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Residential green space and seasonal distress in a cohort of tree pollen allergy patients.

Aerts R, Stas M, Vanlessen N, Hendrickx M, Bruffaerts N, Hoebeke L, Dendoncker N, Dujardin S, Saenen ND, Van Nieuwenhuyse A, Aerts JM, Van Orshoven J, Nawrot TS, Somers B.

Int J Hyg Environ Health. 2019 Oct 15. pii: S1438-4639(19)30439-0. doi: 10.1016/j.ijheh.2019.10.004. [Epub ahead of print]


Tumour Treating Fields in combination with pemetrexed and cisplatin or carboplatin as first-line treatment for unresectable malignant pleural mesothelioma (STELLAR): a multicentre, single-arm phase 2 trial.

Ceresoli GL, Aerts JG, Dziadziuszko R, Ramlau R, Cedres S, van Meerbeeck JP, Mencoboni M, Planchard D, Chella A, Crinò L, Krzakowski M, Rüssel J, Maconi A, Gianoncelli L, Grosso F.

Lancet Oncol. 2019 Oct 15. pii: S1470-2045(19)30532-7. doi: 10.1016/S1470-2045(19)30532-7. [Epub ahead of print]


Malignant Peritoneal Mesothelioma: Patterns of Care and Survival in the Netherlands: A Population-Based Study.

de Boer NL, van Kooten JP, Damhuis RAM, Aerts JGJV, Verhoef C, Madsen EVE.

Ann Surg Oncol. 2019 Oct 16. doi: 10.1245/s10434-019-07803-z. [Epub ahead of print]


Plasma 1α-Hydroxycorticosterone as Biomarker for Acute Stress in Catsharks (Scyliorhinus canicula).

Ruiz-Jarabo I, Barragán-Méndez C, Jerez-Cepa I, Fernández-Castro M, Sobrino I, Mancera JM, Aerts J.

Front Physiol. 2019 Sep 20;10:1217. doi: 10.3389/fphys.2019.01217. eCollection 2019.


The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1.

Moro Chao DH, Wang Y, Foppen E, Ottenhoff R, van Roomen C, Parlevliet ET, van Eijk M, Verhoek M, Boot R, Marques AR, Scheij S, Mirzaian M, Kooijman S, Jansen K, Wang D, Mergen C, Seeley RJ, Tschöp MH, Overkleeft H, Rensen PCN, Kalsbeek A, Aerts JMFG, Yi CX.

Diabetes. 2019 Oct 2. pii: db190049. doi: 10.2337/db19-0049. [Epub ahead of print]


Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish.

Lelieveld LT, Mirzaian M, Kuo CL, Artola M, Ferraz MJ, Peter REA, Akiyama H, Greimel P, van den Berg RJBHN, Overkleeft HS, Boot RG, Meijer AH, Aerts JMFG.

J Lipid Res. 2019 Nov;60(11):1851-1867. doi: 10.1194/jlr.RA119000154. Epub 2019 Sep 27.


Pemetrexed exposure predicts toxicity in advanced non-small-cell lung cancer: A prospective cohort study.

Visser S, Koolen SLW, de Bruijn P, Belderbos HNA, Cornelissen R, Mathijssen RHJ, Stricker BH, Aerts JGJV.

Eur J Cancer. 2019 Nov;121:64-73. doi: 10.1016/j.ejca.2019.08.012. Epub 2019 Sep 24.


Drosophila melanogaster Mutated in its GBA1b Ortholog Recapitulates Neuronopathic Gaucher Disease.

Cabasso O, Paul S, Dorot O, Maor G, Krivoruk O, Pasmanik-Chor M, Mirzaian M, Ferraz M, Aerts J, Horowitz M.

J Clin Med. 2019 Sep 9;8(9). pii: E1420. doi: 10.3390/jcm8091420.


The relation between systemic inflammation and incident cancer in patients with stable cardiovascular disease: a cohort study.

Van't Klooster CC, Ridker PM, Hjortnaes J, van der Graaf Y, Asselbergs FW, Westerink J, Aerts JGJV, Visseren FLJ.

Eur Heart J. 2019 Sep 1. pii: ehz587. doi: 10.1093/eurheartj/ehz587. [Epub ahead of print]


Towards the Optical Detection of Field Cancerization in the Buccal Mucosa of Patients with Lung Cancer.

Bugter O, van Brummelen SE, van der Leest KH, Aerts JGJV, Maat APWM, Baatenburg de Jong RJ, Amelink A, Robinson DJ.

Transl Oncol. 2019 Aug 29;12(12):1533-1538. doi: 10.1016/j.tranon.2019.07.018. [Epub ahead of print]


Predicting factors for chronic colonization of Pseudomonas aeruginosa in bronchiectasis.

Pieters A, Bakker M, Hoek RAS, Altenburg J, van Westreenen M, Aerts JGJV, van der Eerden MM.

Eur J Clin Microbiol Infect Dis. 2019 Aug 31. doi: 10.1007/s10096-019-03675-z. [Epub ahead of print]


An overview of activity-based probes for glycosidases.

Wu L, Armstrong Z, Schröder SP, de Boer C, Artola M, Aerts JM, Overkleeft HS, Davies GJ.

Curr Opin Chem Biol. 2019 Aug 13;53:25-36. doi: 10.1016/j.cbpa.2019.05.030. [Epub ahead of print] Review.


A multicenter, randomized, phase II/III study of dendritic cells loaded with allogeneic tumor cell lysate (MesoPher) in subjects with mesothelioma as maintenance therapy after chemotherapy: DENdritic cell Immunotherapy for Mesothelioma (DENIM) trial.

Belderbos RA, Baas P, Berardi R, Cornelissen R, Fennell DA, van Meerbeeck JP, Scherpereel A, Vroman H, Aerts JGJV.

Transl Lung Cancer Res. 2019 Jun;8(3):280-285. doi: 10.21037/tlcr.2019.05.05.


Referral Patterns and Outcome of Patients With Synchronous Brain Metastases From Non-small Cell Lung Cancer Treated With Gamma Knife Radiosurgery in a Third-Line Treatment Centre in The Netherlands - A Retrospective Analysis.

Ten Berge DMHJ, Aarts MJ, Hanssens PEJ, Beute GN, Aerts JGJV, Kloover JS.

Clin Oncol (R Coll Radiol). 2019 Jul 22. pii: S0936-6555(19)30284-5. doi: 10.1016/j.clon.2019.07.004. [Epub ahead of print]


Intranodal administration of mRNA encoding nucleoprotein provides cross-strain immunity against influenza in mice.

Joe PT, Christopoulou I, van Hoecke L, Schepens B, Ysenbaert T, Heirman C, Thielemans K, Saelens X, Aerts JL.

J Transl Med. 2019 Jul 25;17(1):242. doi: 10.1186/s12967-019-1991-3.


Randomised phase 3 study of adjuvant chemotherapy with or without nadroparin in patients with completely resected non-small-cell lung cancer: the NVALT-8 study.

Groen HJM, van der Heijden EHFM, Klinkenberg TJ, Biesma B, Aerts J, Verhagen A, Kloosterziel C, Pieterman R, van den Borne B, Smit HJM, Hoekstra O, Schramel FMNH, van der Noort V, van Tinteren H, Smit EF, Dingemans AC; NVALT Study Group, the Netherlands.

Br J Cancer. 2019 Aug;121(5):372-377. doi: 10.1038/s41416-019-0533-3. Epub 2019 Jul 24.


Reply to K. Masuda et al.

Fennell DA, Taylor P, Gilligan D, Nakano T, Scherpereel A, Pavlakis N, van Meerbeeck JP, Aerts JGJV, Nowak AK, Kindler H, Baas P.

J Clin Oncol. 2019 Sep 1;37(25):2294-2295. doi: 10.1200/JCO.19.01208. Epub 2019 Jul 22. No abstract available.


A prospective cohort study on the pharmacokinetics of nivolumab in metastatic non-small cell lung cancer, melanoma, and renal cell cancer patients.

Hurkmans DP, Basak EA, van Dijk T, Mercieca D, Schreurs MWJ, Wijkhuijs AJM, Bins S, Hoop EO, Debets R, Joerger M, Odink A, van der Veldt AAM, van der Leest CH, Aerts JGJV, Mathijssen RHJ, Koolen SLW.

J Immunother Cancer. 2019 Jul 19;7(1):192. doi: 10.1186/s40425-019-0669-y.


Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents.

Mieremet A, Boiten W, van Dijk R, Gooris G, Overkleeft HS, Aerts JMFG, Bouwstra JA, El Ghalbzouri A.

Arch Dermatol Res. 2019 Nov;311(9):679-689. doi: 10.1007/s00403-019-01948-3. Epub 2019 Jul 18.


Effect of Pembrolizumab After Stereotactic Body Radiotherapy vs Pembrolizumab Alone on Tumor Response in Patients With Advanced Non-Small Cell Lung Cancer: Results of the PEMBRO-RT Phase 2 Randomized Clinical Trial.

Theelen WSME, Peulen HMU, Lalezari F, van der Noort V, de Vries JF, Aerts JGJV, Dumoulin DW, Bahce I, Niemeijer AN, de Langen AJ, Monkhorst K, Baas P.

JAMA Oncol. 2019 Jul 11. doi: 10.1001/jamaoncol.2019.1478. [Epub ahead of print]


The relation between psychological profiles and quality of life in patients with lung cancer.

van Montfort E, de Vries J, Arts R, Aerts JG, Kloover JS, Traa MJ.

Support Care Cancer. 2019 Jul 1. doi: 10.1007/s00520-019-04923-w. [Epub ahead of print]


iHIVARNA phase IIa, a randomized, placebo-controlled, double-blinded trial to evaluate the safety and immunogenicity of iHIVARNA-01 in chronically HIV-infected patients under stable combined antiretroviral therapy.

de Jong W, Aerts J, Allard S, Brander C, Buyze J, Florence E, van Gorp E, Vanham G, Leal L, Mothe B, Thielemans K, Plana M, Garcia F, Gruters R; iHIVARNA consortium.

Trials. 2019 Jun 17;20(1):361. doi: 10.1186/s13063-019-3409-1.


Blood eosinophil count and GOLD stage predict response to maintenance azithromycin treatment in COPD patients with frequent exacerbations.

Djamin RS, Bafadhel M, Uzun S, Russell REK, Ermens AAM, Kerstens R, Aerts JGJV, Pavord ID, van der Eerden MM.

Respir Med. 2019 Jul - Aug;154:27-33. doi: 10.1016/j.rmed.2019.06.005. Epub 2019 Jun 8.


The prognostic value of early onset, CT derived loss of muscle and adipose tissue during chemotherapy in metastatic non-small cell lung cancer.

Degens JHRJ, Sanders KJC, de Jong EEC, Groen HJM, Smit EF, Aerts JG, Schols AMWJ, Dingemans AC.

Lung Cancer. 2019 Jul;133:130-135. doi: 10.1016/j.lungcan.2019.05.021. Epub 2019 May 20.


Wearable Finger Pulse Oximetry for Continuous Oxygen Saturation Measurements During Daily Home Routines of Patients With Chronic Obstructive Pulmonary Disease (COPD) Over One Week: Observational Study.

Buekers J, Theunis J, De Boever P, Vaes AW, Koopman M, Janssen EV, Wouters EF, Spruit MA, Aerts JM.

JMIR Mhealth Uhealth. 2019 Jun 6;7(6):e12866. doi: 10.2196/12866.


CD45RA+CCR7- CD8 T cells lacking co-stimulatory receptors demonstrate enhanced frequency in peripheral blood of NSCLC patients responding to nivolumab.

Kunert A, Basak EA, Hurkmans DP, Balcioglu HE, Klaver Y, van Brakel M, Oostvogels AAM, Lamers CHJ, Bins S, Koolen SLW, van der Veldt AAM, Sleijfer S, Mathijssen RHJ, Aerts JGJV, Debets R.

J Immunother Cancer. 2019 Jun 8;7(1):149. doi: 10.1186/s40425-019-0608-y.


Scrutinizing the triad of Vibrio tapetis, the skin barrier and pigmentation as determining factors in the development of skin ulcerations in wild common dab (Limanda limanda).

Vercauteren M, De Swaef E, Declercq AM, Polet H, Aerts J, Ampe B, Romalde JL, Haesebrouck F, Devriese L, Decostere A, Chiers K.

Vet Res. 2019 Jun 3;50(1):41. doi: 10.1186/s13567-019-0659-6.


Microbial Communities in Sediments From Four Mildly Acidic Ephemeral Salt Lakes in the Yilgarn Craton (Australia) - Terrestrial Analogs to Ancient Mars.

Aerts JW, van Spanning RJM, Flahaut J, Molenaar D, Bland PA, Genge MJ, Ehrenfreund P, Martins Z.

Front Microbiol. 2019 May 6;10:779. doi: 10.3389/fmicb.2019.00779. eCollection 2019.


Predicting disease-causing variant combinations.

Papadimitriou S, Gazzo A, Versbraegen N, Nachtegael C, Aerts J, Moreau Y, Van Dooren S, Nowé A, Smits G, Lenaerts T.

Proc Natl Acad Sci U S A. 2019 Jun 11;116(24):11878-11887. doi: 10.1073/pnas.1815601116. Epub 2019 May 24.


Prediction of response to pemetrexed in non-small-cell lung cancer with immunohistochemical phenotyping based on gene expression profiles.

Visser S, Hou J, Bezemer K, de Vogel LL, Hegmans JPJJ, Stricker BH, Philipsen S, Aerts JGJV.

BMC Cancer. 2019 May 14;19(1):440. doi: 10.1186/s12885-019-5645-x.


An economic evaluation of adaptation pathways in coastal mega cities: An illustration for Los Angeles.

de Ruig LT, Barnard PL, Botzen WJW, Grifman P, Hart JF, de Moel H, Sadrpour N, Aerts JCJH.

Sci Total Environ. 2019 Aug 15;678:647-659. doi: 10.1016/j.scitotenv.2019.04.308. Epub 2019 Apr 24.


A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

Van Hove H, Martens L, Scheyltjens I, De Vlaminck K, Pombo Antunes AR, De Prijck S, Vandamme N, De Schepper S, Van Isterdael G, Scott CL, Aerts J, Berx G, Boeckxstaens GE, Vandenbroucke RE, Vereecke L, Moechars D, Guilliams M, Van Ginderachter JA, Saeys Y, Movahedi K.

Nat Neurosci. 2019 Jun;22(6):1021-1035. doi: 10.1038/s41593-019-0393-4. Epub 2019 May 6.


Quantification of the tyrosine kinase inhibitor erlotinib in human scalp hair by liquid chromatography-tandem mass spectrometry: Pitfalls for clinical application.

Braal CL, Veerman GDM, Peric R, Aerts JGJV, Mathijssen RHJ, Koolen SLW, de Bruijn P.

J Pharm Biomed Anal. 2019 Aug 5;172:175-182. doi: 10.1016/j.jpba.2019.04.031. Epub 2019 Apr 17.


Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation.

Rakhshandehroo M, van Eijkeren RJ, Gabriel TL, de Haar C, Gijzel SMW, Hamers N, Ferraz MJ, Aerts JMFG, Schipper HS, van Eijk M, Boes M, Kalkhoven E.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Aug;1864(8):1157-1167. doi: 10.1016/j.bbalip.2019.04.016. Epub 2019 Apr 30.


Enhancing Dendritic Cell Therapy in Solid Tumors with Immunomodulating Conventional Treatment.

Belderbos RA, Aerts JGJV, Vroman H.

Mol Ther Oncolytics. 2019 Mar 27;13:67-81. doi: 10.1016/j.omto.2019.03.007. eCollection 2019 Jun 28. Review.


Evidence that the stress hormone cortisol regulates biofilm formation differently among Flavobacterium columnare isolates.

Declercq AM, Cai W, Naranjo E, Thongda W, Eeckhaut V, Bauwens E, Arias C, De La Fuente L, Beck BH, Lange MD, Peatman E, Haesebrouck F, Aerts J, Decostere A.

Vet Res. 2019 Apr 11;50(1):24. doi: 10.1186/s13567-019-0641-3.


Localization of active endogenous and exogenous β-glucocerebrosidase by correlative light-electron microscopy in human fibroblasts.

van Meel E, Bos E, van der Lienden MJC, Overkleeft HS, van Kasteren SI, Koster AJ, Aerts JMFG.

Traffic. 2019 May;20(5):346-356. doi: 10.1111/tra.12641.


Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease.

Wheeler S, Haberkant P, Bhardwaj M, Tongue P, Ferraz MJ, Halter D, Sprong H, Schmid R, Aerts JMFG, Sullo N, Sillence DJ.

Neurobiol Dis. 2019 Jul;127:242-252. doi: 10.1016/j.nbd.2019.03.005. Epub 2019 Mar 12.


Area under the forced expiratory flow-volume loop in spirometry indicates severe hyperinflation in COPD patients.

Das N, Topalovic M, Aerts JM, Janssens W.

Int J Chron Obstruct Pulmon Dis. 2019 Feb 14;14:409-418. doi: 10.2147/COPD.S185931. eCollection 2019.


Early-Stage NSCLC: Advances in Thoracic Oncology 2018.

Osarogiagbon RU, Veronesi G, Fang W, Ekman S, Suda K, Aerts JG, Donington J.

J Thorac Oncol. 2019 Jun;14(6):968-978. doi: 10.1016/j.jtho.2019.02.029. Epub 2019 Mar 7. Review.


Spatiotemporal patterns of extreme sea levels along the western North-Atlantic coasts.

Muis S, Lin N, Verlaan M, Winsemius HC, Ward PJ, Aerts JCJH.

Sci Rep. 2019 Mar 4;9(1):3391. doi: 10.1038/s41598-019-40157-w.


Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish.

Artola M, Kuo CL, Lelieveld LT, Rowland RJ, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2019 Mar 13;141(10):4214-4218. doi: 10.1021/jacs.9b00056. Epub 2019 Mar 4.


Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study.

Fennell DA, Baas P, Taylor P, Nowak AK, Gilligan D, Nakano T, Pachter JA, Weaver DT, Scherpereel A, Pavlakis N, van Meerbeeck JP, Cedrés S, Nolan L, Kindler H, Aerts JGJV.

J Clin Oncol. 2019 Apr 1;37(10):790-798. doi: 10.1200/JCO.2018.79.0543. Epub 2019 Feb 20.


Translating large-scale climate variability into crop production forecast in Europe.

Guimarães Nobre G, Hunink JE, Baruth B, Aerts JCJH, Ward PJ.

Sci Rep. 2019 Feb 4;9(1):1277. doi: 10.1038/s41598-018-38091-4.


Serum levels of hyaluronic acid are associated with COPD severity and predict survival.

Papakonstantinou E, Bonovolias I, Roth M, Tamm M, Schumann D, Baty F, Louis R, Milenkovic B, Boersma W, Stieltjes B, Kostikas K, Blasi F, Aerts JG, Rohde GGU, Lacoma A, Torres A, Welte T, Stolz D.

Eur Respir J. 2019 Mar 7;53(3). pii: 1801183. doi: 10.1183/13993003.01183-2018. Print 2019 Mar.


Frequency of low-grade adverse events and quality of life during chemotherapy determine patients' judgement about treatment in advanced-stage thoracic cancer.

de Mol M, Visser S, den Oudsten BL, Lodder P, van Walree N, Belderbos H, Aerts JG.

Support Care Cancer. 2019 Sep;27(9):3563-3572. doi: 10.1007/s00520-019-4659-x. Epub 2019 Jan 28.


Species-specific differences in nonlysosomal glucosylceramidase GBA2 function underlie locomotor dysfunction arising from loss-of-function mutations.

Woeste MA, Stern S, Raju DN, Grahn E, Dittmann D, Gutbrod K, Dörmann P, Hansen JN, Schonauer S, Marx CE, Hamzeh H, Körschen HG, Aerts JMFG, Bönigk W, Endepols H, Sandhoff R, Geyer M, Berger TK, Bradke F, Wachten D.

J Biol Chem. 2019 Mar 15;294(11):3853-3871. doi: 10.1074/jbc.RA118.006311. Epub 2019 Jan 20.


Correlation between nivolumab exposure and treatment outcomes in non-small-cell lung cancer.

Basak EA, Koolen SLW, Hurkmans DP, Schreurs MWJ, Bins S, Oomen-de Hoop E, Wijkhuijs AJM, Besten ID, Sleijfer S, Debets R, van der Veldt AAM, Aerts JGJV, Mathijssen RHJ.

Eur J Cancer. 2019 Mar;109:12-20. doi: 10.1016/j.ejca.2018.12.008. Epub 2019 Jan 14.


Induction of Peripheral Effector CD8 T-cell Proliferation by Combination of Paclitaxel, Carboplatin, and Bevacizumab in Non-small Cell Lung Cancer Patients.

de Goeje PL, Poncin M, Bezemer K, Kaijen-Lambers MEH, Groen HJM, Smit EF, Dingemans AC, Kunert A, Hendriks RW, Aerts JGJV.

Clin Cancer Res. 2019 Apr 1;25(7):2219-2227. doi: 10.1158/1078-0432.CCR-18-2243. Epub 2019 Jan 14.


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