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Items: 47


Immune checkpoint blockade combined with IL-6 and TGF-β inhibition improves the therapeutic outcome of mRNA-based immunotherapy.

Bialkowski L, Van der Jeught K, Bevers S, Tjok Joe P, Renmans D, Heirman C, Aerts JL, Thielemans K.

Int J Cancer. 2018 Aug 1;143(3):686-698. doi: 10.1002/ijc.31331. Epub 2018 Mar 13.


Dendritic cell immunotherapy followed by cART interruption during HIV-1 infection induces plasma protein markers of cellular immunity and neutrophil recruitment.

van den Ham HJ, Cooper JD, Tomasik J, Bahn S, Aerts JL, Osterhaus ADME, Gruters RA, Andeweg AC; DC-TRN trial investigators.

PLoS One. 2018 Feb 1;13(2):e0192278. doi: 10.1371/journal.pone.0192278. eCollection 2018.


Oncolytic virus-induced cell death and immunity: a match made in heaven?

De Munck J, Binks A, McNeish IA, Aerts JL.

J Leukoc Biol. 2017 Sep;102(3):631-643. doi: 10.1189/jlb.5RU0117-040R. Epub 2017 Jul 18. Review.


Phosphorylated STAT5 regulates p53 expression via BRCA1/BARD1-NPM1 and MDM2.

Ren Z, Aerts JL, Vandenplas H, Wang JA, Gorbenko O, Chen JP, Giron P, Heirman C, Goyvaerts C, Zacksenhaus E, Minden MD, Stambolic V, Breckpot K, De Grève J.

Cell Death Dis. 2016 Dec 22;7(12):e2560. doi: 10.1038/cddis.2016.430.


Combined VEGFR and CTLA-4 blockade increases the antigen-presenting function of intratumoral DCs and reduces the suppressive capacity of intratumoral MDSCs.

Du Four S, Maenhout SK, Niclou SP, Thielemans K, Neyns B, Aerts JL.

Am J Cancer Res. 2016 Nov 1;6(11):2514-2531. eCollection 2016.


Preclinical evaluation of an mRNA HIV vaccine combining rationally selected antigenic sequences and adjuvant signals (HTI-TriMix).

Guardo AC, Joe PT, Miralles L, Bargalló ME, Mothe B, Krasniqi A, Heirman C, García F, Thielemans K, Brander C, Aerts JL, Plana M; iHIVARNA consortium.

AIDS. 2017 Jan 28;31(3):321-332. doi: 10.1097/QAD.0000000000001276.


Disease progression in recurrent glioblastoma patients treated with the VEGFR inhibitor axitinib is associated with increased regulatory T cell numbers and T cell exhaustion.

Du Four S, Maenhout SK, Benteyn D, De Keersmaecker B, Duerinck J, Thielemans K, Neyns B, Aerts JL.

Cancer Immunol Immunother. 2016 Jun;65(6):727-40. doi: 10.1007/s00262-016-1836-3. Epub 2016 Apr 20.


Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours.

Bialkowski L, van Weijnen A, Van der Jeught K, Renmans D, Daszkiewicz L, Heirman C, Stangé G, Breckpot K, Aerts JL, Thielemans K.

Sci Rep. 2016 Mar 2;6:22509. doi: 10.1038/srep22509.


Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed.

Van Liefferinge J, Bentea E, Demuyser T, Albertini G, Follin-Arbelet V, Holmseth S, Merckx E, Sato H, Aerts JL, Smolders I, Arckens L, Danbolt NC, Massie A.

J Comp Neurol. 2016 Apr 1;524(5):1015-32. doi: 10.1002/cne.23889. Epub 2015 Oct 23.


Aging-associated subpopulations of human CD8+ T-lymphocytes identified by their CD28 and CD57 phenotypes.

Onyema OO, Njemini R, Forti LN, Bautmans I, Aerts JL, De Waele M, Mets T.

Arch Gerontol Geriatr. 2015 Nov-Dec;61(3):494-502. doi: 10.1016/j.archger.2015.08.007. Epub 2015 Aug 4.


Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.

Du Four S, Maenhout SK, De Pierre K, Renmans D, Niclou SP, Thielemans K, Neyns B, Aerts JL.

Oncoimmunology. 2015 Jan 22;4(4):e998107. eCollection 2015 Apr.


Location, location, location: functional and phenotypic heterogeneity between tumor-infiltrating and non-infiltrating myeloid-derived suppressor cells.

Maenhout SK, Thielemans K, Aerts JL.

Oncoimmunology. 2014 Dec 15;3(10):e956579. eCollection 2014 Nov. Review.


DC immunotherapy in HIV-1 infection induces a major blood transcriptome shift.

de Goede AL, Andeweg AC, van den Ham HJ, Bijl MA, Zaaraoui-Boutahar F, van IJcken WF, Wilgenhof S, Aerts JL, Gruters RA, Osterhaus AD; DC-TRN trial investigators.

Vaccine. 2015 Jun 9;33(25):2922-9. doi: 10.1016/j.vaccine.2015.04.047. Epub 2015 Apr 24.


AZD1480 delays tumor growth in a melanoma model while enhancing the suppressive activity of myeloid-derived suppressor cells.

Maenhout SK, Du Four S, Corthals J, Neyns B, Thielemans K, Aerts JL.

Oncotarget. 2014 Aug 30;5(16):6801-15.


Immunomodulatory drugs improve the immune environment for dendritic cell-based immunotherapy in multiple myeloma patients after autologous stem cell transplantation.

De Keersmaecker B, Fostier K, Corthals J, Wilgenhof S, Heirman C, Aerts JL, Thielemans K, Schots R.

Cancer Immunol Immunother. 2014 Oct;63(10):1023-36. doi: 10.1007/s00262-014-1571-6. Epub 2014 Jun 20.


Phosphorylated STAT3 physically interacts with NPM and transcriptionally enhances its expression in cancer.

Ren Z, Aerts JL, Pen JJ, Heirman C, Breckpot K, De Grève J.

Oncogene. 2015 Mar 26;34(13):1650-7. doi: 10.1038/onc.2014.109. Epub 2014 May 5.


β₂-adrenergic agonists modulate TNF-α induced astrocytic inflammatory gene expression and brain inflammatory cell populations.

Laureys G, Gerlo S, Spooren A, Demol F, De Keyser J, Aerts JL.

J Neuroinflammation. 2014 Jan 30;11:21. doi: 10.1186/1742-2094-11-21.


HIV-1 evolution in patients undergoing immunotherapy with Tat, Rev, and Nef expressing dendritic cells followed by treatment interruption.

de Goede AL, van Deutekom HW, Vrancken B, Schutten M, Allard SD, van Baalen CA, Osterhaus AD, Thielemans K, Aerts JL, Keşmir C, Lemey P, Gruters RA.

AIDS. 2013 Nov 13;27(17):2679-89. doi: 10.1097/01.aids.0000433813.67662.92.


Enhanced suppressive capacity of tumor-infiltrating myeloid-derived suppressor cells compared with their peripheral counterparts.

Maenhout SK, Van Lint S, Emeagi PU, Thielemans K, Aerts JL.

Int J Cancer. 2014 Mar 1;134(5):1077-90. doi: 10.1002/ijc.28449. Epub 2013 Sep 23.


Modulation of regulatory T cell function by monocyte-derived dendritic cells matured through electroporation with mRNA encoding CD40 ligand, constitutively active TLR4, and CD70.

Pen JJ, De Keersmaecker B, Maenhout SK, Van Nuffel AM, Heirman C, Corthals J, Escors D, Bonehill A, Thielemans K, Breckpot K, Aerts JL.

J Immunol. 2013 Aug 15;191(4):1976-83. doi: 10.4049/jimmunol.1201008. Epub 2013 Jul 10.


Does early cell death cause germ cell loss after intratesticular tissue grafting?

Van Saen D, Goossens E, Aerts JL, Haentjens P, Tournaye H.

Fertil Steril. 2013 Apr;99(5):1264-1272.e1. doi: 10.1016/j.fertnstert.2012.12.019. Epub 2013 Jan 10.


Expansion of polyfunctional HIV-specific T cells upon stimulation with mRNA electroporated dendritic cells in the presence of immunomodulatory drugs.

De Keersmaecker B, Allard SD, Lacor P, Schots R, Thielemans K, Aerts JL.

J Virol. 2012 Sep;86(17):9351-60. doi: 10.1128/JVI.00472-12. Epub 2012 Jun 20.


Proinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapy.

Emeagi PU, Van Lint S, Goyvaerts C, Maenhout S, Cauwels A, McNeish IA, Bos T, Heirman C, Thielemans K, Aerts JL, Breckpot K.

Cancer Res. 2012 Mar 15;72(6):1342-52. doi: 10.1158/0008-5472.CAN-11-2400. Epub 2012 Feb 29.


Sequence evolution and escape from specific immune pressure of an HIV-1 Rev epitope with extensive sequence similarity to human nucleolar protein 6.

Allard SD, de Goede AL, De Keersmaecker B, Heirman C, Lacor P, Osterhaus AD, Demanet C, Thielemans K, Gruters RA, Aerts JL.

Tissue Antigens. 2012 Mar;79(3):174-85. doi: 10.1111/j.1399-0039.2012.01837.x.


A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption.

Allard SD, De Keersmaecker B, de Goede AL, Verschuren EJ, Koetsveld J, Reedijk ML, Wylock C, De Bel AV, Vandeloo J, Pistoor F, Heirman C, Beyer WE, Eilers PH, Corthals J, Padmos I, Thielemans K, Osterhaus AD, Lacor P, van der Ende ME, Aerts JL, van Baalen CA, Gruters RA.

Clin Immunol. 2012 Mar;142(3):252-68. doi: 10.1016/j.clim.2011.10.010. Epub 2011 Nov 16.


The combination of 4-1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV-specific T cell responses.

De Keersmaecker B, Heirman C, Corthals J, Empsen C, van Grunsven LA, Allard SD, Pen J, Lacor P, Thielemans K, Aerts JL.

J Leukoc Biol. 2011 Jun;89(6):989-99. doi: 10.1189/jlb.0810466. Epub 2011 Mar 22.


Fighting with the enemy's weapons? the role of costimulatory molecules in HIV.

De Keersmaecker B, Thielemans K, Aerts JL.

Curr Mol Med. 2011 Apr;11(3):172-96. Review.


Lumenal part of the DC-LAMP protein is not required for induction of antigen-specific T cell responses by means of antigen-DC-LAMP messenger RNA-electroporated dendritic cells.

De Keersmaecker B, Heirman C, Allard S, Bonehill A, Corthals J, Thielemans K, Aerts JL.

Hum Gene Ther. 2010 Apr;21(4):479-85. doi: 10.1089/hum.2009.080.


Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine.

Breckpot K, Aerts-Toegaert C, Heirman C, Peeters U, Beyaert R, Aerts JL, Thielemans K.

J Immunol. 2009 Jan 15;182(2):860-70.


Functional T-cell responses generated by dendritic cells expressing the early HIV-1 proteins Tat, Rev and Nef.

Allard SD, Pletinckx K, Breckpot K, Heirman C, Bonehill A, Michiels A, van Baalen CA, Gruters RA, Osterhaus AD, Lacor P, Thielemans K, Aerts JL.

Vaccine. 2008 Jul 4;26(29-30):3735-41. doi: 10.1016/j.vaccine.2008.04.077. Epub 2008 May 20.


Oncolytic adenoviral mutants induce a novel mode of programmed cell death in ovarian cancer.

Baird SK, Aerts JL, Eddaoudi A, Lockley M, Lemoine NR, McNeish IA.

Oncogene. 2008 May 15;27(22):3081-90. Epub 2007 Dec 10.


Current approaches in dendritic cell generation and future implications for cancer immunotherapy.

Tuyaerts S, Aerts JL, Corthals J, Neyns B, Heirman C, Breckpot K, Thielemans K, Bonehill A.

Cancer Immunol Immunother. 2007 Oct;56(10):1513-37. Epub 2007 May 15. Review.


Expression of human GITRL on myeloid dendritic cells enhances their immunostimulatory function but does not abrogate the suppressive effect of CD4+CD25+ regulatory T cells.

Tuyaerts S, Van Meirvenne S, Bonehill A, Heirman C, Corthals J, Waldmann H, Breckpot K, Thielemans K, Aerts JL.

J Leukoc Biol. 2007 Jul;82(1):93-105. Epub 2007 Apr 20.


Lentiviral vectors for cancer immunotherapy: transforming infectious particles into therapeutics.

Breckpot K, Aerts JL, Thielemans K.

Gene Ther. 2007 Jun;14(11):847-62. Epub 2007 Mar 22. Review.


CD83 expression on dendritic cells and T cells: correlation with effective immune responses.

Aerts-Toegaert C, Heirman C, Tuyaerts S, Corthals J, Aerts JL, Bonehill A, Thielemans K, Breckpot K.

Eur J Immunol. 2007 Mar;37(3):686-95.


Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA.

Michiels A, Breckpot K, Corthals J, Tuyaerts S, Bonehill A, Heirman C, Thielemans K, Aerts JL.

Gene Ther. 2006 Jul;13(13):1027-36. Epub 2006 Mar 2.


Induction of effective therapeutic antitumor immunity by direct in vivo administration of lentiviral vectors.

Dullaers M, Van Meirvenne S, Heirman C, Straetman L, Bonehill A, Aerts JL, Thielemans K, Breckpot K.

Gene Ther. 2006 Apr;13(7):630-40.


Cancer cell dissemination during curative surgery for colorectal liver metastases.

Topal B, Aerts JL, Roskams T, Fieuws S, Van Pelt J, Vandekerckhove P, Penninckx F.

Eur J Surg Oncol. 2005 Jun;31(5):506-11.


Selection of appropriate control genes to assess expression of tumor antigens using real-time RT-PCR.

Aerts JL, Gonzales MI, Topalian SL.

Biotechniques. 2004 Jan;36(1):84-6, 88, 90-1.


Detection of micrometastatic disease and monitoring of perioperative tumor cell dissemination in primary operable breast cancer patients using real-time quantitative reverse transcription-PCR.

Ismail MS, Wynendaele W, Aerts JL, Paridaens R, Gaafar R, Shakankiry N, Khaled HM, Christiaens MR, Wildiers H, Omar S, Vandekerckhove P, Van Oosterom AT.

Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):196-201.


The interferon inducer ampligen [poly(I)-poly(C12U)] markedly protects mice against coxsackie B3 virus-induced myocarditis.

Padalko E, Nuyens D, De Palma A, Verbeken E, Aerts JL, De Clercq E, Carmeliet P, Neyts J.

Antimicrob Agents Chemother. 2004 Jan;48(1):267-74.


Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice.

Padalko E, Verbeken E, Matthys P, Aerts JL, De Clercq E, Neyts J.

BMC Microbiol. 2003 Dec 21;3:25.


Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia - a Europe Against Cancer program.

Gabert J, Beillard E, van der Velden VH, Bi W, Grimwade D, Pallisgaard N, Barbany G, Cazzaniga G, Cayuela JM, Cavé H, Pane F, Aerts JL, De Micheli D, Thirion X, Pradel V, González M, Viehmann S, Malec M, Saglio G, van Dongen JJ.

Leukemia. 2003 Dec;17(12):2318-57. Review.


Real-time quantitative RT-PCR and detection of tumour cell dissemination in breast cancer patients: plasmid versus cell line dilutions.

Ismail MS, Wynendaele W, Aerts JL, Paridaens R, Van Mellaert L, Anné J, Gaafar R, Shakankiry N, Khaled HM, Christiaens MR, Omar S, Vandekerckhove P, Van Oosterom AT.

Ann Oncol. 2003 Aug;14(8):1241-5.


Real-time quantitative reverse transcriptase-polymerase chain reaction as a method for determining lentiviral vector titers and measuring transgene expression.

Lizée G, Aerts JL, Gonzales MI, Chinnasamy N, Morgan RA, Topalian SL.

Hum Gene Ther. 2003 Apr 10;14(6):497-507.


Evaluation of progesterone receptor expression in eosinophils using real-time quantitative PCR.

Aerts JL, Christiaens MR, Vandekerckhove P.

Biochim Biophys Acta. 2002 Jul 3;1571(3):167-72.


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