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Items: 18

1.

Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.

Zhang HC, Derian CK, McComsey DF, White KB, Ye H, Hecker LR, Li J, Addo MF, Croll D, Eckardt AJ, Smith CE, Li Q, Cheung WM, Conway BR, Emanuel S, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE.

J Med Chem. 2005 Mar 24;48(6):1725-8.

PMID:
15771419
2.

3-(7-Azaindolyl)-4-arylmaleimides as potent, selective inhibitors of glycogen synthase kinase-3.

Zhang HC, Ye H, Conway BR, Derian CK, Addo MF, Kuo GH, Hecker LR, Croll DR, Li J, Westover L, Xu JZ, Look R, Demarest KT, Andrade-Gordon P, Damiano BP, Maryanoff BE.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3245-50.

PMID:
15149684
3.

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

Zhang HC, White KB, Ye H, McComsey DF, Derian CK, Addo MF, Andrade-Gordon P, Eckardt AJ, Conway BR, Westover L, Xu JZ, Look R, Demarest KT, Emanuel S, Maryanoff BE.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3049-53.

PMID:
12941331
4.

High-affinity thrombin receptor (PAR-1) ligands: a new generation of indole-based peptide mimetic antagonists with a basic amine at the C-terminus.

Zhang HC, White KB, McComsey DF, Addo MF, Andrade-Gordon P, Derian CK, Oksenberg D, Maryanoff BE.

Bioorg Med Chem Lett. 2003 Jul 7;13(13):2199-203.

PMID:
12798334
5.

Blockade of the thrombin receptor protease-activated receptor-1 with a small-molecule antagonist prevents thrombus formation and vascular occlusion in nonhuman primates.

Derian CK, Damiano BP, Addo MF, Darrow AL, D'Andrea MR, Nedelman M, Zhang HC, Maryanoff BE, Andrade-Gordon P.

J Pharmacol Exp Ther. 2003 Feb;304(2):855-61. Erratum in: J Pharmacol Exp Ther. 2003 Apr;305(1):402.

PMID:
12538843
6.

1,2,4-triazolo[3,4-a]pyridine as a novel, constrained template for fibrinogen receptor (GPIIb/IIIa) antagonists.

Lawson EC, Hoekstra WJ, Addo MF, Andrade-Gordon P, Damiano BP, Kauffman JA, Mitchell JA, Maryanoff BE.

Bioorg Med Chem Lett. 2001 Oct 8;11(19):2619-22.

PMID:
11551763
7.

Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide.

Zhang HC, McComsey DF, White KB, Addo MF, Andrade-Gordon P, Derian CK, Oksenberg D, Maryanoff BE.

Bioorg Med Chem Lett. 2001 Aug 20;11(16):2105-9.

PMID:
11514149
8.

Tritiated photoactivatable analogs of the native human thrombin receptor (PAR-1) agonist peptide, SFLLRN-NH2.

Elliott JT, Hoekstra WJ, Derian CK, Addo MF, Maryanoff BE, Ahern DG, Prestwich GD.

J Pept Res. 2001 Jun;57(6):494-506.

PMID:
11437953
9.

Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats.

Andrade-Gordon P, Derian CK, Maryanoff BE, Zhang HC, Addo MF, Cheung Wm, Damiano BP, D'Andrea MR, Darrow AL, de Garavilla L, Eckardt AJ, Giardino EC, Haertlein BJ, McComsey DF.

J Pharmacol Exp Ther. 2001 Jul;298(1):34-42.

PMID:
11408522
10.

Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.

Zhang HC, Derian CK, Andrade-Gordon P, Hoekstra WJ, McComsey DF, White KB, Poulter BL, Addo MF, Cheung WM, Damiano BP, Oksenberg D, Reynolds EE, Pandey A, Scarborough RM, Maryanoff BE.

J Med Chem. 2001 Mar 29;44(7):1021-4. No abstract available.

PMID:
11297447
11.

Thrombin receptor-activating peptides (TRAPs): investigation of bioactive conformations via structure-activity, spectroscopic, and computational studies.

Ceruso MA, McComsey DF, Leo GC, Andrade-Gordon P, Addo MF, Scarborough RM, Oksenberg D, Maryanoff BE.

Bioorg Med Chem. 1999 Nov;7(11):2353-71.

PMID:
10632045
12.

Design, synthesis, and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor.

Andrade-Gordon P, Maryanoff BE, Derian CK, Zhang HC, Addo MF, Darrow AL, Eckardt AJ, Hoekstra WJ, McComsey DF, Oksenberg D, Reynolds EE, Santulli RJ, Scarborough RM, Smith CE, White KB.

Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62.

13.

Heterocycle-peptide hybrid compounds. Aminotriazole-containing agonists of the thrombin receptor (PAR-1).

McComsey DF, Hawkins MJ, Andrade-Gordon P, Addo MF, Oksenberg D, Maryanoff BE.

Bioorg Med Chem Lett. 1999 May 17;9(10):1423-8.

PMID:
10360749
14.

Macrocyclic hexapeptide analogues of the thrombin receptor (PAR-1) activation motif SFLLRN.

McComsey DF, Hecker LR, Andrade-Gordon P, Addo MF, Maryanoff BE.

Bioorg Med Chem Lett. 1999 Jan 18;9(2):255-60. Erratum in: Bioorg Med Chem Lett 1999 May 17;9(10):1475.

PMID:
10021940
15.

Thrombin receptor (PAR-1) antagonists. Heterocycle-based peptidomimetics of the SFLLR agonist motif.

Hoekstra WJ, Hulshizer BL, McComsey DF, Andrade-Gordon P, Kauffman JA, Addo MF, Oksenberg D, Scarborough RM, Maryanoff BE.

Bioorg Med Chem Lett. 1998 Jul 7;8(13):1649-54.

PMID:
9873407
16.

Novel thieno[2,3-b]- and [3,4-b]pyrans as potassium channel openers. Thiophene systems--XVII.

Press JB, McNally JJ, Sanfilippo PJ, Addo MF, Loughney D, Giardino E, Katz LB, Falotico R, Haertlein BJ.

Bioorg Med Chem. 1993 Dec;1(6):423-35.

PMID:
8087564
18.

Chronic intracerebroventricular infusion of angiotensin II.

Addo MF, Isom GE.

Proc West Pharmacol Soc. 1979;22:247-9. No abstract available.

PMID:
515059

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