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Items: 25


A cellular census of human lungs identifies novel cell states in health and in asthma.

Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA.

Nat Med. 2019 Jul;25(7):1153-1163. doi: 10.1038/s41591-019-0468-5. Epub 2019 Jun 17.


The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.

Deaton DN, Do Y, Holt J, Jeune MR, Kramer HF, Larkin AL, Orband-Miller LA, Peckham GE, Poole C, Price DJ, Schaller LT, Shen Y, Shewchuk LM, Stewart EL, Stuart JD, Thomson SA, Ward P, Wilson JW, Xu T, Guss JH, Musetti C, Rendina AR, Affleck K, Anders D, Hancock AP, Hobbs H, Hodgson ST, Hutchinson J, Leveridge MV, Nicholls H, Smith IED, Somers DO, Sneddon HF, Uddin S, Cleasby A, Mortenson PN, Richardson C, Saxty G.

Bioorg Med Chem. 2019 Apr 15;27(8):1456-1478. doi: 10.1016/j.bmc.2019.02.017. Epub 2019 Feb 11.


Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells.

Wajdner HE, Farrington J, Barnard C, Peachell PT, Schnackenberg CG, Marino JP Jr, Xu X, Affleck K, Begg M, Seward EP.

Physiol Rep. 2017 Mar;5(5). pii: e13166. doi: 10.14814/phy2.13166.


Regulatory T-cell-intrinsic amphiregulin is dispensable for suppressive function.

Carney K, Chang YR, Wilson S, Calnan C, Reddy PS, Chan WY, Gilmartin T, Hernandez G, Schaffer L, Head SR, Morley J, de Mestre A, Affleck K, Garden OA.

J Allergy Clin Immunol. 2016 Jun;137(6):1907-1909. doi: 10.1016/j.jaci.2016.01.030. Epub 2016 Mar 31. No abstract available.


Associations Between Psychiatric Impairment and Sexual Risk Behavior Among Teens in Mental Health Treatment.

Hadley W, Barker DH, Lescano CM, Stewart AJ, Affleck K, Donenberg G, DiClemente R, Brown LK; Project STYLE Study Group.

J HIV AIDS Soc Serv. 2014 Apr;13(2):198-213.


Reliability and Validity of the Dyadic Observed Communication Scale (DOCS).

Hadley W, Stewart A, Hunter HL, Affleck K, Donenberg G, Diclemente R, Brown LK.

J Child Fam Stud. 2013 Feb;22(2):279-287.


Targeting phosphoinositide 3-kinase δ for allergic asthma.

Rowan WC, Smith JL, Affleck K, Amour A.

Biochem Soc Trans. 2012 Feb;40(1):240-5. doi: 10.1042/BST20110665. Review.


Syk-kinase inhibition prevents mast cell activation in nasal polyps.

Patou J, Holtappels G, Affleck K, van Cauwenberge P, Bachert C.

Rhinology. 2011 Mar;49(1):100-6. doi: 10.4193/Rhino09.147.


Enhanced release of IgE-dependent early phase mediators from nasal polyp tissue.

Patou J, Holtappels G, Affleck K, Gevaert P, Perez-Novo C, Van Cauwenberge P, Bachert C.

J Inflamm (Lond). 2009 Apr 20;6:11. doi: 10.1186/1476-9255-6-11.


Human ClCa1 modulates anionic conduction of calcium-dependent chloride currents.

Hamann M, Gibson A, Davies N, Jowett A, Walhin JP, Partington L, Affleck K, Trezise D, Main M.

J Physiol. 2009 May 15;587(Pt 10):2255-74. doi: 10.1113/jphysiol.2009.170159. Epub 2009 Mar 23.


Expression of nonmuscle cofilin-1 and steroid responsiveness in severe asthma.

Vasavda N, Eichholtz T, Takahashi A, Affleck K, Matthews JG, Barnes PJ, Adcock IM.

J Allergy Clin Immunol. 2006 Nov;118(5):1090-6. Epub 2006 Sep 25.


hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels.

Gibson A, Lewis AP, Affleck K, Aitken AJ, Meldrum E, Thompson N.

J Biol Chem. 2005 Jul 22;280(29):27205-12. Epub 2005 May 25.


Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.

Gaul MD, Guo Y, Affleck K, Cockerill GS, Gilmer TM, Griffin RJ, Guntrip S, Keith BR, Knight WB, Mullin RJ, Murray DM, Rusnak DW, Smith K, Tadepalli S, Wood ER, Lackey K.

Bioorg Med Chem Lett. 2003 Feb 24;13(4):637-40.


The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

Rusnak DW, Lackey K, Affleck K, Wood ER, Alligood KJ, Rhodes N, Keith BR, Murray DM, Knight WB, Mullin RJ, Gilmer TM.

Mol Cancer Ther. 2001 Dec;1(2):85-94.


The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.

Rusnak DW, Affleck K, Cockerill SG, Stubberfield C, Harris R, Page M, Smith KJ, Guntrip SB, Carter MC, Shaw RJ, Jowett A, Stables J, Topley P, Wood ER, Brignola PS, Kadwell SH, Reep BR, Mullin RJ, Alligood KJ, Keith BR, Crosby RM, Murray DM, Knight WB, Gilmer TM, Lackey K.

Cancer Res. 2001 Oct 1;61(19):7196-203.


Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.

Cockerill S, Stubberfield C, Stables J, Carter M, Guntrip S, Smith K, McKeown S, Shaw R, Topley P, Thomsen L, Affleck K, Jowett A, Hayes D, Willson M, Woollard P, Spalding D.

Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5.


Isolation and characterisation of a prenylated p-terphenyl metabolite of Aspergillus candidus possessing potent and selective cytotoxic activity; studies on mechanism of action.

Stead P, Affleck K, Sidebottom PJ, Taylor NL, Drake CS, Todd M, Jowett A, Webb G.

J Antibiot (Tokyo). 1999 Feb;52(2):89-95.


Early elemental and ionic changes in cultured cells after stimulation with epidermal growth factor.

Beesley JE, Hall SR, Page MJ, Affleck K.

Scanning Microsc. 1995 Mar;9(1):231-7; discussion 237-8.


Follicle-stimulating hormone pulse amplitude decreases with the onset of the breeding season in the mare.

Hines KK, Affleck KJ, Barrows SP, Murdoch WL, Fitzgerald BP, Loy RG.

Biol Reprod. 1991 Mar;44(3):516-21.


Changes in LH pulse frequency and amplitude in intact mares during the transition into the breeding season.

Fitzgerald BP, Affleck KJ, Barrows SP, Murdoch WL, Barker KB, Loy RG.

J Reprod Fertil. 1987 Mar;79(2):485-93.


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