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Tumour Treating Fields in combination with pemetrexed and cisplatin or carboplatin as first-line treatment for unresectable malignant pleural mesothelioma (STELLAR): a multicentre, single-arm phase 2 trial.

Ceresoli GL, Aerts JG, Dziadziuszko R, Ramlau R, Cedres S, van Meerbeeck JP, Mencoboni M, Planchard D, Chella A, Crinò L, Krzakowski M, Rüssel J, Maconi A, Gianoncelli L, Grosso F.

Lancet Oncol. 2019 Oct 15. pii: S1470-2045(19)30532-7. doi: 10.1016/S1470-2045(19)30532-7. [Epub ahead of print]


Malignant Peritoneal Mesothelioma: Patterns of Care and Survival in the Netherlands: A Population-Based Study.

de Boer NL, van Kooten JP, Damhuis RAM, Aerts JGJV, Verhoef C, Madsen EVE.

Ann Surg Oncol. 2019 Oct 16. doi: 10.1245/s10434-019-07803-z. [Epub ahead of print]


Pemetrexed exposure predicts toxicity in advanced non-small-cell lung cancer: A prospective cohort study.

Visser S, Koolen SLW, de Bruijn P, Belderbos HNA, Cornelissen R, Mathijssen RHJ, Stricker BH, Aerts JGJV.

Eur J Cancer. 2019 Nov;121:64-73. doi: 10.1016/j.ejca.2019.08.012. Epub 2019 Sep 24.


The relation between systemic inflammation and incident cancer in patients with stable cardiovascular disease: a cohort study.

Van't Klooster CC, Ridker PM, Hjortnaes J, van der Graaf Y, Asselbergs FW, Westerink J, Aerts JGJV, Visseren FLJ.

Eur Heart J. 2019 Sep 1. pii: ehz587. doi: 10.1093/eurheartj/ehz587. [Epub ahead of print]


Towards the Optical Detection of Field Cancerization in the Buccal Mucosa of Patients with Lung Cancer.

Bugter O, van Brummelen SE, van der Leest KH, Aerts JGJV, Maat APWM, Baatenburg de Jong RJ, Amelink A, Robinson DJ.

Transl Oncol. 2019 Aug 29;12(12):1533-1538. doi: 10.1016/j.tranon.2019.07.018. [Epub ahead of print]


Predicting factors for chronic colonization of Pseudomonas aeruginosa in bronchiectasis.

Pieters A, Bakker M, Hoek RAS, Altenburg J, van Westreenen M, Aerts JGJV, van der Eerden MM.

Eur J Clin Microbiol Infect Dis. 2019 Aug 31. doi: 10.1007/s10096-019-03675-z. [Epub ahead of print]


A multicenter, randomized, phase II/III study of dendritic cells loaded with allogeneic tumor cell lysate (MesoPher) in subjects with mesothelioma as maintenance therapy after chemotherapy: DENdritic cell Immunotherapy for Mesothelioma (DENIM) trial.

Belderbos RA, Baas P, Berardi R, Cornelissen R, Fennell DA, van Meerbeeck JP, Scherpereel A, Vroman H, Aerts JGJV.

Transl Lung Cancer Res. 2019 Jun;8(3):280-285. doi: 10.21037/tlcr.2019.05.05.


Referral Patterns and Outcome of Patients With Synchronous Brain Metastases From Non-small Cell Lung Cancer Treated With Gamma Knife Radiosurgery in a Third-Line Treatment Centre in The Netherlands - A Retrospective Analysis.

Ten Berge DMHJ, Aarts MJ, Hanssens PEJ, Beute GN, Aerts JGJV, Kloover JS.

Clin Oncol (R Coll Radiol). 2019 Jul 22. pii: S0936-6555(19)30284-5. doi: 10.1016/j.clon.2019.07.004. [Epub ahead of print]


Reply to K. Masuda et al.

Fennell DA, Taylor P, Gilligan D, Nakano T, Scherpereel A, Pavlakis N, van Meerbeeck JP, Aerts JGJV, Nowak AK, Kindler H, Baas P.

J Clin Oncol. 2019 Sep 1;37(25):2294-2295. doi: 10.1200/JCO.19.01208. Epub 2019 Jul 22. No abstract available.


A prospective cohort study on the pharmacokinetics of nivolumab in metastatic non-small cell lung cancer, melanoma, and renal cell cancer patients.

Hurkmans DP, Basak EA, van Dijk T, Mercieca D, Schreurs MWJ, Wijkhuijs AJM, Bins S, Hoop EO, Debets R, Joerger M, Odink A, van der Veldt AAM, van der Leest CH, Aerts JGJV, Mathijssen RHJ, Koolen SLW.

J Immunother Cancer. 2019 Jul 19;7(1):192. doi: 10.1186/s40425-019-0669-y.


Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non-Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial.

Theelen WSME, Peulen HMU, Lalezari F, van der Noort V, de Vries JF, Aerts JGJV, Dumoulin DW, Bahce I, Niemeijer AN, de Langen AJ, Monkhorst K, Baas P.

JAMA Oncol. 2019 Jul 11. doi: 10.1001/jamaoncol.2019.1478. [Epub ahead of print]


The relation between psychological profiles and quality of life in patients with lung cancer.

van Montfort E, de Vries J, Arts R, Aerts JG, Kloover JS, Traa MJ.

Support Care Cancer. 2019 Jul 1. doi: 10.1007/s00520-019-04923-w. [Epub ahead of print]


Blood eosinophil count and GOLD stage predict response to maintenance azithromycin treatment in COPD patients with frequent exacerbations.

Djamin RS, Bafadhel M, Uzun S, Russell REK, Ermens AAM, Kerstens R, Aerts JGJV, Pavord ID, van der Eerden MM.

Respir Med. 2019 Jul - Aug;154:27-33. doi: 10.1016/j.rmed.2019.06.005. Epub 2019 Jun 8.


The prognostic value of early onset, CT derived loss of muscle and adipose tissue during chemotherapy in metastatic non-small cell lung cancer.

Degens JHRJ, Sanders KJC, de Jong EEC, Groen HJM, Smit EF, Aerts JG, Schols AMWJ, Dingemans AC.

Lung Cancer. 2019 Jul;133:130-135. doi: 10.1016/j.lungcan.2019.05.021. Epub 2019 May 20.


CD45RA+CCR7- CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab.

Kunert A, Basak EA, Hurkmans DP, Balcioglu HE, Klaver Y, van Brakel M, Oostvogels AAM, Lamers CHJ, Bins S, Koolen SLW, van der Veldt AAM, Sleijfer S, Mathijssen RHJ, Aerts JGJV, Debets R.

J Immunother Cancer. 2019 Jun 8;7(1):149. doi: 10.1186/s40425-019-0608-y.


Prediction of response to pemetrexed in non-small-cell lung cancer with immunohistochemical phenotyping based on gene expression profiles.

Visser S, Hou J, Bezemer K, de Vogel LL, Hegmans JPJJ, Stricker BH, Philipsen S, Aerts JGJV.

BMC Cancer. 2019 May 14;19(1):440. doi: 10.1186/s12885-019-5645-x.


Quantification of the tyrosine kinase inhibitor erlotinib in human scalp hair by liquid chromatography-tandem mass spectrometry: Pitfalls for clinical application.

Braal CL, Veerman GDM, Peric R, Aerts JGJV, Mathijssen RHJ, Koolen SLW, de Bruijn P.

J Pharm Biomed Anal. 2019 Aug 5;172:175-182. doi: 10.1016/j.jpba.2019.04.031. Epub 2019 Apr 17.


Enhancing Dendritic Cell Therapy in Solid Tumors with Immunomodulating Conventional Treatment.

Belderbos RA, Aerts JGJV, Vroman H.

Mol Ther Oncolytics. 2019 Mar 27;13:67-81. doi: 10.1016/j.omto.2019.03.007. eCollection 2019 Jun 28. Review.


Early-Stage NSCLC: Advances in Thoracic Oncology 2018.

Osarogiagbon RU, Veronesi G, Fang W, Ekman S, Suda K, Aerts JG, Donington J.

J Thorac Oncol. 2019 Jun;14(6):968-978. doi: 10.1016/j.jtho.2019.02.029. Epub 2019 Mar 7. Review.


Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study.

Fennell DA, Baas P, Taylor P, Nowak AK, Gilligan D, Nakano T, Pachter JA, Weaver DT, Scherpereel A, Pavlakis N, van Meerbeeck JP, Cedrés S, Nolan L, Kindler H, Aerts JGJV.

J Clin Oncol. 2019 Apr 1;37(10):790-798. doi: 10.1200/JCO.2018.79.0543. Epub 2019 Feb 20.


Serum levels of hyaluronic acid are associated with COPD severity and predict survival.

Papakonstantinou E, Bonovolias I, Roth M, Tamm M, Schumann D, Baty F, Louis R, Milenkovic B, Boersma W, Stieltjes B, Kostikas K, Blasi F, Aerts JG, Rohde GGU, Lacoma A, Torres A, Welte T, Stolz D.

Eur Respir J. 2019 Mar 7;53(3). pii: 1801183. doi: 10.1183/13993003.01183-2018. Print 2019 Mar.


Frequency of low-grade adverse events and quality of life during chemotherapy determine patients' judgement about treatment in advanced-stage thoracic cancer.

de Mol M, Visser S, den Oudsten BL, Lodder P, van Walree N, Belderbos H, Aerts JG.

Support Care Cancer. 2019 Sep;27(9):3563-3572. doi: 10.1007/s00520-019-4659-x. Epub 2019 Jan 28.


Correlation between nivolumab exposure and treatment outcomes in non-small-cell lung cancer.

Basak EA, Koolen SLW, Hurkmans DP, Schreurs MWJ, Bins S, Oomen-de Hoop E, Wijkhuijs AJM, Besten ID, Sleijfer S, Debets R, van der Veldt AAM, Aerts JGJV, Mathijssen RHJ.

Eur J Cancer. 2019 Mar;109:12-20. doi: 10.1016/j.ejca.2018.12.008. Epub 2019 Jan 14.


Induction of Peripheral Effector CD8 T-cell Proliferation by Combination of Paclitaxel, Carboplatin, and Bevacizumab in Non-small Cell Lung Cancer Patients.

de Goeje PL, Poncin M, Bezemer K, Kaijen-Lambers MEH, Groen HJM, Smit EF, Dingemans AC, Kunert A, Hendriks RW, Aerts JGJV.

Clin Cancer Res. 2019 Apr 1;25(7):2219-2227. doi: 10.1158/1078-0432.CCR-18-2243. Epub 2019 Jan 14.


The clinical impact of Pseudomonas aeruginosa eradication in bronchiectasis in a Dutch referral centre.

Pieters A, Bakker M, Hoek RAS, Altenburg J, van Westreenen M, Aerts JGJV, van der Eerden MM.

Eur Respir J. 2019 Apr 11;53(4). pii: 1802081. doi: 10.1183/13993003.02081-2018. Print 2019 Apr. No abstract available.


Combination Strategies to Optimize Efficacy of Dendritic Cell-Based Immunotherapy.

van Gulijk M, Dammeijer F, Aerts JGJV, Vroman H.

Front Immunol. 2018 Dec 5;9:2759. doi: 10.3389/fimmu.2018.02759. eCollection 2018. Review.


Current State of Dendritic Cell-Based Immunotherapy: Opportunities for in vitro Antigen Loading of Different DC Subsets?

Huber A, Dammeijer F, Aerts JGJV, Vroman H.

Front Immunol. 2018 Dec 3;9:2804. doi: 10.3389/fimmu.2018.02804. eCollection 2018. Review.


The American Society of Clinical Oncology-endorsed American Society for Radiation Oncology Evidence-Based Guideline of stereotactic body radiotherapy for early-stage non-small cell lung cancer: An expert opinion.

Guckenberger M, Aerts JG, Van Schil P, Weder W.

J Thorac Cardiovasc Surg. 2019 Jan;157(1):358-361. doi: 10.1016/j.jtcvs.2018.09.107. Epub 2018 Oct 12. No abstract available. Erratum in: J Thorac Cardiovasc Surg. 2019 Jun;157(6):2549.


Low-dose cyclophosphamide depletes circulating naïve and activated regulatory T cells in malignant pleural mesothelioma patients synergistically treated with dendritic cell-based immunotherapy.

Noordam L, Kaijen MEH, Bezemer K, Cornelissen R, Maat LAPWM, Hoogsteden HC, Aerts JGJV, Hendriks RW, Hegmans JPJJ, Vroman H.

Oncoimmunology. 2018 Jul 30;7(12):e1474318. doi: 10.1080/2162402X.2018.1474318. eCollection 2018.


Circulating desmosine as a biomarker of azithromycin treatment response: a post hoc analysis of the COLUMBUS randomised controlled trial.

Chalmers JD, Djamin RS, Schouten M, Keir HR, Tan B, Aerts JGJV, Huang JT, van der Eerden M.

ERJ Open Res. 2018 Nov 12;4(4). pii: 00136-2018. doi: 10.1183/23120541.00136-2018. eCollection 2018 Oct.


Survival and prognostic factors of pulmonary oligometastases treated with stereotactic body radiotherapy.

Sharma A, Duijm M, Oomen-de Hoop E, Aerts JG, Verhoef C, Hoogeman M, Nuyttens JJ.

Acta Oncol. 2019 Jan;58(1):74-80. doi: 10.1080/0284186X.2018.1521986. Epub 2018 Oct 3.


Autologous Dendritic Cell Therapy in Mesothelioma Patients Enhances Frequencies of Peripheral CD4 T Cells Expressing HLA-DR, PD-1, or ICOS.

de Goeje PL, Klaver Y, Kaijen-Lambers MEH, Langerak AW, Vroman H, Kunert A, Lamers CHJ, Aerts JGJV, Debets R, Hendriks RW.

Front Immunol. 2018 Sep 7;9:2034. doi: 10.3389/fimmu.2018.02034. eCollection 2018.


Renal impairment during pemetrexed maintenance in patients with advanced nonsmall cell lung cancer: a cohort study.

Visser S, Huisbrink J, van 't Veer NE, van Toor JJ, van Boxem AJM, van Walree NC, Stricker BH, Aerts JGJV.

Eur Respir J. 2018 Oct 25;52(4). pii: 1800884. doi: 10.1183/13993003.00884-2018. Print 2018 Oct.


Potential Molecular Signatures Predictive of Lung Cancer Brain Metastasis.

Pedrosa RMSM, Mustafa DAM, Aerts JGJV, Kros JM.

Front Oncol. 2018 May 11;8:159. doi: 10.3389/fonc.2018.00159. eCollection 2018. Review.


Biomarkers in malignant mesothelioma-an unfulfilled need or a waste of resources?

Cornelissen R, Aerts JGJV.

J Thorac Dis. 2018 Apr;10(Suppl 9):S1084-S1087. doi: 10.21037/jtd.2018.03.128. No abstract available.


Treatment Satisfaction of Patients With Advanced Non-Small-cell Lung Cancer Receiving Platinum-based Chemotherapy: Results From a Prospective Cohort Study (PERSONAL).

Visser S, de Mol M, Cheung K, van Toor JJ, van Walree NC, Stricker BH, Den Oudsten BL, Aerts JGJV.

Clin Lung Cancer. 2018 Jul;19(4):e503-e516. doi: 10.1016/j.cllc.2018.03.003. Epub 2018 Mar 17.


Association between single-nucleotide polymorphisms and adverse events in nivolumab-treated non-small cell lung cancer patients.

Bins S, Basak EA, El Bouazzaoui S, Koolen SLW, Oomen-de Hoop E, van der Leest CH, van der Veldt AAM, Sleijfer S, Debets R, van Schaik RHN, Aerts JGJV, Mathijssen RHJ.

Br J Cancer. 2018 May;118(10):1296-1301. doi: 10.1038/s41416-018-0074-1. Epub 2018 Apr 26.


IFNΛ3/4 locus polymorphisms and IFNΛ3 circulating levels are associated with COPD severity and outcomes.

Egli A, Mandal J, Schumann DM, Roth M, Thomas B, Lorne Tyrrell D, Blasi F, Kostikas K, Boersma W, Milenkovic B, Lacoma A, Rentsch K, Rohde GGU, Louis R, Aerts JG, Welte T, Torres A, Tamm M, Stolz D.

BMC Pulm Med. 2018 Mar 21;18(1):51. doi: 10.1186/s12890-018-0616-6.


Factors affecting local control of pulmonary oligometastases treated with stereotactic body radiotherapy.

Sharma A, Duijm M, Oomen-de Hoop E, Aerts JG, Verhoef C, Hoogeman M, Nuyttens JJ.

Acta Oncol. 2018 Aug;57(8):1031-1037. doi: 10.1080/0284186X.2018.1445285. Epub 2018 Feb 28.


Immunotherapy: a new standard of care in thoracic malignancies? A summary of the European Respiratory Society research seminar of the Thoracic Oncology Assembly.

Costantini A, Grynovska M, Lucibello F, Moisés J, Pagès F, Tsao MS, Shepherd FA, Bouchaab H, Garassino M, Aerts JGJV, Mazières J, Mondini M, Berghmans T, Meert AP, Cadranel J.

Eur Respir J. 2018 Feb 14;51(2). pii: 1702072. doi: 10.1183/13993003.02072-2017. Print 2018 Feb.


Treatment selection of early stage non-small cell lung cancer: the role of the patient in clinical decision making.

Mokhles S, Nuyttens JJME, de Mol M, Aerts JGJV, Maat APWM, Birim Ö, Bogers AJJC, Takkenberg JJM.

BMC Cancer. 2018 Jan 15;18(1):79. doi: 10.1186/s12885-018-3986-5.


Autologous Dendritic Cells Pulsed with Allogeneic Tumor Cell Lysate in Mesothelioma: From Mouse to Human.

Aerts JGJV, de Goeje PL, Cornelissen R, Kaijen-Lambers MEH, Bezemer K, van der Leest CH, Mahaweni NM, Kunert A, Eskens FALM, Waasdorp C, Braakman E, van der Holt B, Vulto AG, Hendriks RW, Hegmans JPJJ, Hoogsteden HC.

Clin Cancer Res. 2018 Feb 15;24(4):766-776. doi: 10.1158/1078-0432.CCR-17-2522. Epub 2017 Dec 12.


High and individually variable enzymatic activity precludes accurate determination of pemetrexed, methotrexate and their polyglutamate metabolite concentrations in plasma.

Stoop MP, Visser S, van Dijk E, Aerts JGJV, Stricker BH, Luider TM.

J Pharm Biomed Anal. 2018 Jan 30;148:89-92. doi: 10.1016/j.jpba.2017.09.014. Epub 2017 Sep 14.


Uniform and blinded cause of death verification of the NELSON lung cancer screening participants.

Yousaf-Khan AU, van der Aalst CM, Aerts JGJV, den Bakker MA, de Koning HJ.

Lung Cancer. 2017 Sep;111:131-134. doi: 10.1016/j.lungcan.2017.07.018. Epub 2017 Jul 22.


Is immunotherapy a viable option in treating mesothelioma?

Dumoulin DW, Aerts JG, Cornelissen R.

Future Oncol. 2017 Aug;13(20):1747-1750. doi: 10.2217/fon-2017-0234. Epub 2017 Aug 4. No abstract available.


Novel insights into mesothelioma biology and implications for therapy.

Yap TA, Aerts JG, Popat S, Fennell DA.

Nat Rev Cancer. 2017 Jul 25;17(8):475-488. doi: 10.1038/nrc.2017.42. Review.


Rationally combining immunotherapies to improve efficacy of immune checkpoint blockade in solid tumors.

Dammeijer F, Lau SP, van Eijck CHJ, van der Burg SH, Aerts JGJV.

Cytokine Growth Factor Rev. 2017 Aug;36:5-15. doi: 10.1016/j.cytogfr.2017.06.011. Epub 2017 Jun 28. Review.


Improved diagnosis and prognostication of patients with pleural malignant mesothelioma using biomarkers in pleural effusions and peripheral blood samples - a short report.

Beije N, Kraan J, den Bakker MA, Maat APWM, van der Leest C, Cornelissen R, Van NM, Martens JWM, Aerts JGJV, Sleijfer S.

Cell Oncol (Dordr). 2017 Oct;40(5):511-519. doi: 10.1007/s13402-017-0327-7. Epub 2017 Jun 2.

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