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Items: 30


Preferential Identification of Agonistic OX40 Antibodies by Using Cell Lysate to Pan Natively Paired, Humanized Mouse-Derived Yeast Surface Display Libraries.

Medina-Cucurella AV, Mizrahi RA, Asensio MA, Edgar RC, Leong J, Leong R, Lim YW, Nelson A, Niedecken AR, Simons JF, Spindler MJ, Stadtmiller K, Wayham N, Adler AS, Johnson DS.

Antibodies (Basel). 2019 Feb 19;8(1). pii: E17. doi: 10.3390/antib8010017.


Antibody repertoire analysis of mouse immunization protocols using microfluidics and molecular genomics.

Asensio MA, Lim YW, Wayham N, Stadtmiller K, Edgar RC, Leong J, Leong R, Mizrahi RA, Adams MS, Simons JF, Spindler MJ, Johnson DS, Adler AS.

MAbs. 2019 Jul;11(5):870-883. doi: 10.1080/19420862.2019.1583995. Epub 2019 Mar 21.


Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis.

Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4228-4233. doi: 10.1073/pnas.1718414115. Epub 2018 Apr 2.


A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library.

Adler AS, Bedinger D, Adams MS, Asensio MA, Edgar RC, Leong R, Leong J, Mizrahi RA, Spindler MJ, Bandi SR, Huang H, Tawde P, Brams P, Johnson DS.

MAbs. 2018 Apr;10(3):431-443. doi: 10.1080/19420862.2018.1426422. Epub 2018 Feb 1.


Rare, high-affinity mouse anti-PD-1 antibodies that function in checkpoint blockade, discovered using microfluidics and molecular genomics.

Adler AS, Mizrahi RA, Spindler MJ, Adams MS, Asensio MA, Edgar RC, Leong J, Leong R, Johnson DS.

MAbs. 2017 Nov/Dec;9(8):1270-1281. doi: 10.1080/19420862.2017.1371386. Epub 2017 Aug 28.


Rare, high-affinity anti-pathogen antibodies from human repertoires, discovered using microfluidics and molecular genomics.

Adler AS, Mizrahi RA, Spindler MJ, Adams MS, Asensio MA, Edgar RC, Leong J, Leong R, Roalfe L, White R, Goldblatt D, Johnson DS.

MAbs. 2017 Nov/Dec;9(8):1282-1296. doi: 10.1080/19420862.2017.1371383. Epub 2017 Aug 28.


An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.

Adler AS, McCleland ML, Yee S, Yaylaoglu M, Hussain S, Cosino E, Quinones G, Modrusan Z, Seshagiri S, Torres E, Chopra VS, Haley B, Zhang Z, Blackwood EM, Singh M, Junttila M, Stephan JP, Liu J, Pau G, Fearon ER, Jiang Z, Firestein R.

Genes Dev. 2014 May 15;28(10):1068-84. doi: 10.1101/gad.237206.113. Epub 2014 May 1.


Monoclonal antibody humanness score and its applications.

Gao SH, Huang K, Tu H, Adler AS.

BMC Biotechnol. 2013 Jul 5;13:55. doi: 10.1186/1472-6750-13-55.


Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas.

McCleland ML, Adler AS, Deming L, Cosino E, Lee L, Blackwood EM, Solon M, Tao J, Li L, Shames D, Jackson E, Forrest WF, Firestein R.

Clin Cancer Res. 2013 Feb 15;19(4):773-84. doi: 10.1158/1078-0432.CCR-12-2638. Epub 2012 Dec 6.


An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.

McCleland ML, Adler AS, Shang Y, Hunsaker T, Truong T, Peterson D, Torres E, Li L, Haley B, Stephan JP, Belvin M, Hatzivassiliou G, Blackwood EM, Corson L, Evangelista M, Zha J, Firestein R.

Cancer Res. 2012 Nov 15;72(22):5812-23. doi: 10.1158/0008-5472.CAN-12-1098. Epub 2012 Nov 8.


The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression.

Littlepage LE, Adler AS, Kouros-Mehr H, Huang G, Chou J, Krig SR, Griffith OL, Korkola JE, Qu K, Lawson DA, Xue Q, Sternlicht MD, Dijkgraaf GJ, Yaswen P, Rugo HS, Sweeney CA, Collins CC, Gray JW, Chang HY, Werb Z.

Cancer Discov. 2012 Jul;2(7):638-51. doi: 10.1158/2159-8290.CD-12-0093. Epub 2012 May 10.


CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.

Adler AS, McCleland ML, Truong T, Lau S, Modrusan Z, Soukup TM, Roose-Girma M, Blackwood EM, Firestein R.

Cancer Res. 2012 Apr 15;72(8):2129-39. doi: 10.1158/0008-5472.CAN-11-3886. Epub 2012 Feb 16.


G1 arrest and differentiation can occur independently of Rb family function.

Wirt SE, Adler AS, Gebala V, Weimann JM, Schaffer BE, Saddic LA, Viatour P, Vogel H, Chang HY, Meissner A, Sage J.

J Cell Biol. 2010 Nov 15;191(4):809-25. doi: 10.1083/jcb.201003048. Epub 2010 Nov 8.


The histone demethylase UTX enables RB-dependent cell fate control.

Wang JK, Tsai MC, Poulin G, Adler AS, Chen S, Liu H, Shi Y, Chang HY.

Genes Dev. 2010 Feb 15;24(4):327-32. doi: 10.1101/gad.1882610. Epub 2010 Feb 1.


Molecular framework for response to imatinib mesylate in systemic sclerosis.

Chung L, Fiorentino DF, Benbarak MJ, Adler AS, Mariano MM, Paniagua RT, Milano A, Connolly MK, Ratiner BD, Wiskocil RL, Whitfield ML, Chang HY, Robinson WH.

Arthritis Rheum. 2009 Feb;60(2):584-91. doi: 10.1002/art.24221.


SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, Chua KF.

Cell. 2009 Jan 9;136(1):62-74. doi: 10.1016/j.cell.2008.10.052.


Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes.

Sääf AM, Tengvall-Linder M, Chang HY, Adler AS, Wahlgren CF, Scheynius A, Nordenskjöld M, Bradley M.

PLoS One. 2008;3(12):e4017. doi: 10.1371/journal.pone.0004017. Epub 2008 Dec 24.


A C-terminal sequence in the guanine nucleotide exchange factor Sec7 mediates Golgi association and interaction with the Rsp5 ubiquitin ligase.

Dehring DA, Adler AS, Hosseini A, Hicke L.

J Biol Chem. 2008 Dec 5;283(49):34188-96. doi: 10.1074/jbc.M806023200. Epub 2008 Oct 2.


Reversal of aging by NFkappaB blockade.

Adler AS, Kawahara TL, Segal E, Chang HY.

Cell Cycle. 2008 Mar 1;7(5):556-9. Epub 2007 Dec 26.


Systematic functional characterization of cis-regulatory motifs in human core promoters.

Sinha S, Adler AS, Field Y, Chang HY, Segal E.

Genome Res. 2008 Mar;18(3):477-88. doi: 10.1101/gr.6828808. Epub 2008 Feb 6.


CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression.

Adler AS, Littlepage LE, Lin M, Kawahara TL, Wong DJ, Werb Z, Chang HY.

Cancer Res. 2008 Jan 15;68(2):506-15. doi: 10.1158/0008-5472.CAN-07-3060.


Revealing targeted therapy for human cancer by gene module maps.

Wong DJ, Nuyten DS, Regev A, Lin M, Adler AS, Segal E, van de Vijver MJ, Chang HY.

Cancer Res. 2008 Jan 15;68(2):369-78. doi: 10.1158/0008-5472.CAN-07-0382.


Motif module map reveals enforcement of aging by continual NF-kappaB activity.

Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY.

Genes Dev. 2007 Dec 15;21(24):3244-57. Epub 2007 Nov 30.


A transcriptional program mediating entry into cellular quiescence.

Liu H, Adler AS, Segal E, Chang HY.

PLoS Genet. 2007 Jun;3(6):e91.


Decoding global gene expression programs in liver cancer by noninvasive imaging.

Segal E, Sirlin CB, Ooi C, Adler AS, Gollub J, Chen X, Chan BK, Matcuk GR, Barry CT, Chang HY, Kuo MD.

Nat Biotechnol. 2007 Jun;25(6):675-80. Epub 2007 May 21.


MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species.

Ray S, Atkuri KR, Deb-Basu D, Adler AS, Chang HY, Herzenberg LA, Felsher DW.

Cancer Res. 2006 Jul 1;66(13):6598-605.


From description to causality: mechanisms of gene expression signatures in cancer.

Adler AS, Chang HY.

Cell Cycle. 2006 Jun;5(11):1148-51. Epub 2006 Jun 1. Review.


Genetic regulators of large-scale transcriptional signatures in cancer.

Adler AS, Lin M, Horlings H, Nuyten DS, van de Vijver MJ, Chang HY.

Nat Genet. 2006 Apr;38(4):421-30. Epub 2006 Mar 5.


The Rsp5 ubiquitin ligase binds to and ubiquitinates members of the yeast CIN85-endophilin complex, Sla1-Rvs167.

Stamenova SD, Dunn R, Adler AS, Hicke L.

J Biol Chem. 2004 Apr 16;279(16):16017-25. Epub 2004 Feb 3.

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