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Items: 1 to 50 of 68

1.

Impact of proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab on the postprandial responses of triglyceride-rich lipoproteins in type II diabetic subjects.

Taskinen MR, Björnson E, Andersson L, Kahri J, Porthan K, Matikainen N, Söderlund S, Pietiläinen K, Hakkarainen A, Lundbom N, Nilsson R, Ståhlman M, Adiels M, Parini P, Packard C, Borén J.

J Clin Lipidol. 2019 Dec 12. pii: S1933-2874(19)30363-0. doi: 10.1016/j.jacl.2019.12.003. [Epub ahead of print]

PMID:
31917184
2.

Apolipoprotein B48 metabolism in chylomicrons and very low-density lipoproteins and its role in triglyceride transport in normo- and hypertriglyceridemic human subjects.

Björnson E, Packard CJ, Adiels M, Andersson L, Matikainen N, Söderlund S, Kahri J, Hakkarainen A, Lundbom N, Lundbom J, Sihlbom C, Thorsell A, Zhou H, Taskinen MR, Borén J.

J Intern Med. 2019 Dec 17. doi: 10.1111/joim.13017. [Epub ahead of print]

PMID:
31846520
3.

Contrasting Associations of Body Mass Index and Hemoglobin A1c on the Excess Risk of Acute Myocardial Infarction and Heart Failure in Type 2 Diabetes Mellitus.

Edqvist J, Rawshani A, Adiels M, Björck L, Lind M, Svensson AM, Gudbjörnsdottir S, Sattar N, Rosengren A.

J Am Heart Assoc. 2019 Dec 17;8(24):e013871. doi: 10.1161/JAHA.119.013871. Epub 2019 Dec 10.

4.

Body mass index in women aged 18 to 45 and subsequent risk of heart failure.

Björck L, Lundberg C, Schaufelberger M, Lissner L, Adiels M, Rosengren A.

Eur J Prev Cardiol. 2019 Nov 5:2047487319882510. doi: 10.1177/2047487319882510. [Epub ahead of print]

PMID:
31684761
5.

Higher Body Mass Index in Adolescence Predicts Cardiomyopathy Risk in Midlife.

Robertson J, Schaufelberger M, Lindgren M, Adiels M, Schiöler L, Torén K, McMurray J, Sattar N, Åberg M, Rosengren A.

Circulation. 2019 Jul 9;140(2):117-125. doi: 10.1161/CIRCULATIONAHA.118.039132. Epub 2019 May 28.

6.

BMI, Mortality, and Cardiovascular Outcomes in Type 1 Diabetes: Findings Against an Obesity Paradox.

Edqvist J, Rawshani A, Adiels M, Björck L, Lind M, Svensson AM, Gudbjörnsdottir S, Sattar N, Rosengren A.

Diabetes Care. 2019 Jul;42(7):1297-1304. doi: 10.2337/dc18-1446. Epub 2019 May 2.

PMID:
31048408
7.

Role of apolipoprotein C-III overproduction in diabetic dyslipidaemia.

Adiels M, Taskinen MR, Björnson E, Andersson L, Matikainen N, Söderlund S, Kahri J, Hakkarainen A, Lundbom N, Sihlbom C, Thorsell A, Zhou H, Pietiläinen KH, Packard C, Borén J.

Diabetes Obes Metab. 2019 Aug;21(8):1861-1870. doi: 10.1111/dom.13744. Epub 2019 May 8.

PMID:
30972934
8.

Investigation of human apoB48 metabolism using a new, integrated non-steady-state model of apoB48 and apoB100 kinetics.

Björnson E, Packard CJ, Adiels M, Andersson L, Matikainen N, Söderlund S, Kahri J, Sihlbom C, Thorsell A, Zhou H, Taskinen MR, Borén J.

J Intern Med. 2019 May;285(5):562-577. doi: 10.1111/joim.12877. Epub 2019 Mar 12.

9.

Excess risk of hospitalisation for heart failure among people with type 2 diabetes.

Rosengren A, Edqvist J, Rawshani A, Sattar N, Franzén S, Adiels M, Svensson AM, Lind M, Gudbjörnsdottir S.

Diabetologia. 2018 Nov;61(11):2300-2309. doi: 10.1007/s00125-018-4700-5. Epub 2018 Aug 9.

10.

Niacin action in the atherogenic mixed dyslipidemia of metabolic syndrome: Insights from metabolic biomarker profiling and network analysis.

Adiels M, Chapman MJ, Robillard P, Krempf M, Laville M, Borén J; Niacin Study Group.

J Clin Lipidol. 2018 May - Jun;12(3):810-821.e1. doi: 10.1016/j.jacl.2018.03.083. Epub 2018 Mar 29.

11.

Sulfatide isoform pattern in cerebrospinal fluid discriminates progressive MS from relapsing-remitting MS.

Novakova L, Singh AK, Axelsson M, Ståhlman M, Adiels M, Malmeström C, Zetterberg H, Borén J, Lycke J, Cardell SL, Blomqvist M.

J Neurochem. 2018 Aug;146(3):322-332. doi: 10.1111/jnc.14452. Epub 2018 Jul 3.

12.

Resting heart rate in late adolescence and long term risk of cardiovascular disease in Swedish men.

Lindgren M, Robertson J, Adiels M, Schaufelberger M, Åberg M, Torén K, Waern M, Åberg ND, Rosengren A.

Int J Cardiol. 2018 May 15;259:109-115. doi: 10.1016/j.ijcard.2018.01.110.

13.

Primary aldosteronism and thyroid disorders in atrial fibrillation: A Swedish nationwide case-control study.

Mourtzinis G, Adamsson Eryd S, Rosengren A, Björck L, Adiels M, Johannsson G, Manhem K.

Eur J Prev Cardiol. 2018 May;25(7):694-701. doi: 10.1177/2047487318759853. Epub 2018 Feb 23.

PMID:
29473461
14.

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.

Mardinoglu A, Wu H, Bjornson E, Zhang C, Hakkarainen A, Räsänen SM, Lee S, Mancina RM, Bergentall M, Pietiläinen KH, Söderlund S, Matikainen N, Ståhlman M, Bergh PO, Adiels M, Piening BD, Granér M, Lundbom N, Williams KJ, Romeo S, Nielsen J, Snyder M, Uhlén M, Bergström G, Perkins R, Marschall HU, Bäckhed F, Taskinen MR, Borén J.

Cell Metab. 2018 Mar 6;27(3):559-571.e5. doi: 10.1016/j.cmet.2018.01.005. Epub 2018 Feb 15.

15.

BMI and Mortality in Patients With New-Onset Type 2 Diabetes: A Comparison With Age- and Sex-Matched Control Subjects From the General Population.

Edqvist J, Rawshani A, Adiels M, Björck L, Lind M, Svensson AM, Gudbjörnsdottir S, Sattar N, Rosengren A.

Diabetes Care. 2018 Mar;41(3):485-493. doi: 10.2337/dc17-1309. Epub 2018 Jan 3.

PMID:
29298801
16.

Young women, body size and risk of atrial fibrillation.

Persson CE, Adiels M, Björck L, Rosengren A.

Eur J Prev Cardiol. 2018 Jan;25(2):173-180. doi: 10.1177/2047487317740644. Epub 2017 Nov 2.

PMID:
29095053
17.

Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.

Andersson L, Drevinge C, Mardani I, Dalen KT, Ståhlman M, Klevstig M, Lundqvist A, Haugen F, Adiels M, Fogelstrand P, Asin-Cayuela J, Hultén LM, Levin M, Ehrenborg E, Lee YK, Kimmel AR, Borén J, Levin MC.

Int J Biochem Cell Biol. 2017 Oct;91(Pt A):9-13. doi: 10.1016/j.biocel.2017.07.021. Epub 2017 Aug 12.

PMID:
28811250
18.

Long-term trends in the prevalence of patients hospitalized with ischemic stroke from 1995 to 2010 in Sweden.

Giang KW, Mandalenakis Z, Nielsen S, Björck L, Lappas G, Adiels M, Jern C, Rosengren A.

PLoS One. 2017 Jun 16;12(6):e0179658. doi: 10.1371/journal.pone.0179658. eCollection 2017.

19.

Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD.

Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.

Mol Syst Biol. 2017 Mar 2;13(3):916. doi: 10.15252/msb.20167422.

20.

Kinetics of plasma triglycerides in abdominal obesity.

Björnson E, Adiels M, Taskinen MR, Borén J.

Curr Opin Lipidol. 2017 Feb;28(1):11-18. doi: 10.1097/MOL.0000000000000375. Review.

PMID:
27898581
21.

An evaluation of the performance of SCORE Sweden 2015 in estimating cardiovascular risk: The Northern Sweden MONICA Study 1999-2014.

Karjalainen T, Adiels M, Björck L, Cooney MT, Graham I, Perk J, Rosengren A, Söderberg S, Eliasson M.

Eur J Prev Cardiol. 2017 Jan;24(1):103-110. Epub 2016 Oct 5.

PMID:
27708071
22.

Changes in Dietary Fat Intake and Projections for Coronary Heart Disease Mortality in Sweden: A Simulation Study.

Björck L, Rosengren A, Winkvist A, Capewell S, Adiels M, Bandosz P, Critchley J, Boman K, Guzman-Castillo M, O'Flaherty M, Johansson I.

PLoS One. 2016 Aug 4;11(8):e0160474. doi: 10.1371/journal.pone.0160474. eCollection 2016.

23.

Triglyceride-rich lipoprotein metabolism in women: roles of apoC-II and apoC-III.

Ooi EM, Chan DC, Hodson L, Adiels M, Boren J, Karpe F, Fielding BA, Watts GF, Barrett PH.

Eur J Clin Invest. 2016 Aug;46(8):730-6. doi: 10.1111/eci.12657.

PMID:
27378472
24.

Perilipin 5 is protective in the ischemic heart.

Drevinge C, Dalen KT, Mannila MN, Täng MS, Ståhlman M, Klevstig M, Lundqvist A, Mardani I, Haugen F, Fogelstrand P, Adiels M, Asin-Cayuela J, Ekestam C, Gådin JR, Lee YK, Nebb H, Svedlund S, Johansson BR, Hultén LM, Romeo S, Redfors B, Omerovic E, Levin M, Gan LM, Eriksson P, Andersson L, Ehrenborg E, Kimmel AR, Borén J, Levin MC.

Int J Cardiol. 2016 Sep 15;219:446-54. doi: 10.1016/j.ijcard.2016.06.037. Epub 2016 Jun 16.

25.

Metabolic transformations of dietary polyphenols: comparison between in vitro colonic and hepatic models and in vivo urinary metabolites.

Vetrani C, Rivellese AA, Annuzzi G, Adiels M, Borén J, Mattila I, Orešič M, Aura AM.

J Nutr Biochem. 2016 Jul;33:111-8. doi: 10.1016/j.jnutbio.2016.03.007. Epub 2016 Mar 29.

PMID:
27155917
26.

Targeting acid sphingomyelinase reduces cardiac ceramide accumulation in the post-ischemic heart.

Klevstig M, Ståhlman M, Lundqvist A, Scharin Täng M, Fogelstrand P, Adiels M, Andersson L, Kolesnick R, Jeppsson A, Borén J, Levin MC.

J Mol Cell Cardiol. 2016 Apr;93:69-72. doi: 10.1016/j.yjmcc.2016.02.019. Epub 2016 Feb 28.

27.

ApoA-II HDL Catabolism and Its Relationships With the Kinetics of ApoA-I HDL and of VLDL1, in Abdominal Obesity.

Vergès B, Adiels M, Boren J, Barrett PH, Watts GF, Chan D, Duvillard L, Söderlund S, Matikainen N, Kahri J, Lundbom N, Lundbom J, Hakkarainen A, Aho S, Simoneau-Robin I, Taskinen MR.

J Clin Endocrinol Metab. 2016 Apr;101(4):1398-406. doi: 10.1210/jc.2015-3740. Epub 2016 Feb 2.

28.

Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.

Adiels M, Mardinoglu A, Taskinen MR, Borén J.

Front Physiol. 2015 Nov 20;6:342. doi: 10.3389/fphys.2015.00342. eCollection 2015. Review.

29.

Menopausal Status and Abdominal Obesity Are Significant Determinants of Hepatic Lipid Metabolism in Women.

Hodson L, Banerjee R, Rial B, Arlt W, Adiels M, Boren J, Marinou K, Fisher C, Mostad IL, Stratton IM, Barrett PH, Chan DC, Watts GF, Harnden K, Karpe F, Fielding BA.

J Am Heart Assoc. 2015 Oct 2;4(10):e002258. doi: 10.1161/JAHA.115.002258.

30.

Improved Estimation of Human Lipoprotein Kinetics with Mixed Effects Models.

Berglund M, Adiels M, Taskinen MR, Borén J, Wennberg B.

PLoS One. 2015 Sep 30;10(9):e0138538. doi: 10.1371/journal.pone.0138538. eCollection 2015.

31.

Model-Based Quantification of the Systemic Interplay between Glucose and Fatty Acids in the Postprandial State.

Sips FL, Nyman E, Adiels M, Hilbers PA, Strålfors P, van Riel NA, Cedersund G.

PLoS One. 2015 Sep 10;10(9):e0135665. doi: 10.1371/journal.pone.0135665. eCollection 2015.

32.

Kinetic and Related Determinants of Plasma Triglyceride Concentration in Abdominal Obesity: Multicenter Tracer Kinetic Study.

Borén J, Watts GF, Adiels M, Söderlund S, Chan DC, Hakkarainen A, Lundbom N, Matikainen N, Kahri J, Vergès B, Barrett PH, Taskinen MR.

Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2218-24. doi: 10.1161/ATVBAHA.115.305614. Epub 2015 Aug 27. Erratum in: Arterioscler Thromb Vasc Biol. 2015 Nov;35(11):e57.

33.

Prognostic Significance of Resting Heart Rate and Use of β-Blockers in Atrial Fibrillation and Sinus Rhythm in Patients With Heart Failure and Reduced Ejection Fraction: Findings From the Swedish Heart Failure Registry.

Li SJ, Sartipy U, Lund LH, Dahlström U, Adiels M, Petzold M, Fu M.

Circ Heart Fail. 2015 Sep;8(5):871-9. doi: 10.1161/CIRCHEARTFAILURE.115.002285. Epub 2015 Aug 4.

PMID:
26243796
34.

Imaging of Intracellular and Extracellular ROS Levels in Atherosclerotic Mouse Aortas Ex Vivo: Effects of Lipid Lowering by Diet or Atorvastatin.

Ekstrand M, Gustafsson Trajkovska M, Perman-Sundelin J, Fogelstrand P, Adiels M, Johansson M, Mattsson-Hultén L, Borén J, Levin M.

PLoS One. 2015 Jun 22;10(6):e0130898. doi: 10.1371/journal.pone.0130898. eCollection 2015.

35.

Interrelationships between the kinetics of VLDL subspecies and HDL catabolism in abdominal obesity: a multicenter tracer kinetic study.

Vergès B, Adiels M, Boren J, Barrett PH, Watts GF, Chan D, Duvillard L, Söderlund S, Matikainen N, Kahri J, Robin I, Taskinen MR.

J Clin Endocrinol Metab. 2014 Nov;99(11):4281-90. doi: 10.1210/jc.2014-2365. Epub 2014 Jul 31.

36.

Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation.

van Schalkwijk DB, Pasman WJ, Hendriks HF, Verheij ER, Rubingh CM, van Bochove K, Vaes WH, Adiels M, Freidig AP, de Graaf AA.

PLoS One. 2014 Jul 21;9(7):e100376. doi: 10.1371/journal.pone.0100376. eCollection 2014.

37.

Hepatic lipogenesis and a marker of hepatic lipid oxidation, predict postprandial responses of triglyceride-rich lipoproteins.

Matikainen N, Adiels M, Söderlund S, Stennabb S, Ahola T, Hakkarainen A, Borén J, Taskinen MR.

Obesity (Silver Spring). 2014 Aug;22(8):1854-9. doi: 10.1002/oby.20781. Epub 2014 May 28.

38.

Postprandial hypertriglyceridemia as a coronary risk factor.

Borén J, Matikainen N, Adiels M, Taskinen MR.

Clin Chim Acta. 2014 Apr 20;431:131-42. doi: 10.1016/j.cca.2014.01.015. Epub 2014 Feb 6. Review.

PMID:
24508990
39.

Genetic variation in SULF2 is associated with postprandial clearance of triglyceride-rich remnant particles and triglyceride levels in healthy subjects.

Matikainen N, Burza MA, Romeo S, Hakkarainen A, Adiels M, Folkersen L, Eriksson P, Lundbom N, Ehrenborg E, Orho-Melander M, Taskinen MR, Borén J.

PLoS One. 2013 Nov 20;8(11):e79473. doi: 10.1371/journal.pone.0079473. eCollection 2013.

40.

Dyslipidemia, but not hyperglycemia and insulin resistance, is associated with marked alterations in the HDL lipidome in type 2 diabetic subjects in the DIWA cohort: impact on small HDL particles.

Ståhlman M, Fagerberg B, Adiels M, Ekroos K, Chapman JM, Kontush A, Borén J.

Biochim Biophys Acta. 2013 Nov;1831(11):1609-17. doi: 10.1016/j.bbalip.2013.07.009. Epub 2013 Jul 27.

PMID:
23896361
41.

Cardiac steatosis associates with visceral obesity in nondiabetic obese men.

Granér M, Siren R, Nyman K, Lundbom J, Hakkarainen A, Pentikäinen MO, Lauerma K, Lundbom N, Adiels M, Nieminen MS, Taskinen MR.

J Clin Endocrinol Metab. 2013 Mar;98(3):1189-97. doi: 10.1210/jc.2012-3190. Epub 2013 Feb 15.

PMID:
23418318
42.

A continuous-time adaptive particle filter for estimations under measurement time uncertainties with an application to a plasma-leucine mixed effects model.

Krengel A, Hauth J, Taskinen MR, Adiels M, Jirstrand M.

BMC Syst Biol. 2013 Jan 19;7:8. doi: 10.1186/1752-0509-7-8.

43.

Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro.

Pirazzi C, Adiels M, Burza MA, Mancina RM, Levin M, Ståhlman M, Taskinen MR, Orho-Melander M, Perman J, Pujia A, Andersson L, Maglio C, Montalcini T, Wiklund O, Borén J, Romeo S.

J Hepatol. 2012 Dec;57(6):1276-82. doi: 10.1016/j.jhep.2012.07.030. Epub 2012 Aug 6.

PMID:
22878467
44.

Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant.

Palmer CN, Maglio C, Pirazzi C, Burza MA, Adiels M, Burch L, Donnelly LA, Colhoun H, Doney AS, Dillon JF, Pearson ER, McCarthy M, Hattersley AT, Frayling T, Morris AD, Peltonen M, Svensson PA, Jacobson P, Borén J, Sjöström L, Carlsson LM, Romeo S.

PLoS One. 2012;7(6):e39362. doi: 10.1371/journal.pone.0039362. Epub 2012 Jun 18.

45.

PNPLA3 I148M (rs738409) genetic variant is associated with hepatocellular carcinoma in obese individuals.

Burza MA, Pirazzi C, Maglio C, Sjöholm K, Mancina RM, Svensson PA, Jacobson P, Adiels M, Baroni MG, Borén J, Ginanni Corradini S, Montalcini T, Sjöström L, Carlsson LM, Romeo S.

Dig Liver Dis. 2012 Dec;44(12):1037-41. doi: 10.1016/j.dld.2012.05.006. Epub 2012 Jun 15.

PMID:
22704398
46.

Interleukin 15 mediates joint destruction in Staphylococcus aureus arthritis.

Henningsson L, Jirholt P, Bogestål YR, Eneljung T, Adiels M, Lindholm C, McInnes I, Bulfone-Paus S, Lerner UH, Gjertsson I.

J Infect Dis. 2012 Sep 1;206(5):687-96. doi: 10.1093/infdis/jis295. Epub 2012 Apr 16.

PMID:
22508940
47.

Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity.

Adiels M, Matikainen N, Westerbacka J, Söderlund S, Larsson T, Olofsson SO, Borén J, Taskinen MR.

Atherosclerosis. 2012 May;222(1):222-8. doi: 10.1016/j.atherosclerosis.2012.02.001. Epub 2012 Feb 7.

PMID:
22365426
48.

Clinical dyslipidaemia is associated with changes in the lipid composition and inflammatory properties of apolipoprotein-B-containing lipoproteins from women with type 2 diabetes.

Ståhlman M, Pham HT, Adiels M, Mitchell TW, Blanksby SJ, Fagerberg B, Ekroos K, Borén J.

Diabetologia. 2012 Apr;55(4):1156-66. doi: 10.1007/s00125-011-2444-6. Epub 2012 Jan 18.

PMID:
22252473
49.

Kinetic studies to investigate lipoprotein metabolism.

Borén J, Taskinen MR, Adiels M.

J Intern Med. 2012 Feb;271(2):166-73. doi: 10.1111/j.1365-2796.2011.02497.x. Review.

50.

Evaluation of macrophage-specific promoters using lentiviral delivery in mice.

Levin MC, Lidberg U, Jirholt P, Adiels M, Wramstedt A, Gustafsson K, Greaves DR, Li S, Fazio S, Linton MF, Olofsson SO, Borén J, Gjertsson I.

Gene Ther. 2012 Nov;19(11):1041-7. doi: 10.1038/gt.2011.195. Epub 2011 Dec 1.

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