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Items: 48

1.

Mucosal Gene Expression in Pediatric and Adult Patients With Ulcerative Colitis Permits Modeling of Ideal Biopsy Collection Strategy for Transcriptomic Analysis.

Ouahed J, Gordon W, Canavan JB, Zhou H, Du S, von Schack D, Phillips K, Wang L, Dunn WA 3rd, Field M, Friel S, Griffith A, Evans S, Tollefson S, Carrellas M, Cao B, Merker A, Bousvaros A, Shouval DS; BCH IBD Center; BWH Crohn’s and Colitis Center, Hung K, Lepsy C, Afzelius L, Korzenik JR, Snapper SB.

Inflamm Bowel Dis. 2018 Nov 29;24(12):2565-2578. doi: 10.1093/ibd/izy242.

PMID:
30085215
2.

Mendelian Disease Associations Reveal Novel Insights into Inflammatory Bowel Disease.

Han L, Maciejewski M, Brockel C, Afzelius L, Altman RB.

Inflamm Bowel Dis. 2018 Feb 15;24(3):471-481. doi: 10.1093/ibd/izx087.

3.

A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease.

Han L, Maciejewski M, Brockel C, Gordon W, Snapper SB, Korzenik JR, Afzelius L, Altman RB.

Bioinformatics. 2018 Mar 15;34(6):985-993. doi: 10.1093/bioinformatics/btx651.

4.

Integrated Strategy for Use of Positron Emission Tomography in Nonhuman Primates to Confirm Multitarget Occupancy of Novel Psychotropic Drugs: An Example with AZD3676.

Varnäs K, Juréus A, Johnström P, Ahlgren C, Schött P, Schou M, Gruber S, Jerning E, Malmborg J, Halldin C, Afzelius L, Farde L.

J Pharmacol Exp Ther. 2016 Sep;358(3):464-71. doi: 10.1124/jpet.116.234146. Epub 2016 Jul 11.

PMID:
27402278
5.

The impact of solute carrier (SLC) drug uptake transporter loss in human and rat cryopreserved hepatocytes on clearance predictions.

Lundquist P, Lööf J, Sohlenius-Sternbeck AK, Floby E, Johansson J, Bylund J, Hoogstraate J, Afzelius L, Andersson TB.

Drug Metab Dispos. 2014 Mar;42(3):469-80. doi: 10.1124/dmd.113.054676. Epub 2014 Jan 6.

PMID:
24396146
6.

Functional ATP-binding cassette drug efflux transporters in isolated human and rat hepatocytes significantly affect assessment of drug disposition.

Lundquist P, Englund G, Skogastierna C, Lööf J, Johansson J, Hoogstraate J, Afzelius L, Andersson TB.

Drug Metab Dispos. 2014 Mar;42(3):448-58. doi: 10.1124/dmd.113.054528. Epub 2014 Jan 6.

PMID:
24396144
7.

Prediction of in vivo rat biliary drug clearance from an in vitro hepatocyte efflux model.

Lundquist P, Lööf J, Fagerholm U, Sjögren I, Johansson J, Briem S, Hoogstraate J, Afzelius L, Andersson TB.

Drug Metab Dispos. 2014 Mar;42(3):459-68. doi: 10.1124/dmd.113.054155. Epub 2014 Jan 6.

PMID:
24396143
8.

Cytochrome p450 inhibitory properties of common efflux transporter inhibitors.

Englund G, Lundquist P, Skogastierna C, Johansson J, Hoogstraate J, Afzelius L, Andersson TB, Projean D.

Drug Metab Dispos. 2014 Mar;42(3):441-7. doi: 10.1124/dmd.113.054932. Epub 2014 Jan 6.

PMID:
24396142
9.

Practical use of the regression offset approach for the prediction of in vivo intrinsic clearance from hepatocytes.

Sohlenius-Sternbeck AK, Jones C, Ferguson D, Middleton BJ, Projean D, Floby E, Bylund J, Afzelius L.

Xenobiotica. 2012 Sep;42(9):841-53. doi: 10.3109/00498254.2012.669080. Epub 2012 Apr 18.

PMID:
22509824
10.

Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds.

Sohlenius-Sternbeck AK, Afzelius L, Prusis P, Neelissen J, Hoogstraate J, Johansson J, Floby E, Bengtsson A, Gissberg O, Sternbeck J, Petersson C.

Xenobiotica. 2010 Sep;40(9):637-49. doi: 10.3109/00498254.2010.500407.

PMID:
20624033
11.

State-of-the-art tools for computational site of metabolism predictions: comparative analysis, mechanistical insights, and future applications.

Afzelius L, Arnby CH, Broo A, Carlsson L, Isaksson C, Jurva U, Kjellander B, Kolmodin K, Nilsson K, Raubacher F, Weidolf L.

Drug Metab Rev. 2007;39(1):61-86.

PMID:
17364881
12.

Novel aspects of drug metabolism and transport.

Afzelius L, Ingelman-Sundberg M, Karlgren M, Rodriguez-Antona C.

Drug News Perspect. 2006 Dec;19(10):637-51.

PMID:
17299607
13.

Comparison of methods for the prediction of the metabolic sites for CYP3A4-mediated metabolic reactions.

Zhou D, Afzelius L, Grimm SW, Andersson TB, Zauhar RJ, Zamora I.

Drug Metab Dispos. 2006 Jun;34(6):976-83. Epub 2006 Mar 15.

PMID:
16540587
14.

Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques.

Afzelius L, Raubacher F, Karlén A, Jørgensen FS, Andersson TB, Masimirembwa CM, Zamora I.

Drug Metab Dispos. 2004 Nov;32(11):1218-29.

PMID:
15483192
15.

Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.

Afzelius L, Zamora I, Masimirembwa CM, Karlén A, Andersson TB, Mecucci S, Baroni M, Cruciani G.

J Med Chem. 2004 Feb 12;47(4):907-14.

PMID:
14761192
16.

Predicting drug metabolism: a site of metabolism prediction tool applied to the cytochrome P450 2C9.

Zamora I, Afzelius L, Cruciani G.

J Med Chem. 2003 Jun 5;46(12):2313-24.

PMID:
12773036
17.

Discriminant and quantitative PLS analysis of competitive CYP2C9 inhibitors versus non-inhibitors using alignment independent GRIND descriptors.

Afzelius L, Masimirembwa CM, Karlén A, Andersson TB, Zamora I.

J Comput Aided Mol Des. 2002 Jul;16(7):443-58.

PMID:
12510879
18.

Competitive CYP2C9 inhibitors: enzyme inhibition studies, protein homology modeling, and three-dimensional quantitative structure-activity relationship analysis.

Afzelius L, Zamora I, Ridderström M, Andersson TB, Karlén A, Masimirembwa CM.

Mol Pharmacol. 2001 Apr;59(4):909-19.

PMID:
11259637
19.

Elective lymph node dissection in stage I cutaneous malignant melanoma of the head and neck. A report from the Swedish Melanoma Study Group.

Hansson J, Ringborg U, Lagerlöf B, Afzelius LE, Augustsson I, Blomquist E, Boeryd B, Carlin E, Edström S, Eldh J, et al.

Melanoma Res. 1994 Dec;4(6):407-11.

PMID:
7703722
20.

Cutaneous malignant melanoma of the head and neck. Analysis of treatment results and prognostic factors in 581 patients: a report from the Swedish Melanoma Study Group.

Ringborg U, Afzelius LE, Lagerlöf B, Adami HO, Augustsson I, Blomqvist E, Boeryd B, Carlin E, Edström S, Eldh J, et al.

Cancer. 1993 Feb 1;71(3):751-8.

PMID:
8431856
21.

Salivary duct carcinoma--a clinicopathologic study of 12 cases.

Afzelius LE, Cameron WR, Svensson C.

Head Neck Surg. 1987 Jan-Feb;9(3):151-6.

PMID:
3040624
22.

[Improved treatment of obstructive apnea syndrome with palatopharyngoplasty].

Afzelius LE, Almqvist U, Elmqvist D.

Lakartidningen. 1986 Nov 26;83(48):4099-101. Swedish. No abstract available.

PMID:
3807487
23.

[Musculocutaneous flaps in the reconstruction or resection of oral and pharyngeal cancer].

Relander M, Afzelius LE, Biörklund A, Elner A.

Lakartidningen. 1984 Aug 29;81(35):3028-31. Swedish. No abstract available.

PMID:
6471987
24.

[Histologic scoring system for various cancers of the external ear].

Afzelius LE, Nordgren H.

HNO. 1984 Feb;32(2):63-4. German.

PMID:
6706701
25.

[Dilatation of esophageal strictures using a balloon catheter].

Svensson G, Afzelius LE, Götberg S, Lunderqvist A, Owman T.

HNO. 1984 Jan;32(1):38-41. German.

PMID:
6706697
26.

Studies of Swedish marine organisms. I. Screening of biological activity.

Andersson L, Lidgren G, Bohlin L, Magni L, Ogren S, Afzelius L.

Acta Pharm Suec. 1983;20(6):401-14. No abstract available.

PMID:
6675419
27.

The surgical treatment of chronic parotitis.

Afzelius LE, Walter CG.

J Laryngol Otol. 1982 Dec;96(12):1131-5. No abstract available.

PMID:
7175352
28.

Balloon-catheter dilatation of strictures in the upper digestive tract.

Götberg S, Afzelius LE, Hambraeus G, Hedenbro J, Lunderquist A, Owman T, Svensson G.

Radiologe. 1982 Nov;22(11):479-83. No abstract available.

PMID:
7178479
29.

[Balloon dilatation of esophageal stricture--a new therapeutic method].

Afzelius LE, Hambraeus G, Lunderquist A, Svensson G, Owman T, Götberg S, Hedenbro J, Oscarsson J, Walther B.

Lakartidningen. 1982 Jul 28;79(30-31):2701-2. Swedish. No abstract available.

PMID:
7144350
30.

Neural beta-adrenergic dilatation of the facial vein in man. Possible mechanism in emotional blushing.

Mellander S, Andersson PO, Afzelius LE, Hellstrand P.

Acta Physiol Scand. 1982 Mar;114(3):393-9.

PMID:
6291328
31.

Cervical mycobacteriosis. Relation to BCG vaccination, treatment of results of treatment.

Afzelius LE, Békassy A, Garwicz S.

ORL J Otorhinolaryngol Relat Spec. 1982;44(5):241-3. No abstract available.

PMID:
7133644
32.

Sleep apnea syndrome caused by acromegalia and the treatment with a reduction plasty of the tongue. Case report.

Afzelius LE, Elmqvist D, Laurin S, Risberg AM, Aberg M.

ORL J Otorhinolaryngol Relat Spec. 1982;44(3):142-5.

PMID:
7099578
33.

Obstructive sleep apnea.

Afzelius LE.

N Engl J Med. 1981 Dec 10;305(24):1472. No abstract available.

PMID:
7300868
34.

Sleep apnea syndrome--an alternative treatment to tracheostomy.

Afzelius LE, Elmqvist D, Hougaard K, Laurin S, Nilsson B, Risberg AM.

Laryngoscope. 1981 Feb;91(2):285-91.

PMID:
7464390
35.

[Routine BCG vaccination of newborn infants has ceased. Is mycobacteriosis of the cervical lymph nodes an unforeseen consequence?].

Afzelius LE, Békássy A, Bende M, Garwicz S, Grubb R.

Lakartidningen. 1981 Jan 14;78(3):121-2. Swedish. No abstract available.

PMID:
7206940
36.

[Esophageal stricture-cause and treatment].

Afzelius LE, Gummesson B, Pettersson KI.

Lakartidningen. 1980 Jun 11;77(24):2262-5. Swedish. No abstract available.

PMID:
7401779
37.

Guidelines for prophylactic radical lymph node dissection in cases of carcinoma of the external ear.

Afzelius LE, Gunnarsson M, Nordgren H.

Head Neck Surg. 1980 May-Jun;2(5):361-5.

PMID:
7364589
38.

Vertigo and dizziness of functional origin.

Afzelius LE, Henriksson NG, Wahlgren L.

Laryngoscope. 1980 Apr;90(4):649-56.

PMID:
7359983
39.

Facial fractures. A review of 368 cases.

Afzelius LE, Rosén C.

Int J Oral Surg. 1980 Feb;9(1):25-32.

PMID:
6769827
40.

Influence of seat belt upon maxillofacial fractures.

Afzelius LE, Rosén C.

ORL J Otorhinolaryngol Relat Spec. 1980;42(5):277-81.

PMID:
7454239
41.
42.
43.

Vertigo and dizzines reflecting functional disorders.

Nilsson A, Henriksson NG, Magnusson PA, Afzelius LE.

Adv Otorhinolaryngol. 1979;25:93-9. No abstract available.

PMID:
484363
44.

Fractures of the malar bone. Follow-up study based upon a questionnaire.

Afzelius LE, Rosén C.

ORL J Otorhinolaryngol Relat Spec. 1979;41(4):227-33.

PMID:
228223
45.

Vertigo as reflected by the nystagmogram. A clinical analysis.

Afzelius LE, Henriksson NG, Wahlgren L.

Acta Otolaryngol. 1978 Jul-Aug;86(1-2):123-31.

PMID:
696290
46.

Vertigo and rocking sensation. A clinical analysis.

Henriksson NG, Afzelius LE, Wahlgren L.

ORL J Otorhinolaryngol Relat Spec. 1976;38(4):206-17.

PMID:
1033502
47.

[A case of spontaneous healing of traumatic common carotid artery aneurysm].

Afzelius LE, Ljungberg T, Löfkvist T, Ortegren U.

Radiologe. 1972 Feb;12(2):57-8. German. No abstract available.

PMID:
5027898
48.

STUDIES ON THE SUBSEQUENT FORMATION OF PORTO-SYSTEMIC COMMUNICATIONS AFTER INDUCED PORTAL HYPERTENSION IN THE DOG.

AFZELIUS LE, ARONSEN KF, NYLANDER G.

Acta Chir Scand. 1965 Feb;129:170-6. No abstract available.

PMID:
14319098

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