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Items: 1 to 50 of 207

1.

Deletions on mouse Yq lead to upregulation of multiple X- and Y-linked transcripts in spermatids.

Ellis PJI, Clemente EJ, Ball P, Touré A, Ferguson L, Turner JMA, Loveland KL, Affara NA, Burgoyne PS.

Hum Mol Genet. 2019 Oct 8. pii: ddz192. doi: 10.1093/hmg/ddz192. [Epub ahead of print] No abstract available.

PMID:
31592530
2.

Correction to: Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm.

Touré A, Clemente EJ, Ellis PJI, Mahadevaiah SK, Ojarikre OA, Ball PAF, Reynard L, Loveland KL, Burgoyne PS, Affara NA.

Genome Biol. 2019 Aug 9;20(1):160. doi: 10.1186/s13059-019-1779-z.

3.

Correction: A Genetic Basis for a Postmeiotic X Versus Y Chromosome Intragenomic Conflict in the Mouse.

Cocquet J, Ellis PJI, Mahadevaiah SK, Affara NA, Vaiman D, Burgoyne PS.

PLoS Genet. 2019 Jul 22;15(7):e1008290. doi: 10.1371/journal.pgen.1008290. eCollection 2019 Jul.

4.

A high-throughput method for unbiased quantitation and categorization of nuclear morphology†.

Skinner BM, Rathje CC, Bacon J, Johnson EEP, Larson EL, Kopania EEK, Good JM, Yousafzai G, Affara NA, Ellis PJI.

Biol Reprod. 2019 May 1;100(5):1250-1260. doi: 10.1093/biolre/ioz013.

5.

Automated Nuclear Cartography Reveals Conserved Sperm Chromosome Territory Localization across 2 Million Years of Mouse Evolution.

Skinner BM, Bacon J, Rathje CC, Larson EL, Kopania EEK, Good JM, Affara NA, Ellis PJI.

Genes (Basel). 2019 Feb 1;10(2). pii: E109. doi: 10.3390/genes10020109.

6.

Origin and phylogenetic status of the local Ashanti Dwarf pig (ADP) of Ghana based on genetic analysis.

Osei-Amponsah R, Skinner BM, Adjei DO, Bauer J, Larson G, Affara NA, Sargent CA.

BMC Genomics. 2017 Feb 20;18(1):193. doi: 10.1186/s12864-017-3536-6.

7.

Bruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.

Gunderson AJ, Kaneda MM, Tsujikawa T, Nguyen AV, Affara NI, Ruffell B, Gorjestani S, Liudahl SM, Truitt M, Olson P, Kim G, Hanahan D, Tempero MA, Sheppard B, Irving B, Chang BY, Varner JA, Coussens LM.

Cancer Discov. 2016 Mar;6(3):270-85. doi: 10.1158/2159-8290.CD-15-0827. Epub 2015 Dec 29. Erratum in: Cancer Discov. 2016 Jul;6(7):802.

8.

The pig X and Y Chromosomes: structure, sequence, and evolution.

Skinner BM, Sargent CA, Churcher C, Hunt T, Herrero J, Loveland JE, Dunn M, Louzada S, Fu B, Chow W, Gilbert J, Austin-Guest S, Beal K, Carvalho-Silva D, Cheng W, Gordon D, Grafham D, Hardy M, Harley J, Hauser H, Howden P, Howe K, Lachani K, Ellis PJ, Kelly D, Kerry G, Kerwin J, Ng BL, Threadgold G, Wileman T, Wood JM, Yang F, Harrow J, Affara NA, Tyler-Smith C.

Genome Res. 2016 Jan;26(1):130-9. doi: 10.1101/gr.188839.114. Epub 2015 Nov 11.

9.

Erythropoietin Attenuates Pulmonary Vascular Remodeling in Experimental Pulmonary Arterial Hypertension through Interplay between Endothelial Progenitor Cells and Heme Oxygenase.

van Loon RL, Bartelds B, Wagener FA, Affara N, Mohaupt S, Wijnberg H, Pennings SW, Takens J, Berger RM.

Front Pediatr. 2015 Aug 28;3:71. doi: 10.3389/fped.2015.00071. eCollection 2015.

10.

Expansion of the HSFY gene family in pig lineages : HSFY expansion in suids.

Skinner BM, Lachani K, Sargent CA, Yang F, Ellis P, Hunt T, Fu B, Louzada S, Churcher C, Tyler-Smith C, Affara NA.

BMC Genomics. 2015 Jun 9;16:442. doi: 10.1186/s12864-015-1650-x.

11.

Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma.

Massó-Vallés D, Jauset T, Serrano E, Sodir NM, Pedersen K, Affara NI, Whitfield JR, Beaulieu ME, Evan GI, Elias L, Arribas J, Soucek L.

Cancer Res. 2015 Apr 15;75(8):1675-81. doi: 10.1158/0008-5472.CAN-14-2852.

12.

Karyomapping-a comprehensive means of simultaneous monogenic and cytogenetic PGD: comparison with standard approaches in real time for Marfan syndrome.

Thornhill AR, Handyside AH, Ottolini C, Natesan SA, Taylor J, Sage K, Harton G, Cliffe K, Affara N, Konstantinidis M, Wells D, Griffin DK.

J Assist Reprod Genet. 2015 Mar;32(3):347-56. doi: 10.1007/s10815-014-0405-y. Epub 2015 Jan 6. No abstract available.

13.

Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk.

Quilter CR, Cooper WN, Cliffe KM, Skinner BM, Prentice PM, Nelson L, Bauer J, Ong KK, Constância M, Lowe WL, Affara NA, Dunger DB.

FASEB J. 2014 Nov;28(11):4868-79. doi: 10.1096/fj.14-255240. Epub 2014 Aug 21.

PMID:
25145626
14.

B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas.

Affara NI, Ruffell B, Medler TR, Gunderson AJ, Johansson M, Bornstein S, Bergsland E, Steinhoff M, Li Y, Gong Q, Ma Y, Wiesen JF, Wong MH, Kulesz-Martin M, Irving B, Coussens LM.

Cancer Cell. 2014 Jun 16;25(6):809-821. doi: 10.1016/j.ccr.2014.04.026. Epub 2014 Jun 5.

15.

Thrifty metabolic programming in rats is induced by both maternal undernutrition and postnatal leptin treatment, but masked in the presence of both: implications for models of developmental programming.

Ellis PJ, Morris TJ, Skinner BM, Sargent CA, Vickers MH, Gluckman PD, Gilmour S, Affara NA.

BMC Genomics. 2014 Jan 21;15:49. doi: 10.1186/1471-2164-15-49.

16.

Genome wide analysis reveals single nucleotide polymorphisms associated with fatness and putative novel copy number variants in three pig breeds.

Fowler KE, Pong-Wong R, Bauer J, Clemente EJ, Reitter CP, Affara NA, Waite S, Walling GA, Griffin DK.

BMC Genomics. 2013 Nov 13;14:784. doi: 10.1186/1471-2164-14-784.

17.

Cathepsin C is a tissue-specific regulator of squamous carcinogenesis.

Ruffell B, Affara NI, Cottone L, Junankar S, Johansson M, DeNardo DG, Korets L, Reinheckel T, Sloane BF, Bogyo M, Coussens LM.

Genes Dev. 2013 Oct 1;27(19):2086-98. doi: 10.1101/gad.224899.113. Epub 2013 Sep 24.

18.

Regions of XY homology in the pig X chromosome and the boundary of the pseudoautosomal region.

Skinner BM, Lachani K, Sargent CA, Affara NA.

BMC Genet. 2013 Jan 15;14:3. doi: 10.1186/1471-2156-14-3.

19.

Detailed clinical and molecular study of 20 females with Xq deletions with special reference to menstruation and fertility.

Mercer CL, Lachlan K, Karcanias A, Affara N, Huang S, Jacobs PA, Thomas NS.

Eur J Med Genet. 2013 Jan;56(1):1-6. doi: 10.1016/j.ejmg.2012.08.012. Epub 2012 Oct 8.

PMID:
23059468
20.

A genetic basis for a postmeiotic X versus Y chromosome intragenomic conflict in the mouse.

Cocquet J, Ellis PJ, Mahadevaiah SK, Affara NA, Vaiman D, Burgoyne PS.

PLoS Genet. 2012 Sep;8(9):e1002900. doi: 10.1371/journal.pgen.1002900. Epub 2012 Sep 13. Erratum in: PLoS Genet. 2019 Jul 22;15(7):e1008290.

21.

An association and haplotype analysis of porcine maternal infanticide: a model for human puerperal psychosis?

Quilter CR, Sargent CA, Bauer J, Bagga MR, Reiter CP, Hutchinson EL, Southwood OI, Evans G, Mileham A, Griffin DK, Affara NA.

Am J Med Genet B Neuropsychiatr Genet. 2012 Dec;159B(8):908-27. doi: 10.1002/ajmg.b.32097. Epub 2012 Sep 13.

PMID:
22976950
22.

The polymorphism analysis of CD169 and CD163 related with the risk of porcine reproductive and respiratory syndrome virus (PRRSV) infection.

Ren YW, Zhang YY, Affara NA, Sargent CA, Yang LG, Zhao JL, Fang LR, Wu JJ, Fang R, Tong Q, Xiao J, Li JL, Jiang YB, Chen HC, Zhang SJ.

Mol Biol Rep. 2012 Nov;39(11):9903-9. Epub 2012 Jun 28.

PMID:
22740140
23.

Association of multi-pathogenic infections with BAT2, CXCL12, Mx1 and EHMT2 variations in pigs.

Wang SJ, Liu WJ, Yang LG, Liu HB, Sargent CA, Affara NA, Zhang SJ.

Mol Biol Rep. 2012 Aug;39(8):8169-76. doi: 10.1007/s11033-012-1664-2. Epub 2012 Apr 25.

PMID:
22531939
24.

Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia.

Khulan B, Cooper WN, Skinner BM, Bauer J, Owens S, Prentice AM, Belteki G, Constancia M, Dunger D, Affara NA.

Hum Mol Genet. 2012 May 1;21(9):2086-101. doi: 10.1093/hmg/dds026. Epub 2012 Feb 3.

PMID:
22307237
25.

Differential macrophage programming in the tumor microenvironment.

Ruffell B, Affara NI, Coussens LM.

Trends Immunol. 2012 Mar;33(3):119-26. doi: 10.1016/j.it.2011.12.001. Epub 2012 Jan 23. Review.

26.

DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial.

Cooper WN, Khulan B, Owens S, Elks CE, Seidel V, Prentice AM, Belteki G, Ong KK, Affara NA, Constância M, Dunger DB.

FASEB J. 2012 May;26(5):1782-90. doi: 10.1096/fj.11-192708. Epub 2012 Jan 20.

PMID:
22267336
27.

Effects of FUT1 gene mutation on resistance to infectious disease.

Wang SJ, Liu WJ, Yang LG, Sargent CA, Liu HB, Wang C, Liu XD, Zhao SH, Affara NA, Liang AX, Zhang SJ.

Mol Biol Rep. 2012 Mar;39(3):2805-10. doi: 10.1007/s11033-011-1039-0. Epub 2011 Jun 22.

PMID:
21695432
28.

Effects of the polymorphisms of Mx1, BAT2 and CXCL12 genes on immunological traits in pigs.

Wang SJ, Liu WJ, Sargent CA, Zhao SH, Liu HB, Liu XD, Wang C, Hua GH, Yang LG, Affara NA, Zhang SJ.

Mol Biol Rep. 2012 Mar;39(3):2417-27. doi: 10.1007/s11033-011-0992-y. Epub 2011 Jun 12.

PMID:
21667240
29.

Cloning, mapping and molecular characterization of porcine progesterone receptor membrane component 2 (PGRMC2) gene.

Chen C, Sargent C, Quilter C, Yang Z, Ren J, Affara N, Brenig B, Huang L.

Genet Mol Biol. 2010 Jul;33(3):471-4. doi: 10.1590/S1415-47572010005000057. Epub 2010 Sep 1.

30.

Association of Sly with sex-linked gene amplification during mouse evolution: a side effect of genomic conflict in spermatids?

Ellis PJ, Bacon J, Affara NA.

Hum Mol Genet. 2011 Aug 1;20(15):3010-21. doi: 10.1093/hmg/ddr204. Epub 2011 May 6.

PMID:
21551453
31.

An algorithm for determining the origin of trisomy and the positions of chiasmata from SNP genotype data.

Gabriel AS, Hassold TJ, Thornhill AR, Affara NA, Handyside AH, Griffin DK.

Chromosome Res. 2011 Feb;19(2):155-63. doi: 10.1007/s10577-010-9181-4. Epub 2011 Jan 12.

PMID:
21225334
32.

Deficiency in the multicopy Sycp3-like X-linked genes Slx and Slxl1 causes major defects in spermatid differentiation.

Cocquet J, Ellis PJ, Yamauchi Y, Riel JM, Karacs TP, Rattigan A, Ojarikre OA, Affara NA, Ward MA, Burgoyne PS.

Mol Biol Cell. 2010 Oct 15;21(20):3497-505. doi: 10.1091/mbc.E10-07-0601. Epub 2010 Aug 25.

33.

Analysis of X chromosome genomic DNA sequence copy number variation associated with premature ovarian failure (POF).

Quilter CR, Karcanias AC, Bagga MR, Duncan S, Murray A, Conway GS, Sargent CA, Affara NA.

Hum Reprod. 2010 Aug;25(8):2139-50. doi: 10.1093/humrep/deq158. Epub 2010 Jun 22.

34.

The human RPS4 paralogue on Yq11.223 encodes a structurally conserved ribosomal protein and is preferentially expressed during spermatogenesis.

Lopes AM, Miguel RN, Sargent CA, Ellis PJ, Amorim A, Affara NA.

BMC Mol Biol. 2010 May 7;11:33. doi: 10.1186/1471-2199-11-33.

35.

Stromal regulation of vessel stability by MMP14 and TGFbeta.

Sounni NE, Dehne K, van Kempen L, Egeblad M, Affara NI, Cuevas I, Wiesen J, Junankar S, Korets L, Lee J, Shen J, Morrison CJ, Overall CM, Krane SM, Werb Z, Boudreau N, Coussens LM.

Dis Model Mech. 2010 May-Jun;3(5-6):317-32. doi: 10.1242/dmm.003863. Epub 2010 Mar 11.

36.
37.

FcRgamma activation regulates inflammation-associated squamous carcinogenesis.

Andreu P, Johansson M, Affara NI, Pucci F, Tan T, Junankar S, Korets L, Lam J, Tawfik D, DeNardo DG, Naldini L, de Visser KE, De Palma M, Coussens LM.

Cancer Cell. 2010 Feb 17;17(2):121-34. doi: 10.1016/j.ccr.2009.12.019. Epub 2010 Feb 4.

38.

Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome.

Lopes AM, Burgoyne PS, Ojarikre A, Bauer J, Sargent CA, Amorim A, Affara NA.

BMC Genomics. 2010 Feb 1;11:82. doi: 10.1186/1471-2164-11-82.

39.

Lymphocytes in cancer development: polarization towards pro-tumor immunity.

Ruffell B, DeNardo DG, Affara NI, Coussens LM.

Cytokine Growth Factor Rev. 2010 Feb;21(1):3-10. doi: 10.1016/j.cytogfr.2009.11.002. Epub 2009 Dec 11. Review.

40.

Global transcriptional response of pig brain and lung to natural infection by Pseudorabies virus.

Yuan JF, Zhang SJ, Jafer O, Furlong RA, Chausiaux OE, Sargent CA, Zhang GH, Affara NA.

BMC Microbiol. 2009 Dec 1;9:246. doi: 10.1186/1471-2180-9-246.

41.

The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis.

Cocquet J, Ellis PJ, Yamauchi Y, Mahadevaiah SK, Affara NA, Ward MA, Burgoyne PS.

PLoS Biol. 2009 Nov;7(11):e1000244. doi: 10.1371/journal.pbio.1000244. Epub 2009 Nov 17.

42.

Karyomapping: a universal method for genome wide analysis of genetic disease based on mapping crossovers between parental haplotypes.

Handyside AH, Harton GL, Mariani B, Thornhill AR, Affara N, Shaw MA, Griffin DK.

J Med Genet. 2010 Oct;47(10):651-8. doi: 10.1136/jmg.2009.069971. Epub 2009 Oct 25.

PMID:
19858130
43.

Association analysis between pseudorabies antibody and five single-nucleotide polymorphisms in pigs.

Zhang SJ, Jafer O, Yuan JF, Chen HC, Sargent CA, Wu B, Zhou R, Yang LG, Liu H, Wu JJ, Liu HB, Tong Q, Yu Y, Affara NA.

Animal. 2009 Oct;3(10):1363-7. doi: 10.1017/S1751731109004856.

PMID:
22444930
44.

Transcriptional profiling of rats subjected to gestational undernourishment: implications for the developmental variations in metabolic traits.

Morris TJ, Vickers M, Gluckman P, Gilmour S, Affara N.

PLoS One. 2009 Sep 29;4(9):e7271. doi: 10.1371/journal.pone.0007271.

45.

Design of a high density SNP genotyping assay in the pig using SNPs identified and characterized by next generation sequencing technology.

Ramos AM, Crooijmans RP, Affara NA, Amaral AJ, Archibald AL, Beever JE, Bendixen C, Churcher C, Clark R, Dehais P, Hansen MS, Hedegaard J, Hu ZL, Kerstens HH, Law AS, Megens HJ, Milan D, Nonneman DJ, Rohrer GA, Rothschild MF, Smith TP, Schnabel RD, Van Tassell CP, Taylor JF, Wiedmann RT, Schook LB, Groenen MA.

PLoS One. 2009 Aug 5;4(8):e6524. doi: 10.1371/journal.pone.0006524.

46.

Mapping of 12 porcine fatness candidate genes in known fatness QTL based on human syntenies.

Yusuf M, Musilova P, Kubickova S, Rubes J, Zhang SJ, Affara NA, Sargent CA, Griffin DK.

Anim Genet. 2009 Aug;40(4):579-80. doi: 10.1111/j.1365-2052.2009.01878.x. Epub 2009 Apr 20. No abstract available.

PMID:
19397513
47.

Identification of SNPs in porcine genes expressed during porcine respiratory and reproductive syndrome virus infection.

Jafer O, Zhang S, Sargent C, Mellencamp MA, Evans G, Mileham A, Plastow G, Affara N.

Anim Genet. 2009 Aug;40(4):580-2. doi: 10.1111/j.1365-2052.2009.01879.x. Epub 2009 Mar 20. No abstract available.

PMID:
19392816
48.

Delineating protease functions during cancer development.

Affara NI, Andreu P, Coussens LM.

Methods Mol Biol. 2009;539:1-32. doi: 10.1007/978-1-60327-003-8_1. Review.

PMID:
19377975
49.

Two novel mouse genes mapped to chromosome Yp are expressed specifically in spermatids.

Ferguson L, Ellis PJ, Affara NA.

Mamm Genome. 2009 Apr;20(4):193-206. doi: 10.1007/s00335-009-9175-8. Epub 2009 Mar 24.

PMID:
19308643
50.

Sex ratio bias in early-dead embryos of chickens collected during the first week of incubation.

Li WM, Feng YP, Zhao RX, Fan YZ, Affara NA, Wu JJ, Fang J, Tong Q, Wang C, Zhang SJ.

Poult Sci. 2008 Nov;87(11):2231-3. doi: 10.3382/ps.2008-00139.

PMID:
18931172

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