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Studies on citrullinated LL-37: detection in human airways, antibacterial effects and biophysical properties.

Al-Adwani S, Wallin C, Balhuizen MD, Veldhuizen EJA, Coorens M, Landreh M, Végvári Á, Smith ME, Qvarfordt I, Lindén A, Gräslund A, Agerberth B, Bergman P.

Sci Rep. 2020 Feb 11;10(1):2376. doi: 10.1038/s41598-020-59071-7.


Cathelicidin-related antimicrobial peptide protects against ischaemia reperfusion-induced acute kidney injury in mice.

Pan LL, Liang W, Ren Z, Li C, Chen Y, Niu W, Fang X, Liu Y, Zhang M, Diana J, Agerberth B, Sun J.

Br J Pharmacol. 2020 Jan 24. doi: 10.1111/bph.14998. [Epub ahead of print]


Host-Directed Therapy as a Novel Treatment Strategy to Overcome Tuberculosis: Targeting Immune Modulation.

Ahmed S, Raqib R, Guðmundsson GH, Bergman P, Agerberth B, Rekha RS.

Antibiotics (Basel). 2020 Jan 7;9(1). pii: E21. doi: 10.3390/antibiotics9010021. Review.


Cathelicidin Contributes to the Restriction of Leishmania in Human Host Macrophages.

Crauwels P, Bank E, Walber B, Wenzel UA, Agerberth B, Chanyalew M, Abebe M, König R, Ritter U, Reiling N, van Zandbergen G.

Front Immunol. 2019 Nov 22;10:2697. doi: 10.3389/fimmu.2019.02697. eCollection 2019.


Klebsiella pneumoniae Expressing VIM-1 Metallo-β-Lactamase Is Resensitized to Cefotaxime via Thiol-Mediated Zinc Chelation.

Karadottir H, Coorens M, Liu Z, Wang Y, Agerberth B, Giske CG, Bergman P.

Infect Immun. 2019 Dec 17;88(1). pii: e00756-19. doi: 10.1128/IAI.00756-19. Print 2019 Dec 17.


Low Methoxyl Pectin Protects against Autoimmune Diabetes and Associated Caecal Dysfunction.

Wu C, Pan LL, Luo Y, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Yang G, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J.

Mol Nutr Food Res. 2019 Nov;63(21):e1900307. doi: 10.1002/mnfr.201900307. Epub 2019 Sep 5.


Modulation of Gut Microbiota by Low Methoxyl Pectin Attenuates Type 1 Diabetes in Non-obese Diabetic Mice.

Wu C, Pan LL, Niu W, Fang X, Liang W, Li J, Li H, Pan X, Chen W, Zhang H, Lakey JRT, Agerberth B, de Vos P, Sun J.

Front Immunol. 2019 Jul 30;10:1733. doi: 10.3389/fimmu.2019.01733. eCollection 2019.


Novel aroylated phenylenediamine compounds enhance antimicrobial defense and maintain airway epithelial barrier integrity.

Myszor IT, Parveen Z, Ottosson H, Bergman P, Agerberth B, Strömberg R, Gudmundsson GH.

Sci Rep. 2019 May 8;9(1):7114. doi: 10.1038/s41598-019-43350-z.


Innate lymphoid cell type 3-derived interleukin-22 boosts lipocalin-2 production in intestinal epithelial cells via synergy between STAT3 and NF-κB.

Coorens M, Rao A, Gräfe SK, Unelius D, Lindforss U, Agerberth B, Mjösberg J, Bergman P.

J Biol Chem. 2019 Apr 12;294(15):6027-6041. doi: 10.1074/jbc.RA118.007290. Epub 2019 Feb 19.


Cathelicidin-related antimicrobial peptide protects against myocardial ischemia/reperfusion injury.

Bei Y, Pan LL, Zhou Q, Zhao C, Xie Y, Wu C, Meng X, Gu H, Xu J, Zhou L, Sluijter JPG, Das S, Agerberth B, Sun J, Xiao J.

BMC Med. 2019 Feb 20;17(1):42. doi: 10.1186/s12916-019-1268-y.


A novel cysteine-linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre-clinical trial.

Odeberg J, Wirsén A, Norberg Å, Frie J, Printz G, Lagercrantz H, Gudmundsson GH, Agerberth B, Jonsson B.

Mater Sci Eng C Mater Biol Appl. 2018 Dec 1;93:782-789. doi: 10.1016/j.msec.2018.08.040. Epub 2018 Aug 23.


Immune responses in the treatment of drug-sensitive pulmonary tuberculosis with phenylbutyrate and vitamin D3 as host directed therapy.

Rekha RS, Mily A, Sultana T, Haq A, Ahmed S, Mostafa Kamal SM, van Schadewijk A, Hiemstra PS, Gudmundsson GH, Agerberth B, Raqib R.

BMC Infect Dis. 2018 Jul 4;18(1):303. doi: 10.1186/s12879-018-3203-9.


Lactose Induces Phenotypic and Functional Changes of Neutrophils and Macrophages to Alleviate Acute Pancreatitis in Mice.

Pan LL, Deng YY, Wang R, Wu C, Li J, Niu W, Yang Q, Bhatia M, Gudmundsson GH, Agerberth B, Diana J, Sun J.

Front Immunol. 2018 Apr 17;9:751. doi: 10.3389/fimmu.2018.00751. eCollection 2018.


Daily adjunctive therapy with vitamin D3 and phenylbutyrate supports clinical recovery from pulmonary tuberculosis: a randomized controlled trial in Ethiopia.

Bekele A, Gebreselassie N, Ashenafi S, Kassa E, Aseffa G, Amogne W, Getachew M, Aseffa A, Worku A, Raqib R, Agerberth B, Hammar U, Bergman P, Aderaye G, Andersson J, Brighenti S.

J Intern Med. 2018 Sep;284(3):292-306. doi: 10.1111/joim.12767. Epub 2018 May 23.


The host defense peptide LL-37 is detected in human parotid and submandibular/sublingual saliva and expressed in glandular neutrophils.

Svensson D, Aidoukovitch A, Anders E, Agerberth B, Andersson F, Ekblad E, Ericson D, Nebel D, Voss U, Nilsson BO.

Eur J Oral Sci. 2018 Apr;126(2):93-100. doi: 10.1111/eos.12407. Epub 2018 Feb 9.


Prostaglandin E2 suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection.

Wan M, Tang X, Rekha RS, Muvva SSVJR, Brighenti S, Agerberth B, Haeggström JZ.

FASEB J. 2018 May;32(5):2827-2840. doi: 10.1096/fj.201701308. Epub 2018 Jan 17.


Treatment with Entinostat Heals Experimental Cholera by Affecting Physical and Chemical Barrier Functions of Intestinal Epithelia.

Sarker P, Banik A, Stromberg R, Gudmundsson GH, Raqib R, Agerberth B.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02570-16. doi: 10.1128/AAC.02570-16. Print 2017 Jul.


Assays for Identifying Inducers of the Antimicrobial Peptide LL-37.

Nylén F, Bergman P, Gudmundsson GH, Agerberth B.

Methods Mol Biol. 2017;1548:271-281. doi: 10.1007/978-1-4939-6737-7_19.


The host defense peptide LL-37 a possible inducer of the type I interferon system in patients with polymyositis and dermatomyositis.

Lu X, Tang Q, Lindh M, Dastmalchi M, Alexanderson H, Popovic Silwerfeldt K, Agerberth B, Lundberg IE, Wick C.

J Autoimmun. 2017 Mar;78:46-56. doi: 10.1016/j.jaut.2016.12.003. Epub 2016 Dec 22.


Potent Inducers of Endogenous Antimicrobial Peptides for Host Directed Therapy of Infections.

Ottosson H, Nylén F, Sarker P, Miraglia E, Bergman P, Gudmundsson GH, Raqib R, Agerberth B, Strömberg R.

Sci Rep. 2016 Nov 9;6:36692. doi: 10.1038/srep36692.


Entinostat up-regulates the CAMP gene encoding LL-37 via activation of STAT3 and HIF-1α transcription factors.

Miraglia E, Nylén F, Johansson K, Arnér E, Cebula M, Farmand S, Ottosson H, Strömberg R, Gudmundsson GH, Agerberth B, Bergman P.

Sci Rep. 2016 Sep 16;6:33274. doi: 10.1038/srep33274.


Cathelicidins positively regulate pancreatic β-cell functions.

Sun J, Xu M, Ortsäter H, Lundeberg E, Juntti-Berggren L, Chen YQ, Haeggström JZ, Gudmundsson GH, Diana J, Agerberth B.

FASEB J. 2016 Feb;30(2):884-94. doi: 10.1096/fj.15-275826. Epub 2015 Nov 2.


Significant Effects of Oral Phenylbutyrate and Vitamin D3 Adjunctive Therapy in Pulmonary Tuberculosis: A Randomized Controlled Trial.

Mily A, Rekha RS, Kamal SM, Arifuzzaman AS, Rahim Z, Khan L, Haq MA, Zaman K, Bergman P, Brighenti S, Gudmundsson GH, Agerberth B, Raqib R.

PLoS One. 2015 Sep 22;10(9):e0138340. doi: 10.1371/journal.pone.0138340. eCollection 2015.


Glucocorticoid dexamethasone down-regulates basal and vitamin D3 induced cathelicidin expression in human monocytes and bronchial epithelial cell line.

Kulkarni NN, Gunnarsson HI, Yi Z, Gudmundsdottir S, Sigurjonsson OE, Agerberth B, Gudmundsson GH.

Immunobiology. 2016 Feb;221(2):245-52. doi: 10.1016/j.imbio.2015.09.001. Epub 2015 Sep 3.


Pancreatic β-Cells Limit Autoimmune Diabetes via an Immunoregulatory Antimicrobial Peptide Expressed under the Influence of the Gut Microbiota.

Sun J, Furio L, Mecheri R, van der Does AM, Lundeberg E, Saveanu L, Chen Y, van Endert P, Agerberth B, Diana J.

Immunity. 2015 Aug 18;43(2):304-17. doi: 10.1016/j.immuni.2015.07.013. Epub 2015 Aug 4.


Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing of Mycobacterium tuberculosis in human macrophages.

Rekha RS, Rao Muvva SS, Wan M, Raqib R, Bergman P, Brighenti S, Gudmundsson GH, Agerberth B.

Autophagy. 2015;11(9):1688-99. doi: 10.1080/15548627.2015.1075110.


No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis.

Kienhöfer D, Hahn J, Schubert I, Reinwald C, Ipseiz N, Lang SC, Borràs ÈB, Amann K, Sjöwall C, Barron AE, Hueber AJ, Agerberth B, Schett G, Hoffmann MH.

PLoS One. 2014 Dec 23;9(12):e115474. doi: 10.1371/journal.pone.0115474. eCollection 2014.


Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways.

Kulkarni NN, Yi Z, Huehnken C, Agerberth B, Gudmundsson GH.

Mol Immunol. 2015 Feb;63(2):530-9.


Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns.

Bergman P, Adori C, Vas S, Kai-Larsen Y, Sarkanen T, Cederlund A, Agerberth B, Julkunen I, Horvath B, Kostyalik D, Kalmár L, Bagdy G, Huutoniemi A, Partinen M, Hökfelt T.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):E3735-44. doi: 10.1073/pnas.1412189111. Epub 2014 Aug 18.


A review of the innate immune defence of the human foetus and newborn, with the emphasis on antimicrobial peptides.

Kai-Larsen Y, Gudmundsson GH, Agerberth B.

Acta Paediatr. 2014 Oct;103(10):1000-8. doi: 10.1111/apa.12700. Epub 2014 Jun 23. Review.


Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo.

Wan M, Soehnlein O, Tang X, van der Does AM, Smedler E, Uhlén P, Lindbom L, Agerberth B, Haeggström JZ.

FASEB J. 2014 Aug;28(8):3456-67. doi: 10.1096/fj.14-251306. Epub 2014 Apr 15.


Vitamin D₃ and phenylbutyrate promote development of a human dendritic cell subset displaying enhanced antimicrobial properties.

van der Does AM, Kenne E, Koppelaar E, Agerberth B, Lindbom L.

J Leukoc Biol. 2014 Jun;95(6):883-91. doi: 10.1189/jlb.1013549. Epub 2014 Feb 18.


Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages.

Wan M, van der Does AM, Tang X, Lindbom L, Agerberth B, Haeggström JZ.

J Leukoc Biol. 2014 Jun;95(6):971-81. doi: 10.1189/jlb.0513304. Epub 2014 Feb 18.


Ciprofloxacin Affects Host Cells by Suppressing Expression of the Endogenous Antimicrobial Peptides Cathelicidins and Beta-Defensin-3 in Colon Epithelia.

Sarker P, Mily A, Mamun AA, Jalal S, Bergman P, Raqib R, Gudmundsson GH, Agerberth B.

Antibiotics (Basel). 2014 Jul 25;3(3):353-74. doi: 10.3390/antibiotics3030353.


Characterization of biofilm formation and the role of BCR1 in clinical isolates of Candida parapsilosis.

Pannanusorn S, Ramírez-Zavala B, Lünsdorf H, Agerberth B, Morschhäuser J, Römling U.

Eukaryot Cell. 2014 Apr;13(4):438-51. doi: 10.1128/EC.00181-13. Epub 2013 Dec 2.


Label-free quantitative mass spectrometry reveals novel pathways involved in LL-37 expression.

Cederlund A, Nylén F, Miraglia E, Bergman P, Gudmundsson GH, Agerberth B.

J Innate Immun. 2014;6(3):365-76. doi: 10.1159/000355931. Epub 2013 Nov 16.


Protein biomarkers in vernix with potential to predict the development of atopic eczema in early childhood.

Holm T, Rutishauser D, Kai-Larsen Y, Lyutvinskiy Y, Stenius F, Zubarev RA, Agerberth B, Alm J, Scheynius A.

Allergy. 2014 Jan;69(1):104-12. doi: 10.1111/all.12308. Epub 2013 Nov 11.


Treatment with phenylbutyrate in a pre-clinical trial reduces diarrhea due to enteropathogenic Escherichia coli: link to cathelicidin induction.

Al-Mamun A, Mily A, Sarker P, Tiash S, Navarro A, Akter M, Talukder KA, Islam MF, Agerberth B, Gudmundsson GH, Cravioto A, Raqib R.

Microbes Infect. 2013 Nov;15(13):939-50. doi: 10.1016/j.micinf.2013.08.007. Epub 2013 Sep 7.


Boosting innate immunity: development and validation of a cell-based screening assay to identify LL-37 inducers.

Nylén F, Miraglia E, Cederlund A, Ottosson H, Strömberg R, Gudmundsson GH, Agerberth B.

Innate Immun. 2014 May;20(4):364-76. doi: 10.1177/1753425913493338. Epub 2013 Jul 24.


Cathelicidin LL-37 induces angiogenesis via PGE2-EP3 signaling in endothelial cells, in vivo inhibition by aspirin.

Salvado MD, Di Gennaro A, Lindbom L, Agerberth B, Haeggström JZ.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1965-72. doi: 10.1161/ATVBAHA.113.301851. Epub 2013 Jun 13.


Oral intake of phenylbutyrate with or without vitamin D3 upregulates the cathelicidin LL-37 in human macrophages: a dose finding study for treatment of tuberculosis.

Mily A, Rekha RS, Kamal SM, Akhtar E, Sarker P, Rahim Z, Gudmundsson GH, Agerberth B, Raqib R.

BMC Pulm Med. 2013 Apr 16;13:23. doi: 10.1186/1471-2466-13-23.


The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils--implications for asthma.

Sun J, Dahlén B, Agerberth B, Haeggström JZ.

Allergy. 2013 Mar;68(3):304-11. doi: 10.1111/all.12087. Epub 2013 Jan 18.


Lactose in human breast milk an inducer of innate immunity with implications for a role in intestinal homeostasis.

Cederlund A, Kai-Larsen Y, Printz G, Yoshio H, Alvelius G, Lagercrantz H, Strömberg R, Jörnvall H, Gudmundsson GH, Agerberth B.

PLoS One. 2013;8(1):e53876. doi: 10.1371/journal.pone.0053876. Epub 2013 Jan 10.


Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes.

Diana J, Simoni Y, Furio L, Beaudoin L, Agerberth B, Barrat F, Lehuen A.

Nat Med. 2013 Jan;19(1):65-73. doi: 10.1038/nm.3042. Epub 2012 Dec 16.


Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study.

Bergman P, Norlin AC, Hansen S, Rekha RS, Agerberth B, Björkhem-Bergman L, Ekström L, Lindh JD, Andersson J.

BMJ Open. 2012 Dec 13;2(6). pii: e001663. doi: 10.1136/bmjopen-2012-001663. Print 2012.


The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats.

Hoffmann MH, Bruns H, Bäckdahl L, Neregård P, Niederreiter B, Herrmann M, Catrina AI, Agerberth B, Holmdahl R.

Ann Rheum Dis. 2013 Jul;72(7):1239-48. doi: 10.1136/annrheumdis-2012-202218. Epub 2012 Nov 21.


Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections.

van der Does AM, Bergman P, Agerberth B, Lindbom L.

J Leukoc Biol. 2012 Oct;92(4):735-42. doi: 10.1189/jlb.0412178. Epub 2012 Jun 13. Review.


Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial.

Raqib R, Sarker P, Mily A, Alam NH, Arifuzzaman AS, Rekha RS, Andersson J, Gudmundsson GH, Cravioto A, Agerberth B.

BMC Infect Dis. 2012 May 10;12:111.


Impaired release of antimicrobial peptides into nasal fluid of hyper-IgE and CVID patients.

Cederlund A, Olliver M, Rekha RS, Lindh M, Lindbom L, Normark S, Henriques-Normark B, Andersson J, Agerberth B, Bergman P.

PLoS One. 2011;6(12):e29316. doi: 10.1371/journal.pone.0029316. Epub 2011 Dec 27.


Differential host immune responses to epidemic and endemic strains of Shigella dysenteriae type I.

Sayem MA, Ahmad SM, Rekha RS, Sarker P, Agerberth B, Talukder KA, Raqib R.

J Health Popul Nutr. 2011 Oct;29(5):429-37.

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