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Items: 1 to 50 of 63

1.

Rapid MALDI mass spectrometry imaging for surgical pathology.

Basu SS, Regan MS, Randall EC, Abdelmoula WM, Clark AR, Gimenez-Cassina Lopez B, Cornett DS, Haase A, Santagata S, Agar NYR.

NPJ Precis Oncol. 2019 Jul 4;3:17. doi: 10.1038/s41698-019-0089-y. eCollection 2019.

PMID:
31286061
Free PMC Article
2.

Quantitative Wide-Field Imaging Techniques for Fluorescence Guided Neurosurgery.

Valdes PA, Juvekar P, Agar NYR, Gioux S, Golby AJ.

Front Surg. 2019 Jun 6;6:31. doi: 10.3389/fsurg.2019.00031. eCollection 2019. Review.

3.

A large-scale drug screen identifies selective inhibitors of class I HDACs as a potential therapeutic option for SHH medulloblastoma.

Pak E, MacKenzie EL, Zhao X, Pazyra-Murphy MF, Park PMC, Wu L, Shaw DL, Addleson EC, Cayer SS, Lopez BG, Agar NYR, Rubin LL, Qi J, Merk DJ, Segal RA.

Neuro Oncol. 2019 May 16. pii: noz089. doi: 10.1093/neuonc/noz089. [Epub ahead of print]

PMID:
31111916
4.

Metal Oxide Laser Ionization Mass Spectrometry Imaging (MOLI MSI) Using Cerium(IV) Oxide.

Basu SS, McMinn MH, Giménez-Cassina Lopéz B, Regan MS, Randall EC, Clark AR, Cox CR, Agar NYR.

Anal Chem. 2019 May 21;91(10):6800-6807. doi: 10.1021/acs.analchem.9b00894. Epub 2019 May 8.

PMID:
31025851
5.

Automatic 3D Nonlinear Registration of Mass Spectrometry Imaging and Magnetic Resonance Imaging Data.

Abdelmoula WM, Regan MS, Lopez BGC, Randall EC, Lawler S, Mladek AC, Nowicki MO, Marin BM, Agar JN, Swanson KR, Kapur T, Sarkaria JN, Wells W, Agar NYR.

Anal Chem. 2019 May 7;91(9):6206-6216. doi: 10.1021/acs.analchem.9b00854. Epub 2019 Apr 22.

PMID:
30932478
6.

Genetically Encoded Fluorescent Proteins Enable High-Throughput Assignment of Cell Cohorts Directly from MALDI-MS Images.

Schmitt ND, Rawlins CM, Randall EC, Wang X, Koller A, Auclair JR, Kowalski JM, Kowalski PJ, Luther E, Ivanov AR, Agar NYR, Agar JN.

Anal Chem. 2019 Mar 19;91(6):3810-3817. doi: 10.1021/acs.analchem.8b03454. Epub 2019 Mar 6.

PMID:
30839199
7.

Molecular Characterization of Prostate Cancer with Associated Gleason Score Using Mass Spectrometry Imaging.

Randall EC, Zadra G, Chetta P, Lopez BGC, Syamala S, Basu SS, Agar JN, Loda M, Tempany CM, Fennessy FM, Agar NYR.

Mol Cancer Res. 2019 May;17(5):1155-1165. doi: 10.1158/1541-7786.MCR-18-1057. Epub 2019 Feb 11.

PMID:
30745465
8.

Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial.

Wen PY, Touat M, Alexander BM, Mellinghoff IK, Ramkissoon S, McCluskey CS, Pelton K, Haidar S, Basu SS, Gaffey SC, Brown LE, Martinez-Ledesma JE, Wu S, Kim J, Wei W, Park MA, Huse JT, Kuhn JG, Rinne ML, Colman H, Agar NYR, Omuro AM, DeAngelis LM, Gilbert MR, de Groot JF, Cloughesy TF, Chi AS, Roberts TM, Zhao JJ, Lee EQ, Nayak L, Heath JR, Horky LL, Batchelor TT, Beroukhim R, Chang SM, Ligon AH, Dunn IF, Koul D, Young GS, Prados MD, Reardon DA, Yung WKA, Ligon KL.

J Clin Oncol. 2019 Mar 20;37(9):741-750. doi: 10.1200/JCO.18.01207. Epub 2019 Feb 4.

9.

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma.

Randall EC, Emdal KB, Laramy JK, Kim M, Roos A, Calligaris D, Regan MS, Gupta SK, Mladek AC, Carlson BL, Johnson AJ, Lu FK, Xie XS, Joughin BA, Reddy RJ, Peng S, Abdelmoula WM, Jackson PR, Kolluri A, Kellersberger KA, Agar JN, Lauffenburger DA, Swanson KR, Tran NL, Elmquist WF, White FM, Sarkaria JN, Agar NYR.

Nat Commun. 2018 Nov 21;9(1):4904. doi: 10.1038/s41467-018-07334-3.

10.

Blood-brain-barrier organoids for investigating the permeability of CNS therapeutics.

Bergmann S, Lawler SE, Qu Y, Fadzen CM, Wolfe JM, Regan MS, Pentelute BL, Agar NYR, Cho CF.

Nat Protoc. 2018 Dec;13(12):2827-2843. doi: 10.1038/s41596-018-0066-x.

PMID:
30382243
11.

Rapid discrimination of pediatric brain tumors by mass spectrometry imaging.

Clark AR, Calligaris D, Regan MS, Pomeranz Krummel D, Agar JN, Kallay L, MacDonald T, Schniederjan M, Santagata S, Pomeroy SL, Agar NYR, Sengupta S.

J Neurooncol. 2018 Nov;140(2):269-279. doi: 10.1007/s11060-018-2978-2. Epub 2018 Aug 20.

12.

Efficacy of the MDM2 Inhibitor SAR405838 in Glioblastoma Is Limited by Poor Distribution Across the Blood-Brain Barrier.

Kim M, Ma DJ, Calligaris D, Zhang S, Feathers RW, Vaubel RA, Meaux I, Mladek AC, Parrish KE, Jin F, Barriere C, Debussche L, Watters J, Tian S, Decker PA, Eckel-Passow JE, Kitange GJ, Johnson AJ, Parney IF, Anastasiadis PZ, Agar NYR, Elmquist WF, Sarkaria JN.

Mol Cancer Ther. 2018 Sep;17(9):1893-1901. doi: 10.1158/1535-7163.MCT-17-0600. Epub 2018 Jul 3.

PMID:
29970480
13.

In Vitro Liquid Extraction Surface Analysis Mass Spectrometry (ivLESA-MS) for Direct Metabolic Analysis of Adherent Cells in Culture.

Basu SS, Randall EC, Regan MS, Lopez BGC, Clark AR, Schmitt ND, Agar JN, Dillon DA, Agar NYR.

Anal Chem. 2018 Apr 17;90(8):4987-4991. doi: 10.1021/acs.analchem.8b00530. Epub 2018 Apr 2.

14.

Prostate cancer diagnosis and characterization with mass spectrometry imaging.

Kurreck A, Vandergrift LA, Fuss TL, Habbel P, Agar NYR, Cheng LL.

Prostate Cancer Prostatic Dis. 2018 Sep;21(3):297-305. doi: 10.1038/s41391-017-0011-z. Epub 2017 Dec 5. Review.

15.

Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data.

Sarkaria JN, Hu LS, Parney IF, Pafundi DH, Brinkmann DH, Laack NN, Giannini C, Burns TC, Kizilbash SH, Laramy JK, Swanson KR, Kaufmann TJ, Brown PD, Agar NYR, Galanis E, Buckner JC, Elmquist WF.

Neuro Oncol. 2018 Jan 22;20(2):184-191. doi: 10.1093/neuonc/nox175. Review.

16.

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA.

Cancer Cell. 2017 Oct 9;32(4):411-426.e11. doi: 10.1016/j.ccell.2017.08.018. Epub 2017 Sep 28.

17.

Osteoglycin promotes meningioma development through downregulation of NF2 and activation of mTOR signaling.

Mei Y, Du Z, Hu C, Greenwald NF, Abedalthagafi M, Agar NYR, Dunn GP, Bi WL, Santagata S, Dunn IF.

Cell Commun Signal. 2017 Sep 18;15(1):34. doi: 10.1186/s12964-017-0189-7.

18.

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents.

Cho CF, Wolfe JM, Fadzen CM, Calligaris D, Hornburg K, Chiocca EA, Agar NYR, Pentelute BL, Lawler SE.

Nat Commun. 2017 Jun 6;8:15623. doi: 10.1038/ncomms15623.

19.

Genomic profile of human meningioma cell lines.

Mei Y, Bi WL, Greenwald NF, Agar NY, Beroukhim R, Dunn GP, Dunn IF.

PLoS One. 2017 May 26;12(5):e0178322. doi: 10.1371/journal.pone.0178322. eCollection 2017.

20.

Rapid Mass Spectrometry Imaging to Assess the Biochemical Profile of Pituitary Tissue for Potential Intraoperative Usage.

Huang KT, Ludy S, Calligaris D, Dunn IF, Laws E, Santagata S, Agar NY.

Adv Cancer Res. 2017;134:257-282. doi: 10.1016/bs.acr.2016.11.006. Epub 2016 Dec 28. Review.

PMID:
28110653
21.

A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.

Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD.

Neuro Oncol. 2017 Jun 1;19(6):774-785. doi: 10.1093/neuonc/now261.

22.

Increased expression of programmed death ligand 1 (PD-L1) in human pituitary tumors.

Mei Y, Bi WL, Greenwald NF, Du Z, Agar NY, Kaiser UB, Woodmansee WW, Reardon DA, Freeman GJ, Fecci PE, Laws ER Jr, Santagata S, Dunn GP, Dunn IF.

Oncotarget. 2016 Nov 22;7(47):76565-76576. doi: 10.18632/oncotarget.12088.

23.

First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development.

Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, Sengupta S.

J Biomed Nanotechnol. 2016 Jun;12(6):1297-302.

24.

Label-Free Neurosurgical Pathology with Stimulated Raman Imaging.

Lu FK, Calligaris D, Olubiyi OI, Norton I, Yang W, Santagata S, Xie XS, Golby AJ, Agar NY.

Cancer Res. 2016 Jun 15;76(12):3451-62. doi: 10.1158/0008-5472.CAN-16-0270. Epub 2016 Apr 12.

25.

Translational Breast Cancer Research Consortium (TBCRC) 022: A Phase II Trial of Neratinib for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.

Freedman RA, Gelman RS, Wefel JS, Melisko ME, Hess KR, Connolly RM, Van Poznak CH, Niravath PA, Puhalla SL, Ibrahim N, Blackwell KL, Moy B, Herold C, Liu MC, Lowe A, Agar NY, Ryabin N, Farooq S, Lawler E, Rimawi MF, Krop IE, Wolff AC, Winer EP, Lin NU.

J Clin Oncol. 2016 Mar 20;34(9):945-52. doi: 10.1200/JCO.2015.63.0343. Epub 2016 Feb 1.

26.

Imaging and Mapping of Tissue Constituents at the Single-Cell Level Using MALDI MSI and Quantitative Laser Scanning Cytometry.

Rawlins CM, Salisbury JP, Feldman DR, Isim S, Agar NY, Luther E, Agar JN.

Methods Mol Biol. 2015;1346:133-49. doi: 10.1007/978-1-4939-2987-0_10.

PMID:
26542720
27.

Efficacy of PARP Inhibitor Rucaparib in Orthotopic Glioblastoma Xenografts Is Limited by Ineffective Drug Penetration into the Central Nervous System.

Parrish KE, Cen L, Murray J, Calligaris D, Kizilbash S, Mittapalli RK, Carlson BL, Schroeder MA, Sludden J, Boddy AV, Agar NY, Curtin NJ, Elmquist WF, Sarkaria JN.

Mol Cancer Ther. 2015 Dec;14(12):2735-43. doi: 10.1158/1535-7163.MCT-15-0553. Epub 2015 Oct 5.

28.

MALDI mass spectrometry imaging analysis of pituitary adenomas for near-real-time tumor delineation.

Calligaris D, Feldman DR, Norton I, Olubiyi O, Changelian AN, Machaidze R, Vestal ML, Laws ER, Dunn IF, Santagata S, Agar NY.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9978-83. doi: 10.1073/pnas.1423101112. Epub 2015 Jul 27.

29.

Profiling of adrenocorticotropic hormone and arginine vasopressin in human pituitary gland and tumor thin tissue sections using droplet-based liquid-microjunction surface-sampling-HPLC-ESI-MS-MS.

Kertesz V, Calligaris D, Feldman DR, Changelian A, Laws ER, Santagata S, Agar NY, Van Berkel GJ.

Anal Bioanal Chem. 2015 Aug;407(20):5989-98. doi: 10.1007/s00216-015-8803-2. Epub 2015 Jun 18.

30.

Molecular typing of Meningiomas by Desorption Electrospray Ionization Mass Spectrometry Imaging for Surgical Decision-Making.

Calligaris D, Feldman DR, Norton I, Brastianos PK, Dunn IF, Santagata S, Agar NY.

Int J Mass Spectrom. 2015 Feb 1;377:690-698.

31.

Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.

Du Z, Abedalthagafi M, Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O, Machaidze R, Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, Santagata S.

Oncotarget. 2015 Mar 10;6(7):4704-16.

32.

The Efficacy of the Wee1 Inhibitor MK-1775 Combined with Temozolomide Is Limited by Heterogeneous Distribution across the Blood-Brain Barrier in Glioblastoma.

Pokorny JL, Calligaris D, Gupta SK, Iyekegbe DO Jr, Mueller D, Bakken KK, Carlson BL, Schroeder MA, Evans DL, Lou Z, Decker PA, Eckel-Passow JE, Pucci V, Ma B, Shumway SD, Elmquist WF, Agar NY, Sarkaria JN.

Clin Cancer Res. 2015 Apr 15;21(8):1916-24. doi: 10.1158/1078-0432.CCR-14-2588. Epub 2015 Jan 21.

33.

Reconstruction and Feature Selection for Desorption Electrospray Ionization Mass Spectroscopy Imagery.

Gao Y, Zhu L, Norton I, Agar NY, Tannenbaum A.

Proc SPIE Int Soc Opt Eng. 2014 Mar 12;9036:90360D.

34.

Application of desorption electrospray ionization mass spectrometry imaging in breast cancer margin analysis.

Calligaris D, Caragacianu D, Liu X, Norton I, Thompson CJ, Richardson AL, Golshan M, Easterling ML, Santagata S, Dillon DA, Jolesz FA, Agar NY.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15184-9. doi: 10.1073/pnas.1408129111. Epub 2014 Sep 22.

35.

Intraoperative mass spectrometry mapping of an onco-metabolite to guide brain tumor surgery.

Santagata S, Eberlin LS, Norton I, Calligaris D, Feldman DR, Ide JL, Liu X, Wiley JS, Vestal ML, Ramkissoon SH, Orringer DA, Gill KK, Dunn IF, Dias-Santagata D, Ligon KL, Jolesz FA, Golby AJ, Cooks RG, Agar NY.

Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11121-6. doi: 10.1073/pnas.1404724111. Epub 2014 Jun 30.

36.

KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway.

Li H, Jiang X, Yu Y, Huang W, Xing H, Agar NY, Yang HW, Yang B, Carroll RS, Johnson MD.

Oncogene. 2015 Mar 12;34(11):1432-41. doi: 10.1038/onc.2014.49. Epub 2014 Apr 7.

PMID:
24704824
37.

Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation.

Auclair JR, Salisbury JP, Johnson JL, Petsko GA, Ringe D, Bosco DA, Agar NY, Santagata S, Durham HD, Agar JN.

Proteomics. 2014 May;14(10):1152-7. doi: 10.1002/pmic.201300450. Epub 2014 Apr 17.

38.

A statistical modeling approach for tumor-type identification in surgical neuropathology using tissue mass spectrometry imaging.

Gholami B, Norton I, Eberlin LS, Agar NY.

IEEE J Biomed Health Inform. 2013 May;17(3):734-44.

PMID:
24592474
39.

Mass spectrometry imaging as a tool for surgical decision-making.

Calligaris D, Norton I, Feldman DR, Ide JL, Dunn IF, Eberlin LS, Cooks RG, Jolesz FA, Golby AJ, Santagata S, Agar NY.

J Mass Spectrom. 2013 Nov;48(11):1178-87. doi: 10.1002/jms.3295.

40.

Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging.

Liu X, Ide JL, Norton I, Marchionni MA, Ebling MC, Wang LY, Davis E, Sauvageot CM, Kesari S, Kellersberger KA, Easterling ML, Santagata S, Stuart DD, Alberta J, Agar JN, Stiles CD, Agar NY.

Sci Rep. 2013 Oct 4;3:2859. doi: 10.1038/srep02859.

41.

Rapid, label-free detection of brain tumors with stimulated Raman scattering microscopy.

Ji M, Orringer DA, Freudiger CW, Ramkissoon S, Liu X, Lau D, Golby AJ, Norton I, Hayashi M, Agar NY, Young GS, Spino C, Santagata S, Camelo-Piragua S, Ligon KL, Sagher O, Xie XS.

Sci Transl Med. 2013 Sep 4;5(201):201ra119. doi: 10.1126/scitranslmed.3005954.

42.

Recursive feature elimination for brain tumor classification using desorption electrospray ionization mass spectrometry imaging.

Gholami B, Norton I, Tannenbaum AR, Agar NY.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:5258-61. doi: 10.1109/EMBC.2012.6347180.

43.

Structural characterization of Pandoraea pnomenusa B-356 biphenyl dioxygenase reveals features of potent polychlorinated biphenyl-degrading enzymes.

Colbert CL, Agar NY, Kumar P, Chakko MN, Sinha SC, Powlowski JB, Eltis LD, Bolin JT.

PLoS One. 2013;8(1):e52550. doi: 10.1371/journal.pone.0052550. Epub 2013 Jan 3.

44.

Ambient mass spectrometry for the intraoperative molecular diagnosis of human brain tumors.

Eberlin LS, Norton I, Orringer D, Dunn IF, Liu X, Ide JL, Jarmusch AK, Ligon KL, Jolesz FA, Golby AJ, Santagata S, Agar NY, Cooks RG.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1611-6. doi: 10.1073/pnas.1215687110. Epub 2013 Jan 8.

45.

Casein kinase I epsilon interacts with mitochondrial proteins for the growth and survival of human ovarian cancer cells.

Rodriguez N, Yang J, Hasselblatt K, Liu S, Zhou Y, Rauh-Hain JA, Ng SK, Choi PW, Fong WP, Agar NY, Welch WR, Berkowitz RS, Ng SW.

EMBO Mol Med. 2012 Sep;4(9):952-63. doi: 10.1002/emmm.201101094. Epub 2012 Jun 18.

46.

Classification of astrocytomas and oligodendrogliomas from mass spectrometry data using sparse kernel machines.

Huang J, Gholami B, Agar NY, Norton I, Haddad WM, Tannenbaum AR.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:7965-8. doi: 10.1109/IEMBS.2011.6091964.

47.

A compressive sensing approach for glioma margin delineation using mass spectrometry.

Gholami B, Agar NY, Jolesz FA, Haddad WM, Tannenbaum AR.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:5682-5. doi: 10.1109/IEMBS.2011.6091375.

48.

Classifying human brain tumors by lipid imaging with mass spectrometry.

Eberlin LS, Norton I, Dill AL, Golby AJ, Ligon KL, Santagata S, Cooks RG, Agar NY.

Cancer Res. 2012 Feb 1;72(3):645-54. doi: 10.1158/0008-5472.CAN-11-2465. Epub 2011 Dec 2.

49.

Recent advances in single-cell MALDI mass spectrometry imaging and potential clinical impact.

Boggio KJ, Obasuyi E, Sugino K, Nelson SB, Agar NY, Agar JN.

Expert Rev Proteomics. 2011 Oct;8(5):591-604. doi: 10.1586/epr.11.53. Review.

50.

Desorption electrospray ionization then MALDI mass spectrometry imaging of lipid and protein distributions in single tissue sections.

Eberlin LS, Liu X, Ferreira CR, Santagata S, Agar NY, Cooks RG.

Anal Chem. 2011 Nov 15;83(22):8366-71. doi: 10.1021/ac202016x. Epub 2011 Oct 18.

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