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Afaq F, Elmets CA.

Photodermatol Photoimmunol Photomed. 2018 Jan;34(1):4. doi: 10.1111/phpp.12369. No abstract available.


Tea polyphenols for the prevention of UVB-induced skin cancer.

Sharma P, Montes de Oca MK, Alkeswani AR, McClees SF, Das T, Elmets CA, Afaq F.

Photodermatol Photoimmunol Photomed. 2018 Jan;34(1):50-59. doi: 10.1111/phpp.12356. Epub 2017 Nov 20. Review.


Potential therapeutic targets of epithelial-mesenchymal transition in melanoma.

Pearlman RL, Montes de Oca MK, Pal HC, Afaq F.

Cancer Lett. 2017 Apr 10;391:125-140. doi: 10.1016/j.canlet.2017.01.029. Epub 2017 Jan 25. Review.


Pomegranate for Prevention and Treatment of Cancer: An Update.

Sharma P, McClees SF, Afaq F.

Molecules. 2017 Jan 24;22(1). pii: E177. doi: 10.3390/molecules22010177. Review.


Phytochemicals for the Prevention of Photocarcinogenesis.

Montes de Oca MK, Pearlman RL, McClees SF, Strickland R, Afaq F.

Photochem Photobiol. 2017 Jul;93(4):956-974. doi: 10.1111/php.12711. Epub 2017 Mar 14. Review.


Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype.

Srivastava RK, Li C, Weng Z, Agarwal A, Elmets CA, Afaq F, Athar M.

Sci Rep. 2016 Oct 11;6:34865. doi: 10.1038/srep34865.


Fisetin and Its Role in Chronic Diseases.

Pal HC, Pearlman RL, Afaq F.

Adv Exp Med Biol. 2016;928:213-244. Review.


ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis.

Srivastava RK, Li C, Ahmad A, Abrams O, Gorbatyuk MS, Harrod KS, Wek RC, Afaq F, Athar M.

Arch Biochem Biophys. 2016 Nov 1;609:39-50. doi: 10.1016/ Epub 2016 Sep 13.


Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes.

Li C, Srivastava RK, Weng Z, Croutch CR, Agarwal A, Elmets CA, Afaq F, Athar M.

Am J Pathol. 2016 Oct;186(10):2637-49. doi: 10.1016/j.ajpath.2016.06.012. Epub 2016 Aug 12.


Phytochemicals for the Management of Melanoma.

Pal HC, Hunt KM, Diamond A, Elmets CA, Afaq F.

Mini Rev Med Chem. 2016;16(12):953-79. Review. Erratum in: Mini Rev Med Chem. 2017;17 (15):1500.


Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma.

Pal HC, Diamond AC, Strickland LR, Kappes JC, Katiyar SK, Elmets CA, Athar M, Afaq F.

Oncotarget. 2016 Jan 12;7(2):1227-41. doi: 10.18632/oncotarget.6237.


Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells.

Pal HC, Baxter RD, Hunt KM, Agarwal J, Elmets CA, Athar M, Afaq F.

Oncotarget. 2015 Sep 29;6(29):28296-311. doi: 10.18632/oncotarget.5064.


Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis.

Chamcheu JC, Pal HC, Siddiqui IA, Adhami VM, Ayehunie S, Boylan BT, Noubissi FK, Khan N, Syed DN, Elmets CA, Wood GS, Afaq F, Mukhtar H.

Skin Pharmacol Physiol. 2015;28(4):177-88. doi: 10.1159/000368445. Epub 2015 Jan 22.


Targeting drivers of melanoma with synthetic small molecules and phytochemicals.

Strickland LR, Pal HC, Elmets CA, Afaq F.

Cancer Lett. 2015 Apr 1;359(1):20-35. doi: 10.1016/j.canlet.2015.01.016. Epub 2015 Jan 15. Review.


Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation.

Pal HC, Chamcheu JC, Adhami VM, Wood GS, Elmets CA, Mukhtar H, Afaq F.

Br J Dermatol. 2015 Feb;172(2):354-64. doi: 10.1111/bjd.13513. Epub 2014 Dec 23.


Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K/AKT/NFκB signaling pathways in SKH-1 hairless mice.

Pal HC, Athar M, Elmets CA, Afaq F.

Photochem Photobiol. 2015 Jan-Feb;91(1):225-34. doi: 10.1111/php.12337. Epub 2014 Oct 7.


Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch.

Arumugam A, Weng Z, Chaudhary SC, Afaq F, Elmets CA, Athar M.

Biochem Biophys Res Commun. 2014 Aug 29;451(3):394-401. doi: 10.1016/j.bbrc.2014.07.129. Epub 2014 Aug 2.


Fisetin inhibits human melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathways.

Pal HC, Sharma S, Strickland LR, Katiyar SK, Ballestas ME, Athar M, Elmets CA, Afaq F.

PLoS One. 2014 Jan 23;9(1):e86338. doi: 10.1371/journal.pone.0086338. eCollection 2014.


Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis.

Arumugam A, Weng Z, Talwelkar SS, Chaudhary SC, Kopelovich L, Elmets CA, Afaq F, Athar M.

PLoS One. 2013 Nov 8;8(11):e80076. doi: 10.1371/journal.pone.0080076. eCollection 2013.


Erb-041, an estrogen receptor-β agonist, inhibits skin photocarcinogenesis in SKH-1 hairless mice by downregulating the WNT signaling pathway.

Chaudhary SC, Singh T, Talwelkar SS, Srivastava RK, Arumugam A, Weng Z, Elmets CA, Afaq F, Kopelovich L, Athar M.

Cancer Prev Res (Phila). 2014 Feb;7(2):186-98. doi: 10.1158/1940-6207.CAPR-13-0276. Epub 2013 Nov 11.


Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways.

Pal HC, Sharma S, Strickland LR, Agarwal J, Athar M, Elmets CA, Afaq F.

PLoS One. 2013 Oct 4;8(10):e77270. doi: 10.1371/journal.pone.0077270. eCollection 2013.


Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption.

Srivastava RK, Li C, Chaudhary SC, Ballestas ME, Elmets CA, Robbins DJ, Matalon S, Deshane JS, Afaq F, Bickers DR, Athar M.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):879-87. doi: 10.1016/j.taap.2013.08.004. Epub 2013 Aug 14.


Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein.

Li C, Srivastava RK, Elmets CA, Afaq F, Athar M.

Biochem Biophys Res Commun. 2013 Sep 6;438(4):607-12. doi: 10.1016/j.bbrc.2013.08.008. Epub 2013 Aug 11.


Chlorine induces the unfolded protein response in murine lungs and skin.

Li C, Weng Z, Doran SF, Srivastava RK, Afaq F, Matalon S, Athar M.

Am J Respir Cell Mol Biol. 2013 Aug;49(2):197-203. doi: 10.1165/rcmb.2012-0488RC.


Delphinidin, a dietary antioxidant, induces human epidermal keratinocyte differentiation but not apoptosis: studies in submerged and three-dimensional epidermal equivalent models.

Chamcheu JC, Afaq F, Syed DN, Siddiqui IA, Adhami VM, Khan N, Singh S, Boylan BT, Wood GS, Mukhtar H.

Exp Dermatol. 2013 May;22(5):342-8. doi: 10.1111/exd.12140.


Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs.

Arumugam A, Walsh SB, Xu J, Afaq F, Elmets CA, Athar M.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):177-81. doi: 10.1016/j.bbrc.2012.07.062. Epub 2012 Jul 20.


Differential activation of signaling pathways by UVA and UVB radiation in normal human epidermal keratinocytes.

Syed DN, Afaq F, Mukhtar H.

Photochem Photobiol. 2012 Sep-Oct;88(5):1184-90. doi: 10.1111/j.1751-1097.2012.01115.x. Epub 2012 Mar 19.


Pomegranate fruit extract inhibits UVB-induced inflammation and proliferation by modulating NF-κB and MAPK signaling pathways in mouse skin.

Khan N, Syed DN, Pal HC, Mukhtar H, Afaq F.

Photochem Photobiol. 2012 Sep-Oct;88(5):1126-34. doi: 10.1111/j.1751-1097.2011.01063.x. Epub 2012 Jan 13.


Butein induces apoptosis and inhibits prostate tumor growth in vitro and in vivo.

Khan N, Adhami VM, Afaq F, Mukhtar H.

Antioxid Redox Signal. 2012 Jun 1;16(11):1195-204. doi: 10.1089/ars.2011.4162. Epub 2012 Jan 16.


Polyphenols: skin photoprotection and inhibition of photocarcinogenesis.

Afaq F, Katiyar SK.

Mini Rev Med Chem. 2011 Dec;11(14):1200-15. Review.


Dual inhibition of phosphatidylinositol 3-kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin.

Khan N, Afaq F, Khusro FH, Mustafa Adhami V, Suh Y, Mukhtar H.

Int J Cancer. 2012 Apr 1;130(7):1695-705. doi: 10.1002/ijc.26178. Epub 2011 Aug 26.


Inhibition of human melanoma cell growth by the dietary flavonoid fisetin is associated with disruption of Wnt/β-catenin signaling and decreased Mitf levels.

Syed DN, Afaq F, Maddodi N, Johnson JJ, Sarfaraz S, Ahmad A, Setaluri V, Mukhtar H.

J Invest Dermatol. 2011 Jun;131(6):1291-9. doi: 10.1038/jid.2011.6. Epub 2011 Feb 24.


Natural agents: cellular and molecular mechanisms of photoprotection.

Afaq F.

Arch Biochem Biophys. 2011 Apr 15;508(2):144-51. doi: 10.1016/ Epub 2010 Dec 11. Review.


Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.

Afaq F, Khan N, Syed DN, Mukhtar H.

Photochem Photobiol. 2010 Nov-Dec;86(6):1318-26. doi: 10.1111/j.1751-1097.2010.00815.x. Epub 2010 Oct 14.


Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells.

Suh Y, Afaq F, Khan N, Johnson JJ, Khusro FH, Mukhtar H.

Carcinogenesis. 2010 Aug;31(8):1424-33. doi: 10.1093/carcin/bgq115. Epub 2010 Jun 8.


In vitro and in vivo effects of water extract of white cocoa tea (Camellia ptilophylla) against human prostate cancer.

Peng L, Khan N, Afaq F, Ye C, Mukhtar H.

Pharm Res. 2010 Jun;27(6):1128-37. doi: 10.1007/s11095-010-0052-7. Epub 2010 Mar 12.


Lifestyle as risk factor for cancer: Evidence from human studies.

Khan N, Afaq F, Mukhtar H.

Cancer Lett. 2010 Jul 28;293(2):133-43. doi: 10.1016/j.canlet.2009.12.013. Epub 2010 Jan 18. Review.


Aryl hydrocarbon receptor is an ozone sensor in human skin.

Afaq F, Zaid MA, Pelle E, Khan N, Syed DN, Matsui MS, Maes D, Mukhtar H.

J Invest Dermatol. 2009 Oct;129(10):2396-403. doi: 10.1038/jid.2009.85. Epub 2009 Jun 18.


Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin.

Afaq F, Zaid MA, Khan N, Dreher M, Mukhtar H.

Exp Dermatol. 2009 Jun;18(6):553-61. doi: 10.1111/j.1600-0625.2008.00829.x. Epub 2009 Mar 6.


A plant flavonoid fisetin induces apoptosis in colon cancer cells by inhibition of COX2 and Wnt/EGFR/NF-kappaB-signaling pathways.

Suh Y, Afaq F, Johnson JJ, Mukhtar H.

Carcinogenesis. 2009 Feb;30(2):300-7. doi: 10.1093/carcin/bgn269. Epub 2008 Nov 26.


A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling.

Hafeez BB, Siddiqui IA, Asim M, Malik A, Afaq F, Adhami VM, Saleem M, Din M, Mukhtar H.

Cancer Res. 2008 Oct 15;68(20):8564-72. doi: 10.1158/0008-5472.CAN-08-2232.


A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice.

Khan N, Asim M, Afaq F, Abu Zaid M, Mukhtar H.

Cancer Res. 2008 Oct 15;68(20):8555-63. doi: 10.1158/0008-5472.CAN-08-0240.


Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice.

Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Mukhtar H.

Carcinogenesis. 2008 Oct;29(10):2011-8. doi: 10.1093/carcin/bgn180. Epub 2008 Aug 5.


Inhibition of epidermal growth factor receptor signaling pathway by delphinidin, an anthocyanidin in pigmented fruits and vegetables.

Afaq F, Zaman N, Khan N, Syed DN, Sarfaraz S, Zaid MA, Mukhtar H.

Int J Cancer. 2008 Oct 1;123(7):1508-15. doi: 10.1002/ijc.23675.


Delphinidin inhibits cell proliferation and invasion via modulation of Met receptor phosphorylation.

Syed DN, Afaq F, Sarfaraz S, Khan N, Kedlaya R, Setaluri V, Mukhtar H.

Toxicol Appl Pharmacol. 2008 Aug 15;231(1):52-60. doi: 10.1016/j.taap.2008.03.023. Epub 2008 Apr 9.


Dietary agents for chemoprevention of prostate cancer.

Syed DN, Suh Y, Afaq F, Mukhtar H.

Cancer Lett. 2008 Jul 8;265(2):167-76. doi: 10.1016/j.canlet.2008.02.050. Epub 2008 Apr 18. Review.


Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells.

Khan N, Afaq F, Syed DN, Mukhtar H.

Carcinogenesis. 2008 May;29(5):1049-56. doi: 10.1093/carcin/bgn078. Epub 2008 Mar 20.


Phytochemicals for prevention of solar ultraviolet radiation-induced damages.

Adhami VM, Syed DN, Khan N, Afaq F.

Photochem Photobiol. 2008 Mar-Apr;84(2):489-500. doi: 10.1111/j.1751-1097.2007.00293.x. Epub 2008 Feb 7. Review.


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