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Items: 21


β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.

Adhikari AS, Trivedi DV, Sarkar SS, Song D, Kooiker KB, Bernstein D, Spudich JA, Ruppel KM.

Nat Commun. 2019 Jun 18;10(1):2685. doi: 10.1038/s41467-019-10555-9.


Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.

Trivedi DV, Adhikari AS, Sarkar SS, Ruppel KM, Spudich JA.

Biophys Rev. 2018 Feb;10(1):27-48. doi: 10.1007/s12551-017-0274-6. Epub 2017 Jul 17. Review.


Novel siRNA formulation to effectively knockdown mutant p53 in osteosarcoma.

Kundu AK, Iyer SV, Chandra S, Adhikari AS, Iwakuma T, Mandal TK.

PLoS One. 2017 Jun 21;12(6):e0179168. doi: 10.1371/journal.pone.0179168. eCollection 2017.


A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix.

Owen LM, Adhikari AS, Patel M, Grimmer P, Leijnse N, Kim MC, Notbohm J, Franck C, Dunn AR.

Mol Biol Cell. 2017 Jul 7;28(14):1959-1974. doi: 10.1091/mbc.E17-02-0102. Epub 2017 Jun 7.


The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.

Nag S, Trivedi DV, Sarkar SS, Adhikari AS, Sunitha MS, Sutton S, Ruppel KM, Spudich JA.

Nat Struct Mol Biol. 2017 Jun;24(6):525-533. doi: 10.1038/nsmb.3408. Epub 2017 May 8.


Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin.

Adhikari AS, Kooiker KB, Sarkar SS, Liu C, Bernstein D, Spudich JA, Ruppel KM.

Cell Rep. 2016 Dec 13;17(11):2857-2864. doi: 10.1016/j.celrep.2016.11.040.


Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin.

Spudich JA, Aksel T, Bartholomew SR, Nag S, Kawana M, Yu EC, Sarkar SS, Sung J, Sommese RF, Sutton S, Cho C, Adhikari AS, Taylor R, Liu C, Trivedi D, Ruppel KM.

J Exp Biol. 2016 Jan;219(Pt 2):161-7. doi: 10.1242/jeb.125930. Review.


Allele-specific silencing of mutant p53 attenuates dominant-negative and gain-of-function activities.

Iyer SV, Parrales A, Begani P, Narkar A, Adhikari AS, Martinez LA, Iwakuma T.

Oncotarget. 2016 Feb 2;7(5):5401-15. doi: 10.18632/oncotarget.6634.


Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments.

Hariadi RF, Sommese RF, Adhikari AS, Taylor RE, Sutton S, Spudich JA, Sivaramakrishnan S.

Nat Nanotechnol. 2015 Aug;10(8):696-700. doi: 10.1038/nnano.2015.132. Epub 2015 Jul 6.


Molecular tension sensors report forces generated by single integrin molecules in living cells.

Morimatsu M, Mekhdjian AH, Adhikari AS, Dunn AR.

Nano Lett. 2013 Sep 11;13(9):3985-9. doi: 10.1021/nl4005145. Epub 2013 Aug 28.


Multiplexed single-molecule force proteolysis measurements using magnetic tweezers.

Adhikari AS, Chai J, Dunn AR.

J Vis Exp. 2012 Jul 25;(65). pii: 3520. doi: 10.3791/3520.


Conformational dynamics accompanying the proteolytic degradation of trimeric collagen I by collagenases.

Adhikari AS, Glassey E, Dunn AR.

J Am Chem Soc. 2012 Aug 15;134(32):13259-65. doi: 10.1021/ja212170b. Epub 2012 Aug 1.


MTBP suppresses cell migration and filopodia formation by inhibiting ACTN4.

Agarwal N, Adhikari AS, Iyer SV, Hekmatdoost K, Welch DR, Iwakuma T.

Oncogene. 2013 Jan 24;32(4):462-70. doi: 10.1038/onc.2012.69. Epub 2012 Feb 27.


Strain tunes proteolytic degradation and diffusive transport in fibrin networks.

Adhikari AS, Mekhdjian AH, Dunn AR.

Biomacromolecules. 2012 Feb 13;13(2):499-506. doi: 10.1021/bm2015619. Epub 2012 Jan 24.


αB-crystallin, a small heat shock protein, modulates NF-κB activity in a phosphorylation-dependent manner and protects muscle myoblasts from TNF-α induced cytotoxicity.

Adhikari AS, Singh BN, Rao KS, Rao ChM.

Biochim Biophys Acta. 2011 Aug;1813(8):1532-42. doi: 10.1016/j.bbamcr.2011.04.009. Epub 2011 May 25.


MTBP plays a crucial role in mitotic progression and chromosome segregation.

Agarwal N, Tochigi Y, Adhikari AS, Cui S, Cui Y, Iwakuma T.

Cell Death Differ. 2011 Jul;18(7):1208-19. doi: 10.1038/cdd.2010.189. Epub 2011 Jan 28.


Mechanical load induces a 100-fold increase in the rate of collagen proteolysis by MMP-1.

Adhikari AS, Chai J, Dunn AR.

J Am Chem Soc. 2011 Feb 16;133(6):1686-9. doi: 10.1021/ja109972p. Epub 2011 Jan 19.


Metastatic potential of tumor-initiating cells in solid tumors.

Adhikari AS, Agarwal N, Iwakuma T.

Front Biosci (Landmark Ed). 2011 Jan 1;16:1927-38. Review.


CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance.

Adhikari AS, Agarwal N, Wood BM, Porretta C, Ruiz B, Pochampally RR, Iwakuma T.

Cancer Res. 2010 Jun 1;70(11):4602-12. doi: 10.1158/0008-5472.CAN-09-3463. Epub 2010 May 11.


Mutant p53 gain of oncogenic function: in vivo evidence, mechanism of action and its clinical implications.

Adhikari AS, Iwakuma T.

Fukuoka Igaku Zasshi. 2009 Jun;100(6):217-28. Review.


Heat stress-induced localization of small heat shock proteins in mouse myoblasts: intranuclear lamin A/C speckles as target for alphaB-crystallin and Hsp25.

Adhikari AS, Sridhar Rao K, Rangaraj N, Parnaik VK, Mohan Rao Ch.

Exp Cell Res. 2004 Oct 1;299(2):393-403.


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