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Items: 25


ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males.

Abbeduto L, Thurman AJ, McDuffie A, Klusek J, Feigles RT, Ted Brown W, Harvey DJ, Adayev T, LaFauci G, Dobkins C, Roberts JE.

J Autism Dev Disord. 2019 Mar;49(3):960-977. doi: 10.1007/s10803-018-3796-2.


Curvilinear Association Between Language Disfluency and FMR1 CGG Repeat Size Across the Normal, Intermediate, and Premutation Range.

Klusek J, Porter A, Abbeduto L, Adayev T, Tassone F, Mailick MR, Glicksman A, Tonnsen BL, Roberts JE.

Front Genet. 2018 Aug 24;9:344. doi: 10.3389/fgene.2018.00344. eCollection 2018.


The role of reduced expression of fragile X mental retardation protein in neurons and increased expression in astrocytes in idiopathic and syndromic autism (duplications 15q11.2-q13).

Wegiel J, Brown WT, La Fauci G, Adayev T, Kascsak R, Kascsak R, Flory M, Kaczmarski W, Kuchna I, Nowicki K, Martinez-Cerdeno V, Wisniewski T, Wegiel J.

Autism Res. 2018 Oct;11(10):1316-1331. doi: 10.1002/aur.2003. Epub 2018 Aug 14.


Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety.

Klusek J, LaFauci G, Adayev T, Brown WT, Tassone F, Roberts JE.

J Neurodev Disord. 2017 May 2;9:16. doi: 10.1186/s11689-017-9197-6. eCollection 2017.


An ELISA DYRK1A non-radioactive kinase assay suitable for the characterization of inhibitors.

Liu Y, Adayev T, Hwang YW.

Version 2. F1000Res. 2017 Jan 13 [revised 2017 Jan 1];6:42. doi: 10.12688/f1000research.10582.2. eCollection 2017.


Detection and Quantification of the Fragile X Mental Retardation Protein 1 (FMRP).

LaFauci G, Adayev T, Kascsak R, Brown WT.

Genes (Basel). 2016 Dec 9;7(12). pii: E121. Review.


Fragile X protein in newborn dried blood spots.

Adayev T, LaFauci G, Dobkin C, Caggana M, Wiley V, Field M, Wotton T, Kascsak R, Nolin SL, Glicksman A, Hosmer N, Brown WT.

BMC Med Genet. 2014 Oct 28;15:119. doi: 10.1186/s12881-014-0119-0.


Fragile X screening by quantification of FMRP in dried blood spots by a Luminex immunoassay.

LaFauci G, Adayev T, Kascsak R, Kascsak R, Nolin S, Mehta P, Brown WT, Dobkin C.

J Mol Diagn. 2013 Jul;15(4):508-17. doi: 10.1016/j.jmoldx.2013.02.006. Epub 2013 May 7.


Gene dosage-dependent association of DYRK1A with the cytoskeleton in the brain and lymphocytes of down syndrome patients.

Dowjat K, Adayev T, Kaczmarski W, Wegiel J, Hwang YW.

J Neuropathol Exp Neurol. 2012 Dec;71(12):1100-12. doi: 10.1097/NEN.0b013e31827733c8.


Activity-dependent phosphorylation of dynamin 1 at serine 857.

Xie W, Adayev T, Zhu H, Wegiel J, Wieraszko A, Hwang YW.

Biochemistry. 2012 Aug 28;51(34):6786-96. Epub 2012 Aug 17.


Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice.

Mazur-Kolecka B, Golabek A, Kida E, Rabe A, Hwang YW, Adayev T, Wegiel J, Flory M, Kaczmarski W, Marchi E, Frackowiak J.

J Neurosci Res. 2012 May;90(5):999-1010. doi: 10.1002/jnr.23007. Epub 2012 Jan 18.


Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A).

Adayev T, Wegiel J, Hwang YW.

Arch Biochem Biophys. 2011 Mar 15;507(2):212-8. doi: 10.1016/ Epub 2010 Dec 24.


Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome.

Wegiel J, Kaczmarski W, Barua M, Kuchna I, Nowicki K, Wang KC, Wegiel J, Yang SM, Frackowiak J, Mazur-Kolecka B, Silverman WP, Reisberg B, Monteiro I, de Leon M, Wisniewski T, Dalton A, Lai F, Hwang YW, Adayev T, Liu F, Iqbal K, Iqbal IG, Gong CX.

J Neuropathol Exp Neurol. 2011 Jan;70(1):36-50. doi: 10.1097/NEN.0b013e318202bfa1.


The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome.

Wegiel J, Dowjat K, Kaczmarski W, Kuchna I, Nowicki K, Frackowiak J, Mazur Kolecka B, Wegiel J, Silverman WP, Reisberg B, Deleon M, Wisniewski T, Gong CX, Liu F, Adayev T, Chen-Hwang MC, Hwang YW.

Acta Neuropathol. 2008 Oct;116(4):391-407. doi: 10.1007/s00401-008-0419-6. Epub 2008 Aug 12.


Dual-specificity tyrosine phosphorylation-regulated kinase 1A does not require tyrosine phosphorylation for activity in vitro.

Adayev T, Chen-Hwang MC, Murakami N, Lee E, Bolton DC, Hwang YW.

Biochemistry. 2007 Jun 26;46(25):7614-24. Epub 2007 May 31.


Plasticity of 5-HT 1A receptor-mediated signaling during early postnatal brain development.

Mehta M, Ahmed Z, Fernando SS, Cano-Sanchez P, Adayev T, Ziemnicka D, Wieraszko A, Banerjee P.

J Neurochem. 2007 May;101(4):918-28. Epub 2007 Feb 16.


Trisomy-driven overexpression of DYRK1A kinase in the brain of subjects with Down syndrome.

Dowjat WK, Adayev T, Kuchna I, Nowicki K, Palminiello S, Hwang YW, Wegiel J.

Neurosci Lett. 2007 Feb 8;413(1):77-81. Epub 2006 Dec 4.


MNB/DYRK1A phosphorylation regulates the interactions of synaptojanin 1 with endocytic accessory proteins.

Adayev T, Chen-Hwang MC, Murakami N, Wang R, Hwang YW.

Biochem Biophys Res Commun. 2006 Dec 29;351(4):1060-5. Epub 2006 Nov 7.


Kinetic properties of a MNB/DYRK1A mutant suitable for the elucidation of biochemical pathways.

Adayev T, Chen-Hwang MC, Murakami N, Wegiel J, Hwang YW.

Biochemistry. 2006 Oct 3;45(39):12011-9.


Transmembrane signaling in the brain by serotonin, a key regulator of physiology and emotion.

Adayev T, Ranasinghe B, Banerjee P.

Biosci Rep. 2005 Oct-Dec;25(5-6):363-85. Review.


Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain.

Wegiel J, Kuchna I, Nowicki K, Frackowiak J, Dowjat K, Silverman WP, Reisberg B, DeLeon M, Wisniewski T, Adayev T, Chen-Hwang MC, Hwang YW.

Brain Res. 2004 Jun 4;1010(1-2):69-80.


The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.

Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P.

Biochim Biophys Acta. 2003 Apr 7;1640(1):85-96.


Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the phosphatidylserine-displaying apoptotic cells are phagocytosed by microglia.

Adayev T, Estephan R, Meserole S, Mazza B, Yurkow EJ, Banerjee P.

J Neurochem. 1998 Nov;71(5):1854-64. Erratum in: J Neurochem 1999 Feb;72(2):886.


Apoptosis is associated with an increase in saturated fatty acid containing phospholipids in the neuronal cell line, HN2-5.

Singh JK, Dasgupta A, Adayev T, Shahmehdi SA, Hammond D, Banerjee P.

Biochim Biophys Acta. 1996 Dec 13;1304(3):171-8. Erratum in: Biochim Biophys Acta 1997 Jun 2;1346(2):205-6.


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