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Items: 1 to 50 of 253

1.

DC-SCRIPT deficiency delays mouse mammary gland development and branching morphogenesis.

Tang C, van den Bijgaart RJE, Looman MWG, Tel-Karthaus N, de Graaf AMA, Gilfillan S, Colonna M, Ansems M, Adema GJ.

Dev Biol. 2019 Nov 1;455(1):42-50. doi: 10.1016/j.ydbio.2019.06.023. Epub 2019 Jun 29.

2.

An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells.

Narimatsu Y, Joshi HJ, Nason R, Van Coillie J, Karlsson R, Sun L, Ye Z, Chen YH, Schjoldager KT, Steentoft C, Furukawa S, Bensing BA, Sullam PM, Thompson AJ, Paulson JC, Büll C, Adema GJ, Mandel U, Hansen L, Bennett EP, Varki A, Vakhrushev SY, Yang Z, Clausen H.

Mol Cell. 2019 Jul 25;75(2):394-407.e5. doi: 10.1016/j.molcel.2019.05.017. Epub 2019 Jun 18.

PMID:
31227230
3.

A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis.

Jaeger M, Pinelli M, Borghi M, Constantini C, Dindo M, van Emst L, Puccetti M, Pariano M, Ricaño-Ponce I, Büll C, Gresnigt MS, Wang X, Gutierrez Achury J, Jacobs CWM, Xu N, Oosting M, Arts P, Joosten LAB, van de Veerdonk FL, Veltman JA, Ten Oever J, Kullberg BJ, Feng M, Adema GJ, Wijmenga C, Kumar V, Sobel J, Gilissen C, Romani L, Netea MG.

Sci Transl Med. 2019 Jun 12;11(496). pii: eaar3558. doi: 10.1126/scitranslmed.aar3558.

PMID:
31189718
4.

Immunotherapy and the Interventional Oncologist: Challenges and Opportunities-A Society of Interventional Oncology White Paper.

Erinjeri JP, Fine GC, Adema GJ, Ahmed M, Chapiro J, den Brok M, Duran R, Hunt SJ, Johnson DT, Ricke J, Sze DY, Toskich BB, Wood BJ, Woodrum D, Goldberg SN.

Radiology. 2019 Jul;292(1):25-34. doi: 10.1148/radiol.2019182326. Epub 2019 Apr 23.

5.

Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma.

Santegoets KCM, Gielen PR, Büll C, Schulte BM, Kers-Rebel ED, Küsters B, Bossman SAJFH, Ter Laan M, Wesseling P, Adema GJ.

Cancer Immunol Immunother. 2019 Jun;68(6):937-949. doi: 10.1007/s00262-019-02332-w. Epub 2019 Apr 5.

6.

Sialic acid glycoengineering using N-acetylmannosamine and sialic acid analogs.

Moons SJ, Adema GJ, Derks MT, Boltje TJ, Büll C.

Glycobiology. 2019 Jun 1;29(6):433-445. doi: 10.1093/glycob/cwz026.

PMID:
30913290
7.

Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates.

Cassetta L, Baekkevold ES, Brandau S, Bujko A, Cassatella MA, Dorhoi A, Krieg C, Lin A, Loré K, Marini O, Pollard JW, Roussel M, Scapini P, Umansky V, Adema GJ.

Cancer Immunol Immunother. 2019 Apr;68(4):687-697. doi: 10.1007/s00262-019-02302-2. Epub 2019 Jan 25. Review.

8.

Combined sialic acid and histone deacetylase (HDAC) inhibitor treatment up-regulates the neuroblastoma antigen GD2.

van den Bijgaart RJE, Kroesen M, Wassink M, Brok IC, Kers-Rebel ED, Boon L, Heise T, van Scherpenzeel M, Lefeber DJ, Boltje TJ, den Brok MH, Hoogerbrugge PM, Büll C, Adema GJ.

J Biol Chem. 2019 Mar 22;294(12):4437-4449. doi: 10.1074/jbc.RA118.002763. Epub 2019 Jan 22.

PMID:
30670592
9.

Adjuvants Enhancing Cross-Presentation by Dendritic Cells: The Key to More Effective Vaccines?

Ho NI, Huis In 't Veld LGM, Raaijmakers TK, Adema GJ.

Front Immunol. 2018 Dec 13;9:2874. doi: 10.3389/fimmu.2018.02874. eCollection 2018. Review.

10.

T-Cell Lymphopenia in Patients with Advanced Thyroid Carcinoma Is Associated with Poor Prognosis.

Rabold K, Gielen PR, Kers-Rebel ED, Netea MG, Smit JWA, Adema GJ, Netea-Maier RT.

Oncologist. 2019 Mar;24(3):e106-e110. doi: 10.1634/theoncologist.2018-0422. Epub 2019 Jan 3.

PMID:
30606882
11.

Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids.

Heise T, Pijnenborg JFA, Büll C, van Hilten N, Kers-Rebel ED, Balneger N, Elferink H, Adema GJ, Boltje TJ.

J Med Chem. 2019 Jan 24;62(2):1014-1021. doi: 10.1021/acs.jmedchem.8b01757. Epub 2018 Dec 31.

12.

Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity.

Kullaya V, de Jonge MI, Langereis JD, van der Gaast-de Jongh CE, Büll C, Adema GJ, Lefeber D, Cremers AJ, Mmbaga BT, de Groot PG, de Mast Q, van der Ven AJ.

Infect Immun. 2018 Sep 21;86(10). pii: e00213-18. doi: 10.1128/IAI.00213-18. Print 2018 Oct.

13.

Interactions among myeloid regulatory cells in cancer.

Umansky V, Adema GJ, Baran J, Brandau S, Van Ginderachter JA, Hu X, Jablonska J, Mojsilovic S, Papadaki HA, Pico de Coaña Y, Santegoets KCM, Santibanez JF, Serre K, Si Y, Sieminska I, Velegraki M, Fridlender ZG.

Cancer Immunol Immunother. 2019 Apr;68(4):645-660. doi: 10.1007/s00262-018-2200-6. Epub 2018 Jul 12. Review.

PMID:
30003321
14.

Dendritic Cells Actively Limit Interleukin-10 Production Under Inflammatory Conditions via DC-SCRIPT and Dual-Specificity Phosphatase 4.

Søndergaard JN, van Heeringen SJ, Looman MWG, Tang C, Triantis V, Louche P, Janssen-Megens EM, Sieuwerts AM, Martens JWM, Logie C, Stunnenberg HG, Ansems M, Adema GJ.

Front Immunol. 2018 Jun 22;9:1420. doi: 10.3389/fimmu.2018.01420. eCollection 2018.

15.

Selective Inhibition of Sialic Acid-Based Molecular Mimicry in Haemophilus influenzae Abrogates Serum Resistance.

Heise T, Langereis JD, Rossing E, de Jonge MI, Adema GJ, Büll C, Boltje TJ.

Cell Chem Biol. 2018 Oct 18;25(10):1279-1285.e8. doi: 10.1016/j.chembiol.2018.05.018. Epub 2018 Jul 5.

16.

Sialic Acid Blockade Suppresses Tumor Growth by Enhancing T-cell-Mediated Tumor Immunity.

Büll C, Boltje TJ, Balneger N, Weischer SM, Wassink M, van Gemst JJ, Bloemendal VR, Boon L, van der Vlag J, Heise T, den Brok MH, Adema GJ.

Cancer Res. 2018 Jul 1;78(13):3574-3588. doi: 10.1158/0008-5472.CAN-17-3376. Epub 2018 Apr 27.

17.

Lipid Droplets as Immune Modulators in Myeloid Cells.

den Brok MH, Raaijmakers TK, Collado-Camps E, Adema GJ.

Trends Immunol. 2018 May;39(5):380-392. doi: 10.1016/j.it.2018.01.012. Epub 2018 Feb 22. Review.

PMID:
29478771
18.

Cellular metabolism of tumor-associated macrophages - functional impact and consequences.

Rabold K, Netea MG, Adema GJ, Netea-Maier RT.

FEBS Lett. 2017 Oct;591(19):3022-3041. doi: 10.1002/1873-3468.12771. Epub 2017 Aug 11. Review.

19.

In vivo photoacoustics and high frequency ultrasound imaging of mechanical high intensity focused ultrasound (HIFU) ablation.

Daoudi K, Hoogenboom M, den Brok M, Eikelenboom D, Adema GJ, Fütterer JJ, de Korte CL.

Biomed Opt Express. 2017 Mar 20;8(4):2235-2244. doi: 10.1364/BOE.8.002235. eCollection 2017 Apr 1.

20.

Metabolic Oligosaccharide Engineering with Alkyne Sialic Acids Confers Neuraminidase Resistance and Inhibits Influenza Reproduction.

Heise T, Büll C, Beurskens DM, Rossing E, de Jonge MI, Adema GJ, Boltje TJ, Langereis JD.

Bioconjug Chem. 2017 Jul 19;28(7):1811-1815. doi: 10.1021/acs.bioconjchem.7b00224. Epub 2017 Jun 27.

21.

Impact of MR-guided boiling histotripsy in distinct murine tumor models.

Hoogenboom M, Eikelenboom DC, van den Bijgaart RJE, Heerschap A, Wesseling P, den Brok MH, Fütterer JJ, Adema GJ.

Ultrason Sonochem. 2017 Sep;38:1-8. doi: 10.1016/j.ultsonch.2017.02.035. Epub 2017 Feb 28.

PMID:
28633808
22.

Steering Siglec-Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry.

Büll C, Heise T, van Hilten N, Pijnenborg JF, Bloemendal VR, Gerrits L, Kers-Rebel ED, Ritschel T, den Brok MH, Adema GJ, Boltje TJ.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3309-3313. doi: 10.1002/anie.201612193. Epub 2017 Feb 14.

PMID:
28194834
23.

Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages.

Arts RJ, Plantinga TS, Tuit S, Ulas T, Heinhuis B, Tesselaar M, Sloot Y, Adema GJ, Joosten LA, Smit JW, Netea MG, Schultze JL, Netea-Maier RT.

Oncoimmunology. 2016 Sep 9;5(12):e1229725. doi: 10.1080/2162402X.2016.1229725. eCollection 2016.

24.

Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation.

Büll C, Collado-Camps E, Kers-Rebel ED, Heise T, Søndergaard JN, den Brok MH, Schulte BM, Boltje TJ, Adema GJ.

Immunol Cell Biol. 2017 Apr;95(4):408-415. doi: 10.1038/icb.2016.105. Epub 2016 Nov 22.

PMID:
27874015
25.

Saponin-based adjuvants induce cross-presentation in dendritic cells by intracellular lipid body formation.

den Brok MH, Büll C, Wassink M, de Graaf AM, Wagenaars JA, Minderman M, Thakur M, Amigorena S, Rijke EO, Schrier CC, Adema GJ.

Nat Commun. 2016 Nov 7;7:13324. doi: 10.1038/ncomms13324.

26.

Thermal and mechanical high-intensity focused ultrasound: perspectives on tumor ablation, immune effects and combination strategies.

van den Bijgaart RJ, Eikelenboom DC, Hoogenboom M, Fütterer JJ, den Brok MH, Adema GJ.

Cancer Immunol Immunother. 2017 Feb;66(2):247-258. doi: 10.1007/s00262-016-1891-9. Epub 2016 Sep 1. Review.

27.

Enterovirus Exposure Uniquely Discriminates Type 1 Diabetes Patients with a Homozygous from a Heterozygous Melanoma Differentiation-Associated Protein 5/Interferon Induced with Helicase C Domain 1 A946T Genotype.

Schulte BM, Gielen PR, Kers-Rebel ED, Prosser AC, Lind K, Flodström-Tullberg M, Tack CJ, Elving LD, Adema GJ.

Viral Immunol. 2016 Sep;29(7):389-97. doi: 10.1089/vim.2015.0140. Epub 2016 Aug 2.

PMID:
27482829
28.

Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma.

Kroesen M, Büll C, Gielen PR, Brok IC, Armandari I, Wassink M, Looman MW, Boon L, den Brok MH, Hoogerbrugge PM, Adema GJ.

Oncoimmunology. 2016 Mar 28;5(6):e1164919. doi: 10.1080/2162402X.2016.1164919. eCollection 2016 Jun.

29.

Sialic Acid Mimetics to Target the Sialic Acid-Siglec Axis.

Büll C, Heise T, Adema GJ, Boltje TJ.

Trends Biochem Sci. 2016 Jun;41(6):519-531. doi: 10.1016/j.tibs.2016.03.007. Epub 2016 Apr 13. Review.

PMID:
27085506
30.

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells.

Gram AM, Oosenbrug T, Lindenbergh MF, Büll C, Comvalius A, Dickson KJ, Wiegant J, Vrolijk H, Lebbink RJ, Wolterbeek R, Adema GJ, Griffioen M, Heemskerk MH, Tscharke DC, Hutt-Fletcher LM, Wiertz EJ, Hoeben RC, Ressing ME.

PLoS Pathog. 2016 Apr 14;12(4):e1005550. doi: 10.1371/journal.ppat.1005550. eCollection 2016 Apr.

31.

In vivo MR guided boiling histotripsy in a mouse tumor model evaluated by MRI and histopathology.

Hoogenboom M, Eikelenboom D, den Brok MH, Veltien A, Wassink M, Wesseling P, Dumont E, Fütterer JJ, Adema GJ, Heerschap A.

NMR Biomed. 2016 Jun;29(6):721-31. doi: 10.1002/nbm.3520. Epub 2016 Apr 7.

PMID:
27061290
32.

Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function.

Gielen PR, Schulte BM, Kers-Rebel ED, Verrijp K, Bossman SA, Ter Laan M, Wesseling P, Adema GJ.

Neuro Oncol. 2016 Sep;18(9):1253-64. doi: 10.1093/neuonc/now034. Epub 2016 Mar 22.

33.

Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected β cells.

Schulte BM, Kers-Rebel ED, Bottino R, Piganelli JD, Galama JM, Engelse MA, de Koning EJ, Adema GJ.

Clin Exp Immunol. 2016 Jun;184(3):293-307. doi: 10.1111/cei.12779. Epub 2016 Mar 23.

34.

Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity.

Bol KF, Aarntzen EH, Pots JM, Olde Nordkamp MA, van de Rakt MW, Scharenborg NM, de Boer AJ, van Oorschot TG, Croockewit SA, Blokx WA, Oyen WJ, Boerman OC, Mus RD, van Rossum MM, van der Graaf CA, Punt CJ, Adema GJ, Figdor CG, de Vries IJ, Schreibelt G.

Cancer Immunol Immunother. 2016 Mar;65(3):327-39. doi: 10.1007/s00262-016-1796-7. Epub 2016 Feb 10.

35.

Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals.

Hoogenboom M, van Amerongen MJ, Eikelenboom DC, Wassink M, den Brok MH, Hulsbergen-van de Kaa C, Dumont E, Adema GJ, Heerschap A, Fütterer JJ.

J Ther Ultrasound. 2015 Aug 13;3:14. doi: 10.1186/s40349-015-0035-6. eCollection 2015.

36.

Sialic Acid Glycoengineering Using an Unnatural Sialic Acid for the Detection of Sialoglycan Biosynthesis Defects and On-Cell Synthesis of Siglec Ligands.

Büll C, Heise T, Beurskens DM, Riemersma M, Ashikov A, Rutjes FP, van Kuppevelt TH, Lefeber DJ, den Brok MH, Adema GJ, Boltje TJ.

ACS Chem Biol. 2015 Oct 16;10(10):2353-63. doi: 10.1021/acschembio.5b00501. Epub 2015 Aug 10.

PMID:
26258433
37.

DC-SCRIPT Regulates IL-10 Production in Human Dendritic Cells by Modulating NF-κBp65 Activation.

Søndergaard JN, Poghosyan S, Hontelez S, Louche P, Looman MW, Ansems M, Adema GJ.

J Immunol. 2015 Aug 15;195(4):1498-505. doi: 10.4049/jimmunol.1402924. Epub 2015 Jul 13.

38.

Engineering monocyte-derived dendritic cells to secrete interferon-α enhances their ability to promote adaptive and innate anti-tumor immune effector functions.

Willemen Y, Van den Bergh JM, Lion E, Anguille S, Roelandts VA, Van Acker HH, Heynderickx SD, Stein BM, Peeters M, Figdor CG, Van Tendeloo VF, de Vries IJ, Adema GJ, Berneman ZN, Smits EL.

Cancer Immunol Immunother. 2015 Jul;64(7):831-42. doi: 10.1007/s00262-015-1688-2. Epub 2015 Apr 12.

PMID:
25863943
39.

Increase in both CD14-positive and CD15-positive myeloid-derived suppressor cell subpopulations in the blood of patients with glioma but predominance of CD15-positive myeloid-derived suppressor cells in glioma tissue.

Gielen PR, Schulte BM, Kers-Rebel ED, Verrijp K, Petersen-Baltussen HM, ter Laan M, Wesseling P, Adema GJ.

J Neuropathol Exp Neurol. 2015 May;74(5):390-400. doi: 10.1097/NEN.0000000000000183.

PMID:
25853692
40.

Mechanical high-intensity focused ultrasound destruction of soft tissue: working mechanisms and physiologic effects.

Hoogenboom M, Eikelenboom D, den Brok MH, Heerschap A, Fütterer JJ, Adema GJ.

Ultrasound Med Biol. 2015 Jun;41(6):1500-17. doi: 10.1016/j.ultrasmedbio.2015.02.006. Epub 2015 Mar 23. Review.

PMID:
25813532
41.

Enterovirus-infected β-cells induce distinct response patterns in BDCA1+ and BDCA3+ human dendritic cells.

Schulte BM, Gielen PR, Kers-Rebel ED, Schreibelt G, van Kuppeveld FJ, Adema GJ.

PLoS One. 2015 Mar 25;10(3):e0121670. doi: 10.1371/journal.pone.0121670. eCollection 2015.

42.

Intra-adrenal murine TH-MYCN neuroblastoma tumors grow more aggressive and exhibit a distinct tumor microenvironment relative to their subcutaneous equivalents.

Kroesen M, Brok IC, Reijnen D, van Hout-Kuijer MA, Zeelenberg IS, Den Brok MH, Hoogerbrugge PM, Adema GJ.

Cancer Immunol Immunother. 2015 May;64(5):563-72. doi: 10.1007/s00262-015-1663-y. Epub 2015 Feb 17.

43.

DC-SCRIPT is a novel regulator of the tumor suppressor gene CDKN2B and induces cell cycle arrest in ERα-positive breast cancer cells.

Ansems M, Søndergaard JN, Sieuwerts AM, Looman MW, Smid M, de Graaf AM, de Weerd V, Zuidscherwoude M, Foekens JA, Martens JW, Adema GJ.

Breast Cancer Res Treat. 2015 Feb;149(3):693-703. doi: 10.1007/s10549-015-3281-y. Epub 2015 Feb 8.

44.

Targeted delivery of a sialic acid-blocking glycomimetic to cancer cells inhibits metastatic spread.

Büll C, Boltje TJ, van Dinther EA, Peters T, de Graaf AM, Leusen JH, Kreutz M, Figdor CG, den Brok MH, Adema GJ.

ACS Nano. 2015 Jan 27;9(1):733-45. doi: 10.1021/nn5061964. Epub 2015 Jan 14.

PMID:
25575241
45.

Disease mutations in CMP-sialic acid transporter SLC35A1 result in abnormal α-dystroglycan O-mannosylation, independent from sialic acid.

Riemersma M, Sandrock J, Boltje TJ, Büll C, Heise T, Ashikov A, Adema GJ, van Bokhoven H, Lefeber DJ.

Hum Mol Genet. 2015 Apr 15;24(8):2241-6. doi: 10.1093/hmg/ddu742. Epub 2014 Dec 30.

PMID:
25552652
46.

Human TLR10 is an anti-inflammatory pattern-recognition receptor.

Oosting M, Cheng SC, Bolscher JM, Vestering-Stenger R, Plantinga TS, Verschueren IC, Arts P, Garritsen A, van Eenennaam H, Sturm P, Kullberg BJ, Hoischen A, Adema GJ, van der Meer JW, Netea MG, Joosten LA.

Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):E4478-84. doi: 10.1073/pnas.1410293111. Epub 2014 Oct 6.

47.

HDAC inhibitors and immunotherapy; a double edged sword?

Kroesen M, Gielen P, Brok IC, Armandari I, Hoogerbrugge PM, Adema GJ.

Oncotarget. 2014 Aug 30;5(16):6558-72. Review.

48.

Sweet escape: sialic acids in tumor immune evasion.

Büll C, den Brok MH, Adema GJ.

Biochim Biophys Acta. 2014 Aug;1846(1):238-46. doi: 10.1016/j.bbcan.2014.07.005. Epub 2014 Jul 12. Review.

PMID:
25026312
49.

Sialic acids sweeten a tumor's life.

Büll C, Stoel MA, den Brok MH, Adema GJ.

Cancer Res. 2014 Jun 15;74(12):3199-204. doi: 10.1158/0008-5472.CAN-14-0728. Epub 2014 May 15. Review.

50.

Toll-like receptor 6 stimulation promotes T-helper 1 and 17 responses in gastrointestinal-associated lymphoid tissue and modulates murine experimental colitis.

Morgan ME, Koelink PJ, Zheng B, den Brok MH, van de Kant HJ, Verspaget HW, Folkerts G, Adema GJ, Kraneveld AD.

Mucosal Immunol. 2014 Sep;7(5):1266-77. doi: 10.1038/mi.2014.16. Epub 2014 Mar 26.

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