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Items: 1 to 50 of 56

1.

Structure, function and techniques of investigation of the P2X7 receptor (P2X7R) in mammalian cells.

Di Virgilio F, Jiang LH, Roger S, Falzoni S, Sarti AC, Vultaggio-Poma V, Chiozzi P, Adinolfi E.

Methods Enzymol. 2019;629:115-150. doi: 10.1016/bs.mie.2019.07.043. Epub 2019 Sep 3.

PMID:
31727237
2.

Detection of Extracellular ATP in the Tumor Microenvironment, Using the pmeLUC Biosensor.

De Marchi E, Orioli E, Pegoraro A, Adinolfi E, Di Virgilio F.

Methods Mol Biol. 2020;2041:183-195. doi: 10.1007/978-1-4939-9717-6_13.

PMID:
31646489
3.

Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine.

Chiozzi P, Sarti AC, Sanz JM, Giuliani AL, Adinolfi E, Vultaggio-Poma V, Falzoni S, Di Virgilio F.

Sci Rep. 2019 Apr 24;9(1):6475. doi: 10.1038/s41598-019-42931-2.

4.

Involvement of P2X7 Receptors in the Osteogenic Differentiation of Mesenchymal Stromal/Stem Cells Derived from Human Subcutaneous Adipose Tissue.

Carluccio M, Zuccarini M, Ziberi S, Giuliani P, Morabito C, Mariggiò MA, Lonardo MT, Adinolfi E, Orioli E, Di Iorio P, Caciagli F, Ciccarelli R.

Stem Cell Rev Rep. 2019 Aug;15(4):574-589. doi: 10.1007/s12015-019-09883-6.

PMID:
30955192
5.

Role of the P2X7 receptor in tumor-associated inflammation.

Adinolfi E, De Marchi E, Orioli E, Pegoraro A, Di Virgilio F.

Curr Opin Pharmacol. 2019 Aug;47:59-64. doi: 10.1016/j.coph.2019.02.012. Epub 2019 Mar 25. Review.

PMID:
30921559
6.

The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment.

De Marchi E, Orioli E, Pegoraro A, Sangaletti S, Portararo P, Curti A, Colombo MP, Di Virgilio F, Adinolfi E.

Oncogene. 2019 May;38(19):3636-3650. doi: 10.1038/s41388-019-0684-y. Epub 2019 Jan 17.

7.

Late HCC onset after direct antiviral agents therapy in patients with sustained virological response: do we need to reconsider their efficacy according to long term follow-up?

Perrella A, Izzi A, Punzi R, Adinolfi E, Sbreglia C, Bellopede P, Galeota Lanza A, Martucci F, Rinaldi L.

Scand J Gastroenterol. 2018 Aug;53(8):1025-1026. doi: 10.1080/00365521.2018.1495260. No abstract available.

PMID:
30231805
8.

Extracellular ATP and P2 purinergic signalling in the tumour microenvironment.

Di Virgilio F, Sarti AC, Falzoni S, De Marchi E, Adinolfi E.

Nat Rev Cancer. 2018 Oct;18(10):601-618. doi: 10.1038/s41568-018-0037-0. Review.

PMID:
30006588
9.

Kinin and Purine Signaling Contributes to Neuroblastoma Metastasis.

Ulrich H, Ratajczak MZ, Schneider G, Adinolfi E, Orioli E, Ferrazoli EG, Glaser T, Corrêa-Velloso J, Martins PCM, Coutinho F, Santos APJ, Pillat MM, Sack U, Lameu C.

Front Pharmacol. 2018 May 18;9:500. doi: 10.3389/fphar.2018.00500. eCollection 2018.

10.

Emerging Roles of Purinergic Signaling in Diabetes.

Fotino C, Dal Ben D, Adinolfi E.

Med Chem. 2018;14(5):428-438. doi: 10.2174/1573406414666180226165204. Review.

PMID:
29485002
11.

ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells.

Lecciso M, Ocadlikova D, Sangaletti S, Trabanelli S, De Marchi E, Orioli E, Pegoraro A, Portararo P, Jandus C, Bontadini A, Redavid A, Salvestrini V, Romero P, Colombo MP, Di Virgilio F, Cavo M, Adinolfi E, Curti A.

Front Immunol. 2017 Dec 22;8:1918. doi: 10.3389/fimmu.2017.01918. eCollection 2017.

12.

The P2X7 receptor: A main player in inflammation.

Adinolfi E, Giuliani AL, De Marchi E, Pegoraro A, Orioli E, Di Virgilio F.

Biochem Pharmacol. 2018 May;151:234-244. doi: 10.1016/j.bcp.2017.12.021. Epub 2017 Dec 27. Review.

PMID:
29288626
13.

P2X7 Receptor Orchestrates Multiple Signalling Pathways Triggering Inflammation, Autophagy and Metabolic/Trophic Responses.

Orioli E, De Marchi E, Giuliani AL, Adinolfi E.

Curr Med Chem. 2017;24(21):2261-2275. doi: 10.2174/0929867324666170303161659. Review.

PMID:
28266268
14.

Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells.

Salvestrini V, Orecchioni S, Talarico G, Reggiani F, Mazzetti C, Bertolini F, Orioli E, Adinolfi E, Di Virgilio F, Pezzi A, Cavo M, Lemoli RM, Curti A.

Oncotarget. 2017 Jan 24;8(4):5895-5908. doi: 10.18632/oncotarget.13927.

15.

Extracellular purines, purinergic receptors and tumor growth.

Di Virgilio F, Adinolfi E.

Oncogene. 2017 Jan 19;36(3):293-303. doi: 10.1038/onc.2016.206. Epub 2016 Jun 20. Review.

16.

P2 receptors in cancer progression and metastatic spreading.

Di Virgilio F, Falzoni S, Giuliani AL, Adinolfi E.

Curr Opin Pharmacol. 2016 Aug;29:17-25. doi: 10.1016/j.coph.2016.05.001. Epub 2016 May 24. Review.

PMID:
27262778
17.

P2X7 Receptor as a Therapeutic Target.

De Marchi E, Orioli E, Dal Ben D, Adinolfi E.

Adv Protein Chem Struct Biol. 2016;104:39-79. doi: 10.1016/bs.apcsb.2015.11.004. Epub 2016 Jan 4. Review.

PMID:
27038372
18.

Editorial: Purinergic P2X receptors: physiological and pathological roles and potential as therapeutic targets.

DalBen D, Adinolfi E.

Curr Med Chem. 2015;22(7):782. No abstract available.

PMID:
25645748
19.

The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma.

Amoroso F, Capece M, Rotondo A, Cangelosi D, Ferracin M, Franceschini A, Raffaghello L, Pistoia V, Varesio L, Adinolfi E.

Oncogene. 2015 Oct 8;34(41):5240-51. doi: 10.1038/onc.2014.444. Epub 2015 Jan 26.

PMID:
25619831
20.

Accelerated tumor progression in mice lacking the ATP receptor P2X7.

Adinolfi E, Capece M, Franceschini A, Falzoni S, Giuliani AL, Rotondo A, Sarti AC, Bonora M, Syberg S, Corigliano D, Pinton P, Jorgensen NR, Abelli L, Emionite L, Raffaghello L, Pistoia V, Di Virgilio F.

Cancer Res. 2015 Feb 15;75(4):635-44. doi: 10.1158/0008-5472.CAN-14-1259. Epub 2014 Dec 26.

21.

Purinergic P2X Receptors: Physiological and Pathological Roles and Potential as Therapeutic Targets.

Dal Ben D, Adinolfi E.

Curr Med Chem. 2014 Dec 12. [Epub ahead of print] No abstract available.

PMID:
25515505
22.

P2X receptors: New players in cancer pain.

Franceschini A, Adinolfi E.

World J Biol Chem. 2014 Nov 26;5(4):429-36. doi: 10.4331/wjbc.v5.i4.429. Review.

23.

Emerging roles of P2X receptors in cancer.

Adinolfi E, Capece M, Amoroso F, De Marchi E, Franceschini A.

Curr Med Chem. 2015;22(7):878-90. Review.

PMID:
25312206
24.

Trophic activity of human P2X7 receptor isoforms A and B in osteosarcoma.

Giuliani AL, Colognesi D, Ricco T, Roncato C, Capece M, Amoroso F, Wang QG, De Marchi E, Gartland A, Di Virgilio F, Adinolfi E.

PLoS One. 2014 Sep 16;9(9):e107224. doi: 10.1371/journal.pone.0107224. eCollection 2014.

25.

New intriguing roles of ATP and its receptors in promoting tumor metastasis : presented by Maria P. Abbracchio.

Adinolfi E.

Purinergic Signal. 2013 Dec;9(4):487-90. doi: 10.1007/s11302-013-9401-4. No abstract available.

26.

Purinergic signaling in bone.

Jørgensen NR, Adinolfi E, Orriss I, Schwarz P.

J Osteoporos. 2013;2013:673684. doi: 10.1155/2013/673684. Epub 2013 May 16. No abstract available.

27.

P2X7 Receptor Function in Bone-Related Cancer.

Adinolfi E, Amoroso F, Giuliani AL.

J Osteoporos. 2012;2012:637863. doi: 10.1155/2012/637863. Epub 2012 Aug 16.

28.

The P2X7 receptor is a key modulator of aerobic glycolysis.

Amoroso F, Falzoni S, Adinolfi E, Ferrari D, Di Virgilio F.

Cell Death Dis. 2012 Aug 16;3:e370. doi: 10.1038/cddis.2012.105.

29.

Expression of P2X7 receptor increases in vivo tumor growth.

Adinolfi E, Raffaghello L, Giuliani AL, Cavazzini L, Capece M, Chiozzi P, Bianchi G, Kroemer G, Pistoia V, Di Virgilio F.

Cancer Res. 2012 Jun 15;72(12):2957-69. doi: 10.1158/0008-5472.CAN-11-1947. Epub 2012 Apr 13.

30.

Purinergic signaling in giant cell formation.

Lemaire I, Falzoni S, Adinolfi E.

Front Biosci (Elite Ed). 2012 Jan 1;4:41-55. Review.

PMID:
22201854
31.

The dominant-negative von Willebrand factor gene deletion p.P1127_C1948delinsR: molecular mechanism and modulation.

Casari C, Pinotti M, Lancellotti S, Adinolfi E, Casonato A, De Cristofaro R, Bernardi F.

Blood. 2010 Dec 9;116(24):5371-6. doi: 10.1182/blood-2010-02-268920. Epub 2010 Aug 27.

PMID:
20570857
32.

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor.

Adinolfi E, Cirillo M, Woltersdorf R, Falzoni S, Chiozzi P, Pellegatti P, Callegari MG, Sandonà D, Markwardt F, Schmalzing G, Di Virgilio F.

FASEB J. 2010 Sep;24(9):3393-404. doi: 10.1096/fj.09-153601. Epub 2010 May 7.

PMID:
20453110
33.

cAMP efflux from human trophoblast cell lines: a role for multidrug resistance protein (MRP)1 transporter.

Biondi C, Ferretti ME, Lunghi L, Medici S, Cervellati F, Pavan B, Vesce F, Morano D, Adinolfi E, Bertoni F, Abelli L.

Mol Hum Reprod. 2010 Jul;16(7):481-91. doi: 10.1093/molehr/gaq023. Epub 2010 Mar 15.

PMID:
20231161
34.

P2X(7): a growth-promoting receptor-implications for cancer.

Di Virgilio F, Ferrari D, Adinolfi E.

Purinergic Signal. 2009 Jun;5(2):251-6. doi: 10.1007/s11302-009-9145-3. Epub 2009 Mar 4.

35.

Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis.

Adinolfi E, Callegari MG, Cirillo M, Pinton P, Giorgi C, Cavagna D, Rizzuto R, Di Virgilio F.

J Biol Chem. 2009 Apr 10;284(15):10120-8. doi: 10.1074/jbc.M805805200. Epub 2009 Feb 9.

36.

Somatostatin as a regulator of first-trimester human trophoblast functions.

Biondi C, Ferretti ME, Lunghi L, Medici S, Cervellati F, Abelli L, Bertoni F, Adinolfi E, Vesce F, Bartolini G, Papi A, D'Andrea S, Berton S, Baldassarre G.

Placenta. 2008 Aug;29(8):660-70. doi: 10.1016/j.placenta.2008.05.009. Epub 2008 Jul 9.

PMID:
18617261
37.

P2X(7) receptor: Death or life?

Adinolfi E, Pizzirani C, Idzko M, Panther E, Norgauer J, Di Virgilio F, Ferrari D.

Purinergic Signal. 2005 Sep;1(3):219-27. doi: 10.1007/s11302-005-6322-x. Epub 2005 Jul 29.

38.

Stimulation of P2 (P2X7) receptors in human dendritic cells induces the release of tissue factor-bearing microparticles.

Baroni M, Pizzirani C, Pinotti M, Ferrari D, Adinolfi E, Calzavarini S, Caruso P, Bernardi F, Di Virgilio F.

FASEB J. 2007 Jun;21(8):1926-33. Epub 2007 Feb 21.

PMID:
17314141
39.

Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells.

Pizzirani C, Ferrari D, Chiozzi P, Adinolfi E, Sandonà D, Savaglio E, Di Virgilio F.

Blood. 2007 May 1;109(9):3856-64. Epub 2006 Dec 27.

PMID:
17192399
40.

Involvement of the purinergic P2X7 receptor in the formation of multinucleated giant cells.

Lemaire I, Falzoni S, Leduc N, Zhang B, Pellegatti P, Adinolfi E, Chiozzi P, Di Virgilio F.

J Immunol. 2006 Nov 15;177(10):7257-65.

41.

Stimulation of purinergic receptors modulates chemokine expression in human keratinocytes.

Pastore S, Mascia F, Gulinelli S, Forchap S, Dattilo C, Adinolfi E, Girolomoni G, Di Virgilio F, Ferrari D.

J Invest Dermatol. 2007 Mar;127(3):660-7. Epub 2006 Oct 12.

42.

The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration.

Rossi L, Manfredini R, Bertolini F, Ferrari D, Fogli M, Zini R, Salati S, Salvestrini V, Gulinelli S, Adinolfi E, Ferrari S, Di Virgilio F, Baccarani M, Lemoli RM.

Blood. 2007 Jan 15;109(2):533-42. Epub 2006 Sep 28.

PMID:
17008551
43.

The P2X7 receptor: a key player in IL-1 processing and release.

Ferrari D, Pizzirani C, Adinolfi E, Lemoli RM, Curti A, Idzko M, Panther E, Di Virgilio F.

J Immunol. 2006 Apr 1;176(7):3877-83. Review. Erratum in: J Immunol. 2007 Dec 15;179(12):8569.

44.

Pseudoapoptosis induced by brief activation of ATP-gated P2X7 receptors.

Mackenzie AB, Young MT, Adinolfi E, Surprenant A.

J Biol Chem. 2005 Oct 7;280(40):33968-76. Epub 2005 Jun 30.

45.

Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth.

Adinolfi E, Callegari MG, Ferrari D, Bolognesi C, Minelli M, Wieckowski MR, Pinton P, Rizzuto R, Di Virgilio F.

Mol Biol Cell. 2005 Jul;16(7):3260-72. Epub 2005 May 18. Erratum in: Mol Biol Cell. 2005 Oct;16(10):5054.

46.

The antibiotic polymyxin B modulates P2X7 receptor function.

Ferrari D, Pizzirani C, Adinolfi E, Forchap S, Sitta B, Turchet L, Falzoni S, Minelli M, Baricordi R, Di Virgilio F.

J Immunol. 2004 Oct 1;173(7):4652-60.

47.

Enhanced P2X7 activity in human fibroblasts from diabetic patients: a possible pathogenetic mechanism for vascular damage in diabetes.

Solini A, Chiozzi P, Morelli A, Adinolfi E, Rizzo R, Baricordi OR, Di Virgilio F.

Arterioscler Thromb Vasc Biol. 2004 Jul;24(7):1240-5. Epub 2004 May 20.

PMID:
15155383
48.

Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors.

Adinolfi E, Kim M, Young MT, Di Virgilio F, Surprenant A.

J Biol Chem. 2003 Sep 26;278(39):37344-51. Epub 2003 Jul 17.

49.

Human leukocyte antigen-A, -B, -C and -DR alleles and soluble human leukocyte antigen class I serum level in Ménière's disease.

Melchiorri L, Martini A, Rizzo R, Berto A, Adinolfi E, Baricord OR.

Acta Otolaryngol Suppl. 2002;(548):26-9.

PMID:
12211352
50.

P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia.

Adinolfi E, Melchiorri L, Falzoni S, Chiozzi P, Morelli A, Tieghi A, Cuneo A, Castoldi G, Di Virgilio F, Baricordi OR.

Blood. 2002 Jan 15;99(2):706-8.

PMID:
11781259

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