15(6):R202.

50.

Cancer Prevention and Therapy: Integrating Traditional Korean Medicine Into Modern Cancer Care.

Yoon SW, Jeong JS, Kim JH, Aggarwal BB.

Integr Cancer Ther. 2014 Jul;13(4):310-31. doi: 10.1177/1534735413510023. Epub 2013 Nov 25. Review.

PMID:
24282099

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