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Relationship between rheology and structure of interpenetrating, deforming and compressing microgels.

Conley GM, Zhang C, Aebischer P, Harden JL, Scheffold F.

Nat Commun. 2019 Jun 4;10(1):2436. doi: 10.1038/s41467-019-10181-5.


Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

Lei H, Dirren E, Poitry-Yamate C, Schneider BL, Gruetter R, Aebischer P.

J Cereb Blood Flow Metab. 2019 Jul;39(7):1283-1298. doi: 10.1177/0271678X18756499. Epub 2018 Feb 5.


Modulating the catalytic activity of AMPK has neuroprotective effects against α-synuclein toxicity.

Bobela W, Nazeeruddin S, Knott G, Aebischer P, Schneider BL.

Mol Neurodegener. 2017 Nov 3;12(1):80. doi: 10.1186/s13024-017-0220-x.


Jamming and overpacking fuzzy microgels: Deformation, interpenetration, and compression.

Conley GM, Aebischer P, Nöjd S, Schurtenberger P, Scheffold F.

Sci Adv. 2017 Oct 20;3(10):e1700969. doi: 10.1126/sciadv.1700969. eCollection 2017 Oct.


Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.

Zheng L, Bernard-Marissal N, Moullan N, D'Amico D, Auwerx J, Moore DJ, Knott G, Aebischer P, Schneider BL.

Hum Mol Genet. 2017 Feb 1;26(3):582-598. doi: 10.1093/hmg/ddw418.


Axonal Localization of Integrins in the CNS Is Neuronal Type and Age Dependent.

Andrews MR, Soleman S, Cheah M, Tumbarello DA, Mason MR, Moloney E, Verhaagen J, Bensadoun JC, Schneider B, Aebischer P, Fawcett JW.

eNeuro. 2016 Jul 27;3(4). pii: ENEURO.0029-16.2016. doi: 10.1523/ENEURO.0029-16.2016. eCollection 2016 Jul-Aug.


Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J.

Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11.


A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies.

Lathuilière A, Laversenne V, Astolfo A, Kopetzki E, Jacobsen H, Stampanoni M, Bohrmann B, Schneider BL, Aebischer P.

Brain. 2016 May;139(Pt 5):1587-604. doi: 10.1093/brain/aww036. Epub 2016 Mar 8.


Spinal cord stimulation improves forelimb use in an alpha-synuclein animal model of Parkinson's disease.

Brys I, Bobela W, Schneider BL, Aebischer P, Fuentes R.

Int J Neurosci. 2017 Jan;127(1):28-36. Epub 2016 Feb 8.


In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons.

Mächler P, Wyss MT, Elsayed M, Stobart J, Gutierrez R, von Faber-Castell A, Kaelin V, Zuend M, San Martín A, Romero-Gómez I, Baeza-Lehnert F, Lengacher S, Schneider BL, Aebischer P, Magistretti PJ, Barros LF, Weber B.

Cell Metab. 2016 Jan 12;23(1):94-102. doi: 10.1016/j.cmet.2015.10.010. Epub 2015 Nov 19.


Αlpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.

Bobela W, Aebischer P, Schneider BL.

Biomolecules. 2015 Oct 16;5(4):2675-700. doi: 10.3390/biom5042675. Review.


Tmc gene therapy restores auditory function in deaf mice.

Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR.

Sci Transl Med. 2015 Jul 8;7(295):295ra108. doi: 10.1126/scitranslmed.aab1996.


Channel-mediated lactate release by K⁺-stimulated astrocytes.

Sotelo-Hitschfeld T, Niemeyer MI, Mächler P, Ruminot I, Lerchundi R, Wyss MT, Stobart J, Fernández-Moncada I, Valdebenito R, Garrido-Gerter P, Contreras-Baeza Y, Schneider BL, Aebischer P, Lengacher S, San Martín A, Le Douce J, Bonvento G, Magistretti PJ, Sepúlveda FV, Weber B, Barros LF.

J Neurosci. 2015 Mar 11;35(10):4168-78. doi: 10.1523/JNEUROSCI.5036-14.2015.


SOD1 silencing in motoneurons or glia rescues neuromuscular function in ALS mice.

Dirren E, Aebischer J, Rochat C, Towne C, Schneider BL, Aebischer P.

Ann Clin Transl Neurol. 2015 Feb;2(2):167-84. doi: 10.1002/acn3.162. Epub 2015 Jan 15.


Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology.

Yang S, Cacquevel M, Saksida LM, Bussey TJ, Schneider BL, Aebischer P, Melani R, Pizzorusso T, Fawcett JW, Spillantini MG.

Exp Neurol. 2015 Mar;265:48-58. doi: 10.1016/j.expneurol.2014.11.013. Epub 2014 Dec 4.


A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity.

Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY, Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B.

Hum Mol Genet. 2014 Sep 15;23(18):4887-905. doi: 10.1093/hmg/ddu202. Epub 2014 May 2.


Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration.

Kaplan A, Spiller KJ, Towne C, Kanning KC, Choe GT, Geber A, Akay T, Aebischer P, Henderson CE.

Neuron. 2014 Jan 22;81(2):333-48. doi: 10.1016/j.neuron.2013.12.009.


Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation.

Lathuilière A, Bohrmann B, Kopetzki E, Schweitzer C, Jacobsen H, Moniatte M, Aebischer P, Schneider BL.

Biomaterials. 2014 Jan;35(2):792-802.


Intracerebroventricular injection of adeno-associated virus 6 and 9 vectors for cell type-specific transgene expression in the spinal cord.

Dirren E, Towne CL, Setola V, Redmond DE Jr, Schneider BL, Aebischer P.

Hum Gene Ther. 2014 Feb;25(2):109-20. doi: 10.1089/hum.2013.021. Epub 2014 Jan 15.


A high-capacity cell macroencapsulation system supporting the long-term survival of genetically engineered allogeneic cells.

Lathuilière A, Cosson S, Lutolf MP, Schneider BL, Aebischer P.

Biomaterials. 2014 Jan;35(2):779-91. doi: 10.1016/j.biomaterials.2013.09.071. Epub 2013 Oct 5.


Polo-like kinase 2 regulates selective autophagic α-synuclein clearance and suppresses its toxicity in vivo.

Oueslati A, Schneider BL, Aebischer P, Lashuel HA.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):E3945-54. doi: 10.1073/pnas.1309991110. Epub 2013 Aug 27.


Synergistic effects of GDNF and VEGF on lifespan and disease progression in a familial ALS rat model.

Krakora D, Mulcrone P, Meyer M, Lewis C, Bernau K, Gowing G, Zimprich C, Aebischer P, Svendsen CN, Suzuki M.

Mol Ther. 2013 Aug;21(8):1602-10. doi: 10.1038/mt.2013.108. Epub 2013 May 28.


Astrocyte-neuron co-culture on microchips based on the model of SOD mutation to mimic ALS.

Kunze A, Lengacher S, Dirren E, Aebischer P, Magistretti PJ, Renaud P.

Integr Biol (Camb). 2013 Jul 24;5(7):964-75. doi: 10.1039/c3ib40022k. Epub 2013 May 22.


Direct and retrograde transduction of nigral neurons with AAV6, 8, and 9 and intraneuronal persistence of viral particles.

Löw K, Aebischer P, Schneider BL.

Hum Gene Ther. 2013 Jun;24(6):613-29. doi: 10.1089/hum.2012.174.


Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model.

Dassie E, Andrews MR, Bensadoun JC, Cacquevel M, Schneider BL, Aebischer P, Wouters FS, Richardson JC, Hussain I, Howlett DR, Spillantini MG, Fawcett JW.

Neurobiol Aging. 2013 May;34(5):1355-68. doi: 10.1016/j.neurobiolaging.2012.11.011. Epub 2012 Dec 25.


An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker.

Coune PG, Craveiro M, Gaugler MN, Mlynárik V, Schneider BL, Aebischer P, Gruetter R.

NMR Biomed. 2013 Jan;26(1):43-50. doi: 10.1002/nbm.2817. Epub 2012 Jun 18.


Parkinson's disease: gene therapies.

Coune PG, Schneider BL, Aebischer P.

Cold Spring Harb Perspect Med. 2012 Apr;2(4):a009431. doi: 10.1101/cshperspect.a009431. Review.


Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease.

Mlynárik V, Cacquevel M, Sun-Reimer L, Janssens S, Cudalbu C, Lei H, Schneider BL, Aebischer P, Gruetter R.

J Alzheimers Dis. 2012;31 Suppl 3:S87-99.


Imaging brain amyloid deposition using grating-based differential phase contrast tomography.

Pinzer BR, Cacquevel M, Modregger P, McDonald SA, Bensadoun JC, Thuering T, Aebischer P, Stampanoni M.

Neuroimage. 2012 Jul 16;61(4):1336-46. doi: 10.1016/j.neuroimage.2012.03.029. Epub 2012 Mar 16.


Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

Gaugler MN, Genc O, Bobela W, Mohanna S, Ardah MT, El-Agnaf OM, Cantoni M, Bensadoun JC, Schneggenburger R, Knott GW, Aebischer P, Schneider BL.

Acta Neuropathol. 2012 May;123(5):653-69. doi: 10.1007/s00401-012-0963-y. Epub 2012 Feb 24.


α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.

Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, Masliah E, Lashuel HA.

J Biol Chem. 2012 May 4;287(19):15345-64. doi: 10.1074/jbc.M111.318949. Epub 2012 Feb 7.


Mimicking phosphorylation at serine 87 inhibits the aggregation of human α-synuclein and protects against its toxicity in a rat model of Parkinson's disease.

Oueslati A, Paleologou KE, Schneider BL, Aebischer P, Lashuel HA.

J Neurosci. 2012 Feb 1;32(5):1536-44. doi: 10.1523/JNEUROSCI.3784-11.2012.


Philanthropy: The price of charity.

Aebischer P.

Nature. 2012 Jan 18;481(7381):260. doi: 10.1038/481260a. No abstract available.


Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

Ciron C, Lengacher S, Dusonchet J, Aebischer P, Schneider BL.

Hum Mol Genet. 2012 Apr 15;21(8):1861-76. doi: 10.1093/hmg/ddr618. Epub 2012 Jan 12.


Use of viral vectors to create animal models for Parkinson's disease.

Löw K, Aebischer P.

Neurobiol Dis. 2012 Nov;48(2):189-201. doi: 10.1016/j.nbd.2011.12.038. Epub 2011 Dec 29. Review.


Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool.

Marroquin Belaunzaran O, Cordero MI, Setola V, Bianchi S, Galli C, Bouche N, Mlynarik V, Gruetter R, Sandi C, Bensadoun JC, Molinari M, Aebischer P.

PLoS One. 2011 Apr 20;6(4):e18268. doi: 10.1371/journal.pone.0018268.


A rat model of progressive nigral neurodegeneration induced by the Parkinson's disease-associated G2019S mutation in LRRK2.

Dusonchet J, Kochubey O, Stafa K, Young SM Jr, Zufferey R, Moore DJ, Schneider BL, Aebischer P.

J Neurosci. 2011 Jan 19;31(3):907-12. doi: 10.1523/JNEUROSCI.5092-10.2011.


Rab1A over-expression prevents Golgi apparatus fragmentation and partially corrects motor deficits in an alpha-synuclein based rat model of Parkinson's disease.

Coune PG, Bensadoun JC, Aebischer P, Schneider BL.

J Parkinsons Dis. 2011;1(4):373-87. doi: 10.3233/JPD-2011-11058.


Neuroprotection by gene therapy targeting mutant SOD1 in individual pools of motor neurons does not translate into therapeutic benefit in fALS mice.

Towne C, Setola V, Schneider BL, Aebischer P.

Mol Ther. 2011 Feb;19(2):274-83. doi: 10.1038/mt.2010.260. Epub 2010 Nov 23.


AAV-mediated expression of wild-type and ALS-linked mutant VAPB selectively triggers death of motoneurons through a Ca2+-dependent ER-associated pathway.

Langou K, Moumen A, Pellegrino C, Aebischer J, Medina I, Aebischer P, Raoul C.

J Neurochem. 2010 Aug;114(3):795-809. doi: 10.1111/j.1471-4159.2010.06806.x. Epub 2010 May 8.


Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions.

Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA.

J Neurosci. 2010 Mar 3;30(9):3184-98. doi: 10.1523/JNEUROSCI.5922-09.2010.


Collapsin response mediator protein 4a (CRMP4a) is upregulated in motoneurons of mutant SOD1 mice and can trigger motoneuron axonal degeneration and cell death.

Duplan L, Bernard N, Casseron W, Dudley K, Thouvenot E, Honnorat J, Rogemond V, De Bovis B, Aebischer P, Marin P, Raoul C, Henderson CE, Pettmann B.

J Neurosci. 2010 Jan 13;30(2):785-96. doi: 10.1523/JNEUROSCI.5411-09.2010.


Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery.

Towne C, Pertin M, Beggah AT, Aebischer P, Decosterd I.

Mol Pain. 2009 Sep 8;5:52. doi: 10.1186/1744-8069-5-52.


Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6.

Towne C, Schneider BL, Kieran D, Redmond DE Jr, Aebischer P.

Gene Ther. 2010 Jan;17(1):141-6. doi: 10.1038/gt.2009.119. Epub 2009 Sep 3.


Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model.

Mastroeni R, Bensadoun JC, Charvin D, Aebischer P, Pujol A, Raoul C.

Ann Neurol. 2009 Jul;66(1):117-22. doi: 10.1002/ana.21677.


Response of aged parkinsonian monkeys to in vivo gene transfer of GDNF.

Emborg ME, Moirano J, Raschke J, Bondarenko V, Zufferey R, Peng S, Ebert AD, Joers V, Roitberg B, Holden JE, Koprich J, Lipton J, Kordower JH, Aebischer P.

Neurobiol Dis. 2009 Nov;36(2):303-11. doi: 10.1016/j.nbd.2009.07.022. Epub 2009 Aug 4.


Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons.

Ulusoy A, Sahin G, Björklund T, Aebischer P, Kirik D.

Mol Ther. 2009 Sep;17(9):1574-84. doi: 10.1038/mt.2009.142. Epub 2009 Jul 7.


Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

Chu Y, Dodiya H, Aebischer P, Olanow CW, Kordower JH.

Neurobiol Dis. 2009 Sep;35(3):385-98. doi: 10.1016/j.nbd.2009.05.023. Epub 2009 Jun 6.


Lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAi.

Towne C, Aebischer P.

Methods Mol Biol. 2009;555:87-108. doi: 10.1007/978-1-60327-295-7_7.


Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF.

Redmond DE Jr, Elsworth JD, Roth RH, Leranth C, Collier TJ, Blanchard B, Bjugstad KB, Samulski RJ, Aebischer P, Sladek JR Jr.

J Comp Neurol. 2009 Jul 1;515(1):31-40. doi: 10.1002/cne.22028.

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