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Items: 1 to 50 of 176

1.

Costimulation Induces CD4 T Cell Antitumor Immunity via an Innate-like Mechanism.

Morales Del Valle C, Maxwell JR, Xu MM, Menoret A, Mittal P, Tsurutani N, Adler AJ, Vella AT.

Cell Rep. 2019 Apr 30;27(5):1434-1445.e3. doi: 10.1016/j.celrep.2019.04.016.

2.

Can a nurse-led community-based model of hypertension care improve hypertension control in Ghana? Results from the ComHIP cohort study.

Adler AJ, Laar A, Prieto-Merino D, Der RMM, Mangortey D, Dirks R, Lamptey P, Perel P.

BMJ Open. 2019 Apr 2;9(4):e026799. doi: 10.1136/bmjopen-2018-026799.

3.

The magnitude and severity of abortion-related morbidity in settings with limited access to abortion services: a systematic review and meta-regression.

Calvert C, Owolabi OO, Yeung F, Pittrof R, Ganatra B, Tunçalp Ö, Adler AJ, Filippi V.

BMJ Glob Health. 2018 Jun 29;3(3):e000692. doi: 10.1136/bmjgh-2017-000692. eCollection 2018.

4.

Cochrane corner: text messaging to improve adherence to drugs for secondary prevention of cardiovascular disease.

Adler AJ, Casas JP, Martin N, Free C, Perel P.

Heart. 2018 Nov;104(22):1814-1816. doi: 10.1136/heartjnl-2017-312888. Epub 2018 May 14. No abstract available.

PMID:
29760242
5.

A novel biologic platform elicits profound T cell costimulatory activity and antitumor immunity in mice.

Ryan JM, Mittal P, Menoret A, Svedova J, Wasser JS, Adler AJ, Vella AT.

Cancer Immunol Immunother. 2018 Apr;67(4):605-613. doi: 10.1007/s00262-018-2116-1. Epub 2018 Jan 11.

6.

An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.

Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St Rose MC, Hanley MP, Vella AT, Adler AJ.

J Immunol. 2018 Feb 15;200(4):1513-1526. doi: 10.4049/jimmunol.1701039. Epub 2018 Jan 5.

7.

Macrophage polarization and meta-inflammation.

Li C, Xu MM, Wang K, Adler AJ, Vella AT, Zhou B.

Transl Res. 2018 Jan;191:29-44. doi: 10.1016/j.trsl.2017.10.004. Epub 2017 Nov 3. Review.

8.

Addressing current challenges in cancer immunotherapy with mathematical and computational modelling.

Konstorum A, Vella AT, Adler AJ, Laubenbacher RC.

J R Soc Interface. 2017 Jun;14(131). pii: 20170150. doi: 10.1098/rsif.2017.0150. Review.

9.

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.

Li H, Reksten TR, Ice JA, Kelly JA, Adrianto I, Rasmussen A, Wang S, He B, Grundahl KM, Glenn SB, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Cunninghame Graham DS, Patel K, Adler AJ, Farris AD, Brennan MT, Chodosh J, Gopalakrishnan R, Weisman MH, Venuturupalli S, Wallace DJ, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Vista ES, Edgar CE, Rohrer MD, Stone DU, Vyse TJ, Harley JB, Gaffney PM, James JA, Turner S, Alevizos I, Anaya JM, Rhodus NL, Segal BM, Montgomery CG, Scofield RH, Kovats S, Mariette X, Rönnblom L, Witte T, Rischmueller M, Wahren-Herlenius M, Omdal R, Jonsson R, Ng WF; for UK Primary Sjögren's Syndrome Registry, Nordmark G, Lessard CJ, Sivils KL.

PLoS Genet. 2017 Jun 22;13(6):e1006820. doi: 10.1371/journal.pgen.1006820. eCollection 2017 Jun.

10.

Mobile phone text messaging to improve medication adherence in secondary prevention of cardiovascular disease.

Adler AJ, Martin N, Mariani J, Tajer CD, Owolabi OO, Free C, Serrano NC, Casas JP, Perel P.

Cochrane Database Syst Rev. 2017 Apr 29;4:CD011851. doi: 10.1002/14651858.CD011851.pub2. Review.

11.

Evaluation of a community-based hypertension improvement program (ComHIP) in Ghana: data from a baseline survey.

Lamptey P, Laar A, Adler AJ, Dirks R, Caldwell A, Prieto-Merino D, Aerts A, Pearce N, Perel P.

BMC Public Health. 2017 Apr 28;17(1):368. doi: 10.1186/s12889-017-4260-5.

12.

Cytokines and metabolic factors regulate tumoricidal T-cell function during cancer immunotherapy.

Adler AJ, Mittal P, Ryan JM, Zhou B, Wasser JS, Vella AT.

Immunotherapy. 2017 Jan;9(1):71-82. doi: 10.2217/imt-2016-0097. Review.

13.

Efficacy and safety of ablation for people with non-paroxysmal atrial fibrillation.

Nyong J, Amit G, Adler AJ, Owolabi OO, Perel P, Prieto-Merino D, Lambiase P, Casas JP, Morillo CA.

Cochrane Database Syst Rev. 2016 Nov 22;11:CD012088. Review.

14.

Enhancing the safety of antibody-based immunomodulatory cancer therapy without compromising therapeutic benefit: Can we have our cake and eat it too?

Ryan JM, Wasser JS, Adler AJ, Vella AT.

Expert Opin Biol Ther. 2016;16(5):655-74. doi: 10.1517/14712598.2016.1152256. Epub 2016 Feb 25. Review.

15.

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.

Liu K, Kurien BT, Zimmerman SL, Kaufman KM, Taft DH, Kottyan LC, Lazaro S, Weaver CA, Ice JA, Adler AJ, Chodosh J, Radfar L, Rasmussen A, Stone DU, Lewis DM, Li S, Koelsch KA, Igoe A, Talsania M, Kumar J, Maier-Moore JS, Harris VM, Gopalakrishnan R, Jonsson R, Lessard JA, Lu X, Gottenberg JE, Anaya JM, Cunninghame-Graham DS, Huang AJW, Brennan MT, Hughes P, Illei GG, Miceli-Richard C, Keystone EC, Bykerk VP, Hirschfield G, Xie G, Ng WF, Nordmark G, Eriksson P, Omdal R, Rhodus NL, Rischmueller M, Rohrer M, Segal BM, Vyse TJ, Wahren-Herlenius M, Witte T, Pons-Estel B, Alarcon-Riquelme ME, Guthridge JM, James JA, Lessard CJ, Kelly JA, Thompson SD, Gaffney PM, Montgomery CG, Edberg JC, Kimberly RP, Alarcón GS, Langefeld CL, Gilkeson GS, Kamen DL, Tsao BP, McCune WJ, Salmon JE, Merrill JT, Weisman MH, Wallace DJ, Utset TO, Bottinger EP, Amos CI, Siminovitch KA, Mariette X, Sivils KL, Harley JB, Scofield RH.

Arthritis Rheumatol. 2016 May;68(5):1290-1300. doi: 10.1002/art.39560.

16.

Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis.

Tsurutani N, Mittal P, St Rose MC, Ngoi SM, Svedova J, Menoret A, Treadway FB, Laubenbacher R, Suárez-Ramírez JE, Cauley LS, Adler AJ, Vella AT.

J Immunol. 2016 Jan 1;196(1):124-34. doi: 10.4049/jimmunol.1501217. Epub 2015 Nov 16.

17.

Tumor-Unrelated CD4 T Cell Help Augments CD134 plus CD137 Dual Costimulation Tumor Therapy.

Mittal P, St Rose MC, Wang X, Ryan JM, Wasser JS, Vella AT, Adler AJ.

J Immunol. 2015 Dec 15;195(12):5816-26. doi: 10.4049/jimmunol.1502032. Epub 2015 Nov 11.

18.

Nut consumption for the primary prevention of cardiovascular disease.

Martin N, Germanò R, Hartley L, Adler AJ, Rees K.

Cochrane Database Syst Rev. 2015 Sep 28;(9):CD011583. doi: 10.1002/14651858.CD011583.pub2. Review.

PMID:
26411417
19.

Reducing Cardiovascular Mortality Through Prevention and Management of Raised Blood Pressure: A World Heart Federation Roadmap.

Adler AJ, Prabhakaran D, Bovet P, Kazi DS, Mancia G, Mungal-Singh V, Poulter N.

Glob Heart. 2015 Jun;10(2):111-22. doi: 10.1016/j.gheart.2015.04.006. No abstract available.

PMID:
26213298
20.

Reduced dietary salt for the prevention of cardiovascular disease.

Adler AJ, Taylor F, Martin N, Gottlieb S, Taylor RS, Ebrahim S.

Sao Paulo Med J. 2015 May-Jun;133(3):280-1. doi: 10.1590/1516-3180.20151333T2. Epub 2015 Jun 1. No abstract available.

21.

Anti-inflammatory treatment for carditis in acute rheumatic fever.

Cilliers A, Adler AJ, Saloojee H.

Cochrane Database Syst Rev. 2015 May 28;(5):CD003176. doi: 10.1002/14651858.CD003176.pub3. Review.

PMID:
26017576
22.

Reduced dietary salt for the prevention of cardiovascular disease.

Adler AJ, Taylor F, Martin N, Gottlieb S, Taylor RS, Ebrahim S.

Cochrane Database Syst Rev. 2014 Dec 18;(12):CD009217. doi: 10.1002/14651858.CD009217.pub3. Review.

23.

Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA.

Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS, Guthridge JM, Jacob CO, James JA, Kamen DL, Merrill JT, Sivils KM, Niewold TB, Petri MA, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Vilá LM, Vyse TJ, Kaufman KM, Harley JB, Langefeld CD, Gaffney PM, Brown EE, Edberg JC, Kimberly RP, Ulgiati D, Tsao BP, Boackle SA.

Ann Rheum Dis. 2016 Jan;75(1):242-52. doi: 10.1136/annrheumdis-2014-205584. Epub 2014 Sep 1.

24.

Incidence and risk factors for influenza-like-illness in the UK: online surveillance using Flusurvey.

Adler AJ, Eames KT, Funk S, Edmunds WJ.

BMC Infect Dis. 2014 May 1;14:232. doi: 10.1186/1471-2334-14-232.

25.

Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.

Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcón-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM.

Am J Hum Genet. 2014 Apr 3;94(4):586-98. doi: 10.1016/j.ajhg.2014.03.008.

26.

Estimating the prevalence of obstetric fistula: a systematic review and meta-analysis.

Adler AJ, Ronsmans C, Calvert C, Filippi V.

BMC Pregnancy Childbirth. 2013 Dec 30;13:246. doi: 10.1186/1471-2393-13-246. Review.

27.

Infinium assay for large-scale SNP genotyping applications.

Adler AJ, Wiley GB, Gaffney PM.

J Vis Exp. 2013 Nov 19;(81):e50683. doi: 10.3791/50683.

28.

Striving for synergy: how to improve cancer immunotherapy through multiple agonist costimulation.

Adler AJ, Vella AT.

Immunotherapy. 2013 Dec;5(12):1271-3. doi: 10.2217/imt.13.129. No abstract available.

PMID:
24283834
29.

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain AN, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJ, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF; UK Primary Sjögren's Syndrome Registry, Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL.

Nat Genet. 2013 Nov;45(11):1284-92. doi: 10.1038/ng.2792. Epub 2013 Oct 6.

30.

Obstetric fistula in Southern Sudan: situational analysis and Key Informant Method to estimate prevalence.

Adler AJ, Fox S, Campbell OM, Kuper H.

BMC Pregnancy Childbirth. 2013 Mar 12;13:64. doi: 10.1186/1471-2393-13-64.

31.
32.

CD134/CD137 dual costimulation-elicited IFN-γ maximizes effector T-cell function but limits Treg expansion.

St Rose MC, Taylor RA, Bandyopadhyay S, Qui HZ, Hagymasi AT, Vella AT, Adler AJ.

Immunol Cell Biol. 2013 Feb;91(2):173-83. doi: 10.1038/icb.2012.74. Epub 2013 Jan 8.

33.

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells.

Tewalt EF, Cohen JN, Rouhani SJ, Guidi CJ, Qiao H, Fahl SP, Conaway MR, Bender TP, Tung KS, Vella AT, Adler AJ, Chen L, Engelhard VH.

Blood. 2012 Dec 6;120(24):4772-82. doi: 10.1182/blood-2012-04-427013. Epub 2012 Sep 19.

34.

Quantifying the global burden of morbidity due to unsafe abortion: magnitude in hospital-based studies and methodological issues.

Adler AJ, Filippi V, Thomas SL, Ronsmans C.

Int J Gynaecol Obstet. 2012 Sep;118 Suppl 2:S65-77. doi: 10.1016/S0020-7292(12)60003-4. Review.

PMID:
22920625
35.

Identifying regional variation in the prevalence of postpartum haemorrhage: a systematic review and meta-analysis.

Calvert C, Thomas SL, Ronsmans C, Wagner KS, Adler AJ, Filippi V.

PLoS One. 2012;7(7):e41114. doi: 10.1371/journal.pone.0041114. Epub 2012 Jul 23. Review.

36.

Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus.

Adrianto I, Wang S, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martín J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM.

Arthritis Rheum. 2012 Nov;64(11):3695-705. doi: 10.1002/art.34642.

37.

Anti-inflammatory treatment for carditis in acute rheumatic fever.

Cilliers A, Manyemba J, Adler AJ, Saloojee H.

Cochrane Database Syst Rev. 2012 Jun 13;(6):CD003176. doi: 10.1002/14651858.CD003176.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;(5):CD003176.

PMID:
22696333
38.

Presensitizing with a Toll-like receptor 3 ligand impairs CD8 T-cell effector differentiation and IL-33 responsiveness.

Ngoi SM, St Rose MC, Menoret AM, Smith DE, Tovey MG, Adler AJ, Vella AT.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10486-91. doi: 10.1073/pnas.1202607109. Epub 2012 Jun 11.

39.

A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.

Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM.

Genes Immun. 2012 Jul;13(5):380-7. doi: 10.1038/gene.2012.6. Epub 2012 Apr 5.

40.

Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study.

Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Li H, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ, Alarcón-Riquelme ME, Alarcón GS, Anaya JM, Bae SC, Boackle SA, Brown EE, Chang DM, Cho SK, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Kim JH, Martin J, Merrill JT, Niewold TB, Park SY, Petri MA, Pons-Estel BA, Ramsey-Goldman R, Reveille JD, Scofield RH, Song YW, Stevens AM, Tsao BP, Vila LM, Vyse TJ, Yu CY, Guthridge JM, Kaufman KM, Harley JB, Wakeland EK, Langefeld CD, Gaffney PM, Montgomery CG, Moser KL; BIOLUPUS Network; GENLES Network.

Am J Hum Genet. 2012 Apr 6;90(4):648-60. doi: 10.1016/j.ajhg.2012.02.023. Epub 2012 Mar 29.

41.

Incidence of severe acute maternal morbidity associated with abortion: a systematic review.

Adler AJ, Filippi V, Thomas SL, Ronsmans C.

Trop Med Int Health. 2012 Feb;17(2):177-90. doi: 10.1111/j.1365-3156.2011.02896.x. Epub 2011 Oct 31. Review.

42.

CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation.

Qui HZ, Hagymasi AT, Bandyopadhyay S, St Rose MC, Ramanarasimhaiah R, Ménoret A, Mittler RS, Gordon SM, Reiner SL, Vella AT, Adler AJ.

J Immunol. 2011 Oct 1;187(7):3555-64. doi: 10.4049/jimmunol.1101244. Epub 2011 Aug 31.

43.

Tc17 CD8 T cells: functional plasticity and subset diversity.

Yen HR, Harris TJ, Wada S, Grosso JF, Getnet D, Goldberg MV, Liang KL, Bruno TC, Pyle KJ, Chan SL, Anders RA, Trimble CL, Adler AJ, Lin TY, Pardoll DM, Huang CT, Drake CG.

J Immunol. 2009 Dec 1;183(11):7161-8. doi: 10.4049/jimmunol.0900368. Epub 2009 Nov 16.

44.

Blood feeding by the Rocky Mountain spotted fever vector, Dermacentor andersoni, induces interleukin-4 expression by cognate antigen responding CD4+ T cells.

Boppana VD, Thangamani S, Alarcon-Chaidez FJ, Adler AJ, Wikel SK.

Parasit Vectors. 2009 Oct 8;2(1):47. doi: 10.1186/1756-3305-2-47.

45.

The E3 ubiquitin ligase Cbl-b regulates expansion but not functional activity of self-reactive CD4 T cells.

St Rose MC, Qui HZ, Bandyopadhyay S, Mihalyo MA, Hagymasi AT, Clark RB, Adler AJ.

J Immunol. 2009 Oct 15;183(8):4975-83. doi: 10.4049/jimmunol.0901243.

46.

SAAG-4 is a novel mosquito salivary protein that programmes host CD4 T cells to express IL-4.

Boppana VD, Thangamani S, Adler AJ, Wikel SK.

Parasite Immunol. 2009 Jun;31(6):287-95. doi: 10.1111/j.1365-3024.2009.01096.x.

47.

A novel sphingomyelinase-like enzyme in Ixodes scapularis tick saliva drives host CD4 T cells to express IL-4.

Alarcon-Chaidez FJ, Boppana VD, Hagymasi AT, Adler AJ, Wikel SK.

Parasite Immunol. 2009 Apr;31(4):210-9. doi: 10.1111/j.1365-3024.2009.01095.x.

48.

In vitro and in vivo differentiated effector CD8 T cells display divergent histone acetylation patterns within the Ifng locus.

Bandyopadhyay S, Qui HZ, Adler AJ.

Immunol Lett. 2009 Feb 21;122(2):214-8. doi: 10.1016/j.imlet.2009.01.001. Epub 2009 Feb 3.

49.

Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation.

Bandyopadhyay S, Long M, Qui HZ, Hagymasi AT, Slaiby AM, Mihalyo MA, Aguila HL, Mittler RS, Vella AT, Adler AJ.

J Immunol. 2008 Dec 1;181(11):7728-37.

50.

The IKK-neutralizing compound Bay11 kills supereffector CD8 T cells by altering caspase-dependent activation-induced cell death.

Lee SJ, Long M, Adler AJ, Mittler RS, Vella AT.

J Leukoc Biol. 2009 Jan;85(1):175-85. doi: 10.1189/jlb.0408248. Epub 2008 Oct 15.

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